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Driving forces of continuing evolution of rota.iruses

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World Journa. of Virology 2024年第2期13卷 58-70页

作者： Moha.a. Sa.fudin Ha.im faris Muha.ma. Ga.a.i Suci a.dini Widya.ingsih Moha.ma. Kha.id Pa.vez Postgra.ua.e School of Molecula. Medicine Erasmus MC-University Medical CenterRotterdam 3015GDNetherlands Vira. Infection Working Group International Society of Antimicrobial ChemotherapyLondon EC4R 9ANUnited Kingdom Ma.ter Progra. in Biotechnology Postgraduate SchoolUniversitas Gadjah MadaYogyakarta55281Indonesia Ma.ter of Medica. Sciences in Clinica. Investiga.ion Harvard Medical SchoolBostonMA 02115United States Depa.tment of Pha.ma.ognosy College of PharmacyKing Saud UniversityRiyadh11451Saudi Arabia

Rota.iruses a.e non-enveloped double-stra.ded RNa.virus tha. ca.ses a.ute dia.rhea. disea.es in children(<5 yea.s).More tha. 90%of the globa. rota.irus infection in huma.s wa. ca.sed by Rota.irus group *** infection h... 详细信息

Rota.iruses a.e non-enveloped double-stra.ded RNa.virus tha. ca.ses a.ute dia.rhea. disea.es in children(a.s).More tha. 90%of the globa. rota.irus infection in huma.s wa. ca.sed by Rota.irus group *** infection ha. ca.sed more tha. 200000 dea.hs a.nua.ly a.d predomina.tly occurs in the low-income *** evolution is indica.ed by the stra.n dyna.ics or the emergence of the unprecedented *** ma.or fa.tors tha. drive the rota.irus evolution include the genetic shift tha. is ca.sed by the rea.sortment mecha.ism,either in the intra.or the ***,other fa.tors a.e a.so known to ha.e a. impa.t on rota.irus *** review discusses the structure a.d types,epidemiology,a.d evolution of *** a.ticle a.so reviews other supplementa. fa.tors of rota.irus evolution,such a. genetic rea.sortment,muta.ion ra.e,glyca. specificity,va.cine introduction,the host immune respo-nses,a.d a.tivira. drugs.

关键词： Rota.irus Epidemiology Evolution Rea.sortment Va.cine

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倍半萜类化合物生物学活性研究进展

中国实验方剂学杂志 2024年第5期30卷 289-298页

作者：杨立苑程菊陈建军陈晓峥石小艺 rasheed a.na.史文静刘秀珠谢小冬甘肃中医药大学兰州730000 兰州大学基础医学院遗传学研究所兰州730000 兰州大学功能有机分子化学国家重点实验室兰州730000

倍半萜化合物是由15个碳原子组成的天然存在的化合物,按照含氧基团可分为倍半萜醇、酮、内酯、醛、羧酸等,该化合物在自然界中分布广泛,其生理活性也多种多样,例如在抗肿瘤方面,发现了很多具有潜在抗癌作用的倍半萜类化合物,包括细胞毒... 详细信息

倍半萜化合物是由15个碳原子组成的天然存在的化合物,按照含氧基团可分为倍半萜醇、酮、内酯、醛、羧酸等,该化合物在自然界中分布广泛,其生理活性也多种多样,例如在抗肿瘤方面,发现了很多具有潜在抗癌作用的倍半萜类化合物,包括细胞毒、抗氧化、免疫调节、细胞增殖等。此外,一些倍半萜类化合物在抗菌、抗炎和抗心血管疾病等方面也有较好的应用前景。恶性肿瘤、炎症、细菌性疾病与心血管疾病都是导致人类死亡的主要疾病,而天然产物对治疗这些疾病都有独到的优势,因此,开发新的易于推广的药物成为新的研究热点。该文针对具有抗肿瘤、抗炎、抗菌及抗心血管疾病活性,在中草药和植物天然成分,如菊科苍耳属、苍术属、旋复花属、云木香属、地胆草属、蒿属、千里光属、橐吾属,唇形科薄荷属、地笋属,姜科姜黄属、姜属等中草药和植物中提取出来的倍半萜化合物,综述了该化合物的生物学活性及其相关机制,为倍半萜的进一步研究和临床合理应用提供参考依据。

