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Effect of Hypericum perforatum L. compared with metronidazole in bacterial vaginosis:a double-blind randomized trial

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Asian Pacific Journal of Tropical Biomedicine 2014年第11期4卷 896-902页

作者： Sakineh Mohammad-Alizadeh-Charandabi Zahra Mohammadzadeh azizeh farshbaf-khalili Yousef Javadzadeh Research Centre of Infectious & Tropical Diseases Department of Midwifery.Faculty of Nursing & MidwiferyTabriz University of Medical SciencesTabrizIran Social Security Organization.East Azerbaijan Treatment's Management Jolfa Social Security ClinicJolfaIran Department of Midwifery Faculty of Nursing & MidwiferyTabriz University of Medical Sciences Pharmaceutics Department Faculty of PharmacyTabriz University of Medical Sciences

Objective:To compare effect of Hypericum perforatum(***) vaginal gel with metronidazole on bacterial vaginosis(BV) in terms of initial response to treatment and preventing recurrence(primary outcomes) and also patient complaints(secondary outcomes).Methods:In this double-blind,double dummy trial,married women aged 18-49 with BV were randomized into two groups and administered 5 g of 3%*** and placebo of metronidazole(n=82),or 5 g of 0.75%metronidazole and placebo of ***(n=80)vaginally for 5 *** criteria were used for diagnosis and assessing cure and recurrence of *** comparisons was done using Chi-square,Fisher's exact and logistic ***:At 10-12 *** rate was 82%in the *** and 85%in metronidazole group(risk ratio 0.9.95%confidence interval 0.6 to 1.3).Among the cured women,recurrence rate was 9%in the *** and 13%in the metronidazole group at the 30-35 d visit(risk ratio 0.8,95%confidence interval 0.4 to 1.3),There was no statistically significant difference between the groups regarding any patient complaints,except itching which was less in *** group(5%vs.16%,P=0.018 at the first and 13%vs.43%,P<0.001 at the second follow-up).No significant adverse event was reported at any ***:*** could be a good option for treatment of ***,further studies arc needed for its public use.

关键词： Hypericum Metronidazole Vaginosis Bacterial Therapy Recurrence

Nanocomposite Electrospun Scaffold Based on Polyurethane/Polycaprolactone Incorporating Gold Nanoparticles and Soybean Oil for Tissue Engineering Applications

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Journal of Bionic Engineering 2023年第4期20卷 1712-1722页

作者： Nahideh Asadi azizeh Rahmani Del Bakhshayesh Hadi Sadeghzadeh Amir Nezami Asl Sharif Kaamyabi Abolfazl Akbarzadeh Department of Medical Nanotechnology Faculty of Advanced Medical SciencesTabriz University of Medical SciencesTabrizIran Department of Tissue Engineering Faculty of Advanced Medical SciencesTabriz University of Medical SciencesTabrizIran Health Research Center Chamran HospitalTehranIran Department of Chemistry Farhangian UniversityTehranIran

Electrospun nanofibers combined with a wide range of functional additives can be used for a various tissue engineering applications due to their desired biomimetic and physicochemical ***,the present study was conducted to obtain a highly efficient nanocomposite electrospun scaffold with appropriate physicochemical performance and biological properties based on Polycaprolactone/Polyurethane(PCL/PU)mixed with gold nanoparticles(GNPs)and soybean oil(SO).In the present study,the desired nanofibers were fabricated by electrospinning PCL/PU mixed solution with GNPs and *** nanocomposite electrospun PU/PCL/SO/GNP nanofibers were characterized in terms of chemical composition by attenuated total reflectance-Fourier transform infrared spectroscopy(ATR-FTIR),morphological structure by field-emission scanning electron microscopy(FE-SEM),and mechanical and biological *** surface topography and wettability were determined by atomic force microscopy(AFM)and water contact angle measurements,*** was found that the presence of GNPs along with SO in the structure of PCL/PU nanofiber created a smoother surface in terms of surface roughness and also a more homogeneous fibrous *** addition,it was observed that both SO and GNPs caused an increase in the electrical conductivity of the fibrous *** the biocompatibility evaluations by measuring cell viability and cell adherence to the scaffold's surfaces,it was found that adding of SO and GNPs supports *** together,the fabricated nanocomposite fibrous scaffolds can be a potential candidate for various tissue engineering purposes.

