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Neural Regeneration Research 2021年第4期16卷 635-637页

作者： francesca Grassivaro Gianvito Martino Cinthia farina Institute of Experimental Neurology Division of NeuroscienceSan Raffaele Scientific InstituteMilanItaly Vita-Salute San Raffaele University MilanItaly

Microglia,the tissue resident macrophages of the brain,are increasingly recognized as key players for central nervous system development and *** are long-lived cells deriving from a transient wave of yolk-sac derived erythro-myeloid progenitors early in *** unique ontology has prompted the search for specific markers to be used for their selective investigation and *** first generation of genomewide expression studies has provided a bundle of transcripts(such as Olfml3,fcrls,Tmem119,P2ry12,Gpr34,and Siglech)useful to distinguish microglia from peripheral ***,more recent reports have revealed that microglial phenotype is constantly shaped by the microenvironment in a time-,and context-dependent *** this article,we review data that provide additional pieces to this complex scenario and show the existence of unexpected phenotypic convergence between microglia and peripheral macrophages at certain developmental stages and under pathological *** observations suggest that the two cell types act synergically boosting their mutual activities depending on the *** novel information about the biology of microglia and peripheral macrophages sheds new light about their therapeutic potential for neuroinflammatory and neurodegenerative diseases.

关键词： cell reprogramming cell therapy macrophages microglia neuroinflammation plasticity

动脉硬度和波反射纵向稳定性的遗传和环境决定因素:一项双胞胎研究

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中华高血压杂志 2019年第2期27卷 155-155页

作者：刘青叶鹏 Pucci G Tarnoki AD Medda E Tarnoki DL Littvay L Maurovich-Horvat P Jermendy AL Godor E fejer B Hernyes A Lucatelli P fanelli f farina f Baracchini C Meneghetti G Jermendy G Merkely B Schillaci G fagnani C Stazi MA

研究者旨在评估遗传和环境因素对主动脉脉搏波传导速度(aortic pulse wave velocity, aPWV)和主动脉增强指数(aortic augmentation index,aAIx)纵向变化的影响。研究人员纳入368对意大利和匈牙利成年双胞胎(214对单卵,154对双卵)进行aPW... 详细信息

研究者旨在评估遗传和环境因素对主动脉脉搏波传导速度(aortic pulse wave velocity, aPWV)和主动脉增强指数(aortic augmentation index,aAIx)纵向变化的影响。研究人员纳入368对意大利和匈牙利成年双胞胎(214对单卵,154对双卵)进行aPWV和aAIx(TensioMed动脉造影仪)的重复评估。计算个体内不同波间相关性、双胞胎间波内相关性和双胞胎间不同波间相关性;采用双变量Choiesky模型计算加性遗传(A).共享环境(C)和独特的环境(E)成分。

关键词：环境因素双胞胎遗传动脉硬度稳定性波反射动脉脉搏波传导速度 aortic

Metamorphism and exhumation of basement gneiss domes in the Quadrilátero ferrífero:Two stage dome-and-keel evolution?

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Geoscience frontiers 2019年第5期10卷 1765-1787页

作者： Kathryn Cutts Cristiano Lana fernando Alkmim federico farina Hugo Moreira Viviane Coelho Applied Isotope Research Group Departamento de GeologiaEscola de MinasUniversidade Federal de Ouro PretoMorro do Cruzeiro35400-000Ouro PretoMGBrazil Department of Earth Sciences University of GenevaRue des Maraihers 131205GenevaSwitzerland School of Earth and Environmental Sciences University of PortsmouthBurnaby BuildingBurnaby RoadPortsmouthPO1 3QLUK

The presence of dome-and-keel provinces in Archean cratons has been connected with the initiation of plate tectonics on Earth as these features are most commonly observed in Archean *** Quadrilátero ferrífero in Brazil has been identified as a Paleoproterozoic dome-and-keel province for more than three *** prevailing model suggests that it formed during the Rhyacian Transamazonian orogeny,making it unique among dome-and-keel ***,a lack of appropriate lithologies,datable minerals and the metamorphic overprint of later orogenesis has resulted in a cryptic metamorphic record for the formation of this dome-and-keel province.A clinopyroxene-bearing migmatite from the core of the Bacao dome has peak P-T conditions of 5-7 kbar and 700-750 ℃ and a published age of ca.2730 Ma based on U-Pb ages of zircon from leucosomes,suggesting that this age represents the migmatisation event.A fine-grained epidote-albite-titanite assemblage overprints the coarse-grained clinopyroxene and amphibole,giving P-T conditions of 8-9 kbar and 550℃ with an associated titanite age of ca.2050 Ma.A garnet-bearing amphibolite sample also from the core of the dome has peak P-T conditions of 7-8 kbar and 650-700℃,and texturally late titanite from this sample produces an age of ca.2060 *** additional samples were collected from the edges of the dome.A garnet-gedrite bearing felsic schist produces peak P-T conditions of 8-9 kbar and 650-700℃ on a clockwise P-T *** sample has a U-Pb zircon age of ca.2775 Ma,which could date metamorphism or be the age of its volcaniclastic *** unconstrained titanite from the sample gives an age of ca.2040 Ma.A garnet-bearing amphibolite that occurs as a boudin within the felsic schist gives both zircon and titanite ages of ca.2050 Ma and has peak P-T conditions of 5-6 kbar and 650-700 ℃ on a near isobaric P-T *** amphibolite dike,observed to cross-cut the felsic schist produces a zircon U-Pb age of ca.2760 Ma

