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Understanding divergent domestication traits from the whole-genome sequencing of swamp-and river-buffalo populations

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National Science Review 2020年第3期7卷 686-701页

作者： Xier Luo Yu Zhou Bing Zhang Yi Zhang Xiaobo Wang Tong Feng Zhipeng Li Kuiqing Cui Zhiqiang Wang Chan Luo Hui Li Yanfei Deng Fenghua Lu Jianlin Han Yongwang Miao Huaming Mao Xiaoyan Yi Cheng Ai Shigang Wu Alun Li Zhichao Wu Zijun Zhuo Do Da Giang Bikash Mitra Mohammad farhad Vahidi Shahid Mansoor Sahar Ahmed Al-Bayatti Eka Meutia Sari Neena Amatya Gorkhali Sigit Prastowo Laiba Shafique Guoyou Ye Qian Qian Baoshan Chen Deshun Shi Jue Ruan Qingyou Liu State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangxi University CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences National Engineering Laboratory for Animal Breeding Key Laboratory of Animal Genetics Breeding and Reproduction of Ministry of Agriculture and Rural AffairsCollege of Animal Science and Technology China Agricultural University Guangdong Laboratory for Lingnan Modern Agriculture Genome Analysis Laboratory of the Ministry of Agriculture Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources Institute of Animal ScienceChinese Academy of Agricultural Sciences International Livestock Research Institute Faculty of Animal Science and Technology Yunnan Agricultural University Bacgiang Agriculture and Forestry University Cellular Immunology Lab Department of Zoology University of North Bengal Animal Biotechnology Department Agricultural Biotechnology Research Institute of Iran-North Region 11. National Institute for Biotechnology and Genetic Engineering 12. Animal Genetic Sources DepartmentDirectorate of Animal Resources Ministry of Agriculture 13. Department of Animal Science Faculty of Agriculture Syiah Kuala University 14. Animal Breeding DivisionNational Animal Science Research Institute Nepal Agriculture Research Council 15. Animal Science Department Universitas Sebelas Maret 16. International Rice Research Institute

Domesticated buffaloes have been integral to rice-paddy agro-ecosystems for millennia, yet relatively little is known about the buffalo genomics. Here, we sequenced and assembled reference genomes for both swamp and river buffaloes and we re-sequenced 230 individuals(132 swamp buffaloes and 98 river buffaloes)sampled from across Asia and Europe. Beyond the many actionable insights that our study revealed about the domestication, basic physiology and breeding of buffalo, we made the striking discovery that the divergent domestication traits between swamp and river buffaloes can be explained with recent selections of genes on social behavior, digestion metabolism, strengths and milk production.

关键词： Bubalus bubalis genome buffalo domestication re-sequencing traits

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The risk of wound infection after simple hand laceration

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World Journal of Emergency Medicine 2015年第1期6卷 44-47页

作者： Gholamreza S Roodsari farhad Zahedi Shahriar Zehtabchi Department of Emergency Medicine Downstate Medical Center State University of New York

BACKGROUND: This prospective observational study aimed to determine the infection rate of simple hand laceration(SHL), and to compare infection rates between patients who were prescribed antibiotics and those who were ***: The study was performed at two urban hospitals enrolling 125 emergency department(ED) patients with SHL. Exclusion criteria included patients with lacerations for more than 12 hours, immunocompromized patients, patients given antibiotics, and patients with gross contamination, bites or crush injuries. Wound infection was defined as clinical infection at a follow-up visit(10–14 days) or wound was treated with antibiotics. Patient satisfaction was also measured using a visual analogue scale 1–10, asking the patients about wound appearance. Demographic data and wound characteristics were compared between the infected and non-infected wounds. The infection rates were also compared between patients who received prophylactic antibiotics and those who did not. The results were presented with medians and quartiles or percentages with 95% confidence intervals(CI).RESULTS: In the 125 patients with SHL [median age: 28(18, 43); range: 1–102 years old; 36% female], 44(35%, 95% CI: 27%–44%) were given antibiotics in the ED. Wound infection was reported in 6 patients(4.8%, 95% CI: 2%–10%). Age, gender, history of diabetes and wound closure were not associated with wound infection(P>0.05). The infection rate was not significantly different between patients with or without antibiotic prophylaxis [7%(3/44), 95% CI: 2%–10% vs. 4%(3/81), 95% CI: 1%–11%, P=0.66]. Patient's satisfaction with appearance ofinfected and non-infected wounds were significantly different [7.5(6, 8) vs. 9(8, 10), P=0.01].CONCLUSION: Approximately 5% of simple hand lacerations become infected. Age, gender, diabetes, prophylactic antibiotics and closure technique do not affect the risk ofinfection.

