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Characterization and antimicrobial,antioxidant,and anti-proliferative activities of green synthesized magnesium oxide nanoparticles with shoot extracts of Plicosepalus curviflorus

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Asian Pacific Journal of Tropical Biomedicine 2023年第7期13卷 315-324页

作者： Reem Hamoud Alrashoudi Manal Abudawood Ayesha Mateen Hajera Tabassum Noura Ibrahem Alghumlas Sabiha Fatima Basmah Almaarik farah maqsood Nawal M.Al Musayeib Musarat Amina Clinical Laboratory Sciences Department College of Applied Medical SciencesKing Saud UniversityRiyadh 12372Saudi Arabia Department of Optometry and Vision Science College of Applied Medical ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Pharmacognosy College of PharmacyKing Saud UniversityRiyadh 11495P.O.Box 22452Saudi Arabia

Objective:To synthesize magnesium oxide nanoparticles using ethanol extract of shoots of Plicosepalus curviflorus(PC-MgONPs)and evaluate the antimicrobial,antioxidant,and anti-proliferative activities of ***:The green synthesized PC-MgONPs were characterized by ultraviolet-visible(UV),Fourier-transform infrared spectroscopy,zeta potential,energy dispersive X-ray,and scanning electron ***,we investigated total antioxidant capacity and antimicrobial and anti-proliferative activities using breast cancer cell lines(MDA-231).Results:The UV spectrum of PC-MgONPs showed a sharp absorption peak at 300 *** presence of magnesium,oxygen,and sodium was confirmed by energy dispersive X-ray *** electron microscopy revealed PC-MgONPs as roughly spherical granular structures with sizes ranging from 20.0 to ***-MgONPs showed considerable antimicrobial activities against Escherichia coli,Staphylococcus aureus,methicillin-resistant Staphylococcus aureus,Pseudomonas aeruginosa and Candida albicans with zones of inhibition of 11-17 *** addition,total antioxidant capacity and anti-proliferative activity of PC-MgONPs against MDA-231 cells were ***:The synthesized PC-MgONPs could be a potent antimicrobial,antioxidant and anti-cancer agent,which needs further investigation.

关键词： PC-MgONPs Plicosepalus curviflorus FTIR Antimicrobial Cell viability Antioxidant

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Anti-Radical and Neuroprotective Potential of <i>Ficus infectoria</i>in Scopolamine Induced Memory Impairment in Mice

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Advances in Alzheimer's Disease 2018年第2期7卷 62-77页

作者： Kiran Zahid Syed Muhammad Faheem Ahmad maqsood Ahmed farah Khan Department of Botany Lahore College for Women University Lahore Pakistan UVAS—University of Veterinary and Animal Sciences Lahore Pakistan Riphah International University Lahore Pakistan

Ficus infectoria has a wide distribution in Bangladesh, Nepal, Pakistan, Sri Lanka, Southwest China and Indochina and is an enrich source of phytochemicals thereby possess antibacterial, antifungal and hyperglycaemic activities. In this study, we attempted to examine the cognitive ability of methanolic and ethanolic extract of F. infectoria fruit extract in scopolamine induced memory impairment in mice by using preliminary phytochemical and antioxidant tests, and the cognitive ability of the methanolic and ethanolic fruit extract of F. infectoria. Fruit extract was analyzed in scopolamine amnesia mice using passive avoidance approach. Piracetam was used as a reference drug (200 mg/Kg). Further confirmation was provided by means of mice brain homogenate biochemical tests. Maximum phytochemical, antioxidant activity and nootropic ability were observed in the ethanolic fruit extract of F. infectoria. Plant extract was used at three doses i.e. 75 mg/Kg, 150 mg/Kg and 300 mg/Kg and exhibited nootropic abilities in all tests used. Enhanced SDL value i.e. (291.2 ± 0.33+++###) was observed by the administration of plant extract at all dose range in comparison to reference drug i.e. piracetam (252.8 ± 1.60###) used in the study. The plant extract utilization has showed increase in total protein (25.08 ± 0.26+++### mg/g of tissue) and reduced glutathione content (33.0 ± 0.46+++### nmoles/mg of protein) and vice versa while low malondialehyde (MDA) (9.18 ± 0.17+++### nmoles/mg of protein) and AChE activity (0.067 ± 0.009+++### M/min/g protein). However, opposite situation was observed in the scopolamine amnesia mice. Hence it was concluded the plant extract possessed neuroprotective activity in the scopolamine induced cognitive decline in mice thereby used as cost effective natural medicines in near future.

关键词： Antioxidant Malondialdehyde Reduced Glutathione Acetylcholinestrase Scopolamine Hydrobromide Neuroprotective Ficus infectoria

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