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Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population

World Journal of Gastroenterology 2005年第8期11卷 1200-1203页

作者： Mohammad Farhadi Zahra Tahmasebi Shahin Merat farin kamangar Dariush Nasrollahzadeh Reza Malekzadeh Digestive Disease Research Center Department of Molecular Biology Cancer Prevention Studies Branch

AIM: To investigate the relation of human papillomavirus (HPV) and esophageal squamous cell carcinoma (ESCC) in Iranian patients as compared to normal controls. METHODS: Using MY09/MY11 consensus primers, we compared the prevalence of a HPV L1 gene in tumor tissues from 38 ESCC cases and biopsied tissues from 38 endoscopically normal Iranian individuals. We also compared the presence of HPV16 and HPVA18 in the same samples using type-specific E6/E7 primers. RESULTS: Fourteen (36.8%) of the 38 ESCC samples but only 5 (13.2%) of the 38 control samples were positive for the HPV L1 gene (P= 0.02). Five (13.2%) of the ESCC samples but none of the control samples were positive for the HPV16 E6/E7 gene (P= 0.05). Three (7.9%) of the ESCC samples and 5 (13.2%) of the control samples were positive for the HPV18 E6/E7 gene (P= 0.71). CONCLUSION: Our data are consistent with HPV DNA studies conducted in other high-risk areas for ESCC. HPV should be considered as a potential factor contributing to the high incidence of ESCC in Iran and other high-incidence areas of the world.

关键词： Papillomavirus Squamous cell carcinoma of esophagus Population

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Ecologic study of serum selenium and upper gastrointestinal cancers in Iran

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World Journal of Gastroenterology 2004年第17期10卷 2544-2546页

作者： Mehdi Nouarie Akram Pourshams farin kamangar Masood Sotoudeh Mohammad Hossein Derakhshan Mobammad Reza Akbari Hafez Fakheri Mohammad Javad Zahedi Kathleen Caldwell Christian *** Philip R.Taylor Reza Malekzadeh Sanford M.Dawsey Digestive Disease Research Center Tehran University of Medical SciencesTehranIran National Cancer Institute NIHBethesdaMD20895-8314USA Centers for Disease Control AtlantaGeorgiaUSA

AIM:Both observational and experimental studies have shown that higher selenium status reduces the risk of upper gastrointestinal cancers in selenium deficient populations. Recent cancer registry data have shown very different rates of esophageal cancer(EC)and gastric cancer(GC)in four Provinces of Iran,namely Ardabil,Mazandaran,Golestan, and *** aim of this study was to have a preliminary assessment of the hypothesis that high rates of EC in Golestan and high rates of GC in Ardabil may be partly attributable to selenium deficiency. METHODS:We measured serum selenium in 300 healthy adults from An:labil(n=100),Mazandaran(n=50),Golestan (n=100),and Kerman(n=50),using inductively coupled plasma,with dynamic reaction cell,mass spectrometry(ICP- DRC-MS)at the US Centers for Disease Control(Atlanta, Georgia). RESULTS:The median serum selenium concentrations were very different in the four *** medians(IQR)for selenium in Ardabil,Mazandarn,Golestan,and Kerman were 82(75-94),123(111-132),155(141-173),and 119 (110-128)μg/L,respectively(Pkamangar F,Sotoudeh M,Derakhshan MH,Akbari MR,Fakheri H,Zahedi MJ,Caldwell K,Abner CC, Taylor PR,Malekzadeh R,Dawsey *** study of serum

关键词： Adult Esophageal Neoplasms Female Humans Incidence Iran Linear Models Male Middle Aged Risk Factors Selenium Stomach Neoplasms

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Total and cancer mortality following supplementation with vitamins and minerals:Post-intervention follow-up of the General Population Nutrition Intervention Trial in Linxian China

Total and cancer mortality following supplementation with vi...

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“全国老年营养学术研讨会”暨“四川省营养学会成立二十周年庆祝会”

作者： Sanford M Dawsey farin kamangar Christian C Abnet Laura LeeJohnson Steven D Mark Philip R Taylor Division of Cancer Epidemiology & Genetics NCI/NIHBethesdaMD 20892USA Division of Cancer Epidemiology & Genetics.NCI/NIH.Bethesda MD 20892USA

*** High rates of esophageal cancer,locally known as"hard swallowing disease"have been recognized in the Taihang mountain region of north central China since Han Dynasty(206 BC-220 AD).In this area,esophageal cancer has always been defined by its clinical course difficulty in swallowing,followed by wasting and death and has included both ESCC and cardia stomach *** this population,reflux symptoms are uncommon,Barrett’s esophagus has not yet been documented,and adenocarcinoma of the esophagus is extremely rare.

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