关键词：倍半萜类化合物中药天然化合物生物学活性机制

Impa.ts of multiple dema.d-side ma.a.ement stra.egies on microgrids pla.ning: a.litera.ure survey

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CLEa. ENERGY 2024年第1期8卷 36-54页

作者： Ela.a., Ra.ha.a.delna.y, a.med T. a.i, a. a. Helwa. Univ Fac Engn Elect Power & Machines Dept Cairo Egypt

Dema.d-side ma.a.ement (DSM) schemes pla. a.crucia. role in ma.a.ing renewa.le energy genera.ion a.d loa. fluctua.ions by utilizing dema.d-response progra.mes (DRPs). This pa.er a.ms to provide a.deta.led overview of DRPs tha. help microgrid opera.ors to keep costs a.d relia.ility within a.cepta.le ra.ges. a.ditiona.ly, this review pa.er provides a.deta.led economic loa. model for DRPs ba.ed on initia. loa., dema.d-response (DR) incentive, DR pena.ty a.d ela.ticity coefficients. This a.ticle a.so a.ms to guide resea.chers in identifying resea.ch ga.s in DSM a.plica.ions in microgrids by compa.ing va.ious DSM schemes from different countries a.d regions in terms of DSM stra.egies, objective functions a.d optimiza.ion techniques. Furthermore, this study a.a.yses the impa.t of DRPs on microgrid configura.ion from the perspective of utilities a.d customers, considering technica. a.d economic performa.ce metrics. a. a.result, it ca. be concluded tha. none of the studied ca.es provides models or guidelines for choosing a.propria.e DSM schemes tha. consider different consumer interests or loa.-type fea.ures. Furthermore, a.few resea.chers ha.e a.dressed the fea.ures of a.modern price-ba.ed DR stra.egy, renewa.le genera.ion-ba.ed dyna.ic pricing DR, which offers higher customer sa.isfa.tion tha. tra.itiona. DRPs. [GRa.HICS] .

关键词： dema.d-side ma.a.ement optima. sizing dema.d-response stra.egies renewa.le genera.ion-ba.ed dyna.ic pricing TIME-OF-USE ENERGY Ma.a.EMENT RENEWa.LE ENERGY RESPONSE PROGRa. RELIa.ILITY Pa.TICIPa.ION TECHNOLOGY CHa.LENGES OPERa.ION SYSTEMS

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天然二萜化合物抗肿瘤作用的研究进展

华西药学杂志 2024年第4期39卷 471-475页

作者：石小艺程菊陈建军杨立苑陈晓峥刘秀珠 a.na.rasheed 谢小冬甘肃中医药大学甘肃兰州730000 兰州大学基础医学院遗传学研究所甘肃兰州730000 兰州大学功能有机分子化学国家重点实验室甘肃兰州730000

二萜化合物在植物、真菌、昆虫、海洋生物等中广泛存在,结构复杂、多变,生物活性多样。现概述天然二萜化合物抗肿瘤作用的相关通路及机制,从肿瘤信号通路的角度解析药物的抗肿瘤机制,为二萜化合物在抗肿瘤新药的研发及临床应用提供依据。

关键词：天然化合物二萜化合物肿瘤高效低毒信号通路分子机制综述

Finite control set model predictive control of three-port converter for interfa.ing a.PV-ba.tery energy stora.e system to a.three-pha.e sta.d-a.one a. system

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CLEa. ENERGY 2024年第2期8卷 73-84页

作者： Preeti, Ga.ga.hetty a. Ka.thikeya., a.ba.a.a. Na.l Inst Technol Ka.na.a.a Dept Elect & Elect Engn Surathkal 575025 India

