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Otosclerosis: Contribution of Computed Tomography and Radio-Anatomical Correlations

Open Journal of Clinical Diagnostics 2015年第2期5卷 74-80页

作者： Khaled Khamassi Madiha Mahfoudhi Hejer Mbarek farah Hedhili Ayoub Ben Yahia Lobna Bougacha Jihen Ben Hafdhallah Najla Mnif Rim Lahiani Mamia Ben Salah Department of Otorhinolaryngology—Head and Neck Surgery Charles Nicolle Hospital Tunis Tunisia Department of Internal Medicine A Charles Nicolle Hospital Tunis Tunisia Department of Radiology Charles Nicolle Hospital Tunis Tunisia

Otosclerosis is an osteodystrophia of the otic capsule, responsible for hearing loss by blocking of the stapes footplate. The purpose of this study was to evaluate the reliability of computed tomography (CT) in the positive diagnosis of otosclerosis, to compare the radiological findings to those intraoperatively, and to seek a correlation between imaging data and postoperative audiometric results. This is a retrospective study of 60 patients having otosclerosis, treated in our department between 2009 and 2011. All patients underwent an otoscopic examination, pure tone and vocal audiometry, impedancemetry and petrous CT scan. At petrous CT scan, a footplate thickening was found in 9 cases. Labyrinthine bone hypodensity was noted in 51 cases. Sensitivity of CT in the diagnosis of otosclerosis was 100%. Regarding the operative findings and their correlation with imaging, we found that among the 7 facial canal procidences reported intraoperatively, CT had identified 6, with a sensitivity of 86%. Of the 53 facial nerve in normal position intraoperatively, CT had only identified 34, with a specificity of 64%. Regarding the ossicles, there were 6 cases of abnormalities of the incus, among them 3 were identified on CT, with a sensitivity of 50%. The 54 patients with normal ossicular chain intraoperatively were all identified as such on CT, with a specificity of 100% (p = 0.001). For correlation between imaging and postoperative results, it was found that patients with extended otosclerosis had lower postoperative audiometric improvement than those having localized disease (p < 0.05). Computed tomography is necessary for the diagnosis of otosclerosis. It also helps, with good sensitivity and specificity, seeking for anatomical variants that the surgeon could possibly encounter during surgical procedure. Finally, there is a statistically significant correlation between imaging data and postoperative audiometric results, allowing establishing a functional prognosis even before

关键词： Otosclerosis Computed Tomography Hearing Loss Audiometry

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细胞介导免疫在小鼠抗假丝酵母菌感染中的作用

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国际口腔医学杂志 2008年第4期35卷 411-413页

作者：胡雁 Camile S.farah Robert B.Ashman 中山大学光华口腔医学院口腔生物学教研室广东广州510055 澳大利亚昆士兰大学牙学院口腔生物学研究中心

细胞介导免疫是一个复杂的系列反应过程,当抗原进入机体后,抗原呈递细胞呈递抗原信息给T细胞,使之被激活后变成辅助性T细胞(CD4+)。此时,CD4细胞又可分为分泌白细胞介素-2和干扰素-γ的辅助性T细胞(Th1)及分泌白细胞介素-10的辅助性T细... 详细信息

细胞介导免疫是一个复杂的系列反应过程,当抗原进入机体后,抗原呈递细胞呈递抗原信息给T细胞,使之被激活后变成辅助性T细胞(CD4+)。此时,CD4细胞又可分为分泌白细胞介素-2和干扰素-γ的辅助性T细胞(Th1)及分泌白细胞介素-10的辅助性T细胞(Th2)。在假丝酵母菌感染时,Th1反应激活中性粒细胞和巨噬细胞,促进宿主抗假丝酵母菌;Th2反应则抑制宿主的抗感染作用。细胞介导免疫在系统性假丝酵母菌感染中的作用一直存在争议,但在口腔黏膜抗假丝酵母菌感染中的作用是肯定的。

关键词：细胞介导免疫假丝酵母菌感染小鼠

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Etiology of Upper GI Bleeding on Endoscopy

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Neuroscience & Medicine 2018年第1期9卷 16-21页