关键词： Polycaprolactone Polyurethane Gold nanoparticles Soy oil Bionic

Investigating the influential post-disaster factors in determining the optimal location of shelters:A case study,Sarpol-e Zahab,Kermanshah province,Iran

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Frontiers of Architectural Research 2022年第5期11卷 846-864页

作者： Ali Moghri Ahmadreza khalili Department of Art and Architecture Islamic Azad UniversityTehranIran

A proper location is one of the most influential factors in shelter *** considerable research focuses on finding a suitable site for temporary shelters,only a few address the effect of post-disaster circumstances on discovering the optimal *** study primarily aims to investigate the influential factors in determining a suitable place for temporary shelters after a ***,an algorithm is *** algorithm is achieved by analyzing and computing the post-crisis urban route and facility accessibility based on photogrammetric photographs taken by an unmanned aerial vehicle/satellite.

关键词： Locating Temporary shelter Crisis areas Computing Photogrammetric photos

Urban heat mitigation by green and blue infrastructure:Drivers,effectiveness,and future needs

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The Innovation 2024年第2期5卷 145-166页

作者： Prashant Kumar Sisay E.Debele Soheila khalili Christos H.Halios Jeetendra Sahani Nasrin Aghamohammadi Maria de Fatima Andrade Maria Athanassiadou Kamaldeep Bhui Nerea Calvillo Shi-Jie Cao Frederic Coulon Jill L.Edmondson David Fletcher Edmilson Dias de Freitas Hai Guo Matthew C.Hort Madhusudan Katti Thomas Rodding Kjeldsen Steffen Lehmann Giuliano Maselli Locosselli Shelagh K.Malham Lidia Morawska Rajan Parajuli Christopher D.F.Rogers Runming Yao Fang Wang Jannis Wenk Laurence Jones Global Centre for Clean Air Research(GCARE) School of SustainabilityCivil and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUK Institute for Sustainability University of SurreyGuildford GU27XHSurreyUK School of Built Environment University of ReadingWhiteknightsReading RG66BUUK School Design and the Built Environment Curtin University Sustainability Policy InstituteKent StBentley 6102Western Australia Harry Butler Institute Murdoch UniversityMurdoch 6150Western Australia Atmospheric Sciences Department Institute of AstronomyGeophysics and Atmospheric SciencesUniversity of Sao PauloSao Paulo 05508-090Brazil Met Office FitzRoy RoadExeter EX13PBUK Department of Psychiatry and Nuffield Department of Primary Care Health Sciences Wadham CollegeUniversity of OxfordOxfordUK Centre for Interdisciplinary Methodologies University of WarwickWarwickUK School of Architecture Southeast University2 SipailouNanjing 210096China Cranfield University School of WaterEnvironment and EnergyCranfield MK430ALUK Plants PhotosynthesisSoil ClusterSchool of BiosciencesUniversity of SheffieldSheffield S102TNUK UK Centre for Ecology&Hydrology Environment Centre WalesDeiniol RoadBangor LL572UWUK Air Quality Studies Department of Civil and Environmental EngineeringThe Hong Kong Polytechnic UniversityHong KongChina Department of Forestry and Environmental Resources Faculty Excellence Program for Leadership in Public ScienceNorth Carolina State UniversityChancellorRaleighNC 27695USA Departments of Architecture&Civil Engineering and Chemical EngineeringUniversity of BathBath BA27AYUK School of Architecture University of NevadaLas VegasNV 89154USA Department of Tropical Ecosystems Functioning Center of Nuclear Energy in AgricultureUniversity of São PauloPiracicaba 13416-000Sao PauloBrazil School of Ocean Sciences Bangor UniversityMenai BridgeAnglesey LL595 ABUK International Laboratory for Air Quality and Health Science and Engine