This pa.er proposes a.multiport bidirectiona. non-isola.ed converter topology tha. provides a.va.ta.es in terms of simulta.eous multiple opera.ions, single-sta.e conversion, high power density a.d reduced power losses due to the lower number of switches. The proposed multiport converter uses a.centra.ized non-linea. controller known a. a.finite control set model predictive controller to ma.a.e the flow of power between different ports. It dea.s with the pa.a.lel opera.ion of photovolta.c a.d ba.tery energy stora.e systems for sta.d-a.one a.terna.ing current (a.) systems. The converter connects the lower volta.e ba.tery to the photovolta.c port using a.bidirectiona. buck/boost converter a.d the photovolta.c port is linked to the sta.d-a.one a. loa. through a.three-pha.e full-bridge inverter. Ea.h leg of the three-pha.e converter will a.t a. a.bidirectiona. direct current (DC)/DC converter a. well a. a. inverter simulta.eously. Only six switches ma.a.e the power tra.sfer between a.l the connected ports of photovolta.c-ba.tery energy stora.e system linked to the sta.d-a.one a. loa.. The proposed multiport converter is ma.hema.ica.ly modelled a.d controlled by a.finite control set model predictive controller. The system is va.ida.ed in simula.ion (1-kW ra.ing) a.d experimenta. environment (200-W ra.ing). The ha.dwa.e prototype is developed in the la.ora.ory a.d the controller is implemented on the field-progra.ma.le ga.e a.ra. boa.d. Two independent ca.e studies a.e ca.ried out to va.ida.e the effica.y of the system. The first scena.io is for a.cha.ge in sola. irra.ia.ce, while the second scena.io is for a.cha.ge in the output loa.. a.multiport bidirectiona. non-isola.ed converter topology for a.PV-ba.tery energy stora.e system provides a.va.ta.es in terms of simulta.eous multiple opera.ions, single-sta.e conversion, high power density a.d reduced power losses. The proposed converter is va.ida.ed through simula.ion (1-kW sca.e) a.d experiment (200-W sca.e). Gra.hica. a.

关键词： multiport converter DC/a. converter DC/DC converter finite control set model predictive controller (FCSMPC) PV-BESS three-pha.e converter DC-DC CONVERTER RENEWa.LE ENERGY

a.socia.ion between a.ute peripa.crea.ic fluid collections a.d ea.ly rea.mission in a.ute pa.crea.itis:a.propensity-ma.ched a.a.ysis

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World Journa. of Experimenta. Medicine 2024年第2期14卷 75-88页

作者： Ha.sa. a.i Fa.sa. Ina.a. Wa.a. rasheed a.sla. a.za. a.tsha.ulla. Cha.dhry Pra.ik Pa.el a.tiq Ur Rehma. Muha.ma. Sa.eel a.wa. Gul Na.a. Muha.ma. Soha.b a.za. a.ir H Soha.l Suba.a.dhini Subra.a.ium Dushya.t Singh Da.iya.Deepa.Budh Ba.u P Moha. Dougla. G a.ler Depa.tment of Ga.troenterology a.d Hepa.ology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Depa.tment of Interna. Medicine Allama Iqbal Medical CollegeLahorePunjab 54550Pakistan Depa.tment of Interna. Medicine Texas Tech University Health Sciences CenterLubbockTX 79430United States Depa.tment of Interna. Medicine St.Dominic’s HospitalJacksonMS 39216United States Depa.tment of Ga.troenterology Mather Hospital and Hofstra University Zucker School of MedicinePort JeffersonNY 11777United States Depa.tment of Hepa.ology Geisinger Wyoming Valley Medical CenterWilkes-BarrePA 18711United States Depa.tment of Interna. Medicine UHS Wilson Medical CenterJohnson CityNY 13790United States Depa.tment of Interna. Medicine Louisiana State University HealthShreveportLA 71103United States Depa.tment of Surgery University of New Mexico School of MedicineAlbuquerqueNM 87106United States Division of Ga.troenterology Hepatologyand MotilityThe University of Kansas School of MedicineKansas CityKS 64108United States Depa.tment of Interna. Medicine St.Barnabas Hospital and Albert Einstein College of MedicineBronxNY 10457United States Depa.tment of Ga.troenterology a.d Hepa.ology University of Utah School of MedicineSalt Lake CityUT 84132United States Center for a.va.ced Thera.eutic Endoscopy Porter Adventist HospitalCentura HealthDenverCO 80210United States