作者： Junaid Khan Muhammad Ali Hareem Bakhsh Sobhi Sheikh Moazzam Waheed Ifrah Shahnawaz Muhammad Abdullah Sardar Muhammad Omer Naseem Omer Kamal farah Bashir Muhammad Nadeem University College of Medicine University of Lahore Lahore Pakistan King Edward Medical University Lahore Pakistan Liaquat University of Medical and Health Sciences Jamshoro Pakistan University at Buffalo Buffalo NY USA

Background: Several circumstances and conditions lead to UGIB. The commonest among them peptic ulcer to an approximation of 50% in cases. The second major cause may be esoghageal varices and third is mallory-weis tears. There are also other causes, which may include erosins, tumors and other malformations like arteriovenous. Methods: This was an observational retrospective study of all patients referred to endoscopy. The study exclusion criteria include all patients who had repeat endoscopies within one month of the previous endoscopy whereas all the patients with UGIB were included in this study. Results: We retrieved data of total 150 patients who had experienced upper gastrointestinal endoscopy during the selected time period covered in the study, March 2015 to February 2016. The mean age of the patients was 43.3 ± 13.80. 80 (53.3%) of the patients were male and 70 (46.7%) were females. Exploring more into UGIB causes the majority of patients were with esophageal varices 68 (45.3%) with male to female share was 2:1. The second most cause was esophagitis (n = 22, (14.67%)), the distribution of the cause was similar in male to female. Conclusion: We may conclude from our findings that the most common cause of UGIB is esophageal varices in our population.

关键词： Upper Gastrointestinal Endoscopy Esophageal Varices Upper Gastrointestinal Bleeding Peptic Ulcer

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A Comparative Study of Smugel and KY Jelly Vaginal Lubricating Gels

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Journal of Reproduction and Contraception 2013年第2期24卷 76-87页

作者： Jael A. OBIERO Robert KUNYERA Kenneth K. WAITITU Isaac MULEI Idle O. farah Kavoo LINGE Walter JAOKO Peter G. MWETHERA Department of Reproductive Health and Biology Institute of Primate Research Department of Medical Microbiology University of Nairobi-Kenyatta National Hospital Department of Veterinary Pathology University of Nairobi Department of Obstetrics & Gynaecology Nairobi Hospital Department of Obstetrics & Gynaecology University of Stellenbosch

Objective To assess the safety of Smugel compared with KY Jelly vaginal lubricating gel in baboon （Papio anubis） vagina. Methods Ten sexually mature olive female baboons were used in this study. Vaginal pH, blood chemistry, vaginal flora, vaginal and cervical histology were evaluated at baseline and after administration of15 ml of either Smugel or KY Jelly gel twice a week for 5 weeks to each randomized treatment group. Results Basal vaginal pH was 5.8± 0. 8. There was no significant difference in the vaginal pH of Smugel compared with KY Jelly treated animals or baseline data （P〉0. 05）. Similarly, analysis of blood chemistry parameters revealed no significant differences. The most frequently isolated microorganisms both at baseline and during treatment included Corynebacterium glucuronolyticum, C. renale group, Lactococcus raffinolactis, Leuconostoc lactis, Lactobacillus acidophilus, L. fermentum, L. salivarius, Staphylococcus aureus, S. xyloxus, S. hyicus, Aerococus viridians, Escherichia coli and Candida albicans. No detectable histological changes were observed in the vaginal or cervical sections examined. Conclusion Smugel, compared with KY Jelly did not induce any adverse event that may facilitate transmission of sexual transmitted infection （STI） pathogens including HIV.

关键词： Papio anubis women vaginal lubrication

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Effectiviness, Safety and Satisfaction in Teleurology

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Open Journal of Urology 2022年第7期12卷 383-393页

作者： Thome Barros Junior Marcos Kalaf farah Albeny Igor José Caetano De Lima Guilherme Bastos Palitot De Brit Moacir Cavalcante De Albuquerque Neto Fábio Oliveira Vilar Federal University of Pernambuco Recife Brazil Hospital of Clinics of Federal University of Pernambuco Recife Brazil

