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Journal of Rare Earths 2009年第3期27卷 357-362页

作者： Masoumeh Tabatabaee Mahboubeh A. Sharif fatemeh Vakili Saina Saheli Department of Chemistry Islamic Azad University Yazd Branch Department of Chemistry Islamic Azad University Qom Branch

A new lanthanum complex formulated as {（bpyH2）[La（btc）（H2O）4（NO3）]·2H2O}n （1）（btcH4=benzene-1,2,4,5-tetracarboxylic acid; bpy=4,4＇-bipyridine） was hydrothermally synthesized. The complex was characterized by FT-IR spectroscopy, elemental analysis and X-ray diffraction. X-ray crystal structural analysis revealed that the compound belonged to the monoclinic space group C2/c with cell parameters a= 1.42806（7） nm, b=1.10258（5） nm, c=1.60333（8） nm and β=101.9400（10）°. The complex was polymeric with La^III atoms linked by four O atoms from two carboxylate groups of one benzene-1,2,4,5-tetracarboxylate. The LaIn atom was ten coordinated in a distorted tetracapped trigonal prism. In the crystal structure, a wide range of noncovalent interactions consisting of hydrogen bonding （of the types of O-H…O, N-H…O and C-H…O） and ion pairing interactions connected the various components into a supramolecular structure.

关键词： lanthanum(III) complex hydrothermal synthesis coordination polymer hydrogen bonding benzene-1,2,4,5-tetracarboxylic acid rare earths

Inhibitory effect of gold nanoparticles conjugated with interferon gamma and methionine on breast cancer cell line

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Asian Pacific Journal of Tropical Biomedicine 2016年第2期6卷 173-178页

作者： Nastaran Mohseni fatemeh Salehi Sarvestani Mehdi Shafiee Ardestani fatemeh Kazemi-Lomedasht Masoud Ghorbani Biotechnology Research Center Biotechnology Department Venom and Biotherapeutics Molecules Laboratory Pasteur Institute of Iran Department of Biology Science and Research Branch Islamic Azad University Department of Radiopharmacy Faculty of Pharmacy Tehran University of Medical Sciences Research and Development Department Pasteur Institute of Iran Department of Virology University of Ottawa

Objective: To develop a gold nanoparticles complex conjugated with interferon-gamma(IFN-g) and methionine along with application of hyperthermia using near-infrared laser beams for the treatment of cancer ***: Gold nanorods(10 nm) were conjugated with IFN-g and methionine using carbodiimide family and characterized after purification by dialysis bags. Breast cancer cells were cultured and incubated with gold nanorods at different concentrations followed by irradiation with near-infrared laser beam. Samples were then evaluated for their viability in order to determine the effect of treatment and variables by MTT ***: Zetasizer results confirmed the conjugation of gold nanorods with methionine and IFN-g. The median percentage of cell viability in 0.30 mg/m L concentration of gold nanorods was 82%. The cell viability reached to 85% at the same concentration of gold nanorods, which existed in the assayed complex. The results of MTT assay showed that the 0.60 mg/m L concentration of gold nanoparticles complex was toxic on tumor cells(P < 0.05). After exposure to hyperthermia, the viability of cells at 6 min decreased to77% in 0.30 mg/m L concentration of gold nanorods ***: The size and concentration of gold nanorods was not cytotoxic. However,their presence during irradiation near-infrared laser increased the number of dead cells during the treatment of cells.

关键词： Gold nanorods Breast cancer cell line Interferon gamma Near-infrared laser

Long term exposure to ambient air particulate matter and mortality effects in Megacity of Tehran,Iran:2012-2017

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Particuology 2021年第5期19卷 139-146页

作者： Mehdi Fazlzadeh Roohollah Rostami fatemeh Yousefian Masud Yunesian Hosna Janjani Social Determinants of Health Research Center Ardabil University of Medical SciencesArdabilIran Research Center for Health Sciences and Technologies Semnan University of Medical SciencesSemnanIran Department of Environmental Health Engineering School of Public HealthTehran University of Medical SciencesTehranIran Department of Research Methodology and Data Analysis Institute for Environmental ResearchTehran University of Medical SciencesTehranIran

