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Antioxidant activity profiling by spectrophotometric methods of aqueous methanolic extracts of Helichrysum stoechas subsp. rupestre and Phagnalon saxatile subsp. saxatile

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Chinese Journal of Natural Medicines 2014年第6期12卷 415-422页

作者： farah Haddouchi Tarik Mohammed Chaouche Riadh Ksouri Faten Medini Fatima Zohra Sekkal Abdelhafid Benmansour Laboratory of Natural Products Department of Biology Faculty of Sciences Abou Bekr Belkad University Laboratory of Plant Adaptation to Abiotic Stresses Biotechnologic Center in Borj-Cedria Technopol (CBBC) Department of Biotechnology Faculty of Natural Science and Life Abdelel Hamid Ibn Badiss University Mostaganem 27000 Algeria

AIM: The aqueous methanolic extracts of two plants from Algeria, Helichrysum stoechas subsp. rupestre and Phagnalon saxatile subsp. saxatile, were investigated for their antioxidant activity. METHOD: Total phenolics, flavonoids, and tannins were determined by spectrophotometric techniques..In vitro antioxidant and radical scavenging profiling was determined by spectrophotometric methods, through: Total antioxidant capacity, and radical scavenging effects by the DPPH and ABTS methods, reducing and chelating power, and blanching inhibition of the β-carotene. RESULTS: All of the extracts showed interesting antioxidant and radical scavenging activity. The highest contents in phenolics, tannins, and the highest total antioxidant capacity as gallic acid equivalents of 97.5 ± 0.33 mg GAE/g DW was obtained for the flowers of H. stoechas subsp. rupestre extract in the phosphomolybdenum assay. An extract of the leafy stems of P. saxatile subsp. saxatile revealed the highest content of flavonoids, and the highest antioxidant activity by the radical scavenging and β-carotene assays when compared with standards. The best activity was by the scavenging radical DPPH with an IC50 value of 5.65 ± 0.10 μg·mL-1. CONCLUSION: The studied medicinal plants could provide scientific evidence for some traditional uses in the treatment of diseases related to the production of reactive oxygen species(ROS) and oxidative stress.

关键词： Helichrysum stoechas subsp.rupestre Phagnalon saxatile subsp.saxatile Phenolic compounds Antioxidant activity

Performance of the hybrid growth sequencing batch reactor(HG-SBR) for biodegradation of phenol under various toxicity conditions

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Journal of Environmental Sciences 2019年第1期31卷 64-72页

作者： NikAthirah Yusoff Soon-An Ong Li-Ngee Ho Yee-Shian Wong farah Naemah Mohd Saad WanFadhilah Khalik Sin-Li Lee School of Environmental Engineering University Malaysia Perlis School of Materials Engineering University Malaysia Perlis

Hybrid growth microorganisms in sequencing batch reactors have proven effective for treating the toxic compound phenol, but the toxicity effect under different toxicity conditions has rarely been discussed. Therefore, the performance of the HG-SBR under toxic, acute and chronic organic loading can provide the overall operating conditions of the system. Toxic organic loading(TOL) was monitored during the first 7 hr while introducing50 mg/L phenol to the system. The system was adversely affected with the sudden introduction of phenol to the virgin activated sludge, which caused a low degradation rate and high dissolved oxygen consumption during TOL. Acute organic loading(AOL) had significant effects at high phenol concentrations(600, 800 1000 mg/L). The specific oxygen uptake rate(SOUR) gradually decreased to 4.9 mg O_2/(g MLVSS·hr) at 1000 mg/L of phenol compared to 12.74 mg O_2/(g MLVSS·hr) for 200 mg/L of phenol. The HG-SBR was further monitored during chronic organic loading(COL) over 67 days. The effects of organic loading were more apparent at 800 mg/L and 1000 mg/L phenol concentrations, as the removal range was between 22%–30% and 18%–46% respectively, which indicated the severe effects of COL.

关键词： Toxic organic loading Acute organic loading Chronic organic loading Phenol Sequencing batch reactor

Role of the cation-chloride-cotransporters in the circadian system

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Asian Journal of Pharmaceutical Sciences 2021年第5期16卷 589-597页

作者： Shihan Salihu Nur farah Meor Azlan Sunday Solomon Josiah Zhijuan Wu Yun Wang Jinwei Zhang Institute of Biomedical and Clinical Sciences Medical SchoolCollege of Medicine and HealthUniversity of ExeterHatherly LaboratoriesExeter EX44PSUK Department of Neurology Institutes of Brain ScienceState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceInstitute of Biological ScienceZhongshan HospitalFudan UniversityShanghai 200032China

The circadian system plays an immense role in controlling physiological processes in our *** suprachiasmatic nucleus (SCN) supervises this system,regulating and harmonising the circadian rhythms in our *** neurons present in the SCN are GABAergic *** GABA is considered the main inhibitory neurotransmitter of the CNS,recent studies have shown that excitatory responses were recorded in this *** responses are enabled by an increase in intracellular chloride ions[Cl;];*** chloride (Cl;) levels in GABAergic neurons are controlled by two solute carrier 12 (SLC12)cation-chloride-cotransporters (CCCs):Na^(+)/K^(+)/Cl^(-)co-transporter (NKCC1) and K^(+)/Cl^(-)cotransporter (KCC2),that respectively cause an influx and efflux of Cl^(-).Recent works have found altered expression and/or activity of either of these co-transporters in SCN neurons and have been associated with circadian *** this review,we summarize and discuss the role of CCCs in circadian rhythms,and highlight these recent advances which attest to CCC’s growing potential as strong research and therapeutic targets.

