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Comparison of cross sectional optical coherence tomography images of elevated optic nerve heads across acquisition devices and scan protocols

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Eye and Vision 2018年第1期5卷 163-171页

作者： Megh D.Patel fareshta khushzad Heather E.Moss Department of Ophthalmology Stanford University2370 Watson Courtsuite 200Palo AltoCA 94303USA Department of Neurology and Neurological Sciences Stanford University2370 Watson Courtsuite 200Palo AltoCA 94303USA

Background:Optic nerve head measurements extracted from optical coherence tomography(OCT)show promise for monitoring clinical conditions with elevated optic nerve *** aim of this study is to compare reliability within and between raters and between image acquisition devices of optic nerve measurements derived from OCT scans in eyes with varying degrees of optic nerve ***:Wide angle line scans and narrow angle radial scans through optic nerve heads were obtained using three spectral domain(SD)OCT devices on 5 subjects(6 swollen optic nerves,4 normal optic nerves).Three raters independently semi-manually segmented the internal limiting membrane(ILM)and Bruch’s membrane(BM)on each scan using customized *** rater segmented each scan *** were qualitatively and quantitatively ***-rater,intra-rater and inter-device reliability was assessed for the optic nerve cross sectional area calculated from the ILM and BM segmentations using intraclass correlation coefficients and graphical ***:Line scans from all devices were qualitatively *** scans for which frame rate could not be adjusted were of lower ***-rater reliability for segmentation and optic nerve cross sectional area was better than inter-rater reliability,which was better than inter-device reliability,though all ICC exceeded *** was not impacted by the degree of optic nerve ***:SD-OCT devices acquired similar quality scans of the optic nerve head,with choice of scan protocol affecting the *** image derived markers,variability between devices was greater than that attributable to inter and intra-rater differences.

关键词： Optic nerve head Optical coherence tomography Bruch’s membrane Inner limiting membrane Comparison

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