Introduction: Telemedicine has been used as a tool for improving access to health services worldwide. The aim of the present study is thus to evaluate the effectiveness of urological consultation by videoconference, perceptions regarding safety on the part of medical teams providing video consultation services and patient satisfaction after a urological appointment. Materials and Methods: A cross-sectional, observational, and analytical study was carried out with 50 volunteers referred from the basic health unit for a urology appointment. All patients were evaluated remotely by videoconference and in person by different urology teams. Results: The study revealed that effectiveness in terms of the degree of match between diagnoses performed by video consultation and those performed in person was 92%. The urology team’s perception regarding safety, measured using an in-house safety questionnaire, was high for both videoconferencing and in-person consultations and there was no statistical difference between the two (overall safety score for video consultation compared to in-person consultation was 9.7 ± 0.8 compared to 9.6 ± 0.8 and the p-value was 0.3 for Student’s t-test). Patient satisfaction with the appointment was similarly high for both groups, averaging 9.72 ± 0.4 among patients who attended a video consultation and 9.82 ± 0.4 among those whose consultation was conducted in person, with a p-value of 0.10478 for Student’s t-test. Conclusion: Video consultation in urology is an effective way to perform diagnoses, with high levels of perceived safety among urologists and high satisfaction rates among patients.

关键词： Urology Telemedicine Telecommunications Appointments and Schedules

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History (Whose Story?)“Written With Lighting”: A Cinematic Representation of the “Traumatic Past “of the Germans in World War Ⅰ

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Psychology Research 2019年第3期9卷 110-115页

作者： Farhat Tasannum farah American International University-Bangladesh DhakaBangladesh

The powerful ability of film to present the traumatized German war veteran that traces how some of the most vulnerable members of society, marginalized and persecuted as ‘enemies of the nation,’ attempted to regain authority over their own minds and reclaim the authentic memory of the Great War under Weimar Germany and the Third Reich. The mentally disabled survivor of the trenches became a focus of debate between competing social and political groups, each attempting to construct their own versions of the national community and the memory of the war experience. By examining the psychological effects of war on ordinary Germans and the way these war victims have shaped perceptions of madness and mass violence, the expressionist cinema explores how the classical German cinema of the Weimar Republic was haunted by the horrors of World War I and the the devastating effects of the nation's defeat. This paper purposes to analyse how this post-traumatic cinema transformed extreme psychological states into visual expression;how it pushed the limits of cinematic representation with its fragmented story lines, distorted perspectives, and stark lighting;and how it helped create a modernist film language that anticipated film noir and remains incredibly influential today.

关键词： Great War trauma Germans cinematic representation German Expressionist Films

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Reverse vaccinology assisted designing of multiepitope-based subunit vaccine against SARS-CoV-2

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Infectious Diseases of Poverty 2020年第5期9卷 117-117页

作者： Muhammad Tahir ul Qamar farah Shahid Sadia Aslam Usman Ali Ashfaq Sidra Aslam Israr Fatima Muhammad Mazhar Fareed Ali Zohaib Ling-Ling Chen College of Life Science and Technology Guangxi UniversityNanningP.R.China Department of Bioinformatics and Biotechnology Government College University Faisalabad(GCUF)FaisalabadPakistan 不详

Background:Coronavirus disease 2019(COVID-19)linked with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)cause severe illness and life-threatening pneumonia in *** current COVID-19 pandemic demands an effective vaccine to acquire protection against the ***,the present study was aimed to design a multiepitope-based subunit vaccine(MESV)against ***:Structural proteins(Surface glycoprotein,Envelope protein,and Membrane glycoprotein)of SARS-CoV-2 are responsible for its prime *** of proteins were downloaded from GenBank and several immunoinformatics coupled with computational approaches were employed to forecast B-and T-cell epitopes from the SARS-CoV-2 highly antigenic structural proteins to design an effective ***:Predicted epitopes suggested high antigenicity,conserveness,substantial interactions with the human leukocyte antigen(HLA)binding alleles,and collective global population coverage of 88.40%.Taken together,276 amino acids long MESV was designed by connecting 3 cytotoxic T lymphocytes(CTL),6 helper T lymphocyte(HTL)and 4 B-cell epitopes with suitable adjuvant and *** MESV construct was non-allergenic,stable,and highly *** docking showed a stable and high binding affinity of MESV with human pathogenic toll-like receptors-3(TLR3).Furthermore,in silico immune simulation revealed significant immunogenic response of ***,MEV codons were optimized for its in silico cloning into the Escherichia coli K-12 system,to ensure its increased ***:The MESV developed in this study is capable of generating immune response against ***,if designed MESV further investigated experimentally,it would be an effective vaccine candidate against SARS-CoV-2 to control and prevent COVID-19.

