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Wegener’s Granulomatosis Presenting with Bilateral Excavated Nodules

Open Journal of Pathology 2012年第2期2卷 26-28页

作者： Emna Braham Hajer Racil Houda Ben Rejeb Moncef Hamdane Abdellatif Chabou faouzi el mezni Department of Pathology Abderrahmen Mami Hospital Ariana Tunisia Department of Pneumology Abderrahmen Mami Hospital Ariana Tunisia

Wegener’s granulomatosis (WG) is a systemic inflammatory disease whose histopathologic features often include necrosis, granuloma formation, and vasculitis of small-to-medium-sized vessels. We report a new case of Wegener’s granulomatosis occurring in a 41-year-old man who was admitted for respiratory symptoms, fever, asthenia, night sweats and weight loss since one month. Chest X-ray and computed tomography showed multiple bilateral pulmonary excavated lesions. A trransparietal lung biopsy was performed. Histological examination showed an area of necrosis, surrounded by a palisade of histiocytes. Some of the histiocytes were multinucleated and formed true granulomas within the wall of the adjacent pulmonary artery. Serology was strongly positive for ANCA. A diagnosis of Wegener granulomatosis was conducted and the patient was started on cyclophosphamide and methylprednisolone as an initial treatment, with a favorable evolution.

关键词： Vasculitis Wegener Pathology Lung Granulomatous Inflammation

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Asthma-Like Tracheo-Bronchial Amyloidosis

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Open Journal of Respiratory Diseases 2012年第2期2卷 57-59页

作者： Fatma Chermiti Ben Abdallah Hanene Smadhi Ridha Mahouachi Amel Chtourou Sofia Taktak Ayda Ayadi faouzi el mezni Ali Ben Kheder Anatomy-Pathology Department Abderrahmen Mami Hospital Ariana Tunisia Pneumology IV Department Abderrahmen Mami Hospital Ariana Tunisia

Localized bronchial Amyloidosis is an uncommon disease of unknown origin. Clinical signs are not specific. Tracheobronchial symptoms are the most frequent. We report a case of a 31 year-old man complaining of asthma-like dyspnea. Bronchoscopy was performed because of ineffectiveness of antiasthmatic treatment, showed a submucosal infiltration with stenosis of both right and left upper bronchi and a complete stenosis of intermediate troncus. Multiple biopsies were performed and concluded to Amyloidosis of AL type. Oral corticosteroids were indicated with clinical improvement.

关键词： Amyloidosis Biopsy Histology Corticosteroids

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AME国际病例001|胸壁滑膜肉瘤:病例报告及文献综述

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临床与病理杂志 2015年第1期35卷 27-30页

作者： Emna Braham Slim Aloui Samira Aouadi Ikram Drira Tarek Kilani faouzi el mezni 王斌 Department of pathologyp Abderrahmen Mami Hospital Ariana Tunisia Department of Pneumology Abderrahmen Mami Hospital Ariana Tunisia Departmernt of Thoracic Surgery Abderrahmen Mami Hospital Arianaj Tunisia

滑膜肉瘤是一种恶性软组织肿瘤,多发生于青壮年的四肢。然而,胸壁滑膜肉瘤则非常少见,文献中仅有数例报道。一名57岁老年女性因胸痛就诊。影像学检查发现,右胸壁肿瘤破坏了第8肋骨中部,胸肌和胸膜外脂肪出现不均匀增强信号表明其亦受到... 详细信息

滑膜肉瘤是一种恶性软组织肿瘤,多发生于青壮年的四肢。然而,胸壁滑膜肉瘤则非常少见,文献中仅有数例报道。一名57岁老年女性因胸痛就诊。影像学检查发现,右胸壁肿瘤破坏了第8肋骨中部,胸肌和胸膜外脂肪出现不均匀增强信号表明其亦受到累及。行胸壁切除术。组织学和免疫组化结果显示滑膜肉瘤。对患者进行辅助化疗,然而治疗过程中失访。6个月后,患者再次就诊时发现,胸壁出现复发的巨大肿瘤。

关键词：滑膜肉瘤胸壁外科组织学

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Epidemiology of Pemphigus: A Single Center Experience in Morocco

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International Journal of Dermatology and Venereology 2022年第1期5卷 20-26页

作者： Farah el Hadadi Line mezni Karima Senouci Laila Benzekri Nadia Ismaili Mariame Meziane Department of Dermatology-Venereology Ibn Sina University HospitalMohammed V UniversityRabat 10100Morocco

Objective:Pemphigus is a life threatening autoimmune bullous disease which involves the skin and mucous membranes of the stratified squamous *** global distribution of Pemphigus varies according to genetic,ethnic,socioeconomic,and cultural *** purpose of our study is to evaluate the epidemiological features of pemphigus a single center in Morocco and compare our results with those reported ***:A retrospective analysis was conducted of 302 pemphigus patients seen between 1990 and 2020 in the Dermatology Department of Ibn Sina Hospital(Rabat,Morocco).We further collected all the Moroccan scientific researches published by now to ***:The average annual incidence was 0.32/100,000 *** incidence doubled to 0.72 in *** most common variant was pemphigus vulgaris(125 cases)followed by pemphigus erythematosus(99 cases),pemphigus foliaceous(40 cases),and vegetans(27 cases).The female to male ratio was 0.75,the average age at onset was 53 years old and the mean duration of the disease before diagnosis was ***:This study joins the main characteristics of pemphigus in the Maghreb and around the world(pemphigus vulgaris most frequent subtype).In 2020,an epidemiological peak occurred during the coronavirus disease 2019 pandemic;probably related to stress and delayed time consultation for fear of contracting the severe acute respiratory syndrome coronavirus 2.

关键词： pemphigus epidemiology Rabat Morocco autoimmune bullous disease desmoglein

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