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Comparison of the effects of acute and chronic psychological stress on metabolic features in rats

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第11期13卷 904-912页

作者： fatemeh rostamkhani Homeira ZARDOOZ Saleh ZAHEDIASL Babak FARROKHI Neuroscience Research Center Shahid Beheshti University of Medical SciencesTehranIran Department of Biology Shahre-Rey BranchIslamic Azad UniversityTehranIran Department of Physiology Faculty of MedicineShahid Beheshti University of Medical SciencesTehranIran Endocrine Research Center Research Institute for Endocrine SciencesShahid Beheshti University of Medical SciencesTehranIran Department of Immunology Faculty of MedicineShahid Beheshti University of Medical SciencesTehranIran

This study was aimed to compare the effects of acute and chronic psychological stress on metabolic factors. Forty-two male Wistar rats were divided into control and stressed groups. Stress was applied by a communication box acutely (1 d) and chronically (15 and 30 d). Blood sampling was carried out by retro-orbital-puncture method. The plasma levels of glucose, cholesterol, triglyceride, insulin, and corticosterone were measured. In addition, feed and water intake, latency to eat and drink, adrenal and body weights were determined. Acute and chronic psychological stress did not significantly change basal plasma corticosterone levels. However, immediately (1 min) after acute exposure to stress, plasma corticosterone level increased compared to that before stress exposure. Acute stress increased plasma insulin levels significantly. Fifteen days of stress exposure resulted in plasma glucose increase. Chronic stress significantly increased feed intake, latency to eat, and adrenal weight compared to acute stress. The body weights of both control and stressed groups increased markedly during the experiment. Homeostasis model assessment of insulin resistance (HOMA-IR) index did not change significantly in the stressed group. In conclusion, application of acute and chronic psychological stress leads to different metabolic and/or behavioral changes but the metabolic changes resulting from acute exposure to stress seem to be more pronounced.

关键词： Psychological stress Corticosterone Insulin Glucose Cholesterol Triglyceride

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