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Single intratesticular injection of blood-serum-derived exosomes can potentially alleviate testopathy following testicular torsion

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Animal Models and Experimental Medicine 2022年第4期5卷 362-368页

作者： Mona Keivan Fatemeh Mansouri Torghabeh Samira Davoodi Shima Moradi Maryamneghari Reza Dadfar Member of Research Committee Medical SchoolKermanshah University of Medical SciencesKermanshahIran Department of Physiology Sciences Medical SchoolMashhad University of Medical SciencesMashhadIran Department of Anatomical Sciences Medical SchoolKermanshah University of Medical SciencesKermanshahIran Department of Anatomical Sciences Faculty of MedicineAJA University of Medical SciencesTehranIran

Background:Testicular torsion(TT)is an acute inflammatory process leading to male infertility.Today,anti-i nflammatory effects of exosomes derived from blood serum are used in various laboratory procedures.In the present study,the anti-i nflammatory effects of blood-serum-derived exosomes in treatment of acute inflammation following TT in mice were evaluated.Materials and Methods:Eighteen male mice were grouped as healthy control,TT,and TT+exosome.TT was induced surgically,and exosomes were extracted from blood serum and administrated by a single intratesticular injection(10 IU).Malondialdehyde(MDA)and Griess assays were used to evaluate the level of oxidative stress.Sperm indices,testosterone(Tes),and apoptotic gene expression(p-53,Bcl2,and Caspase-3)were also assessed.H&E and immunohistochemistry(IHC)stainings were used for histopathological investigations.Data analysis was applied by SPSS(v.19)software.Results:Oxidative stress and apoptotic genes expression were increased significantly(p<0.05)in TT group compared with control.Sperm parameters and Tes were significantly increased,and expression of apoptotic genes was significantly reduced in TT+exosome group(p<0.05).Conclusion:Since the blood-serum-derived exosomes have anti-i nflammatory features,the intratesticular application of blood-serum-derived exosomes can be used clinically in acute phase of orchitis following TT to inhibit testicular inflammation.

关键词： anti-i nflammation exosome parameter sperm testicular torsion

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