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Vacuoles of Candida yeast as a specialized niche for Helicobacter pylori

World Journal of Gastroenterology 2014年第18期20卷 5263-5273页

作者： farideh siavoshi Parastoo Saniee Department of Microbiology School of BiologyUniversity College of SciencesUniversity of TehranTehran 14176-14411Iran

Helicobacter pylori(***)are resistant to hostile gastric environments and antibiotic therapy,reflecting the possibility that they are protected by an ecological niche,such as inside the vacuoles of human epithelial and immune *** yeast may also provide such an alternative niche,as fluorescently labeled *** were observed as fast-moving and viable bacterium-like bodies inside the vacuoles of gastric,oral,vaginal and foodborne Candida *** addition,***-specific genes and proteins were detected in samples extracted from these *** *** present within these yeasts produce peroxiredoxin and thiol peroxidase,providing the ability to detoxify oxygen metabolites formed in immune ***,these bacteria produce urease and VacA,two virulence determinants of *** that influence phago-lysosome fusion and bacterial survival in *** observations of *** cells in new generations of yeasts along with amplification of ***-specific genes from consecutive generations indicate that new yeasts can inherit the intracellular *** as part of their vacuolar ***,it is proposed that yeast vacuoles serve as a sophisticated niche that protects *** against the environmental stresses and provides essential nutrients,including ergosterol,for its growth and *** intracellular establishment inside the yeast vacuole likely occurred long ago,leading to the adaptation of *** to persist in phagocytic *** presence of these bacteria within yeasts,including foodborne yeasts,along with the vertical transmission of yeasts from mother to neonate,provide explanations for the persistence and propagation of *** in the human *** Topic Highlight reviews and discusses recent evidence regarding the evolutionary adaptation of *** to thrive in host cell vacuoles.

关键词： Helicobacter pylori Intracellular Candida Vacuole

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Candida accommodates non-culturable Helicobacter pylori in its vacuole-Koch's postulates aren't applicable

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World Journal of Gastroenterology 2018年第2期24卷 310-314页

作者： farideh siavoshi Parastoo Saniee Department of Microbiology School of Biology University College of Sciences University of Tehran Department of Microbiology and Microbial Biotechnology Faculty of Life Sciences and Biotechnology Shahid Beheshti University G.C.

The following are the responses to the "letter to the editor"("Helicobacter is preserved in yeast vacuoles! Does Koch's postulates confirm it?") authored by Nader Alipour and Nasrin Gaeini that rejected the methods, results, discussions and conclusions summarized in the review article authored by siavoshi F and Saniee P. In the article, 7 papers, published between 1998 and 2013, were reviewed. The 7 papers had been reviewed and judged very carefully by the assigned expertise of the journals involved, including the reviewers of the World Journal of Gastroenterology(WJG), before publication. In the review article, 121 references were used to verify the methods, results and discussions of these 7 papers. The review article was edited by the trustworthy British editor of the(WJG), and the final version was rechecked and finally accepted by the reviewers of(WJG). None of the reviewers made comments like those in this "letter to the editor", especially the humorous comments, which seem unprofessional and nonscientific. Above all, the authors' comments show a lack of understanding of basic and advanced microbiology, e.g. bacterial endosymbiosis in eukaryotic cells. Accordingly, their comments all through the letter contain misconceptions. The comments are mostly based on personal conclusions, without any scientific support. It would have been beneficial if the letter had been reviewed by the reviewers of the article by siavoshi and Saniee.

关键词： Helicobacterpylori Intracellular occurrence Candida yeast 16S DNA detection

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Reciprocal impact of host factors and Helicobacter pylori genotypes on gastric diseases

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World Journal of Gastroenterology 2015年第31期21卷 9317-9327页

作者： Sahar Honarmand-Jahromy farideh siavoshi Reza Malekzadeh Taher Nejad Sattari Saeid Latifi-Navid Department of Biology Tehran Science and Research BranchIslamic Azad University Department of Microbiology School of BiologyUniversity College of SciencesUniversity of Tehran Digestive Disease Research Institute Tehran University of Medical Sciences Department of Biology Faculty of SciencesUniversity of Mohaghegh Ardabili