Ambient particulate matter(PM)is the major environmental concern in Tehran,*** to such particles is a serious global health concern and substantial evidence indicates that exposure to particulate matter contributes to cardiovascular and respiratory ***,we provide a detailed health impact of ambient air pollution in Tehran by linking PM pollution with mortality caused by cardiovascular and respiratory *** quality data of PM obtained from Tehran Air Quality Monitoring Stations(TAQMSs)during 2012–*** mining methods conducted by Spatio-temporal outlier detection and“Air Pollution and Health:a European Approach(APHEA)project”was applied to impute missing ***-series data were analyzed to estimate the associations between PM pollution and cause-specific mortality at different lags in *** on descriptive analysis,PM_(2.5) is expected to be a major influencing factor in the increased cardiovascular-related death(CVD)and respiratory dysfunction related death(RD)*** cross-correlation analysis showed the same source for PM_(2.5) and PM_(10) in the ambient air of ***,the results indicated delays of about 7-15 days from the increased concentrations of PMs and the observed rising in CVD and RD *** analysis showed a more decreasing trend for PM_(2.5) pollutions than PM_(10) pollution and a slightly increasing trend for cause-specific deaths during *** term exposure to high PM levels increases the CVD and RD deaths and control strategies along with control regulations should be considered to control PM.

关键词： Air pollution Particulate matter Cardiovascular related death Respiratory dysfunction related death Tehran

Procedure for determining the number of thermal diffusion columns in square cascade for separation of Ne stable isotopes

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Nuclear Science and Techniques 2023年第5期34卷 47-55页

作者： fatemeh Mansourzadeh Mohammad Mahdi Shadman Javad Karimi Sabet Valiyollah Ghazanfari Nuclear Fuel Cycle Research School Nuclear Science and Technology Research InstituteTehranIran

The thermal diffusion column represents one method of separating stable *** method is advantageous for smallscale operations because of the simplicity of the apparatus and small inventory,especially in gas-phase ***,it has attracted attention for its applicability in tritium and noble gas separation *** this study,the R cascade was used to design and determine the number of columns.A square cascade was adopted for the final design because of its flexibility,and calculations were performed to separate 20Ne and 22Ne *** the R cascades that enriched the Ne isotopes by more than 99%were investigated,the number of columns was determined,and the square cascade parameters were optimized using the specified ***,a calculation code“RSQ_CASCADE”was developed.A unit separation factor of three was considered,and the number of studied stages ranged from 10 to *** results showed that the column separation power,relative total flow rate,and required number of columns were linearly related to the number of *** separation power and relative total flow decreased and the number of columns increased as the stage number ***,a cascade of 85 columns is recommended to separate the stable Ne *** calculations yielded a 17-stage square cascade with five columns in each *** changing the stage cut,feed point,and cascade feed flow rate,the best parameters for the square cascade were determined according to the cascade and column separation *** the column separation power had a maximum value in cascade feed 50,it was selected for separating Ne isotopes.

关键词： Stable isotope Thermal diffusion Cascade Separation Neon

Does insect mother know under what conditions it will make their offspring live？

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Insect Science 2017年第1期24卷 141-149页

作者： fatemeh Kohandani Guillaume Jean Le Goff Thierry Hance Earth and Life Institute Biodiversity Research Centre Universite Catholique de Louvain 4 Place Croix du Sud 1348 Louvain-la-Neuve Belgium

According to the optimal oviposition theory, the larval success of insects depends on the oviposition site selection by females. Females are expected to choose a site with many resources and few competitors or predators to allow the best performance for their progeny, assuming that ＂mother knows best.＂ However, this is not systematically observed. The Aphidoletes aphidimyza larvae are generalist aphid predators and females consequently lay their eggs near or inside aphid colonies. The goal of this study was to investigate the impact ofintraspecific competition on oviposition behavior of A. aphidimyza females. First, we counted the number of eggs laid by a female on a leaf with 20 aphids, in the presence of 0, 2, 4, or 6 conspecific eggs or in the absence of eggs but in presence of 3 virgin females. The same experiment was also performed under choice condition with 2 oviposition sites. Our results show that the presence of low densities ofconspecific eggs, or the presence of conspecific females, have no significant impact on the number of eggs laid by A. aphidimyza females. One of the hypotheses advanced to explain these results is the advantages of conspecifics presence. At low densities, the presence of eggs on an oviposition site can indicate the suitability of the site for the females. The conspecific presence can also insure a dilution effect against predator and increase the presence of potential mating partners for this monogenic species.