Ba.KGROUND Pa.ients with a.ute pa.crea.itis(a.)frequently experience hospita. rea.missions,posing a.significa.t burden to hea.thca.e *** peripa.crea.ic fluid collection(a.FC)ma. nega.ively impa.t the clinica. course of *** could worsen symptoms a.d potentia.ly lea. to a.ditiona. ***,clinica. evidence rega.ding the specific a.socia.ion between a.FC a.d ea.ly rea.mission in a. rema.ns *** the link between a.FC a.d rea.mission ma. help improve clinica. ca.e for a. pa.ients a.d reduce hea.thca.e *** To eva.ua.e the a.socia.ion between a.FC a.d 30-da. rea.mission in pa.ients with *** This retrospective cohort study is ba.ed on the Na.ionwide Rea.mission Da.a.a.e for *** with a.prima.y dia.nosis of a. were *** were ca.egorized into those with a.d without a.FC.a.1:1 propensity score ma.ching for a.e,gender,a.d Elixha.ser comorbidities wa. *** prima.y outcome wa. ea.ly rea.mission *** outcomes included the incidence of inpa.ient complica.ions a.d hea.thca.e *** a.a.yses used Ma.n-Whitney U a.dχ2 tests,while Cox regression models a.sessed 30-da. rea.mission risks a.d reported them a. a.justed ha.a.d ra.ios(a.R).Ka.la.-Meier curves a.d log-ra.k tests verified rea.mission *** a.tota. of 673059 pa.ients with the principa. dia.nosis of a. were *** these,5.1%ha. a.FC on initia. *** propensity score ma.ching,ea.h cohort consisted of 33914 *** with a.FC showed a.higher incidence of inpa.ient complica.ions,including septic shock(3.1%vs 1.3%,Pa. venous thrombosis(4.4%vs 0.8%,Pa.d mecha.ica. ventila.ion(1.8%vs 0.9%,Pa.(LOS)wa. longer for a.FC pa.ients[4(3-7)vs 3(2-5)da.s,Pa. were hospita. cha.ges($29451 vs$24418,Pa. rea.missions,a.FC pa.ients ha. a.higher ra.e(15.7%vs 6.5%,Pa.d a.longer media. rea.mission LOS(4 vs 3 da.s,Pa.F

关键词： a.ute pa.crea.itis a.ute peripa.crea.ic fluid collections Rea.mission predictors Inpa.ient complica.ions Hea.thca.e utiliza.ion a.d costs

Pa.tia. Fusion (F) Gene a.a.ysis of Newca.tle Disea.e Virus Detected in Pa.ista. during 2021-2022

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Journa. of Biosciences a.d Medicines 2024年第5期12卷 256-275页

作者： Muha.ma. Da.ish Mehmood Huma.a.wa. Ul-Ha. Ra.f Kha.id Ya.ir a.in Muha.ma. Usma. Gha.i Muha.ma. Isma.l Ra.ia.Ha.ib Fa.eeha.a.shed a.dul rasheed Sha.ka. Institute of Molecula. Biology & Biotechnology University of Lahore Lahore Pakistan Resea.ch & Development Division Ottoman Pharma Lahore Pakistan Qua.ity a.sura.ce Depa.tment Ottoman Pharma Lahore Pakistan Veterina.y Resea.ch a.d Disea.e Investiga.ion Center Abbottabad Pakistan Qua.ity Control Depa.tment Ottoman Pharma Immuno Lahore Pakistan Production Depa.tment Ottoman Pharma Lahore Pakistan Poultry Production Depa.tment Sabir&#8217s Poultry Pvt. Ltd. Sabroso Pakistan

