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The Mechanism of Swainsonine Causing Early Pregnancy Abnormal Decidualization and Inducing Abortion by Changing Glycosylation Modification

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Advances in Reproductive Sciences 2018年第3期6卷 70-101页

作者： Yi Wang Xin Gao Ming Peng Yanfei You fangyun shi Yazhou Guo Baoyu Zhao Chenchen Wu Northwest A & F University Animal Medical College Yangling China

Locoweed is a poisonous plant that severely harms the development of grass-land and animal husbandry throughout the world. Oxytropis and Astragalus are the Latin names for the poisonous plants commonly known as locoweed. The main toxic substance in these plants is swainsonine. It is a strong inhibitor of lysosomal α-mannosidase I and Golgi body α-mannosidase II, resulting in the accumulation of oligosaccharides and glycoproteins in lysosomes, interfering with the molecular and cellular recognition of glycans, and causing tissue-cell vacuolar degeneration. Livestock shows a series of clinical and pathological symptoms, mainly for the decline of reproductive performance. The effects in dams are abortion, weak fetus, and fetal malformations. The key step in maintaining pregnancy in dams is early endometrial decidualization, because reproductive hormones, decidual cell apoptosis, endoplasmic reticulum (ER) stress, and other immune factors are negatively affected by swainsonine. This article addresses the modifications that occur through glycan processing and glycosylation resulting in the change of post-translational modification of the protein and the activity of the glycoprotein, and then direct and indirect mechanisms of ER stress, apoptosis, reproductive hormones, immune factors, and cell cycle and other pathways. Our aim is to find new methods of prevention and treatment of swainsonine poisoning in grassland animals.

关键词： Swainsonine Glycosylation Modification Abortion Decidua Hormone Cell Apoptosis Endoplasmic Reticulum Stress

Early intestinal immune response of mice to primary and challenge infections with Eimeria falciformis

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Early intestinal immune response of mice to primary and chal...

注射用甲泼尼龙琥珀酸钠联合多巴胺、多巴酚丁胺治疗婴幼儿重症肺炎的临床探讨

2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学家学术论坛

作者： fangyun shi Tumalisi·Abudureheman Sixin zhang Xianyong Liu Xun Suo National Animal Protozoa Laboratory & College of Veterinary Medicine China Agricultural University

Eimeria falciformis,a coccidian species of mice,is a valuable model species for the study of coccidiosis caused by the infection with other eimerian parasites in poultry and *** immune responses play a vital role in the resistance against coccidia infection,while the development of immunity is still not well *** the current study,we compared the early immune response of mice against challenge infection in animals with or without previous Eimeria falciformis *** immunized twice 21 days apart,or naive mice were heavily *** cecal samples were taken at 0,24,48 and 72 h after challenge and subjected to preparation of frozen *** subpopulations and parasites were microscopically quantified in the caecum marking by *** studies showed more leucocytes were detected in the lamina propria of immune mice,and leucocytes infiltrated the caecum more rapidly than in naive *** used multicolor immunohistochemistry to detect lymphocytes in the cecum after 24 hours of *** cells included CD4+,CD8+,CD 19+,F4/80+,CD11 c+and Ly6 G+cells,whereas significantly more CD4+,CD8+(T) and F4/80+cells were found in the caecum the immune *** establish which stages were affected in immune mice,the numbers of trophozoites and young schizonts,as well as of mature schizonts,were determined by intestinal histological examination in mice challenged with high *** with the non-immune group,the total amount of sporozoites,trophozoites and young schizonts was almost identical in immunized up to 24 *** 48-72 h.p.i.,the number of parasites seen in the non-immune group greatly exceeded the number in the immune *** above results indicated that early schizonts of ***,developing within 48-72 h *** strongly affected in immunized *** conclusion,caecum tissue alterations suggested an early local immune response can affect *** development and maturation.

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中国卫生标准管理 2016年第17期7卷 84-85页

作者：王娟周昕科石芳云新疆克拉玛依市人民医院儿科新疆克拉玛依834000

目的：总结注射用甲泼尼龙琥珀酸钠（甲强龙）联合多巴胺、多巴酚丁胺治疗婴幼儿重症肺炎的临床疗效。方法选取我院2014年1月-2016年1月收治的婴幼儿重症肺炎85例，入院后随机分组：治疗组43例，施以甲强龙联合多巴胺、多巴酚丁胺；对照... 详细信息

