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Rising serum potassium and creatinine concentrations after prescribing renin-angiotensin-aldosterone system blockade: how much should we worry?

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World Journal of Pediatrics 2021年第5期17卷 552-554页

作者： farahnak assadi Division of Nephrology Department of PediatricsRush University Medical Center445 E.North Water StreetSuite 1804ChicagoILUSA

Renin-angiotensin-aldosterone system(RAAS)blockade is often the first-line medication for treating pediatric and adult patients with hypertension,especially those with preexisting chronic kidney disease(CKD)[1,2].However,the rise in serum creatinine and potassium concentrations following RAAS blocked may pose therapeutic challenges whether it is safe to treat hypertensive patients with CKD,by inhibiting[3].Thus,many clinicians neglect to use angiotensin-converting enzyme inhibitor(ACEI)or angiotensin receptor blockade(ARB)especially in patients with CKD because of fear in either reduction of glomerular filtration rate(GFR)or elevation in serum creatinine and potassium concentrations.

关键词： creatinine aldosterone hypertensive

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A wake-up call to action for smoking cessation interventions

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World Journal of Pediatrics 2021年第4期17卷 434-437页

作者： farahnak assadi Division of Nephrology Department of PediatricsRush University Medical Center445 East North Water StreetChicagoIL60611USA

Recent data obtained through analysis of the World Health Organization(WHO)on Tobacco epidemic 2019 indicate that about 5 million people(65%)of the world's population are now covered by at least by one MPOWER measure(Monitor tobacco use and prevention policies;protect people from tobacco smoke;offer help to quit tobacco use;warn about the dangers of tobacco;enforce bans on tobacco advertising,promotion and sponsorship;raise taxes on tobacco)at the highest achievement levels,which has been quadrupled since 2007,when one billion people(15%)were covered^([1]).Of the 5 million people protected by at least one complete POWER measure,3.9 billion live in low-and middle-income *** and Turkey are the only two middle-income countries that have adopted all POWER measures at the highest level.

关键词： measures income prevention

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Impact of dyslipidemia on estimated glomerular filtration rate in apparently healthy children and adolescents:the CASPIAN-V study

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World Journal of Pediatrics 2019年第5期15卷 471-475页

作者： Mohammad Moafi farahnak assadi Ramin Heshmat Mehri Khoshhali Mostafa Qorbani Mohammad E.Motlagh Razieh Dashti Majzoubeh Taheri Roya Kelishadi Child Growth and Development Research Center Research Institute for Primordial Prevention of Non-communicable DiseaseIsfahan University of Medical SciencesIsfahanIran Department of Pediatric Nephrology Rush University Medical Center445 E.North Water StreetSuite 1804ChicagoIL 60611USA Department of Epidemiology Chronic Diseases Research CenterEndocrinology and Metabolism Population Sciences InstituteTehran University of Medical SciencesTehranIran Department of Biostatistics Child Growth and Development Research CenterResearch Institute for Primordial Prevention of Non-communicable DiseaseIsfahan University of Medical SciencesIsfahanIran Department of Epidemiology Non-communicable Diseases Research CenterAlborz University of Medical SciencesKarajIran Department of Pediatrics Ahvaz Jundishapur University of Medical SciencesAhvazIran Bureau of Family PopulationYouth and School HealthMinistry of Health and Medical EducationTehranIran Population Youth and School HealthMinistry of Health and Medical EducationTehranIran Pediatrics Department Child Growth and Development Research CenterResearch Institute for Primordial Prevention of Non-communicable DiseaseIsfahan University of Medical SciencesIsfahanIran

Background Chronic kidney disease(CKD)is a leading risk factor for development of cardiovascular disease(CVD).Dyslipidemia is also known as risk factor for CVD ***,the association of dyslipidemia with glomerular injury among healthy children and adolescents remains *** aimed to investigate the relationship between estimated glomerular filtration rate(eGFR)and lipid profile risk factors among healthy children and *** In this nationwide survey,3808 participants(1992 males,1816 females),aged 7-18 years,were selected by cluster random sampling method from 30 provinces in *** mass index(BMI)and systolic and diastolic blood pressures were *** samples were obtained for serum creatinine,fasting blood glucose,total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),and triglyceride(TG)*** was estimated using Schwartz *** Girls had higher eGFR than boys(P=0.04).In a multiple regression analysis,eGFR demonstrated a positive correlation with systolic blood pressure,BMI,fasting glucose,TC,HDL-C,and *** the analysis of covariance,TC,HDL-C,and TG showed a negative correlation with eGFR after adjustments for BMI,systolic and diastolic blood pressures,and fasting glucose(OR=0.56,95%CI=0.29-0.89).Conclusion The study showed that dyslipidemia is associated with reduced eGFR among the healthy children and adolescents.

关键词： Adolescents Children Dyslipidemia Estimated glomerular filtration rate

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