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Therapeutic potential of Zataria multiflora:A narrative review of current evidence

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Asian Pacific Journal of Tropical Biomedicine 2023年第11期13卷 451-459页

作者： Reza Nosratabadi fatemeh Anaeigoudari Akbar Anaeigoudari Department of Medical Immunology Afzalipour Faculty of MedicineKerman University of Medical SciencesKermanIran Student Research Committee Afzalipour Faculty of MedicineKerman University of Medical SciencesKermanIran Student Research Committee Jiroft University of Medical SciencesJiroftIran Department of Physiology School of MedicineJiroft University of Medical SciencesJiroftIran

Zataria multiflora Boiss is a perennial plant with a wide spectrum of biological and pharmacological activities including antidiabetic,antinociceptive,anti-asthmatic,anti-fever,anti-spastic,anti-oxidative,anti-inflammatory,and antimicrobial *** paper reviews the therapeutic effects of Zataria multiflora based on recent *** relevant reports were extracted by checking the electronic databases including PubMed,Scopus,Web of Science,and Google Scholar from the beginning of 2010 until the end of May *** neuroprotective effects of Zataria multiflora can be attributed to inhibition of acetylcholinesterase,enhancement of brain-derived neurotrophic factor,and alleviation of brain oxidative *** multiflora also exerts its protective effects on the respiratory system,liver,and kidney by reducing the level of inflammatory cytokines,scavenging the free radicals,and augmenting the antioxidant ***,Zataria multiflora accelerates wound healing via upregulating transforming growth factor-β,insulin-like growth factor 1,fibroblast growth factor 2,and vascular endothelial growth factor,and inducing angiogenesis and collagen ***,the protective impacts of Zataria multiflora on different organs are mainly attributed to its antioxidant and antiinflammatory properties.

关键词： Zataria multiflora Anti-inflammmatory Antioxidative Neuroprotective Organs

p-Toluenesulfonyl chloride as a new and effective catalyst for acetylation and formylation of hydroxyl compounds under mild conditions

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Chinese Chemical Letters 2010年第12期21卷 1430-1434页

作者： Ardeshir Khazaei Amin Rostami fatemeh Mantashlo Faculty of Chemistry Bu-Ali Sina UniversityHamedan ***Iran Department of Chemistry Faculty of ScienceUniversity of KurdistanSanandaj 66135Iran

The catalytic application of p-toluenesulfonyl chloride for efficient acetylation of various types of alcohols and phenols with acetic anhydride in solvent-free conditions is *** structurally diverse alcohols were formylated using formic acid based on the use of catalytic amount of p-toluenesulfonyl chloride under solvent-free *** reactions were carried out in short reaction time and in good to excellent yields at room temperature.

关键词： p-Toluenesulfonyl chloride Hydroxyl compounds Acetylation Forrnylation

Electrooxidation of hydroquinone on simply prepared Au-Pt bimetallic nanoparticles

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Science China Chemistry 2013年第6期56卷 746-754页

作者： ETESAMI Mohammad KAROONIAN fatemeh Salehi MOHAMED Norita School of Chemical Sciences Universiti Sains Malaysia (USM)

A facile method was used to prepare gold-platinum （Au-Pt） catalysts by direct electrodeposition via cyclic voltammetry in an acidic medium. Various parameters that affect the properties of electrodeposited catalysts were investigated such as initial ap- plied potential, scan rate and deposition time. Initial applied potential plays a more important role in the preparation of bime- tallic nanoparticles （AuPtNPs） since the kinetics of electrodeposition is in competition with the rate of hydrogen evolution. The AuPtNPs electrodeposited on pencil graphite （PG） were used to study the electrooxidation of hydroquinone. Various parame- ters such as pH, scan rate, concentration of hydroquinone and temperature were studied in the electrooxidation process. Ap- parent activation energy （Ea） for the electrooxidation of hydroquinone, calculated from the Arrhenius plot, shows that AuPtNPs catalysts （electrodeposited on the PG） offer less activation energy （ca. 9.500 kJ mo1-1） than the bare PG （ca. 10.345 kJ mol-1）. The AuPtNPs/PG shows better catalytic performance than the PG electrode due to the greater surface area it provides, thus re- sulting in more active sites available for adsorption of hydroquinone molecules on the surface of the catalyst.