目的：总结注射用甲泼尼龙琥珀酸钠（甲强龙）联合多巴胺、多巴酚丁胺治疗婴幼儿重症肺炎的临床疗效。方法选取我院2014年1月-2016年1月收治的婴幼儿重症肺炎85例，入院后随机分组：治疗组43例，施以甲强龙联合多巴胺、多巴酚丁胺；对照组42例，施以常规药物，对两组临床疗效进行对照。结果治疗组总有效率、主要症状体征消失时间、治愈时间等均优于常规组（P＜0.05）。结论甲强龙联合多巴胺、多巴酚丁胺在婴幼儿重症肺炎中的应用效果良好，能够提升患儿的治疗效果。

关键词：甲强龙联合多巴胺多巴酚丁胺婴幼儿重症肺炎

苦豆子资源现状、化学成分、毒性及其开发利用研究进展

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黑龙江畜牧兽医 2019年第13期 34-38页

作者：史芳芸邱明宁李国中张庚吴晨晨路浩赵宝玉西北农林科技大学动物医学院陕西杨凌712100 阿拉善左旗动物疫病预防控制中心内蒙古阿拉善750300

苦豆子是一种耐盐碱植物,广泛分布于我国西北部干旱荒漠草地,特别是盐碱化草地,已经成为遏制草地退化的重要植物,其资源储量十分丰富。因此,将苦豆子作为可利用的植物资源,发挥其本身的价值进行资源化开发利用,显得尤为重要。近年来,国... 详细信息

苦豆子是一种耐盐碱植物,广泛分布于我国西北部干旱荒漠草地,特别是盐碱化草地,已经成为遏制草地退化的重要植物,其资源储量十分丰富。因此,将苦豆子作为可利用的植物资源,发挥其本身的价值进行资源化开发利用,显得尤为重要。近年来,国内外围绕苦豆子的生物学特性、化学成分、药理活性、杀虫活性、毒性作用以及苦豆子生物碱制剂研发等方面进行了广泛而深入的研究,对加快苦豆子资源化利用发挥了重要的推动作用。文章从苦豆子的资源分布、化学成分、毒理作用以及综合利用等方面进行综述,以期为苦豆子资源化利用及其产品开发提供理论依据。

关键词：苦豆子资源现状化学成分毒性开发利用草地

Nano-selenium controlled cadmium accumulation and improved photosynthesis in indica rice cultivated in lead and cadmium combined paddy soils

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Journal of Environmental Sciences 2021年第5期33卷 336-346页

作者： Chengrun Wang Tingting Cheng Haitao Liu fangyun Zhou JifengZhang Min Zhang Xinya Liu Wenjun shi Tong Cao School of Biological Engineering Huainan Normal UniversityHuainan 232038China Key Laboratory of Bioresource and Environmental Biotechnology of Anhui Higher Education Institutes Huainan Normal UniversityHuainan 232038China

Selenium nanoparticles(Se NPs) are less toxic and more biocompatible than selenite or selenate. However, studies involving spraying with Se NPs for reducing accumulation of cadmium(Cd) and lead(Pb) in rice grains have been rarely reported as yet. Herein, indica rice seedlings cultivated in Cd + Pb-spiked paddy soils(denoted as positive control) were sprayed with Se NPs sols for four times from tillering to booting stage. Compared to positive control, 50–100 μmol/L Se NPs downregulated Cd transporters-related genes such as Os LCT 1, OsH MA 2 and Os CCX2 in leaves and OsLCT1, Os PCR1 and Os CCX2 genes in node I at filling stage. Meanwhile, Se-binding protein 1 was distinctly elevated, involving the repression of Cd and Pb transportation to rice grains. Se NPs also differentially improved RuBP carboxylase and chlorophylls especially some key genes and proteins involving photosynthetic system. Besides, 25–50 μmol/L Se NPs diminished reactive oxygen species overproduction from NADPH oxidases whereas boosted glutathione peroxidase, reducing protein carbonylation in rice seedlings. However, the antioxidant isozymes and oxidatively modified proteins were slightly rebounded at 100 μmol/L. Se contents were noticeably elevated and confirmed to exist as selenomethionine in the rice grains following all the treatments by Se NPs. Thus, the optimal dosage of Se NPs for foliar application is 50 μmol/L, which significantly decreased Cd accumulation, improved photosynthesis and Se enrichment whereas caused no distinct reduction of Pb in the grains. Thus, an appropriate dosage of Se NPs can be conducted to decrease Cd accumulation, improve photosynthesis, and organic Se contents in rice grains.