关键词： Aphidoletes aphidimyza clutch size dilution effect intraspecific competition optimal oviposition predatory larvae

A green method for the synthesis of bis-indolylmethanes and 3,3'-indolyloxindole derivatives using cellulose sulfuric acid under solvent-free conditions

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Chinese Chemical Letters 2010年第2期21卷 183-186页

作者： Heshmatollah Alinezhad Asefeh Hagh Haghighi fatemeh Salehian Faculty of Chemistry Mazandaran University

A highly efficient green protocol for the preparation of bis-indolylmethanes,bis-2-methylindolylmethanes,bis-1-methylindolylmethanes and 3,3 -diindolyloxindole derivatives from the reaction of indoles with various aldehydes and ketones in the presence of cellulose sulfuric acid under solvent-free conditions is *** significant features of this procedure are high yields of the products,mild reaction,solvent-free condition and non-toxicity of the catalyst.

关键词： Aldehydes Ketones Cellulose sulfuric acid Bis-indolylmethanes 3,3’-Diindolyloxindole derivatives

Insight into DNA protection ability of medicinal herbs and potential mechanisms in hydrogen peroxide damages model

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Asian Pacific Journal of Tropical Biomedicine 2018年第2期8卷 120-129页

作者： Zahra Sabahi fatemeh Soltani Mahmoodreza Moein Medicinal Plants Processing Research Center Shiraz University of Medical Sciences Biotechnology Research Center Institute of Pharmaceutical Technology Mashhad University of Medical Sciences Department of Pharmacognosy School of Pharmacy Shiraz University of Medical Sciences

DNA damage is one of the most important consequences of oxidative stress in the cells. If DNA repair is unable to modify these inducible DNA damages, genomic instability may lead to mutation, cancer, aging and many other diseases. Single cell gel electrophoresis or comet assay is a common and versatile method to quantify these types of DNA damages. DNA damages induced by hydrogen peroxide(H_2O_2) are one of the proper models for measurement of protective ability of different compounds. So the main aim of this review is to provide an overview about protection ability of medicinal plants and their potential mechanism against H_2O_2 induced DNA damages. In this review, relevant researches on the effect of medicinal plants on DNA damages induced by H_2O_2 and possible molecular mechanisms are *** seems that, medicinal plants are considered as therapeutic key factors to protect DNA from consequences caused by oxidative stress. Sufficient in vitro evidences introduce them as DNA protective agents through different mechanisms including antioxidant activity and some other cellular mechanisms. Moreover, in order to correlate the antigenotoxicity effects with their potential antioxidant property, most of medicinal plants were evaluated in term of antioxidant activity using standard methods. This review highlights the preventive effects of herbal medicine against oxidative DNA damages as well as provides rational possibility to engage them in animal studies and future clinical investigations.

关键词： Herbal medicine DNA damage Comet assay Hydrogen peroxide Single cell gel electrophoresis

Comparison of the effects of acute and chronic psychological stress on metabolic features in rats

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第11期13卷 904-912页

作者： fatemeh ROSTAMKHANI Homeira ZARDOOZ Saleh ZAHEDIASL Babak FARROKHI Neuroscience Research Center Shahid Beheshti University of Medical SciencesTehranIran Department of Biology Shahre-Rey BranchIslamic Azad UniversityTehranIran Department of Physiology Faculty of MedicineShahid Beheshti University of Medical SciencesTehranIran Endocrine Research Center Research Institute for Endocrine SciencesShahid Beheshti University of Medical SciencesTehranIran Department of Immunology Faculty of MedicineShahid Beheshti University of Medical SciencesTehranIran

This study was aimed to compare the effects of acute and chronic psychological stress on metabolic factors. Forty-two male Wistar rats were divided into control and stressed groups. Stress was applied by a communication box acutely (1 d) and chronically (15 and 30 d). Blood sampling was carried out by retro-orbital-puncture method. The plasma levels of glucose, cholesterol, triglyceride, insulin, and corticosterone were measured. In addition, feed and water intake, latency to eat and drink, adrenal and body weights were determined. Acute and chronic psychological stress did not significantly change basal plasma corticosterone levels. However, immediately (1 min) after acute exposure to stress, plasma corticosterone level increased compared to that before stress exposure. Acute stress increased plasma insulin levels significantly. Fifteen days of stress exposure resulted in plasma glucose increase. Chronic stress significantly increased feed intake, latency to eat, and adrenal weight compared to acute stress. The body weights of both control and stressed groups increased markedly during the experiment. Homeostasis model assessment of insulin resistance (HOMA-IR) index did not change significantly in the stressed group. In conclusion, application of acute and chronic psychological stress leads to different metabolic and/or behavioral changes but the metabolic changes resulting from acute exposure to stress seem to be more pronounced.