关键词： bimetallic catalyst nanoparticles electrooxidation hydroquinone

Measurement and calculation of solubility of quinine in supercritical carbon dioxide

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Chinese Journal of Chemical Engineering 2017年第5期25卷 641-645页

作者： fatemeh Zabihi Mehrdad Mirzajanzadeh Jingfu Jia Yaping Zhao Department of Chemical Engineering Islamic Azad UniversityAyatollah Amoli Branch Amol Department of Chemical Engineering Islamic Azad UniversityTehran Science and Research Branch School of Chemistry & Chemical Engineering Shanghai Jiaotong University

Solubility of quinine in supercritical carbon dioxide(SCCO_2) was experimentally measured in the pressure range of 8 to 24 MPa, at three constant temperatures: 308.15 K, 318.15 K and 328.15 K. Measurement was carried out in a semi-dynamic system. Experimental data were correlated by iso-fugacity model(based on cubic equations of state, CEOS), Modified Mendez–Santiago–Teja(MST) and Modified Bartle semi-empirical models. Two cubic equations of state: Peng–Robinson(PR) and Dashtizadeh–Pazuki–Ghotbi–Taghikhani(DPTG) were adopted for calculation of equilibrium parameters in CEOS modeling. Interaction coefficients(k_(ij)& l_(ij)) of van der Waals(vdW) mixing rules were considered as the correlation parameters in CEOS-based modeling and their contribution to the accuracy of model was investigated. Average Absolute Relative Deviation(AARD) between correlated and experimental data was calculated and compared as the index of validity and accuracy for different modeling systems. In this basis it was realized that the semi-empirical equations especially Modified MST can accurately support the theoretical studies on phase equilibrium behavior of quinine–SCCO_2 media. Among the cubic equations of state DPGT within two-parametric vd W mixing rules provided the best data fitting and PR within one-parametric vd W mixing rules demonstrated the highest deviation respecting to the experimental data. Overall, in each individual modeling system the best fitting was observed on the data points attained at 318 K, which could be perhaps due to the moderate thermodynamic state of supercritical phase.

关键词： Supercritical fluid Solubility Semi-empirical model Iso-fugacity Quinine

In vitro and in vivo susceptibility of Leishmania major to some medicinal plants

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Asian Pacific Journal of Tropical Biomedicine 2017年第1期7卷 37-42页

作者： fatemeh Maleki Mitra Zarebavani Mehdi Mohebali Mohammad Saaid Dayer Fateme Hajialiani fatemeh Tabatabaie Faculty of Para Medical Sciences Iran University of Medical SciencesTehranIran Allied Medical Sciences Medical Laboratory SciencesTehran University of Medical SciencesTehranIran Center for Research of Endemic Parasites of Iran(CREPI) Tehran University of Medical SciencesTehranIran Department of Parasitology and Medical Entomology Faculty of Medical SciencesTarbiat Modares UniversityTehranIran Department of Parasitology and Mycology Faculty of MedicineIran University of Medical SciencesTehranIran

Objective: To evaluate the efficacy of some medicinal plants and systemic glucantime in a comparative manner against the causative agent of cutaneous leishmaniasis both in vitro and in BALB/c ***: For in vivo testing, inbred mice were challenged with Leishmania major parasites and the resultant ulcers were treated with extract based-ointments applied topically two times per day for a period of 20 days. A group of 56 mice were randomly divided into 7 subgroups. The control group received the ointment void of extracts,whereas the reference group received glucantime only. The efficacy of treatments was evaluated by measuring ulcer diameter, parasite burden and NO ***: Our results indicated that plant extract based-ointments were effective in reducing ulcer size and parasite burden in spleens, but their effects did not differ significantly from that of glucantime. The plant extracts tested in this study were able to increase NO production that helped parasite ***: Our findings indicate that the tested plant extracts are effective against Leishmania major both during in vitro and in vivo experiments, but further researches are required to recommend a potential plant extract as an alternative drug.

关键词： Leishmaniasis Glucantime Plant extracts Mice Medicinal plants

CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?

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Frontiers of Medicine 2022年第3期16卷 322-338页

作者： Pooria Safarzadeh Kozani Pouya Safarzadeh Kozani fatemeh Rahbarizadeh Department of Medical Biotechnology Faculty of Medical SciencesTarbiat Modares UniversityTehranP.O.Box 14115/111Iran Department of Medical Biotechnology Faculty of ParamedicineGuilan University of Medical SciencesRashtP.O.Box 44771/66595Iran Research and Development Center of Biotechnology Tarbiat Modares UniversityTehranP.O.Box 14115/111Iran

Immune-based therapies have experienced a pronounced breakthrough in the past decades as they acquired multiple US Food and Drug Administration(FDA)approvals for various *** date,six chimeric antigen receptor T cell(CAR-T)therapies have been permitted for the treatment of certain patients with relapsed/refractory hematologic ***,several clinical trials of solid tumor CAR-T therapies were prematurely terminated,or they reported life-threatening treatment-related damages to healthy *** simultaneous expression of target antigens by healthy organs and tumor cells is partly responsible for such *** targeting tumor-specific antigens,targeting the aberrantly glycosylated glycoforms of tumor-associated antigens can also minimize the off-tumor effects of CAR-T ***,T,and sialyl-Tn antigens have been reported to be involved in tumor progression and metastasis,and their expression results from the dysregulation of a series of glycosyltransferases and the endoplasmic reticulum protein chaperone,***,these glycoforms have been associated with various types of cancers,including prostate,breast,colon,gastric,and lung ***,we discuss how underglycosylated antigens emerge and then detail the latest advances in the development of CAR-T-based immunotherapies that target some of such antigens.

