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Salsola imbricata *** acetic acid-induced inflammatory bowel disease by modulating dysregulated antioxidant enzyme system and cytokine signaling pathways in mice

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Asian Pacific Journal of Tropical Biomedicine 2021年第12期11卷 527-534页

作者： faraza javed Qaiser Jabeen Department of Pharmacology Faculty of PharmacyThe Islamia University of BahawalpurPakistan

Objective:To explore the protective effect of the crude extract of Salsola imbricata against acetic acid-induced inflammatory bowel disease in mice and its mechanism of ***:Ethanolic crude extract of Salsola imbricata was characterized by *** imbricata extract at different doses was administered and ulcerative colitis was induced by 200μL,7.5%acetic acid and macroscopic parameters were evaluated to assess the homeostatic condition of intestinal mucosa along with hematological and biochemical *** levels of malondialdehyde,glutathione peroxidase 1,superoxide dismutase,and catalase were determined in colon *** cytokines including interleukin(IL)-1β,IL-6,and tumor necrosis factor-α(TNF-α)were quantified by *** extent of tissue damage was assessed by histological ***:Phytochemical analysis confirmed the presence of phytochemicals including quercetin,gallic acid,syringic acid,benzoic acid and chlorogenic acid in the crude *** crude extract of Salsola imbricata(300 and 500 mg/kg)markedly decreased malondialdehyde and nitric oxide(P<0.01)and increased antioxidant activities of glutathione peroxidase 1(P<0.001)and superoxide dismutase(P<0.001).Moreover,it decreased the levels of IL-1β,IL-6 and TNF-αsignificantly(P<0.001)and reduced the damage to the colon mucosa,promoting tissue healing and ***:Salsola imbricata extract restores the colonic epithelial layers by maintaining mucosal homeostasis and cell integrity by modulating antioxidant defense system and inflammatory cytokine signaling in ulcerative colitis mice.

关键词： Salsola imbricata Acetic acid Antioxidant enzymes Cytokines Inflammation Reactive oxygen species

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Glinus lotoides ethanolic extract alleviates LPS-induced anxiety and depression-like behavior by modulating antioxidant and inflammatory biomarkers in rats

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Asian Pacific Journal of Tropical Biomedicine 2022年第2期12卷 78-86页

作者： Ambreen Mehmood Awan Wafa Majeed faraza javed Bilal Aslam Asra Iftikhar Hafiza Arooj Kanwal Sobia Fiaz Institute of Physiology and Pharmacology University of AgricultureFaisalabadPakistan Department of Pharmacology Faculty of Pharmacythe Islamia University of BahawalpurBahawalpurPakistan Department of Pharmacy University of FaisalabadFaisalabadPakistan Department of Pharmacy University of AgricultureFaisalabadPakistan

Objective:To explore the protective role of Glinus lotoides ethanolic extract in a depression model through modulating oxidant/antioxidant enzyme system and inflammatory ***:Phytochemical constituents of Glinus lotoides ethanolic extract were evaluated qualitatively and quantitatively along with *** were divided into six *** normal control and the intoxicated groups received normal saline,and the standard group received imipramine,while the remaining groups received 100,300,and 500 mg/kg Glinus lotoides ethanolic *** groups received treatments for 14 ***(LPS)were then administered i.p.(0.83 mg/kg)to all groups except the normal control *** 24 h,anxiety and depression-like behaviors were evaluated by performing behavioral analysis(open field,tail suspension,forced swim,sucrose preference test),and determining total oxidant status,total antioxidant capacity,catalase,and biochemical parameters[malondialdehyde,glutathione,superoxide dismutase,tumor necrosis factor(TNF)-alpha and interleukin(IL)-6].Results:Phytochemical studies confirmed the presence of phenols and flavonoids and HPLC analysis showed the presence of gallic acid,quercetin,chlorogenic,and caffeic *** oxidant status was significantly decreased,while total antioxidant capacity was significantly increased in the Glinus lotoides ethanolic extract treated ***,Glinus lotoides ethanolic extract diminished malondialdehyde,IL-6,and TNF-alpha levels,while increasing superoxide dismutase,catalase,and glutathione ***:Glinus lotoides ethanolic crude extract shows significant antidepressant activity by modulating oxidative and biochemical parameters that supports its folkloric use in traditional systems of medicine.

关键词： Glinus lotoides Biochemical markers Depression Traditional medicine Nervous system Anxiety Antioxidant Inflammation

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