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Nuclear Science and Techniques 2023年第5期34卷 47-55页

作者： fatemeh Mansourzadeh Mohammad Mahdi Shadman Javad Karimi Sabet Valiyollah Ghazanfari Nuclear Fuel Cycle Research School Nuclear Science and Technology Research InstituteTehranIran

The thermal diffusion column represents one method of separating stable *** method is advantageous for smallscale operations because of the simplicity of the apparatus and small inventory,especially in gas-phase ***,it has attracted attention for its applicability in tritium and noble gas separation *** this study,the R cascade was used to design and determine the number of columns.A square cascade was adopted for the final design because of its flexibility,and calculations were performed to separate 20Ne and 22Ne *** the R cascades that enriched the Ne isotopes by more than 99%were investigated,the number of columns was determined,and the square cascade parameters were optimized using the specified ***,a calculation code“RSQ_CASCADE”was developed.A unit separation factor of three was considered,and the number of studied stages ranged from 10 to *** results showed that the column separation power,relative total flow rate,and required number of columns were linearly related to the number of *** separation power and relative total flow decreased and the number of columns increased as the stage number ***,a cascade of 85 columns is recommended to separate the stable Ne *** calculations yielded a 17-stage square cascade with five columns in each *** changing the stage cut,feed point,and cascade feed flow rate,the best parameters for the square cascade were determined according to the cascade and column separation *** the column separation power had a maximum value in cascade feed 50,it was selected for separating Ne isotopes.

关键词： Stable isotope Thermal diffusion Cascade Separation Neon

RNA sequencing role and application in clinical diagnostic

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Pediatric Investigation 2022年第1期6卷 29-35页

作者： fatemeh Peymani Aiman Farzeen Holger Prokisch School of Medicine Institute of Human GeneticsTechnical University of MunichMunichGermany Institute of Neurogenomics Computational Health CenterHelmholtz Centre MunichNeuherbergGermany

Although whole-exome sequencing and whole-genome sequencing has tremendously improved our understanding of the genetic etiology of human disorders,about half of the patients still do not receive a molecular *** high fraction of variants with uncertain significance and the challenges of interpretation of noncoding variants have urged scientists to implement RNA sequencing(RNA-seq)in the diagnostic approach as a high throughput assay to complement genomic data with functional ***-seq data can be used to identify aberrantly spliced genes,detect allele-specific expression,and identify gene expression *** eight studies utilizing RNA-seq,a mean diagnostic uplift of 15%has been ***,we provide an overview of how RNA-seq has been implemented to aid in identifying the causal variants of Mendelian disorders.

关键词： Aberrant expression Clinical diagnosis Gene expression outliers Genetics diagnosis RNA phenotype RNA sequencing Transcriptome

A review: Systematic research approach on toxicity model of liver and kidney in laboratory animals

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Animal Models and Experimental Medicine 2022年第5期5卷 436-444页

作者： Abbasali Abbasnezhad fatemeh Salami Reza Mohebbati Department of Physiology Faculty of MedicineGonabad University of Medical SciencesGonabadIran Department of Physiology Faculty of MedicineMashhad University of Medical SciencesMashhadIran Applied Biomedical Research Center Mashhad University of Medical SciencesMashhadIran

Therapeutic experiments are commonly performed on laboratory animals to inves-tigate the possible mechanism(s)of action of toxic agents as well as drugs or sub-stances under *** use of toxins in laboratory animal models,including rats,is intended to cause *** study aimed to investigate different models of hepatotoxicity and nephrotoxicity in laboratory animals to help researchers advance their research *** current narrative review used databases such as Medline,Web of Science,Scopus,and Embase and appropriate keywords until June *** and hepatotoxicity models derived from some toxic agents such as cisplatin,acetaminophen,doxorubicin,some anticancer drugs,and other materials through various signaling pathways are *** understand the models of renal or hepatotoxicity in laboratory animals,we have provided a list of toxic agents and their toxicity procedures in this review.

