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Metformin alleviates cholestasis-associated nephropathy through regulating oxidative stress and mitochondrial function

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Liver Research 2021年第3期5卷 171-180页

作者： Mohammad Mehdi Ommati Hamidreza Mohammadi Khadijeh Mousavi Negar Azarpira Omid farshad Reyhaneh Dehghani Asma Najibi Sedigheh Kamran Hossein Niknahad Reza Heidari College of Life Sciences Shanxi Agricultural UniversityTaiguShanxiChina Pharmaceutical Sciences Research Center Shiraz University of Medical SciencesShirazIran Department of Pharmacology and Toxicology School of PharmacyShiraz University of Medical SciencesShirazIran Transplant Research Center Shiraz University of Medical SciencesShirazIran Department of Chemistry Payame Noor UniversityTehranIran

Background and aim:Cholestasis-associated renal injury or cholemic nephropathy(CN)is a serious clinical *** studies mentioned that oxidative stress and mitochondrial impairment play a role in *** is no specific pharmacological intervention for *** is an anti-diabetic drug administered for *** the other hand,novel pharmacological properties have emerged for this *** effect of metformin on oxidative stress parameters has been well-recognized in different experimental *** has also been found that metformin positively affected mitochondrial *** current study aimed to evaluate the effects of metformin in an animal model of ***:Rats underwent bile duct ligation(BDL)and were treated with metformin(250 and 500 mg/kg)for 14 consecutive *** weeks after the BDL operations,urine,serum,and kidney samples were collected and ***:Markers of oxidative stress,including reactive oxygen species(ROS)formation,lipid peroxida-tion,protein carbonylation,depleted antioxidant capacity,and decreased glutathione(GSH)levels were detected in BDL ***,mitochondrial indices,including adenosine triphosphate(ATP)level,dehydrogenase activity,mitochondrial membrane potential,and mitochondrial permeability,were impaired in the kidney of cholestatic *** histopathological alterations in cholestatic animals included tubular degeneration and interstitial inflammation,cast formation,and *** was found that metformin significantly alleviated oxidative stress and improved mitochondrial indices in the kidney of cholestatic *** histopathological alterations were also mitigated in metformin-treated ***:Metformin could be a candidate for managing *** nephroprotective role of metformin is primarily associated with its effects on oxidative stress parameters and mitochondrial function.

关键词： Metformin Bile acids Cholestasis Cirrhosis Oxidative stress Mitochondrial function Energy crisis Cholemic nephropathy(CN) Renal failure

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Sexual dimorphism in the number of microglial cells isolated from neonate mice

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Precision Medicine Research 2021年第3期3卷 12-16页

作者： Maryam Khajeh-Mobarakeh farshad Homayouni Moghadam Department of Biology ACECR Institute of Higher EducationIsfahanIran Department of animal Biotechnology Cell Science Research CenterRoyan Institute for BiotechnologyACECRIsfahanIran

Background:Microglia are brain resident macrophages originating from mesodermal/mesenchymal cells that migrate into the CNS as early as embryonic day 9 in mice(E9)prior to the emergence of neurons and other *** have variety of neuro-developmental and homeostatic functions during early embryonic central nervous system development and later in the adult *** may be responsible for mediating some gender-related structural and functional differences in the ***,identifying the microglia content and amount of migrated microglia in embryonic stage would be helpful to determine the function of microglia in induction of brain gender-related *** of its complexity to determine the exact number of microglia in embryo,and since most studies harvest microglia form neonate mice,but it is not completely determined yet if there is any difference in the content of microglia in male and female ***:Brains were extracted from male and female neonates to prepare mixed glia,then microglia were extracted from cultured mixed glia using shaking *** microglia were counted,cultured and gone under microscopic and flow cytometry ***:The number of microglia harvested from male and female pubs is different and presumably male pubs have more microglia ab *** assessments on presence of amoeboid,rod like and ramified types showed that both genders have similar ***:Presence of a greater number of ab initio microglia in male neonates could indicate that gender-difference in the number of microglia may play a role in gender-dependent brain development from infancy.

关键词： Microglia Gender Brain Sex Neonatal Mixed glia

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Amperometric Hydrogen Peroxide Biosensor Based on Horseradish Peroxidase Entrapped in Titania Sol-Gel Film on Screen-Printed Electrode

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American Journal of Analytical Chemistry 2013年第11期4卷 607-615页

作者： Reza E. Sabzi Fereshteh Rasouli farshad Kheiri Department of Chemical Engineering Urmia University of Technology Urmia Iran Department of Chemistry Faculty of Science Urmia University Urmia Iran Department of Chemistry Faculty of Science Urmia University Urmia Iran Institute of Biotechnology Urmia University Urmia Iran