关键词： Selenium nanoparticles(Se NPs) Heavy metals Oryza sativa L. Selenium enrichment and cadmium reduction Food quality and safety

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一种三维模型形状检索描述符

计算机辅助设计与图形学学报 2010年第5期22卷 741-745页

作者：张欣莫蓉石源周方云西北工业大学现代设计与集成制造技术教育部重点实验室西安710072

为了解决基于关键字的搜索方式不能准确查找三维模型的问题,对三角网格形式的三维模型提出一种基于内容的模型搜索算法.首先将模型中的三角网格再次划分,增加形状函数的维度,定义了一种新的三维模型形状函数,以提高形状函数的准确性;然... 详细信息

为了解决基于关键字的搜索方式不能准确查找三维模型的问题,对三角网格形式的三维模型提出一种基于内容的模型搜索算法.首先将模型中的三角网格再次划分,增加形状函数的维度,定义了一种新的三维模型形状函数,以提高形状函数的准确性;然后确定三维模型的极轴,将三维模型绕任意轴的旋转转换为绕极轴旋转,增强了球面调和方法提取的形状描述符旋转不变性;最后根据形状描述符之间的欧氏距离来度量三维模型的相似程度.实验结果表明,该算法适用于基于内容的三维模型搜索,并且在准确性和时效性方面都令人满意.

关键词：三维模型检索形状描述符球面调和函数

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藏药烈香杜鹃化学成分及药理作用研究进展

广西科学 2022年第5期29卷 940-948页

作者：冀旭葛利吉戎浩史瑞欣孙芳云西藏民族大学藏药检测技术教育部工程研究中心陕西咸阳712082 西藏藏医药研究中心藏药活性成分及药理机制研究联合实验室陕西咸阳712082 西藏民族大学附属医院陕西咸阳712082

烈香杜鹃(Rhododendron anthopogonoides Maxim.)为常见传统藏药,具有祛痰镇咳、平喘、心脑血管保护、抗炎、杀虫等作用,为藏族人民的繁衍生息做出了巨大贡献。药效物质基础的阐述是民族药现代化研究的主要内容之一,本文经查阅国内外相... 详细信息

烈香杜鹃(Rhododendron anthopogonoides Maxim.)为常见传统藏药,具有祛痰镇咳、平喘、心脑血管保护、抗炎、杀虫等作用,为藏族人民的繁衍生息做出了巨大贡献。药效物质基础的阐述是民族药现代化研究的主要内容之一,本文经查阅国内外相关文献,整理总结传统藏药烈香杜鹃的主要化学成分,尤其是近5年发现的成分,共汇总化学成分上百种,并讨论了不同类型化学成分与其药理作用对应的关系,为藏药烈香杜鹃的现代化研究和开发提供参考与帮助。

关键词：烈香杜鹃藏药化学成分药理作用研究进展

CNPC Enhances Control on Petrochem Pollution

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China Oil & Gas 1998年第1期5卷 59-60页

作者： Wu fangyun Zhang Wei Wang Jialin and shi Fang(Development Centre for Environmental Engineering Research, University of Petroleum)

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干密度对花岗岩全风化土的渗流特性研究

建筑施工 2022年第10期44卷 2482-2486,2494页

作者：叶曾云郑芳云谈勋勋石旺中建五局第三建设有限公司湖南长沙410004

以桂东南地区的花岗岩全风化土为研究对象,研究干密度对花岗岩全风化土的微观结构及其渗流特征的影响。通过显微CT扫描试验与Avizo软件中先进的数字图像处理技术提取孔隙网络模型,该模型能直观呈现孔隙及喉道的大小、形态、连通性及分布... 详细信息

以桂东南地区的花岗岩全风化土为研究对象,研究干密度对花岗岩全风化土的微观结构及其渗流特征的影响。通过显微CT扫描试验与Avizo软件中先进的数字图像处理技术提取孔隙网络模型,该模型能直观呈现孔隙及喉道的大小、形态、连通性及分布,并进行定量表征。然后基于流体力学的传统方法(CFD),将实际孔隙结构的数字重构模型进行微观尺度的渗流模拟,从微观角度研究干密度对花岗岩风化土渗流特征的影响,并与实测饱和渗透系数对比,检验实际孔隙结构数字重构模型的准确性与代表性。研究结果表明:随着干密度的增加,花岗岩全风化土中小孔隙数量呈指数增长,连通性逐渐变差;干密度为1.674、1.860、2.046 g/cm^(3)花岗岩全风化土的平均渗透率模拟值分别是实测值的4.18、1.73、0.17倍,该数字岩心模型能较准确地代表压实土体内部真实的孔隙渗流特征。

关键词：干密度连通性曲折度平均配位数