关键词： animal drug toxicity drug-induced abnormality liver dysfunction renal injury

Sphingosine phosphate lyase insufficiency syndrome:a systematic review

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World Journal of Pediatrics 2023年第5期19卷 425-437页

作者： Zahra Pournasiri Abbas Madani fatemeh Nazarpack John A.Sayer Zahra Chavoshzadeh fatemeh Nili Paulina Tran Julie D.Saba Mahnaz Jamee Pediatric Nephrology Research Center Research Institute for Children’s HealthShahid Beheshti University of Medical SciencesTehranIran Department of Pediatric Nephrology Children’s Medical CenterPediatric Chronic Kidney Disease Research CenterTehran University of Medical SciencesTehranIran Translational and Clinical Research Institute Faculty of Medical SciencesNewcastle UniversityCentral ParkwayNewcastle upon TyneNE13BZUK Renal Services Newcastle Upon Tyne Hospitals NHS Foundation TrustNewcastle upon TyneNE77DNUK NIHR Newcastle Biomedical Research Centre Newcastle UniversityNewcastle upon TyneNE45PLTyne and WearUK Immunology and Allergy Department Mofid Children’s HospitalShahid Beheshti University of Medical SciencesTehran15514-15468Iran Department of Pathology Imam Khomeini Complex HospitalTehran University of Medical SciencesTehranIran Allergy Immunology Division Department of PediatricsChildren’s Hospital of PhiladelphiaPhiladelphiaUSA Perelman School of Medicine at the University of Pennsylvania PhiladelphiaUSA Division of Hematology/Oncology Department of PediatricsUniversity of CaliforniaSan FranciscoCAUSA

Background Sphingosine-1-phosphate lyase insufficiency syndrome(SPLIS)or nephrotic syndrome type-14 is caused by biallelic mutations in ***,we conducted a systematic review to delineate the characteristics of SPLIS *** A literature search was performed in PubMed,Web of Science,and Scopus databases,and eligible studies were *** all patients,demographic,clinical,laboratory,and molecular data were collected and *** Fifty-five SPLIS patients(54.9%male,45.1%female)were identified in 19 *** consanguinity and positive family history were reported in 70.9%and 52.7%of patients,*** patients(54.9%)primarily manifested within the first year of life,nearly half of whom survived,while all patients with a prenatal diagnosis of SPLIS(27.5%)died at a median[interquartile(IQR)]age of 2(1.4–5.3)months(P=0.003).The most prevalent clinical feature was endocrinopathies,including primary adrenal insufficiency(PAI)(71.2%)and hypothyroidism(32.7%).Kidney disorders(42,80.8%)were mainly in the form of steroid-resistant nephrotic syndrome(SRNS)and progressed to end-stage kidney disease(ESKD)in 19(36.5%)patients at a median(IQR)age of 6(1.4–42.6)*** 30 different mutations in SGPL1,the most common was c.665G>A(***222Gln)in 11(20%)***-six(49.1%)patients with available outcome were deceased at a median(IQR)age of 5(1.5–30.5)months,mostly following ESKD(23%)or sepsis/septic shock(23%).Conclusion In patients with PAI and/or SRNS,SGPL1 should be added to diagnostic genetic panels,which can provide an earlier diagnosis of SPLIS and prevention of ESKD and other life-threatening complications.

关键词： Nephrotic syndrome type 14 Immunodeficiency Lymphopenia Sphingosine-1-phosphate lyase 1 Sphingosine-1-phosphate lyase insufficiency syndrome

Central Granular Cell Odontogenic Tumor: A Literature Review of Cases Reported in the Last 71 Years with a New Case Report

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Chinese Medical Sciences Journal 2023年第2期38卷 138-146页

作者： fatemeh Mashhadiabbas Sanaz GholamiToghchi Roohollah Safarpour Department of Oral and Maxillofacial Pathology School of DentistryShahid Beheshti University of Medical SciencesTehran ***Iran Department of Oral and Maxillofacial Pathology School of DentistryLorestan University of Medical SciencesKhorramabad ***Iran

Central granular cell odontogenic tumors(CGCOTs)are rare,benign,slowly growing odontogenic *** to their uncertain histogenesis,CGCOTs are still not included as a distinct entity in the WHO classification(2017)of odontogenic *** report a case of CGCOT involving the right side of maxillary anterior region of a 39-year-old white *** staining showed that granular cells positively expressed CD68 and vimentin,and negatively expressed S-100 ***,we searched Pub Med,Google Scholar,and Scopus databases to summary the clinico-pathological features of 51 reported cases of *** results showed that the granular cells of 28.6%cases were immunopositive for vimentin and CD68,and odontogenic epithelial cells were positive immunoreactivity for *** findings reinforced the mesenchymal origin of granular cells and the odontogenic nature of epithelium islands.

