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Synergetic effect of Egyptian propolis in immunization of BALB/c mice against bovine cysticercosis

Asian Pacific Journal of Tropical Biomedicine 2015年第4期5卷 324-330页

作者： Omnia mohamed Kandil Somia Ayesh Nassar Soad mohamed Nasr Hatem Abdel Mawgoud Shalaby Seham Hendawy faragalla mohamed el moghazy Department of Parasitology and Animal Diseases National Research Centre Biology Department College of Science and Humanity Studies Salman Bin Abdul Aziz University

Objective: To evaluate the synergetic effect of an ethanolic extract of Egyptian propolis in immunization of BALB/c mice with Taenia saginata(T. saginata) crude antigen against bovine cysticercosis, with reference to its effects on liver and kidney ***: Sixty female mice BALB/c strain weighing 20 to 25 g and 6-8 weeks old were randomly allocated into six groups of ten mice each. Mice in groups 1 and 2(G1 and G2) were immunized intraperitoneally with 100 μg of T. saginata crude antigen in 100 μL phosphate buffer saline emulsified in Freund's adjuvant. Besides, the mice in G2 were administered with propolis extract simultaneously with immunization. Control mice were either administered with propolis extract(G3) or injected with the same volume of phosphate buffer saline emulsified in Freund's adjuvant(G4). The mice in G5 were non-immunized infected control while, those in G6 were non-immunized non-infected control. Two weeks after the last immunization, each mouse was challenged intraperitoneally with 5 000 oncospheres except those of G6. Ethanolic extract of propolis was prepared at a dose 50 mg/kg body ***: After 24 weeks of challenge, the mice in G2 showed the highest level of protection(100%), with no cyst being detected rather than mice in G1(33.3% protection). Additionally,the elISA results, in this study, showed higher antibody titer in G2 with reduction the alteration in liver and kidney functions compared to ***: Egyptian propolis could increase the level of protection against experimental challenge infection with T. saginata eggs when administered simultaneously with immunization. Furthermore, it could enhance the production of antibodies to immunized antigen and decrease the alteration in liver and kidney functions.

关键词： Taenia saginata Vaccine BALB/c mice elISA Serum biochemistry

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Hepatobiliary & Pancreatic Diseases International 2009年第4期8卷 358-362页

作者： Mohammed Saied Hedaya Walid mohamed el moghazy Shinji Uemoto Department of Hepato-Biliary-Pancreatic and Transplant Surgery Kyoto UniversityJapan Department of General Surgery Theodore Bilharz Research InstituteGizaEgypt Department of Surgery Sohag UniversityEgypt

BACKGROUND:Liver transplantation currently represents the ultimate therapy for bleeding esophageal varices in patients with liver *** is the only therapy that cures both portal hypertension and the underlying liver *** outcome of liver transplantation is thought to be correlated with several *** this study,the clinical outcome of living-related liver transplantation(LRLT) was evaluated in patients with variceal bleeding,and the prognostic indicators of short-term survival in these patients were identified. METHODS:We reviewed retrospectively 121 patients with a history of variceal bleeding who had received LRLT from 1998 to *** clinical outcomes were analyzed,and the risk factors for short-term survival were defined. RESULTS:The 3-month survival rate of patients with variceal bleeding was 83.4%,while that of non-bleeders was 87%.Sepsis was the commonest cause of death in both *** vein diameter and blood transfusion were the only independent prognostic factors for short-term survival among variceal bleeders. CONCLUSION:The outcome of LRLT in recipients with variceal bleeding is based on the improvement of portal hemodynamics,by minimizing intraoperative blood loss and subsequent blood transfusion.

关键词： living-related liver transplantation outcome prognostic factors variceal bleeding

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