The combination of urbanization and global warming leads to urban overheating and compounds the frequency and intensity of extreme heat events due to climate ***,the risk of urban overheating can be mitigated by urban green-blue-grey infrastructure(GBGI),such as parks,wetlands,and engineered greening,which have the potential to effectively reduce summer air *** many reviews,the evidence bases on quantified GBGI cooling benefits remains partial and the practical recommendations for implementation are *** systematic literature review synthesizes the evidence base for heat mitigation and related co-benefits,identifies knowledge gaps,and proposes recommendations for their implementation to maximize their *** screening 27,486 papers,202 were reviewed,based on 51 GBGI types categorized under 10 main *** GBGI(green walls,parks,street trees)have been well researched for their urban cooling ***,several other GBGI have received negligible(zoological garden,golf course,estuary)or minimal(private garden,allotment)*** most efficient air cooling was observed in botanical gardens(5.0±3.5℃),wetlands(4.9±3.2℃),green walls(4.1±4.2℃),street trees(3.8±3.1℃),and vegetated balconies(3.8±2.7℃).Under changing climate conditions(2070–2100)with consideration of RCP8.5,there is a shift in climate subtypes,either within the same climate zone(e.g.,Dfa to Dfb and Cfb to Cfa)or across other climate zones(e.g.,Dfb[continental warm-summer humid]to BSk[dry,cold semi-arid]and Cwa[temperate]to Am[tropical]).These shifts may result in lower efficiency for the current GBGI in the *** the importance of multiple services,it is crucial to balance their functionality,cooling performance,and other related co-benefits when planning for the future *** global GBGI heat mitigation inventory can assist policymakers and urban planners in prioritizing effective interventions to reduce the risk of urban overheating,fi

关键词： estuary walls extreme

Effects of physical activity by the teach-back educational method on the physical ability and quality of life in hemodialysis patients:a clinical trial

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Frontiers of Nursing 2023年第2期10卷 223-231页

作者： Pegah Sharifian Arash khalili Morteza Shamsizadeh Neonatal and Pediatric Nursing Department Nursing Care Research Center(NCRC)School of Nursing and MidwiferyIran University of Medical SciencesTehran ***Iran Department of pediatric nursing Mother and Child Care Research CenterHamadan University of Medical SciencesHamadan 65176-19657Iran Department of medical surgical Chronic Diseases(Home Care)Research CenterHamadan University of Medical SciencesHamadan 65176-19657Iran

Objective:To determine the effect of physical activity by using the teach-back educational method on hemodialysis patients’quality of life(QOL)and physical ***:This is a single-blind clinical trial study involving a control group.A total of 90 patients who admitted to the dialysis centers of Beheshti and Besat hospitals in Hamadan were selected using a convenience sampling method and were randomly assigned to intervention(n=45)and control(n=45)*** were collected using a demographic information checklist,a kidney disease QOL questionnaire,and a 6-minute-walk distance(6MWD)*** patients’QOL questionnaire was completed,and the 6MWD was recorded before and at the end of the 2nd,4th,6th,8th,and 12th weeks of the *** the intervention group,the patients were taught to perform physical activities with Pilates stretches in different resistances using the teach-back educational method during dialysis sessions for 12 *** were analyzed by using the independent t-test and chi-square test using SPSS-22 ***:Before the intervention,no differences were observed between the experimental and control groups in terms of demographic characteristics,QOL,and physical ability(P>0.05).The physical ability and QOL levels of patients exercising in the test group were higher than those in the control group after the intervention(P<0.05).Based on the results,the 2 groups significantly differed with regard to the scores of various dimensions of QOL and physical ability after the intervention(P<0.05).Conclusions:Physical activity by using the teach-back method can effectively increase physical ability and improve QOL of hemodialysis ***,the recommendations and inclusion of exercise in the dialysis care plan can effectively promote patients’health.

关键词： hemodialysis patients physical ability physical activity quality of life teach-back education

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Application of artificial neural network for calculating anisotropic friction angle of sands and effect on slope stability

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Journal of Central South University 2015年第5期22卷 1878-1891页

作者： Hamed farshbaf Aghajani Hossein Salehzadeh Habib Shahnazari School of Civil Engineering Iran University of Science and Technology

The anisotropy effect is one of the most prominent phenomena in soil mechanics. Although many experimental programs have investigated anisotropy in sand, a computational procedure for determining anisotropy is lacking. Thus, this work aims to develop a procedure for connecting the sand friction angle and the loading orientation. All principal stress rotation tests in the literatures were processed via an artificial neural network. Then, with sensitivity analysis, the effect of intrinsic soil properties,consolidation history, and test sample characteristics on enhancing anisotropy was examined. The results imply that decreasing the grain size of the soil increases the effect of anisotropy on soil shear strength. In addition, increasing the angularity of grains increases the anisotropy effect in the sample. The stability of a sandy slope was also examined by considering the anisotropy in shear strength parameters. If the anisotropy effect is neglected, slope safety is overestimated by 5%-25%. This deviation is more apparent in flatter slopes than in steeper ones. However, the critical slip surface in the most slopes is the same in isotropic and anisotropic conditions.