关键词： central granular cell odontogenic tumor central granular cell odontogenic fibroma odontogenic tumor granular cell ameloblastic fibroma histogenesis

Effects of variations of voltage and pH value on the shear strength of soil and durability of different electrodes and piles during electrokinetic phenomenon

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第2期14卷 625-636页

作者： fatemeh Sadeghian Soheil Jahandari Abdolhosein Haddad Haleh Rasekh Jie Li Department of Civil Engineering Semnan UniversitySemnanIran Centre for Infrastructure Engineering Western Sydney UniversityPenrith2000Australia School of Civil and Environmental Engineering University of Technology SydneySydney2007Australia School of Engineering RMIT UniversityMelbourne3000Australia

Electrokinetic(EK)treatment is an effective method in accelerating the consolidation and improving the geotechnical properties of fine-grained *** method stabilizes the soil and increases the bearing capacity of piles by improving the soil shear *** the soil p H,due to the occurrence of chemical reactions of electrolysis in the soil,can increase its shear ***,the electrodes used in this method corrode due to the change in the soil p H,which in turn reduces the electrical *** corrosion and loss of electrical potential can significantly reduce the efficiency of the EK *** addition,when using the EK method to increase the bearing capacity of piles,changing the p H can cause corrosion and damage to the *** of the most important factors influencing the change in the p H of soil is the voltage applied during the EK *** was reported that increasing the voltage affects the intensity of chemical reactions and electroosmotic flow and thus increases the efficiency of ***,very limited research has been conducted on the effect of voltage on the performance of EK *** the present study,the effects of three voltages on soil p H and corrosion resistance of four types of electrodes including iron(Ir),stainless steel(St),copper(Co),and aluminium(Al)were *** addition,the effects of p H variations on the corrosion rate of three types of piles including steel pile(SP),reinforced cement concrete pile(RCCP),and reinforced lime-cement concrete pile(RLCCP)were *** was observed that increasing the voltage from a specific limit had no effect on the intensity of electrolysis reactions and the soil p H adjacent to the electrodes did not change more than a specific ***,increasing the voltage to higher than 35 V(i.e.45 V)did not increase the volume of drained water from the soil,but caused more electric current than the allowable current for Ir,St,and Al electrodes,and the corrosion inte

关键词： Electrokinetic(EK) Pile pH variation Voltage Electrode Corrosion resistance

Comprehensive unified model and simulation approach for microstructure evolution

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ChemPhysMater 2022年第2期1卷 133-147页

作者： Mohammad Bagher Nasiri fatemeh Iranshahi Institute of Materials Science Joining and FormingGraz University of TechnologyGraz 8010Austria

The prediction of microstructure constituents and their morphologies is of great importance for the evaluation of material properties and design of advanced *** have been considerable efforts to model and simulate microstructure evolution using a wide spectrum of models and simulation *** paper initially reviews the atomistic and mesoscale simulation approaches for microstructure evolution,emphasizing their advantages and *** approaches,such as molecular dynamics,are restricted by the scale of the studied system because they are computationally *** mesoscale simulation approaches,such as phase field,cellular automata,and Monte Carlo,have inconsistent phenomenological equations,each of which only describes one aspect of microstructure *** provide comprehensive insight into microstructure evolution,a unified model that is capable of equally evaluating the nucleation and growth processes is *** this paper,a physics-based model is proposed that incorporates statistical mechanics,the energy conservation law,and the force equilibrium concept to include all aspects of microstructure evolution.A compatible simulation approach is also described to simulate microstructure evolution during thermomechanical ***,the microstructure evolution of AISI 304 austenitic steel during isothermal heat treatment and fusion welding is simulated and *** use of fundamental physical rules instead of phenomenological equations,together with the real spatial and temporal scales of the proposed model,facilitates the comparison of the simulation results with experimental *** examine the accuracy of the proposed simulation approach,the isothermal heat treatment simulation results are compared with experimental data over a broad region of temperatures and time periods.

关键词： Modeling and simulation of microstructure evolution Austenitic stainless steel Phase transformation Grain growth Nucleation and growth

Groundwater quality in the vicinity of a dumpsite in Lagos metropolis,Nigeria

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Geography and Sustainability 2023年第4期4卷 379-390页

作者： Carla S.S.Ferreira Onyanta Adama-Ajonye Anosike EIkenna Zahra kalantari Department of Physical Geography and Bolin Centre for Climate Research Stockholm UniversitySE-10691 StockholmSweden Polytechnic Institute of Coimbr1 Applied Research InstituteRua da Misericórdi1Lagar dos Cortiços-S.Martinho do Bispo3045-093 Coimbr1Portugal Research Centre for Natural Resources Environment and Society(CERNAS)Polytechnic Institute of Coimbr1Bencant13045-601 Coimbr1Portugal Department of Human Geography Stockholm UniversitySE-10691 StockholmSweden University of Lagos Akok1Yab1LagosNigeria Department of Sustainable Development Environmental Science and EngineeringKTH Royal Institute of TechnologySE-10044 StockholmSweden

