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Vasodilator response to Psidium guajaveleaves of mesenteric bed vessels from diabetic and non-diabetic rats

Journal of Diabetes Mellitus 2014年第1期4卷 6-11页

作者： Habeib Zaheri Golam Reza Farshidfar Nepton Soltani fatemah kharazmi Mohammad Kamalinajad Department of Biochemistery Faculty of Medicine Hormozgan University of Medical Sciences Bandar Abbas Iran Department of Biology Faculty of Science Shahid Bahonar University Kermam Iran Department of Pharmacognosy Faculty of Pharmacy Shahid Bahashti University of Medical Sciences Tehran Iran Department of Physiology Faculty of Medicine and Research Center for Molecular Medicine Hormozgan University of Medical Sciences Bandar Abbas Iran

Mortality from cardiovascular abnormalities is almost three times more prevalent in the diabetic population than that in the general population. Psidium guajave has been used traditionally for a long time as a medicinal herb to cure diabetes. Endothelial dependent vasorelaxation effect of Psidium guajave extract on normal aortic rings was observed. This study was designed to investigate the endothelium and nitric oxide roles inPGE-induced vasorelaxation in diabetic rat vessel. Diabetes was induced by a single intraperitoneal injection of streptozotocin. Eight weeks later, superior mesenteric arteries of non-diabetic and diabetic groups were isolated and perfused according to the McGregor method. Prepared vascular beds were constricted with phenylephrine to induce 70% - 75% of maximal constriction. Psidium guajave extract at concentrations of 0.1 to 4 mg/100ml added to the medium and perfusion pressure was recorded. Baseline perfusion pressure of diabetic group was significantly higher than non-diabetic rats in both intact and denuded endothelium. Psidium guajave extract caused a significantly dose depended decrease in perfusion pressure in non-diabetic and diabetic groups in both intact and denuded endothelium. In the presence of N (ω)-nitro-L-arginine methyl ester, Psidium guajave ex-tractinduced relaxation in intact mesenteric beds of non-diabetic and diabetic animals was not suppressed. From the results of this study, it may be concluded that vasorelaxatory effect of Psidium guajave extract is not mediated by endothelium and nitric oxide in both diabetic and non-diabetic vessel and supports the use of the plant’s leaves as a natural, adjunct phytomedicine in the management of diabetes vessel complications.

关键词： Psidium guajave Linn Extract Diabetes Mellitus Mesenteric Bed Vasorelaxation Nitric Oxide

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Agmatine ameliorates diabetes type 2-induced nephropathy in rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第1期14卷 8-16页

作者： fatemah O.Kamel Ohoud Shagroud Mai AAlim A.Sattar Ahmad Gamal S Abd El-Aziz Abdulhadi S.Burzangi Duaa Bakhshwin Maha Jamal Shahid Karim Department of Clinical Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Anatomy Faculty of MedicineKing Abdulaziz UniversityJeddah 21589Saudi Arabia

Objective:To assess the nephroprotective potential of agmatine in a rat model of streptozotocin-induced diabetic ***:A single dose of streptozotocin(40 mg/kg)coupled with a fructose diet induced diabetes in Wistar ***(40 and 80 mg/kg)was administered to rats for 12 *** body weight and fasting blood glucose were measured *** level,urine output,total protein,albumin,blood urea nitrogen,creatinine,and cystatin-C were also determined at the end of the ***,superoxide dismutase,glutathione,interleukin-1β,interleukin-6,and tumor necrosis factor-alpha were evaluated in kidney *** study was also performed using hematoxylin and eosin ***:Agmatine at both doses significantly increased final body weight,and lowered fasting blood glucose,urine output,insulin,total protein,albumin,blood urea nitrogen,creatinine,and cystatin-C levels compared with the diabetic group(P<0.05).Inflammatory markers and antioxidant effect were significantly improved in agmatine-treated ***,the histopathological changes in renal structure were ameliorated by agmatine ***:Agmatine alleviates diabetic nephropathy by improving renal functions and reducing inflammation and oxidative *** molecular mechanisms of its nephroprotective actions need to be investigated in future study.