关键词： GABAergic Na^(+)-K^(+)-2Cl^(-)cotransporter 1(NKCC1) K^(+)-2Cl^(-)cotransporter 2(KCC2) WNK3-SPAK/OSR1,Chloride(Cl^(-)) homoostasis Suprachiasmatic nucleus(SCN) Circadian rhythms

Typical atrial flutter from blunt cardiac injury:an atypical cause

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Journal of Geriatric Cardiology 2021年第2期18卷 155-157页

作者： Naji Maaliki Fadi Kandah Aleem Azal Ali James farah Temitope Akinjogbin Francesco Franchi Internal Medicine University of Florida College of Medicine-JacksonvilleFloridaUSA General Surgery University of Florida College of Medicine-JacksonvilleFloridaUSA Division of Cardiology University of Florida College of Medicine-JacksonvilleFloridaUSA

Atrial flutter(AFL)is a detrimental cardiac arrhythmia caused by multiple pathologic *** unsuspecting cases,however,may be an inciting *** them is blunt cardiac injury(BCI),characterized by nonpenetrating mediastinal trauma,leading to arrhythmias due to myocardial tissue *** is a rare sequela of BCI that has seldom been *** present a case of a healthy 50-year-old lady who was incidentally diagnosed with AFL in the setting of BCI.

关键词： cardiac injury atypical

An Improved Method for Preparation of Uniform and Functional Mitochondria from Fresh Liver

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Journal of Clinical and Translational Hepatology 2019年第1期7卷 46-50页

作者： Nagham Khouri farah Xiaocong Liu Catherine H.Wu George Y.Wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Background and Aims:As the major energy source for mammalian cells,mitochondria have been the subject of numerous ***,the isolation and purification of healthy mitochondria,especially from fresh tissue,remains *** most popular methods and kits involve various centrifugation steps which require substantial time and equipment but do not consistently provide pure preparations of functional *** aim of this study was to determine whether methods could be devised to improve the purity and yield of functional mitochondria from fresh ***:Fresh mouse liver was homogenized,and cells *** size analysis,quantitation of mitochondrial DNA,mitochondrial oxygen consumption,and purity of mitochondria(by electron microscopy)were measured in samples after various purification steps and significant differences ***:A two-step procedure consisting of centrifugation followed by filtration through 1.2μand 0.8μfilters resulted in uniform mitochondrial preparations with diameters between 520-540 nm,and approximately 5-times more pure *** mitochondria thus obtained had oxygen consumption and sensitivities to mitochondrial inhibitors that were indistinguishable from those purified by centrifugation *** microscopy confirmed the presence of more uniform and 4-5 times greater concentrations of mitochondria compared to centrifugation ***:A two-step procedure consisting of sequential centrifugation followed by filtration is a rapid method for the production of highly purified,uniform and functional mitochondria.

关键词： Mitochondria Isolation Filtration Purified Uniform Functional

Distribution of different hepatitis C virus genotypes in patients with hepatitis C virus infection

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World Journal of Gastroenterology 2010年第16期16卷 2005-2009页

作者： farah Bokharaei Salim Hossein Keyvani Afsaneh Amiri Fatemeh Jahanbakhsh Sef idi Ramin Shakeri Farhad Zamani Virology Department Iran University of Medical Sciences GI and Liver Disease Research Centre Iran University of Medical Sciences Digestive Disease Research Centre Tehran University of Medical Sciences

AIM:To investigate the presence of mixed infection and discrepancy between hepatitis C virus(HCV) genotypes in plasma,peripheral blood mononuclear cells(PBMCs),and liver biopsy ***:From September 2008 up to April 2009,133 patients with chronic hepatitis C referred to Firouzgar Hospital for initiation of an antiviral therapy were recruited in the *** milliliters of peripheral blood was collected from each patient and liver biopsy was performed in those who gave consent or had *** genotyping was done using INNO-LiPATM HCV in serum,PBMCs,and liver biopsy specimens and then conf irmed by sequencing of 5'-UTR ***:The mean age of patients was 30.3 ± 17.1 *** transfusion was seen in 124(93.2%) of *** HCV genotypes were found in 3(2.3%) of 133 plasma samples,9(6.8%) of 133 PBMC samples,and 8(18.2%) of 44 liver biopsy *** is notable that the different genotypes found in PBMCs were not the same as those found in plasma and liver biopsy ***:Our study shows that a signif icant proportion of patients with chronic hepatitis C are affected by multiple HCV genotypes which may not be detectable only in serum of patients.

