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Randomised controlled trial of triclosan coated vs uncoated sutures in primary hip and knee arthroplasty

World Journal of Orthopedics 2019年第7期10卷 268-277页

作者： Mohamed Sukeik David George Ayman Gabr Rami Kallala Peter Wilson fares sami haddad Department of Trauma and Orthopaedics University College London HospitalLondon NW1 2BUUnited Kingdom Department of Trauma and Orthopaedics Dr.Sulaiman Al-Habib Hospital–Al KhobarKing Salman Bin Abdulaziz RdAl BandariyahAl Khobar 34423Saudi Arabia Department of Clinical Microbiology UCLHLondon NW1 2PGUnited Kingdom

BACKGROUND Triclosan-coated vicryl plus suture(Ethicon, Inc.) was developed to reduce microbial colonisation during surgical procedures. However, its effect on wound healing and surgical site infections remain unclear after hip and knee arthroplasty *** To determine the effect of triclosan-coated sutures(TCS) vs non-coated sutures on wound healing, following primary hip and knee *** A single-centred, double-blind randomised controlled trial(RCT) was undertaken. We randomly allocated patients to receive either the triclosan-coated sutures(TCS vicryl plus) or non-coated sutures(NCS vicryl) during the closure of unilateral primary hip and knee arthroplasties. We utilised the ASEPSIS wound scoring system to evaluate wound healing for the first 6 weeks *** One hundred and fifty patients undergoing primary total hip or knee arthroplasty over a one-year period were included. Eighty-one were randomised to the TCS group and 69 to the NCS group. Despite no statistically significant difference in the ASEPSIS scores among the study groups(P = 0.75), sensitivity analysis using the Mann Whitney test(P = 0.036) as well as assessment of the wound complications at 6 weeks follow up, demonstrated significantly higher wound complication rates in the TCS group(8 vs 1, P = 0.03).CONCLUSION No clear advantage was demonstrated for using the TCS. However, larger multicentred RCTs are required to validate their use in hip and knee arthroplasty surgery.

关键词： Triclosan Hip Knee Replacement Arthroplasty Wound healing Complications

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