关键词： Agmatine Type 2 diabetes Nephropathy Oxidative stress Nephroprotection

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Neuroprotective effect of liraglutide and memantine in a rat model of Alzheimer’s disease

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Asian Pacific Journal of Tropical Biomedicine 2024年第5期14卷 207-214页

作者： Duaa M.Bakhshwin Foziya W.Alhalabi Mohamad Omar Barasheed Ahmed M.Bakhshwin Maha H.Jamal Mohammed A.Bazuhair fatemah O.Kamel Rania M.Magadmi Zoheir A Damanhouri Samar M.Alsaggaf Department of Clinical Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Hera General Hospital MakkahSaudi Arabia Department of Pathology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Clinical Anatomy Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia

Objective:To assess the effect of memantine combined with liraglutide on aluminum chloride(AlCl_(3))and D-galactose(D-GAL)-induced neurotoxicity in ***:Male Wistar rats were divided into 5 groups of 5 animals each:the positive control,the negative control,the memantine-treated group,the liraglutide-treated group,and the combination group treated with memantine and ***_(3)and D-GAL were used to induce *** tests,brain beta-amyloid protein,and oxidative stress biomarkers were ***:The Morris water maze test indicated an enhanced memory in the combination ***,the combination treatment of liraglutide and memantine resulted in a remarkable reduction in the beta-amyloid protein level in the brain *** inflammation and oxidative stress biomarkers were significantly reduced,and the levels of antioxidant parameters were ***:The combination of liraglutide and memantine exerts neuroprotective effects and enhances memory and cognitive functions in rats with Alzheimer’s disease.

关键词： Alzheimer’s disease Cognitive function Glucagonlike peptide-1 Liraglutide Memantine

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Traversable wormhole solutions in the f(R)theories of gravity under the Karmarkar condition

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Chinese Physics C 2022年第9期46卷 276-286页

作者： Adnan Malik fatemah Mofarreh Aqsa Zia Akram Ali Department of Mathematics University of Management and TechnologySialkot CampusPakistan Mathematical Science Department Faculty of Science Princess Nourah bint Abdulrahman University.Riyadh 11546 Saudi Arabia Department of Mathematics College of ScienceKing Khalid University9004 AbhaSaudi Arabia

This paper examines traversable wormhole models in the f(R) theories of gravity by applying the Karmarkar condition. For this purpose, we consider spherically symmetric space-time to examine the structure of wormholes. First, we investigate wormholes and their geometry using the redshift function under various conditions. Subsequently, we discuss the embedding diagram of the upper and lower universe using radial coordinates in two and three-dimensional Euclidean affine space. Three exclusive models are considered for the f(R) theories of gravity,and the radial and tangential pressures are observed. Furthermore, by taking a definite shape function, we observe the behavior of energy conditions. We determine that energy conditions are violated, and their violation is generic and represents the presence of exotic matter. According to Einstein’s field theory, the existence of wormholes is predicated on the occurrence of rare material. Hence, we conclude that our study is more realistic and stable.

关键词： wormhole geometry Karmarkar condition red shift function energy conditions

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Exact Solutions and Finite Time Stability of Linear Conformable Fractional Systems with Pure Delay

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Computer Modeling in Engineering & Sciences 2023年第2期134卷 927-940页

作者： Ahmed M.Elshenhab Xingtao Wang fatemah Mofarreh Omar Bazighifan School of Mathematics Harbin Institute of TechnologyHarbin150001China Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Mathematical Science Department Faculty of SciencePrincess Nourah Bint Abdulrahman UniversityRiyadh11546Saudi Arabia Section of Mathematics International Telematic University UninettunoRoma00186Italy

We study nonhomogeneous systems of linear conformable fractional differential equations with pure *** using new conformable delayed matrix functions and the method of variation,we obtain a representation of their *** an application,we derive a finite time stability result using the representation of solutions and a norm estimation of the conformable delayedmatrix *** obtained results are new,and they extend and improve some existing ***,an example is presented to illustrate the validity of our theoretical results.