Inappropriate management of municipal solid waste dumpsites is a major cause of groundwater contamination in developing countries,but the extent of the problem is not *** study investigated groundwater quality in the vicinity of Olusosun dumpsite in Lagos,Nigeria,the most populous city in sub-Saharan *** 2020,monthly groundwater samples were collected in 17 wells and boreholes used as drinking water sources,and analysed for 20 physico-chemical *** between sites and seasons were statistically assessed,together with changes in water quality index(WQI).The results indicated that heavy metals(Pb^(2+),Ni^(+),Mn^(2+),Fe^(2+),Cr^(6+)),cations(Ca^(2+),Mg^(2+),K^(+)),total hardness and pH were the main parameters impairing water *** water quality standards from both the World Health Organization and Nigeria government were exceeded more often in the wet season than in the dry *** groundwater properties were negatively correlated with distance to dumpsite(e.g.,Fe^(2+),Pb^(2+),NO_(3)^(−)).Significant differences between sites were identified,but with no clear spatial *** varied from excellent(6%-24%of the sites over the study period)to unsuitable for drinking water purposes(12%-18%),with good quality prevailing at most sites(35%-47%).Although groundwater quality declined at 24%of the sites over 2020,the results indicated improvements compared with previous *** strategies must be implemented to safeguard public health and the sustainability of water resources.

关键词： Municipal solid waste dumpsite Groundwater quality Seasonal variation Heavy metals Nigeria

Generating hourly electricity demand data for large-scale single-family buildings by a decomposition-recombination method

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Energy and Built Environment 2023年第4期4卷 418-431页

作者： Mengjie Han fatemeh Johari Pei Huang Xingxing Zhang School of Information and Engineering Dalarna UniversityFalun 79188Sweden Built Environment Energy Systems Group Department of Civil and Industrial EngineeringUppsala UniversityUppsala 75121Sweden

Household electricity demand has substantial impacts on local grid operation,energy storage and the energy per-formance of *** demand data at district or urban level helps stakeholders understand the demand patterns from a granular time scale and provides robust evidence in energy ***,such type of data is often expensive and time-consuming to collect,process and *** built upon smart meter data have to deal with challenges of privacy and security in the whole *** data due to confiden-tiality concerns or system failure can further increase the difficulty of modeling and *** addition,methods using historical data to make predictions can largely vary depending on data quality,local building envi-ronment,and dynamic *** these challenges,this paper proposes a statistical method to generate hourly electricity demand data for large-scale single-family buildings by decomposing time series data and recom-bining them into *** proposed method used public data to capture seasonality and the distribution of residuals that fulfill statistical characteristics.A reference building was used to provide empirical parameter settings and validations for the studied *** illustrative case in a city of Sweden using only annual total demand was presented for deploying the proposed *** results showed that the proposed method can mimic reality well and represent a high level of similarity to the real *** average monthly error for the best month reached 15.9%and the best one was below 10%among 11 tested *** than 0.6%improper synthetic values were found in the studied region.

关键词： Data generation Time series decomposition Hourly electricity demand Large-scale buildings

A Deep Learning Approach for Detecting Covid-19 Using the Chest X-Ray Images

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Computers, Materials & Continua 2023年第1期74卷 751-768页

作者： fatemeh Sadeghi Omid Rostami Myung-Kyu Yi Seong Oun Hwang Department of Industrial Engineering Sharif University of TechnologyTehran14588-89694Iran Department of Industrial Engineering University of HoustonHoustonTX77204USA Department of Computer Engineering Gachon UniversitySeongnam13120Korea

Real-time detection of Covid-19 has definitely been the most widely-used world-wide classification problem since the start of the pandemic from 2020 until *** the meantime,airspace opacities spreads related to lung have been of the most challenging problems in this area.A common approach to do on that score has been using chest X-ray images to better diagnose positive Covid-19 *** to most other classification problems,machine learning-based approaches have been the first/most-used candidates in this *** schemes based on machine/deep learning have been proposed in recent years though increasing the performance and accuracy of the system has still remained an open *** this paper,we develop a novel deep learning architecture to better classify the Covid-19 X-ray *** do so,we first propose a novel multi-habitat migration artificial bee colony(MHMABC)algorithm to improve the exploitation/exploration of artificial bee colony(ABC)*** that,we optimally train the fully connected by using the proposed MHMABC algorithm to obtain better accuracy and convergence rate while reducing the execution *** experiment results on Covid-19 X-ray image dataset show that the proposed deep architecture has a great performance in different important optimization ***,it will be shown that the MHMABC algorithm outperforms the state-of-the-art algorithms by evaluating its performance using some wellknown benchmark datasets.

关键词： ChestX-ray image processing evolutionary deep learning covid-19