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自体骨髓源性细胞疗法联合物理治疗可促进慢性脊髓损伤患者的功能恢复(英文)

中华神经外科疾病研究杂志 2013年第1期 24-24页

作者： El-Kheir WA Gabr H Awad MR Ghannam O Barakat Y farghali ha Maadawi ZM Ewes I Sabaawy HE

pinal cord injuries(SCI) cause sensory loss and motor paralysis and are treated with physical therapy,but most patients fail to recover due to limited neural *** we describe a strategy in which treatment with autologous adherent bone marrow cells is combined with physical therapy to improve motor and sensory functions in early-stage chronic SCI *** a phase Ⅰ/Ⅱ controlled single-blind clinical trial(*** identifier:NCT00816803),70 chronic cervical and thoracic SCI patients with injury durations of at least 6 months were treated with either intrathecal injection(s) of autologous adherent bone marrow cells combined with physical therapy,or with physical therapy *** were evaluated with clinical examinations,electrophysiological somatosensory evoked potential,MRI imaging,and functional independence *** cervical and thoracic SCI patients treated with autologous adherent bone marrow cells combined with physical therapy showed functional improvements over patients in the control group treated with physical therapy alone,and there were no cell therapy-related side *** 18 months posttreatment,23 of the 50 cell therapy treated cases(46 percent) showed sustained improvement using the American Spinal Injury Association(ASIA) Impairment Scale(AIS).Compared to those patients with cervical injuries,a higher rate of functional improvement was achieved in thoracic SCI patients with shorter durations of injury and smaller cord ***,when combined with physical therapy,autologous adherent bone marrow cell therapy appears to be a safe and promising therapy for patients with chronic spinal cord *** controlled multicenter trials are warranted.

关键词： SCI

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