关键词： Sao francisco Craton Zircon U-Pb Titanite U-Pb Phase diagrams Dome-and-keel

Lightweight SOA-Based Twin-Engine Architecture for Enterprise Systems in fixed and Mobile Environments

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China Communications 2016年第9期13卷 183-194页

作者： Tongguang Zhang Shuai Zhao Budan Wu Maurizio farina Bo Cheng Junliang Chen State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing 100876China Adaptive Software Company Via Posillipo 255Naples 80123Italy

Mobile devices as a popular computing platform for enterprise systems have enabled certain tasks to be executed out of ***,the work may be interrupted due to the server shutdown or network disconnection when employees access traditional single-engine Business Process Management *** overcome this defect,we present a lightweight twin-engine architecture based on Service Oriented Architecture(SOA).In this paper,we discuss in detail the design and implementation of the architecture,and present a trigger mechanism to activate engines according to the states of hybrid environments since it is critical for the two types of engines to cooperate closely in hybrid environments with fixed and mobile computing *** experimental results validate the usability of the architecture.

关键词： twin-engine SOA enterprise system mobile environment

The soluble glycoprotein NMB(GPNMB)produced by macrophages induces cancer sternness and metastasis via CD44 and IL-33

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Cellular & Molecular Immunology 2021年第3期18卷 711-722页

作者： M.Liguori E.Digifico A.Vacchini R.Avigni f.S.Colombo E.M.Borroni f.M.farina S.Milanesi A.Castagna L.Mannarino I.Craparotta S.Marchini E.Erba N.Panini M.Tamborini V.Rimoldi P.Allavena C.Belgiovine IRCCS Humanitas Clinical and Research Center Via Manzoni 5620089 RozzanoMlItaly Department of Biomedical Sciences Humanitas Universityvia Rita Levi Montalcini 420089 Pieve EmanueleItaly Department of Medical Biotechnologies and Translational Medicine Universita degli Studi di MilanoVia Fratelli Cervi20090 SegrateItaly Department of Oncology Mario Negri Institute for Pharmacological Research IRCCS20156 MilanItaly

In cancer,myeloid cells have tumor-supporting *** reported that the protein GPNMB(glycoprotein nonmetastatic B)was profoundly upregulated in macrophages interacting with tumor ***,using mouse tumor models,we show that macrophage-derived soluble GPNMB increases tumor growth and metastasis in Gpnmb-mutant mice(DBA/2J).GPNMB triggers in the cancer cells the formation of self-renewing spheroids,which are characterized by the expression of cancer stem cell markers,prolonged cell survival and increased tumor-forming *** the CD44 receptor,GPNMB mechanistically activates tumor cells to express the cytokine IL-33 and its receptor UR1L. We also determined that recombinant IL-33 binding to IL-1R1L is sufficient to induce tumor spheroid formation with features of cancer stem ***,our results reveal a new paracrine axis,GPNMB and IL-33,which is activated during the cross talk of macrophages with tumor cells and eventually promotes cancer cell survival,the expansion of cancer stem cells and the acquisition of a metastatic phenotype.

关键词： cancer stem cells GPNMB IL-33 metastasis tumor associated macrophages

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现代雷达信号处理技术的前景

火控雷达技术 1992年第2期21卷 42-50,41页

作者： A.farina f.A.studer 夏京祥

本文主要研究监视雷达的数据处理技术。旨在评述雷达信号处理机的主要功能和一些实施情况。

关键词：雷达信号处理

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雷达及其他探测器联网的现在与未来

系统工程与电子技术 1987年第5期 33-42页

作者： A.farina f.A.Studer 张以森

本文评述了熟知的包含多部雷达的系统的概念,并介绍了已经实现的用于空中交通管制(ATC)的这类系统的两个例子。文中讨论了探测器联网的一些新的研究领域。首先一个就是多站雷达系统,在这种系统中联网既可以通过窄带,也可以通过宽带数据... 详细信息