关键词： Representation of solutions conformable fractional derivative conformable delayed matrix function conformable fractional delay differential equations finite time stability

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Spatially asymmetric cascade nanocatalysts for enhanced chemodynamic therapy

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Nano Research 2023年第7期16卷 9642-9650页

作者： Minchao Liu Hongyue Yu Liang Chen Tiancong Zhao Meng Fang Mengli Liu Qiaoyu Zhou fatemah Farraj AlHarbi Ahmed Mohamed El-Toni Fan Zhang Dongyuan Zhao Xiaomin Li Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersiChemShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200433China Department of Musculoskeletal Cancer Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Physics College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia King Abdullah Institute for Nanotechnology King Saud UniversityRiyadh 11451Saudi Arabia

Chemodynamic therapy(CDT)based on cascade catalytic nanomedicine has emerged as a promising cancer treatment ***,most of the reported cascade catalytic systems are designed based on symmetric-or co-assembly of multiple catalytic active sites,in which their functions are difficult to perform independently and may interfere with each *** in cascade catalytic system that involves fragile natural-enzymes,the strong oxidation of free-radicals toward natural-enzymes should be carefully considered,and the spatial distribution of the multiple catalytic active sites should be carefully organized to avoid the degradation of the enzyme catalytic ***,a spatially-asymmetric cascade nanocatalyst is developed for enhanced CDT,which is composed by a Fe_(3)O_(4)head and a closely connected mesoporous silica nanorod immobilized with glucose oxidase(mSiO_(2)-GOx).The mSiO_(2)-GOx subunit could effectively deplete glucose in tumor cells,and meanwhile produce a considerable amount of H_(2)O_(2)for subsequent Fenton reaction under the catalysis of Fe_(3)O_(4)subunit in the tumor *** the advantage of the spatial isolation of mSiO_(2)-GOx and Fe_(3)O_(4)subunits,the catalysis of GOx and freeradicals generation occur at different domains of the asymmetric nanocomposite,minimizing the strong oxidation of free-radicals toward the activity of GOx at the other *** addition,direct exposure of Fe_(3)O_(4)subunit without any shelter could further enhance the strong oxidation of free-radicals toward ***,compared with traditional core@shell structure,the long-term stability and efficiency of the asymmetric cascade catalytic for CDT is greatly increased by 138%,thus realizing improved cancer cell killing and tumor restrain efficiency.

关键词： mesoporous nanocatalytic medicine chemodynamic therapy asymmetric nanostructure core@shell

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On Proximal Relations in Transformation Semigroups Arising from Generalized Shifts

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Analysis in Theory and Applications 2022年第1期38卷 110-120页

作者： fatemah Ayatollah Zadeh Shirazi Amir Fallahpour Mohammad Reza Mardanbeigi Zahra Nili Ahmadabadi Faculty of Mathematics Statistics and Computer Science College of ScienceUniversity of TehranEnghelab Ave.f TehranIran Faculty of Mathematics and Computer Science College of ScienceAmirkabir University of TechnologyTehranIran Islamic Azad University Science and Research Branch TehranIran

For a finite discrete topological space X with at least two elements,a nonempty setГ,and a map p■is a generalized *** this text for■is bijective}we study proximal relations of transformation semigroups(S,X^(Г))and(H,XX^(Г)).Regarding proximal relation we prove:■is infinite■.Moreover,for infinite T,both transformation semigroups(S,X^(Г)and(H,XX^(Г))are regionally proximal,i.e.,■is finite.

关键词： Generalized shift proximal relation transformation semigroup

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Meeting the ADA Guidelines of Diabetic Care at King Fahd Hospital of University, Khobar, Eastern Province, Saudi Arabia in 2012

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Journal of Life Sciences 2013年第7期7卷 760-765页

作者： Waleed AlBaker fatemah AlFaraj Reem AlArgan Ammar Khamis Internal Medicine Endocrinology KFUH Khobar Saudi Arabia Department of Family and Community Medicine Faculty of Medicine University of Dammam Khobar Saudi Arabia

The main purpose of this study is determining the extent of achieving American Diabetes Association （ADA） targets in diabetes type I and II at KFUH （King Fahd Hospital of University） in the year of 2012. Observational, cross sectional, retrospective study was conducted on 479 patients; the informations were reviewed using Quadramed CPR system. All the data obtainedwere analyzed by medical statistician using SPSS program. The results show that only 19.0% was achieved the target of HbA~; and the targets of LDL, HDL and TG were achieved in 38.4%, 35.9%, and 48.2% respectively. The routine ophthalmology and dietitian review were found to be in only 32.1% and 27.3%, respectively. The use of medications recommended by ADA was 51.4% for aspirin and 54.7 % for both statin and ACE inhibitor. The present study indicated that most of the ADA guidelines were not achieved in our diabetic patients being followed in our center, which is almost similar to other studies in most of the parameters. The achievement of diabetes targets is a difficult task but may not be impossible. It requires a multidisciplinary approach. So, further studies are needed to determine the reasons behind the gap between practice and guidelines.