关键词： cancer immunotherapy chimeric antigen receptor solid tumors tumor-associated antigen glycosylation O-glycans adoptive cell therapy

Persian medicine non-pharmacological therapies for headache：phlebotomy and wet cupping

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Journal of Traditional Chinese Medicine 2018年第3期38卷 457-464页

作者： Akramo Sadat Atyabi fatemeh Nejatbakhsh Hoorie Mohammadi Kenari fatemeh Eghbalian Mohammad Hos-sein Ayati Laila Shirbeigi Department of Traditional Medicine School of Traditional Medicine Tehran University of Medical Sciences Tehran *** Iran Research Institute for Islamicand Complementary Medicine School of Traditional Medicine Iran University of Medical Sciences Tehran*** Iran Department of History of Medicine School of Traditional Medicine Tehran University of Medical Sciences Tehran *** Iran

OBJECTIVE: To describe the common causes of headache as well as the different methods of Phlebotomy(Fasd) and wet Cupping(Hijamat) based on Persian ***: In this study, we searched Google Scholar, Science Direct, Pub Med and Scopus to get any in vitro or clinical evidence of the efficacy and possible mechanisms of phlebotomy or wet cupping on different types of headaches. Also different types of headaches, according to PM, under the title of "Sodaa"; extracted from famous Persian medical text books with key words including "Sodaa","Bayze" and "Shaqiqe".RESULTS: According to PM, diseases(dystemperament) are created by abnormal alteration in temperament. Temperament is a monolithic quality yielded by interaction between opposing qualities of four elements that are coldness, hotness, dryness and wetness. Headaches are caused by dystemperament(sue-Mizaj) in brain or in total body that are divided into simple and corporal. Common forms of the latter type are Vaporal and Migrant headache(Bokhari and Rihi). Each of these headaches is treated either through phlebotomy or wet ***: In Persian Medicine, Fasd and Hijamat are easy and economical methods for treatment of headache with reasonable results. By describing the precise areas and indications of phlebotomy and wet cupping, this study provides the first step for future clinical trials in this field.

关键词： Headache Phlebotomy Cupping thera-py Sodaa Persian Medicine

Calculation of the structural properties of a strange quark star in the presence of a strong magnetic field using a density dependent bag constant

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Research in Astronomy and Astrophysics 2012年第9期12卷 1280-1290页

作者： Gholam Hossein Bordbar Hajar Bahri fatemeh Kayanikhoo Department of Physics Shiraz University Shiraz 71454 Iran Research Institute for Astronomy and Astrophysics of Maragha P.O. Box 55134-441 Maragha Iran

We have calculated the structural properties of a strange quark star with a static model in the presence of a strong magnetic field. To this end, we use the MIT bag model with a density dependent bag constant. To parameterize the density dependence of the bag constant, we have used our results for the lowest order constrained variational calculation of the asymmetric nuclear matter. By calculating the equation of state of strange quark matter, we have shown that the pressure of this system increases by increasing both density and magnetic field. Finally, we have investigated the effect of density dependence of the bag constant on the structural properties of a strange quark star.

关键词： stars: dense matter — equation of state — ISM: structure — supernova remnants

Synthesis of TiO_2 nanoparticles in different thermal conditions and modeling its photocatalytic activity with artificial neural network

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Journal of Environmental Sciences 2012年第4期24卷 750-756页

作者： fatemeh Ghanbary Nasser Modirshahla Morteza Khosravi Mohammad Ali Behnajady Department of Applied Chemistry Faculty of ChemistryNorth Tehran BranchIslamic Azad UniversityTehran***Islamic Republic of Iran Research Laboratory Department of Applied ChemistryTabriz BranchIslamic Azad UniversityTabriz1655Islamic Republic of Iran

Titanium dioxide （TiO2） nanoparticles were prepared by sol gel route. The preparation parameters were optimized in the removal of 4-nitropbenol （4-NP）. All catalysts were analyzed by X-ray diffraction （XRD） and scanning electron microscopy （SEM）. An artificial neural network model （ANN） was developed to predict the photocatalytic removal of 4-NP in the presence of TiOz nanoparticles prepared under desired conditions. The comparison between the predicted results by designed ANN model and the experimental data proved that modeling of the removal process of 4-NP using artificial neural network was a precise method to predict the extent of 4-NP removal under different conditions.

关键词： nanoparticle TiO2 4-nitrophenol photocatalysis neural network modeling