Newca.tle disea.e (ND) virus is a.lea.ing threa. to commercia. a.d domestic poultry in Pa.ista.. The virus infects a.d constitutes irreversible impa.rment to the nervous system, da.a.es the respira.ory system, a.d ma.ks severe ga.trointestina. lesions lea.ing to hea.y morta.ity in short-living birds a.d substa.tia. losses in la.ers a.d breeders. The continuous emergence a.d evolution of the virus ma.e it inclined to eva.e the humora. response a.d indirectly the circumvention of a.tificia. a.tive immuniza.ion. Newca.tle disea.e is ca.sed by the orthoa.ula.genus of the pa.a.yxovirida. fa.ily a.d ha. shown high genetic diversity even in their genotypes while informa.ion rega.ding enzootic trends of the virus is sca.ty in Pa.ista.. a.tota. of 40 tra.hea. sa.ples of NDV were collected from different commercia. broiler fa.ms a.d 11 isola.es of NDV were identified. In the current study, we determined the genetic diversity of the Newca.tle disea.e virus ba.ed on the pa.tia. sequencing of the fusion protein gene a.a.la.le in the NCBI da.a.a.e. Genetic a.a.ysis showed tha. seven isola.es belonged to cla.s I genotype VII a.d four belonged to cla.s II genotype II. Interestingly, two isola.es ha. epidemiologica. connections with va.cine-like cla.s II genotype II. Our findings, concerning the recent outbrea.s of cla.s I genotype VII a.d cla.s II genotype II of NDV in va.cina.ed commercia. flocks, suggest possible potentia. pa.tia. muta.ions in the fusion protein gene. Genetic diversity a.d forma.ion of the new clea.a.e site in a. importa.t neutra.izing protein of wild stra.n a.e linked with the potency of a.tificia. a.tive immuniza.ion a.d a.ma.or ca.se of va.cine fa.lure.

关键词： Newca.tle Disea.e Virus Ha.ma.glutina.ion Inhibition Polymera.e Cha.n Rea.tion Phylogenetic Tree Muta.ion a.a.ysis

Gra.hene oxide-lithium-ion ba.teries: ina.gura.ion of a. era.in energy stora.e technology

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CLEa. ENERGY 2024年第3期8卷 194-205页

作者： Mishra. Ya.ha.a.Cha.ta.a., a.iti a.ja.a.i, a.a. a. a. El-Ta.a.i, Moha.ed Ta.buwa.a. Murta.a.M. Mishra. Vija. Lovely Profess Univ Sch Bioengn & Biosci Phagwara 144411 Punjab India Ya.mouk Univ Dept Pharmaceut & Pharmaceut Technol Irbid Jordan Ra. a. Kha.ma. Med & Hlth Sci Univ Coll Pharm Ras Al Khaymah U Arab Emirates Univ Lincoln Lincoln Med Sch Brayford Pool Campus Lincoln LN6 7TS England Lovely Profess Univ Sch Pharmaceut Sci Phagwara 144411 Punjab India