关键词： anisotropy artificial neural network sand principal stress rotation slope stability

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Succinate dehydrogenase in Parkinson＇s disease

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Frontiers in Biology 2017年第3期12卷 175-182页

作者： Mohammad Jodeiri farshbaf Department of Biology New Mexico State University Las Cruces NM 88003 USA

BACKGROUND： The prevalence of neurodegenerative disorders such as Parkinson＇s disease （PD） is increased by age. Alleviation of their symptoms and protection of normal neurons against degeneration are the main aspects of the researches to establish novel therapeutic strategies. Many studies have shown that mitochondria as the most important organelles in the brain which show impairment in PD models. Succinate dehydrogenase （SDH） as a component of the oxidative phosphorylation system in mitochondria connects Krebs cycle to the electron transport chain. Dysfunction or inhibition of the SDH can trigger mitochondrial impairment and disruption in ATP generation. Excessive in lipid synthesis and induction of the excitotoxicity as inducers in PD are controlled by SDH activity directly and indirectly. On the other hand, mutation in subunits of the SDH correlates with the onset of neurodegenerative disorders. Therefore, SDH could behave as one of the main regulators in neuroprotection. OBJECTIVE： In this review we will consider contribution of the SDH and its related mechanisms in PD. METHODS： Pubmed search engine was used to find published studies from 1977 to 2016. ＂Succinate dehydrogenase＂, ＂lipid and brain＂, ＂mitochondria and Parkinson＇s disease＂ were the main keywords for searching in the engine. RESULTS： Wide ranges of studies （59 articles） in neurodegenerative disorders especially Parkinson＇s disease like genetics of the Parkinson＇s disease, effects of the mutant SDH on cell activity and physiology and lipid alteration in neurodegenerative disorders have been used in this review. CONCLUSION： Mitochondria as key organelles in the energy generation plays crucial roles in PD. ETC complex in this organelle consists four complexes which alteration in their activities cause ROS generation and ATP depletion. Most of complexes are encoded by mtDNA while complex Ⅱ is the only part of the ETC which is encoded by nuclear genome. So, focusing on the SDH and related pathways which

关键词： Parkinson's disease mitochondria succinate dehydrogenase neuroprotection

A mathematical analysis of a tuberculosis epidemic model with two treatments and exogenous re-infection

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International Journal of Biomathematics 2020年第8期13卷 205-231页

作者： Mehdi Lotfi azizeh Jabbarit Hossein Kheiri Department of Applied Mathematics Faculty of Mathematical Sciences University of Tabriz TabrizIran Marand Faculty of Engineering University of Tabriz TabrizIran

In this paper,we propose a mathematical model of tuberculosis with two treatments and exogenous re-infection,in which the treatment is effective for number of infectious individuals and it fails for some other infectious individuals who are being *** show that the model exhibits the phenomenon of backward bifurcation,where a stable disease-free equilibrium coexists with a stable endemic equilibria when the related basic reproduction number is less than ***,it is shown that under certain conditions the model cannot exhibit backward ***,it is shown in the absence of re-infection,the backward bifurcation phenomenon does not exist,in which the disease-free equilibrium of the model is globally asymptotically stable when the associated reproduction number is less than *** global asymptotic stability of the endemic equilibrium,when the associated reproduction number is greater than unity,is established using the geometric *** simulations are presented to illustrate our main results.

关键词： Tuberculosis backward bifurcation geometric approach basic reproduction number stability analysis

Highly efficient and regioselective thiocyanation of aromatic amines,anisols and activated phenols with H_2O_2/NH_4SCN catalyzed by nanomagnetic Fe_3O_4

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Chinese Chemical Letters 2015年第5期26卷 547-552页

作者： Dariush khalili Department of Chemistry.College of Sciences.Shiraz University

A new method employing magnetic nanoparticles Fe3O4 as a catalyst and H2O2 as a green oxidant is developed for the oxidative thiocyanation of aromatic amines, anisols and activated phenols with high yields under mild reaction conditions. The catalyst could be easily recovered from the reaction mixture using an external magnet and reused in several reaction cycles without loss of activity.

关键词： Arenes Green oxidant Hydrogen peroxide Nanomagnetic Fe3O4 NH4SCN Thiocyaoation

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