关键词： Diabetes, HbA1c LDL-C ACEI ophthalmology visit.

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Comprehensive analysis of relativistic embedded class-I exponential compact spheres in f(R,φ)gravity via Karmarkar condition

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Communications in Theoretical Physics 2023年第10期75卷 100-110页

作者： Zoya Asghar Adnan Malik M Farasat Shamir fatemah Mofarreh National University of Computer and Emerging Sciences Lahore CampusPakistan School of Mathematical Sciences Zhejiang Normal UniversityJinhuaZhejiangChina Department of Mathematics University of Management and TechnologySialkot CampusPakistan Mathematical Science Department Faculty of Science Princess Nourah bint Abdulrahman University Riyadh 11546Saudi Arabia

In this article,we use the prominent Karmarkar condition to investigate some novel features of astronomical objects in the f(R,φ)gravity;R andφrepresent the Ricci curvature and the scalar field,*** is worth noting that we classify the exclusive set of modified field equations using the exponential type model of the f(R,φ)theory of gravity f(R,φ)=φ(R+α(eβR-1)).We show the embedded class-I approach via a static,spherically symmetric spacetime with an anisotropic *** accomplish our objective,we use a particular interpretation of metric potential(grr)that has already been given in the literature and then presume the Karmarkar condition to derive the second metric *** employ distinct compact stars to determine the values of unknown parameters emerging in metric *** ensure the viability and consistency of our exponential model,we execute distinct physical evolutions,*** graphical structure of energy density and pressure evolution,mass function,adiabatic index,stability,equilibrium,and energy *** investigation reveals that the observed anisotropic findings are physically appropriate and have the highest level of precision.

关键词： stellar structures metric potentials f(R,φ)theory of gravity Karmarkar condition

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Reliability and validity of the Arabic version of the PedsQLTM4.0 generic ore scales and PedsQLTM3.0 diabetes module

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Journal of Diabetes Mellitus 2012年第3期2卷 301-307页

作者： Majedah Abdul-Rasoul fatemah AlOtaibi Maria AlMahdi Hessa AlKandari Department of Pediatrics Adan Hospital Ministry of Health Kuwait City State of Kuwait Department of Pediatrics Faculty of Medicine Kuwait University Safat State of Kuwait Department of Pediatrics Farwaniya Hospital Ministry of Health Kuwait City State of Kuwait

Background: Health related quality of life (HRQOL) has become a field of extensive research involving children and adolescents with diabetes. There are no HRQOL instruments designed or adapted for the Arabic culture and language. The objectives of the study are to test the Arabic translated version of the PedsQLTM 4.0 Generic Core Scales (GCS) and the PedsQLTM 3.0 Diabetes Module (DM) in children and adolescents with type 1 diabetes (T1DM) in Kuwait and analyse their psychometric properties. Methods: After the process of translation, committee review and pre-testing (linguistic validation), 131 children and adolescents with and 104 without T1DM, with their parents completed the Arabic version of GCS. Those with T1DM completed the Arabic DM. Demographic and diabetes-related data were collected using specially designed questionnaires. Internal consistency was checked by Cronbach’s alpha coefficient. The intraclass correlations coefficient, celling and floor effects and construct validity were assessed to determine the psychometric properties of both instruments. Results: Cronbach’s alpha of the child self-report and parent proxy-report was greater than 0.70, for both instruments, indicating internal consistency reliability. Items of both instruments had minimal missing responses, and required a brief time (5 - 7 minutes) to finish indicating their feasibility. No floor effect was demonstrated. Ceiling effect ranged from 5.8% to 15.8%. The GCS distinguished between healthy and diabetic children. The intraclass correlation coefficient (ICC) between child self-report and parent proxy-report of GCS scores showed good to excellent agreement, p < 0.001. However, in the DM reports, the correlation was lower, but still significant. Girls reported lower HRQOL scores in worries and communication subscales of the diabetes module than boys, p < 0.05. Conclusions: The Arabic version of the PedsQL GCS and PedsQL DM showed sufficient feasibility, reliability and validity to be used

关键词： Children Quality of Life Children and Adolescents PedsQLTM Generic Core Score PedsQLTM Diabetes Module Type 1 Diabetes

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