关键词： SARS-CoV-2 COVID-19 Structural protein Epitope Vaccine Multiepitope-based subunit vaccine Immunoinformatics

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小鼠念珠菌感染模型和遗传因素研究

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实验动物与比较医学 2008年第1期28卷 57-61页

作者：章小缓胡雁 Camile S farah Robert B Ashman 中山大学光华口腔医学院广州510055 澳大利亚昆士兰大学牙学院

白色念珠菌是能感染人类皮肤和粘膜的真菌。当宿主的免疫系统受到抑制时,可导致念珠菌病。建立动物实验模型对研究不同类型的人类念珠菌病非常必要,如系统性和皮肤粘膜的念珠菌感染模型。目前,最为常见的是系统性念珠菌动物模型。而能... 详细信息

白色念珠菌是能感染人类皮肤和粘膜的真菌。当宿主的免疫系统受到抑制时,可导致念珠菌病。建立动物实验模型对研究不同类型的人类念珠菌病非常必要,如系统性和皮肤粘膜的念珠菌感染模型。目前,最为常见的是系统性念珠菌动物模型。而能准确反映人类皮肤粘膜念珠菌感染的动物模型仍未稳定建立。值得庆幸的是,特异性基因剔除小鼠(specific-gene knock out mice)的出现为研究念珠菌与宿主的免疫应答提供了更为直接和准确的模型。

关键词：白色念珠菌动物模型基因剔除鼠

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草药监测的主要问题

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药物不良反应杂志 2000年第2期2卷 105-108页

作者： Mohamed H.farah I.Ralph Edwards Marie Lindquist WHO国际药物监测合作中心

为确保草药制品的安全性,必须对植物进行正确鉴定,草药名称必须依据植物的国际命名法,否则,信息在交流时可能造成巨大混乱,甚至变得毫无价值。草药如果正确使用通常是安全而有效的,许多病人经草药治疗后其健康有极大改善,每种药物都有... 详细信息

为确保草药制品的安全性,必须对植物进行正确鉴定,草药名称必须依据植物的国际命名法,否则,信息在交流时可能造成巨大混乱,甚至变得毫无价值。草药如果正确使用通常是安全而有效的,许多病人经草药治疗后其健康有极大改善,每种药物都有利弊两方面。

关键词：草药监测不良反应草药分类标准化

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亚洲面孔的解构班加罗尔Misu餐厅

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室内设计与装修 2020年第7期 61-67页

作者：小麦(编译) 无 Dhaval Shellugar farah Ahmed Shruthy Bothra Rishika Gokul Rao Kadam(摄影) 不详 FADD Studio

想象一下,教堂建筑结构下的亚洲餐厅;想象一下你沿着中央岛,边走边欣赏着身边和上方支撑着天花的金属柱体和拱门;想象一下,阳光透过两边的彩色玻璃,在空气中流淌;想象一下墙面上手绘的壁画……这就是Misu餐厅给食客们带来的奇妙体验。M... 详细信息

想象一下,教堂建筑结构下的亚洲餐厅;想象一下你沿着中央岛,边走边欣赏着身边和上方支撑着天花的金属柱体和拱门;想象一下,阳光透过两边的彩色玻璃,在空气中流淌;想象一下墙面上手绘的壁画……这就是Misu餐厅给食客们带来的奇妙体验。Misu餐厅位于印度南部的班加罗尔,是FADD设计工作室设计的第二家Misu餐厅,也是对其所在旧建筑策划的一场华丽演变,更是设计师对概念与材料相融合的一次全新尝试。他们有意赋予空间一种未完成感,以吸引食客一次次前来,似乎每次来都会有些什么进展和新鲜似的。

关键词：设计工作室建筑策划教堂建筑班加罗尔彩色玻璃印度南部餐厅拱门

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