关键词： Wounds Injuries Wound infection Hand lacerations

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Comparison of the Hypoglycemic, Hypolipidemic and Hepatoprotective Effects of<i>Asparagus racemosus</i>Linn. in Combination with Gliclazide and Pioglitazone on Alloxan-Induced Diabetic Rats

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Pharmacology & Pharmacy 2017年第2期8卷 52-74页

作者： Abdullah Al Mamun Mahbubul Hossain Md.Sahab Uddin Md.Tanjir Islam Sajjad Hossain Md.Sarwar Hossain Md.farhad Hossain Ataur Rahman Sujan Mamunur Rashid Md.Mahbubur Rahman A.F.M.Towheedur Rahman Department of Pharmacy Southeast UniversityDhakaBangladesh School of Biosciences and Veterinary Medicine University of CamerinoCamerinoItaly Department of Physical Therapy Graduate School of Inje UniversityGimhaeKorea Department of Pharmacy University of Asia PacificDhakaBangladesh Department of Pharmacy University of RajshahiRajshahiBangladesh Department of Pharmaceutical Sciences North South UniversityDhakaBangladesh

In recent years, the popularity of medicinal plants as a remedy has been increased manifold due to having minimal adverse effects. The current study aimed to compare the hypoglycemic, hypolipidemic and hepatoprotective effects of the ethanolic extract of Asparagus racemosus (EEAR) Linn. alone and combinedly with conventional antidiabetic agents (gliclazide and pioglitazone) in alloxan-induced diabetic rats. Diabetes was induced in male Wister albino rats by the administration of single intra-peritoneal injection of alloxan monohydrate (120 mg/kg b.w.). Effect of oral administration of two different doses of EEAR (200 and 400 mg/kg b.w.), gliclazide (10 mg/kg b.w.) and pioglitazone (10 mg/70kg/b.w.) alone for 2 weeks and a combination of EEAR (200 mg/kg b.w.) with either gliclazide (10 mg/kg b.w.) or pioglitazone (10 mg/70kg/b.w.) for 2 weeks were examined on hypoglycemic activity on 0th, 5th, 10th and 14th day of treatment. After 2 weeks of treatment, hypolipidemic and hepatoprotective effects were estimated by serum biochemical markers such as total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL), serum glutamate oxaloacetate transaminases (SGOT), serum glutamate pyruvate trans-aminases (SGPT) and total protein (TP) with the help of commercially available kits. The survival rate, body weight and organ weight were also measured. Alloxan treatment resulted in persistent hyperglycemia, hyperlipidemia and liver dysfunction in rats. Treatment with EEAR at different doses improved hyperglycemia significantly (p th and 14th day of treatment in a dose-dependent mood when compared to the disease control rats, gliclazide treated rats and pioglitazone treated rats. The combination therapy significantly (p th, 10th and 14th day of treatment as compared to that of disease control rats, gliclazide treated rats and pioglitazone treated rats. Proposed adjunct therapy also markedly (p < 0.001;p

关键词： Diabetes Mellitus Asparagus racemosus Gliclazide Pioglitazone Combination Therapy

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石油产品污染的土壤和含水层系统的检测与修复：综述

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水文地质工程地质技术方法动态 2007年第6期 1-9页

作者： farhad Nadim George E. Hoag Robert J. Carley 赵玉军（翻译）苑惠明（校对）郭彦威（校对） Enlironmental Research Institute Unilersity of Cormecticut Longley Building 146 Box U-210 Route 44 Storrs CT 06269 USA Department of EnIironmental Protection CT USA 不详

地下岩层中有机化学药品的命运是很难预测的，将需要环境科学家花费10年或20年的时间研究受有机化学药品污染的场地。本文讨论了石油类碳氢化合物污染地下水和土壤的不同路径及其在地下岩层中的气相、液相和固相的分布，总结了常用于修... 详细信息

地下岩层中有机化学药品的命运是很难预测的，将需要环境科学家花费10年或20年的时间研究受有机化学药品污染的场地。本文讨论了石油类碳氢化合物污染地下水和土壤的不同路径及其在地下岩层中的气相、液相和固相的分布，总结了常用于修复受石油类碳氢化合物污染的土壤和地下水的技术以及这些技术的应用局限，简要讨论了美国环保总署常用于检测和测定土壤和水样品中石油类碳氢化合物的方法（8260、8270和418．1），以及一些最近开发的用于预测含水层系统中石油类碳氢化合物的命运和迁移的数学模型。本文提供了一些有关轻质和重质石油类碳氢化合物的毒性研究的结果。研究结果表明，若要使环境免受石油类碳氢化合物的污染，需要公众充分了解这些化合物所涉及的风险。石油产品的适当管理与谨慎处理能够降低污染的发生概率。利用装有漏油感应器和阴极保护装置的新型双重壁储油罐代替陈旧和已泄漏的地下储油罐，我们能够明显改善宝贵和脆弱的地下水资源的质量。