AIM: To assess the impact of Helicobacter pylori(H. pylori) genotypes and patient age and sex on the development of gastric ***: H. pylori-infected patients(n = 233) referred to the endoscopy unit at Tehran University of Medical Sciences(Tehran,Iran) were diagnosed with chronic gastritis(CG),gastric ulcer(GU),or duodenal ulcer(DU). Brucella blood agar was used for biopsy cultures and H. pylori isolation under microaerobic conditions. H. pylori isolates were confirmed with biochemical tests and through amplification of the 16 S r RNA gene. DNA was extracted from fresh cultures of the H. pylori isolates and used for amplification of vac A alleles and the cag A gene. Statistical analysis was performed to determine the association between H. pylori genotypes,age( 40 years) and sex of the patient,and gastric ***: CG was the most prevalent gastric disease(113/233; 48.5%),compared to GU(64/233; 27.5%)and DU(56/233; 24%). More patients were male,and gastric diseases were more frequent in patients > 40 years(P 40 years was more common in females(18.5%) than males(11.6%)(P = 0.05),whereas a diagnosis of GU or DU in patients > 40 years was more frequent in males(14.6% vs 10.7% and 12.4% vs 4.3%,respectively). Overall,genotyping of the H. pylori isolates revealed that the vac A s1(82%),vac A m2(70%),and cag A+(72.5%) alleles were more frequent than vac A s2(18%),vac A m1(29.2%),and cag A-(all P < 0.05). The vac A s1m2 cag A+ genotype was the most prevalent within the three disease groups. vac A s1m2 frequency was 56.2% with a similar occurrence in all diagnoses,while vac A s1m1 appeared more often in DU patients(33.9%). A genotype of vac A s2m2 occurred in 15% of isolates and was more common in CG patients(21.2%); vac A s2m1 was the leas

关键词： Age Gastric disease Gender Genotype Helicobacter p

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Protective effect of essential oil of Pistacia atlantica Desf. on peptic ulcer: role of α-pinene

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Journal of Traditional Chinese Medicine 2017年第1期37卷 57-63页

作者： Zahra Memariani Mohammad Sharifzadeh Mahbubeh Bozorgi Mannan Hajimahmoodi Mohammad Hosein Farzaei Mahdi Gholami farideh siavoshi Parastoo Saniee Department of Traditional Pharmacy School of Traditional MedicineTehran University of Medical SciencesTehran ***Iran Research Center of Traditional Medicine and History of Medical Sciences Babol University of Medical SciencesMazandaran ***Iran Department of Pharmacology and Toxicology Faculty of Pharmacyand Pharmaceutical Sciences Research CenterTehran University of Medical SciencesTehran ***Iran Department of Drug and Food Control Faculty of PharmacyTehran University of Medical SciencesTehran ***Iran Pharmaceutical Sciences Research Center Faculty of PharmacyKermanshah University of Medical SciencesKermanshah ***Iran Medical Biology Research Center Kermanshah University of Medical SciencesKermanshah ***Iran Department of Microbiology School of BiologyUniversity College of SciencesUniversity of TehranTehran ***Iran

OBJECTIVE: To evaluate the efficacy of Pistacia atlantica Desf. oleoresin essential oil on peptic ulcer(PU) and its antibacterial effect on metronidazole-resistant Helicobacter pylori, as well as chemi-cal composition of the essential ***: The essential oil was standardized using gas chromatography mass spectrometry(GC/MS) analysis. Acute toxicity of the essential oil was assessed in animal model. In vitro anti-Helicobacter pylori activity was performed through disc diffusion and minimum inhibitory concentration method. For gastroprotective assay, rats received Pistacia atlantica Desf. essential oil(25, 50 and 100 mg/kg orally) 1 h before induction of ulcer by ***(ulcer index and protection rate) and microscopic examination were ***: The GC/MS analysis of the essential oil led to the identification of twenty constituents andα-pinene is predominant constituent. The essential oil was safe up to 2000 mg/kg. All Helicobacter pylori strains were susceptible to the essential oil and the MIC ranged from 275 to 1100 μg/m L. The ulcer index for treated groups was significantly reduced compared to control(P < 0.001) with EC50 value of 12.32 mg/kg. In microscopic examination, Pistacia atlantica attenuated destruction and necrosis of gastric ***: Current study exhibited protective effect of standardized Pistacia atlantica essential oil against ethanol-induced gastric ulcer and its antibacterial activity on Helicobacter pylori. α-pinene might be the responsible agent.

关键词： Peptic ulcer Pistacia Oils volatile Oleoresins Gastroprotective Helicobacter pylori Medicine traditional

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