关键词： Psychological stress Corticosterone Insulin Glucose Cholesterol Triglyceride

Prediction of Proteins Associated with COVID-19 Based Ligand Designing and Molecular Modeling

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Computer Modeling in Engineering & Sciences 2020年第12期125卷 907-926页

作者： Majid Monajjemi Rahim Esmkhani fatemeh Mollaamin Sara Shahriari Department of Chemical Engineering Central Tehran BranchIslamic Azad UniversityTehran14987-54891Iran Department of Chemistry Khoy BranchIslamic Azad UniversityKhoy58159-88838Iran Department of Chemistry Central Tehran BranchIslamic Azad UniversityTehran***Iran

Current understanding about how the virus that causes COVID-19 spreads is largely based on what is known about similar *** of the Natural products are suitable drugs against SARS-CoV-2 main *** recognizing a strong inhibitor,we have accomplished dock-ing studies on the major virus protease with 4 natural product species as anti COVID-19(SARS-CoV-2),namely“Vidarabine”,“Cytarabine”,“Gem-citabine”and“Matrine”which have been extracted fromGillan’s leaves *** are known as Chuchaq,Trshvash,Cote-Couto and Khlvash in *** these four studied compounds,Cytarabine appears as a suitable com-pound with high effectiveness inhibitors to this *** by this work we present a method on the Computational Prediction of Protein Structure Associated with COVID-19 Based Ligand Design and Molecular *** this investigation,auto dock software(iGEM-DOCK)has been used and via this tool,the suitable receptors can be distinguished in whole COVID-19 component structures for forming a complex.“iGEMDOCK”is suitable to define the binding site *** docking simulation and NMR inves-tigation,we have demonstrated these compounds exhibit a suitable binding energy around 9 Kcal/mol with various ligand proteins modes in the bind-ing to COVID-19 ***,these data need further evaluation for repurposing these drugs against COVID-19 viruses,in both vivo&vitro.

关键词： COVID-19 receptor binding domain Gillan’s leaves plants angiotensin converting enzyme-2 protease domain

Prevalence of asthma symptoms in Golestan schoolchildren aged 6-7 and 13-14 years in Northeast Iran

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Frontiers of Medicine 2016年第3期10卷 345-350页

作者： fatemeh Mehravar Soheil Rafiee Behnaz Bazrafshan Mahmoud Khodadost Clinical Research Development Unit (CRDU) lmam Hossein Hospital Shahroud University of Medical Sciences Shahroud Iran Research Center of Infectious Diseases Golestan University of Medical Sciences Gorgan Iran Medical Cellular and Molecular Research Center Golestan University of Medical Sciences Gorgan Iran Gastroenterology and Liver Diseases Research Center Baqiyatallah University of Medical Science and Departments of Epidemiology Iran University of Medical Sciences Tehran Iran

Asthma is the most common chronic disease among children, and its incidences are often imminent among elementary schoolchildren. This study aimed to examine the prevalence of asthma symptoms in Golestan schoolchildren aged 6-7 and 13-14 years in Northeast Iran. The prevalence rate was compared according to age group （aged 6-7 years vs. aged 13-14 years） and gender （male vs. female）. In this cross-sectional study, 1706 Iranian schoolchildren aged 6-7 and 13-14 years in Golestan Province were enrolled. Participants completed questionnaires between February and July 2014. Asthma symptoms were assessed using the questionnaire of the International Study of Asthma and Allergies in Childhood protocol in Persian. The logistic regression model was used to estimate the odds ratios （ORs） and 95% confidence intervals （CIs） of the asthma symptoms for each of the gender and age groups. The prevalence rates of ＂current asthma＂ symptoms and ＂asthma ever＂ in all the children were estimated as 9.5%and 7.5%, respectively. The prevalence of asthma （＂asthma ever＂ and ＂wheezing in the past 12 months＂） in junior high schoolchildren （aged 13-14 years） is higher than that in elementary schoolchildren （aged 6-7 years）（P 〈 0.05）. The prevalence of the severity of wheezing in girls is lower than that in boys （OR = 1.7, 95%CI = 1.06-2.96, P = 0.02）. Asthma is still a major public health problem. This study shows that the prevalence of the asthma symptoms in boys is lower than that in girls in both age groups, and the severity of asthma in girls is higher than that in boys aged 13-14 years.

关键词： asthma asthma symptoms epidemiology childhood chronic disease