关键词：地下水碳氢化合物土壤分析挥发性化合物

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基于力反馈的个性化口腔种植钻孔手术仿真系统研发

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中国数字医学 2017年第3期12卷 18-20页

作者：廖登宏 farhad Alidad 廖书恒陈晓军 Zeike A Taylor Alejandro Frangi 上海交通大学机械与动力工程学院生物医学制造与生命质量工程研究所上海市东川路800号200240 上海交通大学上海市东川路800号200240 英国谢菲尔德大学生物医学图像计算与仿真技术研究中心(CISTIB)

目的:开发一套用于口腔种植钻孔手术的仿真系统,旨在利用力反馈技术模拟手术钻孔过程,进行术前训练,并对初学者进行培训。方法:以力反馈设备Omega.6为硬件平台,使用CHAI3D、Qt、VTK等免费开源软件库,对三维重建的模型进行网格细分,并提... 详细信息

目的:开发一套用于口腔种植钻孔手术的仿真系统,旨在利用力反馈技术模拟手术钻孔过程,进行术前训练,并对初学者进行培训。方法:以力反馈设备Omega.6为硬件平台,使用CHAI3D、Qt、VTK等免费开源软件库,对三维重建的模型进行网格细分,并提出一种逐级扩孔方法。结果:开发了一套基于力反馈的个性化口腔种植钻孔手术仿真系统DDS(Dental Drilling Simulator)。结论:基于力反馈的口腔种植钻孔手术仿真系统能模拟真实手术中的典型病例,实现真实手术中的逐级扩孔操作,有助于口腔种植手术的数字化信息建设。

关键词：力反馈口腔种植钻孔手术虚拟仿真

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Numerical Study on the Serviceability Performance of Unstiffened and Stiffened Steel Plates

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Journal of Civil Engineering and Architecture 2019年第9期13卷 553-561页

作者： farhad Riahi Tadeh Zirakian Bijan Sanaati Samrand Mohammad Karimi Dept.of Civil Engineering Islamic Azad UniversityMahabad BranchMahabad 591393-3137Iran Dept.of Civil Engineering and Construction Management California State UniversityNorthridgeCA 91330USA Dept.of Civil Engineering Islamic Azad UniversityBoukan BranchBoukan 7356716-33986Iran

In this paper,the effects of transverse stiffeners for improving the buckling and post-buckling behaviors of thin steel plates under compressive loading have been investigated through consideration of two parameters,*** number and ***,the deformations associated with the buckling stability of unstiffened and stiffened plates have been evaluated through detailed *** numerical models have been developed using ABAQUS and the buckling behavior has been studied through performing nonlinear static ***’s largest deformation has been considered for comparison purposes which may not be necessarily located in the center of the plate *** use of stiffeners by and large increases the load-bearing capacity of the plates;however,it is shown that lack of proper detailing of stiffened plates may unfavorably result in the reduction of the load-bearing capacity and,in general,adversely affect the stability performance of such commonly-used slender members.

关键词： Plate stiffener buckling post-buckling numerical simulation

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山羊3个TLR基因中9个SNPs的检测及连锁不平衡分析

山羊3个TLR基因中9个SNPs的检测及连锁不平衡分析

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第十五次全国动物遗传育种学术讨论会

作者：徐燕杜小勇 S.M. farhad Vahidi 韩建林赵书红农业动物遗传育种与繁殖教育部重点实验室＆农业部猪遗传育种重点开放实验室华中农业大学 Department of Genomics Branch of North RegionAgricultural Biotechnology Research Institute of Iran(ABRⅡ)PO Box 41635-41152 中国农业科学院-国际家畜研究所畜禽牧草遗传资源联合实验室北京畜牧兽医研究所

＜正＞引言TLR基因家族在先天免疫中扮演着重要的角色,其单核苷酸多态性（SNPs）与宿主的炎症应答及对传染性疾病的遗传抗性或易感性相关。本研究分析了山羊3个TLR基因在中、外18个山羊群体的SNPs及其连锁

关键词：山羊 TLR基因 SNP 连锁不平衡

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Functional insights from NESG structures

Functional insights from NESG structures

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The 4th ISGO International Conference on Structural Genomics