We report the fabrication of disposable and flexible Screen-Printed Electrodes (SPEs). This new type of screen-printed electrochemical platform consists of Ag nanoparticles (AgNPs) and graphite composite. For this purpose, silver nanoparticles were first synthesized by a chemical reduction method. The morphology and structure of the AgNPs were analyzed using a Scanning Electron Microscope (SEM) and UV-Visible spectroscopy. Graphite was chosen as the working electrode material for the fabrication of a thick-film. The fabrication of a screen-printed hydrogen peroxide biosensor consisting of three electrodes on a polyethylene terephthalate (PET) substrate was performed with a spraying approach (working, counter and reference: enzyme electrode, graphite, pseudo reference: Ag/AgCl). This biosensor was fabricated by immobilizing the peroxidase enzyme (HRP) in a Titania sol-gel membrane which was obtained through a vapor deposition method. The biosensor had electrocatalytic activity in the reduction of H2O2 with linear dependence on H2O2 concentration in the range of 10-5 to 10-3 M;the detection limit was 4.5 × 10-6 M.

关键词： Screen-Printed Electrode Ag Nanoparticle Titania Sol-Gel Biosensor

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The Selection of Equipment and Parameters for Green Salt Production by Hydro-fluorination of UO2

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材料科学与工程（中英文B版） 2012年第1期2卷 1-6页

作者： Hasanzadeh Abdolmajid Faghihi farshad Tavakoli Hossin Zarean Amir School of Mechanical Engineering University of Shiraz Shiraz 71348-51154 Iran Department of Chemical Engineering Sharif University of Technology Tehran Iran Schools of Chemical Gas and Petroleum Engineering University of Shiraz Shiraz 71348-51154 Iran

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Serum Vitamin D Levels and Severity of Liver Dysfunction in Cirrhotic Patients

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International Journal of Clinical Medicine 2017年第6期8卷 402-411页

作者： Kambiz Yazdanpanah farshad Sheykhesmeeili Baran Parhizkar Abbas Ghasemi Associate Professor Department of Hepatology and Gastroenterology Towhid Hospital University of Kurdistan Head of Department of Internal University of Kurdistan Kurdistan Iran Assistant Professor and Head of Department of Hepatology and Gastroenterology Towhid Hospital University of Kurdistan Kurdistan Iran Assistant Professor Department of Hepatology and Gastroenterology Towhid Hospital University of Kurdistan Kurdistan Iran Chief Resident of Internal Medicine Department of Hepatology and Gastroenterology Towhid Hospital University of Kurdistan Kurdistan Iran

Background and objective: Cirrhosis affects hundreds of millions of patients all around the world. Vitamin D deficiency is frequently observed in chronic hepatic disease. Vitamin D level may be an important survival marker in advanced liver cirrhosis. Material and Methods: The study is a sectional one of the descriptive-analytical type, where 90 of the patients with hepatic cirrhoses were selected with census sampling method. In all the cirrhotic patients, for diagnosis in clinical findings, the serological marker, autoantibodies were stable;biochemical endoscopy and imaging were the histological evidence and examinations and were then analyzed by SPSS version 22 software. Results: Based on the study, from the aspect of Child-Pugh classification, the highest vitamin D levels had the highest value in Child-Pugh class A with a frequency of 13 (43%) in the form of insufficiency, and had the highest value in Child-Pugh class B and C in the form of slight deficiency. Conclusion: It was specified based on the results obtained from the research that different vitamin D levels and liver failure severity have a significant relationship with each other (p < 0.05) in patients suffering from hepatic cirrhosis, such that the serum vitamin D level decreases as liver failure severity increases.

关键词： Cirrhosis Vitamin D Liver Child-Pugh

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A New Approach to Analyzing Behavioral Change Propagation in Redesigning of Drone Camera Stabilizer

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Engineering（科研） 2021年第12期13卷 707-738页

作者： Hamid Reza Moghadas Najaf Abad Ali Mahmoodi farshad Pazooki Department of Aerospace Engineering Faculty of Engineering SRBIA University Tehran Iran

Redesigning of complex products is not an easy task. Engineering change requirements can be extracted at any stage of the product redesign process, and it makes the management of engineering change become a challenging mission. The motivation for this study is to find the shortest path of behavioral change propagation (BCP), minimize the BCP, access to the special behavioral elements in order to better managing the BCP and classifying the behavioral attribute of the elements in terms of their relationship to change by betweenness centrality coefficient (BNCC), clustering coefficient (CLC), reachability coefficient (RC) and change propagation index (CPI). In this article, the procedure of managerial decision-making is proposed by combining system restrictions in behavioral clustering design structure matrix (BCDSM) with optimization algorithms. The practicality of suggested method is verified in redesign procedure of a phantom drone camera stabilizer as a case study. The results, indicate that the absorption of change by behavioral elements is dominant in the mechanical (63.9%), electrical (61.1%) and thermal (38.9%) behaviors of the drone camera stabilizer system in redesign process. These elements are best candidates for reducing the cost and time of behavioral changes in the system redesign and are desirable for the designer.