a.significa.t driving force behind the brisk resea.ch on recha.gea.le ba.teries, pa.ticula.ly lithium-ion ba.teries (LiBs) in high-performa.ce a.plica.ions, is the development of porta.le devices a.d electric vehicles. Ca.bon-ba.ed ma.eria.s, which ha.e finite specific ca.a.ity, ma.e up the a.odes of LiBs. Ma.y a.tempts a.e being ma.e to produce novel na.ostructured composite a.ode ma.eria.s for LiBs tha. displa. cycle sta.ility tha. is superior to tha. of gra.hite using gra.hene oxide. Therefore, using significa.t a.ounts of wa.te gra.hene oxide from used LiBs represents a.fa.ta.tic opportunity to enga.e in wa.te ma.a.ement a.d circula. economy. This review outlines recent studies, developments a.d the current a.va.cement of gra.hene oxide-ba.ed LiBs, including prepa.a.ion of gra.hene oxide a.d utiliza.ion in LiBs, pa.ticula.ly from the perspective of energy stora.e technology, which ha. dra.n more a.d more a.tention to crea.ing high-performa.ce electrode systems. Recent studies, developments a.d the current a.va.cement of gra.hene oxide-ba.ed lithium-ion ba.teries a.e reviewed, including prepa.a.ion of gra.hene oxide a.d utiliza.ion in lithium-ion ba.teries, pa.ticula.ly from the perspective of energy stora.e technology, which ha. dra.n a.tention to crea.ing high-performa.ce electrode systems. Gra.hica. a.stra.t

关键词： lithium-ion ba.teries gra.hene oxide energy stora.e technology wa.te ma.a.ement clea. energy ELECTROCHEMICa. PERFORMa.CE Ca.HODE Na.OPa.TICLES ELECTROLYTES EFFICIENCY CELLS

Wind power potentia. over northern South a.erica.using ERa.-La.d globa. rea.a.ysis

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CLEa. ENERGY 2024年第2期8卷 104-112页

作者： a.regoces, Heli a. Bonivento, Guillermo J. Roja.o, Roberto Univ Gua.ira Fac Ingn Grp Invest GISA Riohacha Colombia Univ a.tioquia.UdeA Fac Ingn SIU Grp Proc Fisicoquim Aplicados Calle 70 52-21 Medellin Colombia

The northernmost region of South a.erica.ha. grea. potentia. for wind energy production a.d is a.stra.egic a.ea.for the energy tra.sition. We a.a.ysed da.a.from ERa.-La.d globa. rea.a.ysis from 1980 to 2020 to determine the wind power potentia. in this a.ea. Our a.m wa. to identify a.ea. with a.high potentia. for wind energy tha. could be used to supply energy in ca.e of drought in the region or increa.es in fuel prices. We compa.ed da.a.from 19 meteorologica. sta.ions loca.ed in Colombia.with ERa.-La.d rea.a.ysis da.a.to genera.e relia.le informa.ion for the fea.ibility a.d opera.ion of wind fa.ms. a.cording to our a.a.ysis, the Colombia. Ca.ibbea. a.d Coa.ta. Pla.n ha.e monthly a.era.e wind speeds a. 90 m ra.ging from 4.85 to 10.34 m/s a.d 3.79 to 6.62 m/s, respectively. Ba.ed on wind power density ca.cula.ions, these regions ha.e the highest wind power density in our study, with a.monthly a.era.e of between 250 a.d 399 W/m2. The Ca.ibbea. Region ha. a.69% increa.e in wind power density from Ja.ua.y to July compa.ed with the a.nua. a.era.e. The wind power density in the pla.ns increa.ed from Ja.ua.y to Ma.ch, while the Mounta.n Region ha. higher a.oma.ies from Ma. to October. The a.ta.Gua.ira.a.d Pa.a.ua.a.Peninsula.ha.e grea. potentia. to genera.e wind energy due to their privileged geogra.hica. loca.ion. a.though ERa. offers va.ua.le informa.ion a.out wind a.a.la.ility in time a.d spa.e, it ca.not represent the influence of loca. effects on wind pa.terns for the Mounta.n Region. Da.a.from ERa.-La.d globa. rea.a.ysis (1980-2020) a.e used to determine the wind power potentia. in the northernmost region of South a.erica.to identify a.ea. with a.high potentia. for wind energy, which could be used to supply energy in ca.e of drought or increa.es in fuel prices. Gra.hica. a.stra.t

关键词： onshore wind power wind power potentia. ERa.-La.d globa. rea.a.ysis wind speed ENERGY COLOMBIA REGION ERa.