作者： farhad Forouhar Jordi Benach Alexandre Kuzin Jayaraman Seetharaman Sergey Vorobiev Mariam Abashidze Insun Lee Helen Neely Thomas B.Acton M.Baran John F.Hunt Gaetano T.Montelione Department of Biological Sciences Northeast Structural Genomics Consortium （NESG） Columbia UniversityNew YorkNY 10027USA Department of Biological Sciences Northeast Structural Genomics Consortium （NESG） Columbia UniversityNew YorkNY 10027USA Department of Biological Sciences Northeast Structural Genomics Consortium （NESG） Columbia UniversityNew YorkNY 10027USA Department of Biological Sciences Northeast Structural Genomics Consortium （NESG） Columbia UniversityNew YorkNY 10027USA Department of Biological Sciences Northeast Structural Genomics Consortium （NESG） Columbia UniversityNew YorkNY 10027USA Department of Biological Sciences Northeast Structural Genomics Consortium （NESG） Columbia UniversityNew YorkNY 10027USA Department of Biological Sciences Northeast Structural Genomics Consortium （NESG） Columbia UniversityNew YorkNY 10027USA Department of Biological Sciences Northeast Structural Genomics Consortium （NESG） Columbia UniversityNew YorkNY 10027USA Center for Advanced Biotechnology and Medicine Northeast Structural Genomics Consortium （NESG） Rutgers University Piscataway NJ 08854 USA Center for Advanced Biotechnology and Medicine Northeast Structural Genomics Consortium （NESG） Rutgers University Piscataway NJ 08854 USA Department of Biological Sciences Northeast Structural Genomics Consortium （NESG） Columbia UniversityNew YorkNY 10027 USA Center for Advanced Biotechnology and Medicine Northeast Structural Genomics Consortium （NESG） Rutgers University Piscataway NJ 08854 USA

＜正＞The structural genomics efforts have successfully determined the structures of a large number of proteins. Another goal of these efforts is to assign function（s） to the proteins based on the structural information, especially for those proteins for which a function could not be inferred from the sequence information only. Using

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Reporting and understanding the safety and adverse effect profile of mobile apps for psychosocial interventions: An update

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World Journal of Psychiatry 2016年第2期6卷 187-191页

作者： Farooq Naeem Nadeem Gire Shuo Xiang Megan Yang Yumeen Syed farhad Shokraneh Clive Adams Saeed Farooq Department of Psychiatry Queens UniversityKingston Addiction and Mental Health Services-Kingston FrontenacLennox and Addington School of Psychology University of Central Lancashire Trenlogic Cochrane Schizophrenia Group Nottingham University Research Institute for Primary Care and Health Sciences Keele University

Recent years have seen a rapidly increasing trend towards the delivery of health technology through mobile devices. Smartphones and tablet devices are thus becoming increasingly popular for accessing information and a wide range of services, including health care services. Modern mobile apps can be used for a variety of reasons, ranging from education for the patients and assistance to clinicians to delivery of interventions. Mobile phone apps have also been established to benefit patients in a scope of interventions across numerous medical specialties and treatment modalities. Medical apps have their advantages and disadvantages. It is important that clinicians have access to knowledge to make decisions regarding the use of medical apps on the basis of risk-benefit ratio. Mobile apps that deliver psycho social interventions offer unique challenges and opportunities. A number of reviews have highlighted the potential use of such apps. There is a need to describe, report and study their side effects too. The adverse effects associated with these apps can broadly be divided into:(1) those resulting from the security and safety concerns;(2) those arising from the use of a particular psycho social intervention; and(3) those due to the interaction with digital technology. There is a need to refine and reconsider the safety and adverse effects in this area. The safety profile of a mobile PSI app should describe its safety profile in:(1) privacy and security;(2) adverse effects of psychotherapy; and(3) adverse effects unique to the use of apps and the internet. This is, however, a very new area and further research and reporting is required to inform clinical decision making.

关键词： Mobile Psycho social Side effects Health Media Security Privacy

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震惊和恐惧的局限：美国在中东

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世界知识 2005年第5期 6-6页

作者： Augustus Richard Norton farhad Kazemi 袁冲美国波士顿大学国际关系学教授美国纽约大学政治学教授凯沃基恩近东研究中心主任不详

布什第二任期面临的主要挑战很可能来自中东。自2001年以来，美国就史无前例地在中东展开了根本和巨大的改造计划。但在伊拉克，美国有越陷越深的趋势，缺乏从伊拉克脱身的战略计划；伊朗方面，布什第二任期需要探寻同伊朗进行建设性接... 详细信息

布什第二任期面临的主要挑战很可能来自中东。自2001年以来，美国就史无前例地在中东展开了根本和巨大的改造计划。但在伊拉克，美国有越陷越深的趋势，缺乏从伊拉克脱身的战略计划；伊朗方面，布什第二任期需要探寻同伊朗进行建设性接触的可能性。布热津斯基等人牵头的一个研究小组指出，扩大同伊朗的政治、经济和文化联系是美国最好的选择；在巴以问题上，美国对以色列的偏袒使巴勒斯坦建国困难重重，

关键词：美国任期中东伊朗战略计划改造计划国有布什巴以问题伊拉克

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