关键词： Behavioral Change Propagation Behavioral Clustering Design Structure Matrix Drone Camera Stabilizer

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A Rare Case of Thymic Carcinoma

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Surgical Science 2011年第3期2卷 144-146页

作者： farshad Anvari Arnold M. Schwartz Gregory Trachiotis 不详

Thymic carcinomas are unusual tumors of the thymus gland. Basaloid carcinoma, an unusal epithelioid varient of a thymic carcinoma, is a rare histopathological subtype, and is not well charecterized in the literature. We present the anatomical and histogical features of a basoloid thymic carcinoma, and discuss current diagnosis and imaging strategies, as well as the operative and oncologic care of this type of thymmic carcinoma. Basaloid carcinomas of the thymus after complete surgical resection and adjuvant therapy genarally have a favorable long-term prognosis.

关键词： Thymus Thymic Carcinoma

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Synthesis and Characterization of Sol-Gel Derived MgO/CNTs Nanocomposite

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Journal of Chemistry and Chemical Engineering 2010年第7期4卷 29-34页

作者： Ali Asghar Hosseini farshad Taleshi Mahmoud Tajbakhsh Maryam Farhang Physic Department Faculty of Science University of Mazandaran Babolsar 47416-95447 Iran Faculty of Chemistry University of Mazandaran Babolsar 47416-95447 Iran

In this research, synthesis of magnesium oxide-multi walled carbon nanotube （MgO/MWCNTs） nanocomposite is reported using sol-gel method in which magnesium nitrate is added to aqueous solution. The structure of MWCNTs and MgO/MWCNTs composite has been characterized by analyzing the X-ray diffraction pattern （XRD）, Fourier Transform Infrared （FT-IR） spectra and Scanning Electron Microscopy （SEM） images. Experimental results indicate that the surface of purified MWCNTs sample is covered homogenously by a layered of MgO nanoparticles.

关键词： MgO/MWCNTs nanocomposite spectroscopy Sol-Gel SEM.

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Hydrocarbon production rates in Fischer-Tropsch synthesis over a Fe/Cu/La/Si catalyst

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Journal of Energy Chemistry 2013年第1期22卷 119-129页

作者： Ali Nakhaei Pour farshad Riyahi Mohammad Reza Housaindokht Mohammad Irani Seyed Mehdi Kamali Shahri Behnam Hatami Department of Chemistry Ferdowsi University of Mashhad Department of Chemical Engineering Petroleum University of Technology (PUT) Research Institute of Petroleum Industry of National Iranian Oil Company Chemical Engineering Department Penn State University University Park

The detailed kinetics of Fischer-Tropsch synthesis over an industrial Fe/Cu/La/Si catalyst was studied in a continuous spinning basket re- actor under the conditions relevant to industrial operations. Reaction rate equations were derived on the basis of Langmuir-Hinshelwood- Hougen-Watson type models for Fischer-Tropsch synthesis based on possible reactions sets originated from the carbide, enolic and combined enol/carbide mechanisms. Kinetic model candidates were evaluated by the global optimization of kinetic parameters, which were realized by first minimization of multi-response objective functions with conventional Levenberg-Marquardt method. It was found that an enolic mech- anism based model could produce a good fit of the experimental data. The activation energy for paraffin formation is 95 ***1-1 which is smaller than that for olefin formation （121 ***-1）.

关键词： Fischer-Tropsch synthesis kinetics iron catalysts catalysts selectivity

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A Hybrid Statistical Model to Generate Pronunciation Variants of Words

A Hybrid Statistical Model to Generate Pronunciation Variant...

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IEEE自然语言处理与知识工程国际学术会议

作者： Bahram Vazirnezhad farshad Almasganj Mahmood Bijankhan Biomedical Engineering Faculty Amirkabir University of Technology Tehran Research Center of Intelligent Signal ProcessingTehran Biomedical Engineering Faculty Amirkabir University of Technology Tehran Research Center of Intelligent Signal ProcessingTehran Research Center of Intelligent Signal Processing Tehran Letters and Humanities Faculty Tehran UniversityTehran

＜正＞Generating pronunciation variants of words is an important applicable subject in speech researches and is used extensively in automatic speech segmentation and recognition systems. In this way, Decision trees are extremely used to model pronunciation variants of words and sub-word unites. In the case of word unites and very large vocabulary, to train necessary decision trees we will need a huge amount of speech utterances which contains all of the needed words with a sufficient number of each one. This approach besides demanding very large data, for new words will need some new extra corpus. To solve these problems we have used generalized decision trees, that each tree is trained for a group of words with similar phonemic structure instead of a single word. These trees can predict regions of the words in which substitution, deletion and insertion of phonemes would occur. Next to this step, appropriate statistical contextual rules, which are extracted from a large speech corpus, will be applied to these regions in order to generate words variants. This new hybrid d-tree/c-rule approach takes into account word phonological structures, stress, and phone context information simultaneously and an ordinary size speech corpus will be sufficient to train its models. By using the word variants obtained by this method in the lexicon of "SHENAVA", a Persian ACSR, a relative WER% reduction of as high as 6% was obtained.

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