关键词： Chronic hepatitis C virus infection Mixed hepat itis C virus infection Peripheral blood mononuclear cells Hepatocyte

Effect of particle size distribution on magnetic behavior of nanoparticles with uniaxial anisotropy

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Chinese Physics B 2018年第9期27卷 572-576页

作者： S Rizwan Ali farah Naz Humaira Akber M Naeem S Imran Ali S Abdul Basit M Sarim Sadaf Qaseem Department of Physics Federal Urdu University of Arts Science and Technology Department of Applied Chemistry and Chemical Technology University of Karachi Department of Computer Science Federal Urdu University of Arts Science and Technology

The effect of particle size distribution on the field and temperature dependence of the hysteresis loop features like coercivity（HC）, remanence（MR）, and blocking temperature（TB） is simulated for an ensemble of single domain ferromagnetic nanoparticles with uniaxial anisotropy. Our simulations are based on the two-state model for T 〈 TB and the metropolis Monte-Carlo method for T 〉 TB. It is found that the increase in the grain size significantly enhances HC and TB. The presence of interparticle exchange interaction in the system suppresses HC but causes MRto significantly *** results show that the parameters associated with the particle size distribution（D（d,δ）） such as the mean particle size d and standard-deviation δ play key roles in the magnetic behavior of the system.

关键词： magnetic nanoparticles Monte Carlo simulations size distribution interparticle interaction hysteresis

Measuring Global Warming: Global and Hemisphere Mean Temperature Anomalies Predictions Using Sliced Functional Time Series (SFTS) Model

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Open Journal of Applied Sciences 2019年第5期9卷 316-334页

作者： farah Yasmeen Karachi University Karachi Pakistan

In this study, the sliced functional time series (SFTS) model is applied to the Global, Northern and Southern temperature anomalies. We obtained the combined land-surface air and sea-surface water temperature from Goddard Institute for Space Studies (GISS), NASA. The data are available for Global mean, Northern Hemisphere mean and Southern Hemisphere means (monthly, quarterly and annual) since 1880 to present (updated through March 2019). We analyze the global surface temperature change, compare alternative analyses, and address the questions about the reality of global warming. We detected the outliers during the last century not only in global temperature series but also in northern and southern hemisphere series. The forecasts for the next twenty years are obtained using SFTS models. These forecasts are compared with ARIMA, Random Walk with drift and Exponential Smoothing State Space (ETS) models. The comparison is made on the basis of root mean square error (RMSE), mean absolute percentage error (MAPE) and the length of prediction intervals.

关键词： Temperature Series Hemispheric Temperature Temperature Anomalies Global Warming Weather Prediction Sliced Functional Time Series Outliers

Patients ≥ 75 years with acute coronary syndrome but without critical epicardial coronary disease： prevalence, characteristics, and outcome

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Journal of Geriatric Cardiology 2015年第1期12卷 11-16页

作者： Vincent Wong Ahmed farah Hubertus von Korn Nedim Memisevic Stefan Richter KetevanTukhiashvili Bernward Lauer Marc-Alexander Ohlow Cardiology Clinic Zentralklinik Bad Berka Robert-Koch-Allee 9 99437 Bad Berka Germany

Objective Absence of significant epicardial coronary artery disease （CAD） in patients with acute onset of chest pain and elevation of myocardial necrosis markers is occasionally observed. The aim of this study was to analyse the clinical characteristics and outcome of such patients with advanced age. Methods We retrospectively analysed 4,311 patients with acute onset of chest pain plus necrosis marker elevation. Two hundred and seventy two patients without CAD on angiogram （6.3%） were identified. Out of them, 50 （1.2%） patients 〉 75 years （Group Ⅰ） were compared with （1） 222 acute coronary syndrome （ACS） patients without CAD on angiogram 〈 75 years （Group Ⅱ）, and （2） 610 consecutive patients ≥ 75 years with Non-ST-elevation Myocardial Infarction （NSTEMI） undergoing percutaneous coronary intervention （Group Ⅲ）. Results Group 1 compared to Group III patients made up for more females （64.0% vs. 49.2%; P 〈 0.0001）, and had more severe anginal symptoms on presentation [Canadian Cardiovascular Society （CCS） class Ⅰ/Ⅱ, 26.0% vs. 49.8%; P = 0.02]. Group I patients also had lower troponin levels （0.62 ± 0.8 ng/mL vs. 27 ± 74 ng/mL; P 〈 0.02）, lower leukocyte count （9.4 ± 3.13 × 10^9 vs. 12 ± 5.1 × 10^9; P = 0.001 ） and better preserved left ventricular function （56.7% ± 14.3 % vs. 45% ± 1 1%; P 〈 0.0001 ）. Event-free survival （cardiac death, myocardial infarction, recurrent angina, and re-hospitalisation） was more frequent in Group Ⅰ and Ⅱ patients compared to Group III patients （64.9%, 66.7%, and 41.6%, respectively; P 〈 0.0001）. Conclusions ACS in patients 〉 75 years without CAD is very infrequent, associated with a （1） similar outcome compared to ACS patients 〈 75 years without CAD, and （2） significant better outcome compared to NSTEMI patients 〉 75 years.

关键词： Acute coronary syndrome Angina Biological markers Coronary stenosis Myocarditis Syndrome