本文评述了熟知的包含多部雷达的系统的概念,并介绍了已经实现的用于空中交通管制(ATC)的这类系统的两个例子。文中讨论了探测器联网的一些新的研究领域。首先一个就是多站雷达系统,在这种系统中联网既可以通过窄带,也可以通过宽带数据线路实现。本文对两种情况下信号与数据处理的一些新方式进行了探讨。另一个研究领域就是除雷达以外的探测器的联网。本文讨论了多个探测器联网的优点与问题。同时也提出了这类系统中有关设计、在线管理与控制方面的技术问题。

关键词：雷达跟踪数据研究领域测量值传感器探测器

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非高斯杂波中雷达目标信号检测:理论和应用

现代雷达 1987年第2期 62-68页

作者： A.farina A.Russo f.Scannapieco 崔子岩意大利塞莱尼亚电子工业公司雷达部意大利塞莱尼亚电子工业公司雷达部意大利塞莱尼亚电子工业公司雷达部

本文是作者在论文[1～3]研究基础上的继续和深入,作了理论上的结论并给出了结果。这箱论文的目的是多方面的。首先,对数学背景作了简要的修正,以便推导适于任何类型的目标和杂波概率密度和自相关函数的雷达检测算法。应用这个理论的相... 详细信息

本文是作者在论文[1～3]研究基础上的继续和深入,作了理论上的结论并给出了结果。这箱论文的目的是多方面的。首先,对数学背景作了简要的修正,以便推导适于任何类型的目标和杂波概率密度和自相关函数的雷达检测算法。应用这个理论的相应条件是要导出目标和杂波过程的适当的数学模型。我们特别对于对数正态分布和韦布尔(Weibull)分布的情况下作了推导。并且在对相干回波序列的模型进行推导时,得到了非常好的结果。然后,引入“漂白—高斯化”滤波器的重要概念,并以其为基础,得到了雷达检测方案。当杂波的幅度概率密度呈对数正态分布或韦布尔分布时,应用上述理论得到了完全新的检测方案,并计算了相应的检测性能。本文另一新颖之处是所提出的检测方案具有自适应特点。详细地说,提出了“漂白—高斯化”滤波器的权值的直接估值方法。本文给出了检测失损与距离单元数目之关系,权值的平均值是沿这些距离单元进行估计的。本文对不同的被处理的脉冲数再和不同的杂波和目标信号的参数时的检测损失作了计算。另外,研究了直接计算恒虚警率检测门限的自适应特性,并估算了相应的检测损失。

关键词：对数正态分布概率密度目标信号权值自相关函数韦布尔分布杂波滤波器电子设备

深冷和去应力处理对AISID2工具钢回火碳化物析出的影响

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热处理 2015年第4期30卷 49-53页

作者： P.f.da Silva farina A.Bellegard farina C.Antonio Barbosa H.Goldenstein 顾剑锋 Escola Polite'cnica da Universidade de So Paulo Villares Metals SA 本刊编委会上海交通大学

研究了深冷和去应力处理对D2冷作工具钢回火碳化物析出的影响。深冷处理温度为-196℃,保温时间分别为2 h、24 h和30 h;去应力处理工艺为130℃×90 min。所有试样都与经常规工艺热处理的试样作了对比。采用金相分析、X-射线衍射(XRD)和... 详细信息

研究了深冷和去应力处理对D2冷作工具钢回火碳化物析出的影响。深冷处理温度为-196℃,保温时间分别为2 h、24 h和30 h;去应力处理工艺为130℃×90 min。所有试样都与经常规工艺热处理的试样作了对比。采用金相分析、X-射线衍射(XRD)和温差电势法研究了经深冷和去应力处理的试样。除了OM外,还选用了扫描电镜(SEM)和场发射扫描电镜(SEM-fEG)进行微观组织表征。结果表明,经深冷或去应力处理的试样中二次碳化物(微米级)析出未发生变化。经深冷处理但未经去应力处理的试样基体中,回火二次碳化物(纳米级)比较细小而弥散。回火二次碳化物的细化可能是回火过程中碳化物的原位析出所致。

关键词：去应力深冷处理工具钢

最佳的与通用的MTI和多卜勒处理器的性能比较

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系统工程与电子技术 1986年第5期 31-39页

作者： E.D’Addio A.farina f.A.Studer 刘凤华张以森

一、引言在文献[1—4]中,已经建立了在热噪声和已知统计性质的杂波中检测有用信号的理论。设接收的N个相干脉冲串叠加有高斯分布的干扰过程,初始相位是随机的,幅度A为常数或未知,则使输出信号功率与干扰功率之比最大的处理器是一个相... 详细信息

一、引言在文献[1—4]中,已经建立了在热噪声和已知统计性质的杂波中检测有用信号的理论。设接收的N个相干脉冲串叠加有高斯分布的干扰过程,初始相位是随机的,幅度A为常数或未知,则使输出信号功率与干扰功率之比最大的处理器是一个相干的、线性横向滤波器,如图1所示。

关键词：处理器二项式多卜勒频率 MTI 最佳滤波器杂波干扰噪声干扰脉冲数杂波谱性能比较