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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang fangyuan cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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文创产品设计与传统文化元素的融合探索

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玩具世界 2025年第1期 130-132页

作者：程方园张明常州大学南京艺术学院

近年来,随着国家经济的迅猛发展,文创产品日益受到大众的喜爱与推崇。中华民族的传统文化博大精深,拥有数千年的深厚底蕴,将其融入文创产品设计中具有深远意义。基于此,文章探索文创产品设计与传统文化元素的融合价值及策略,以期推动文... 详细信息

近年来,随着国家经济的迅猛发展,文创产品日益受到大众的喜爱与推崇。中华民族的传统文化博大精深,拥有数千年的深厚底蕴,将其融入文创产品设计中具有深远意义。基于此,文章探索文创产品设计与传统文化元素的融合价值及策略,以期推动文创产业的繁荣发展和传统文化的传承与创新。

关键词：文创产品设计传统文化元素融合策略

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Porous Single-Crystalline Monolith to Enhance Catalytic Activity and Stability

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Research 2022年第4期2022卷 347-358页

作者： Xiaoyan Yu fangyuan cheng Xiuyun Duan Kui Xie Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002China University of Chinese Academy of Sciences Bejing 100049China Fujian Science Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108 FujianChina Key Laboratory of Design e Assembly of Functional Nanostructures Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002China

Engineering the catalytic activity and stability of materials would require the identification of the structural features that can tailor active sites at *** single crystals combine the ordered lattice structures and disordered interconnected pores,and they would therefore provide the advantages of precise structure features to identify and engineer the active sites at ***,we fabricate porous single-crystalline vanadium nitride(VN)at centimeter scale and further dope Fe(Fe0.1V0.9N)and Co(Co0.1V0.9N)in lattice to engineer the active sites at *** demonstrate that the active surface is composed of unsaturated coordination of V-N,Fe-N,and Co-N structures which lead to the generation of high-density active sites at the porous single-crystalline monolith *** interconnected pores aid the pore-enhanced fluxion to facilitate species diffusion in the porous *** the nonoxidative dehydrogenation of ethane to ethylene,we demonstrate the outstanding performance with ethane conversion of 36%and ethylene selectivity of 99%at 660°*** stability as a result of their single-crystalline structure,the monoliths achieve the outstanding performance without degradation being observed even after 200 hours of a continuous operation in a monolithic *** work not only demonstrates the effective structural engineering to simultaneously enhance the stability and overall performance for practically useful catalytic materials but also provide a new route for the element doping of porous single crystals at large scale for the potential application in other fields.

关键词： surface crystalline stability

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Intelligent checking model of Chinese radiotelephony read-backs in civil aviation air traffic control

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Chinese Journal of Aeronautics 2018年第12期31卷 2280-2289页

作者： Guimin JIA fangyuan cheng Jinfeng YANG Dan LI Tianjin Key Lab for Advanced Signal Processing Civil Aviation University of China

Federal Aviation Administration(FAA) and NASA technical reports indicate that the misunderstanding in radiotelephony communications is a primary causal factor associated with operation errors, and a sizable proportion of operation errors lead to read-back errors. We introduce deep learning method to solve this problem and propose a new semantic checking model based on Long Short-Time Memory network(LSTM) for intelligent read-back error checking. A meanpooling layer is added to the traditional LSTM, so as to utilize the information obtained by all the hidden activation vectors, and also to improve the robustness of the semantic vector extracted by LSTM. A MultiLayer Perceptron(MLP) layer, which can maintain the information of different regions in the concatenated vectors obtained by the mean-pooling layer, is applied instead of traditional similarity function in the new model to express the semantic similarity of the read-back pairs quantitatively. The K-Nearest Neighbor(KNN) classifier is used to verify whether the read-back pairs are consistent in semantics according to the output of MLP layer. Extensive experiments are conducted and the results show that the proposed model is more effective and more robust than the traditional checking model to verify the semantic consistency of read-backs automatically.

关键词： Air traffic control Chinese radiotelephony read-backs LSTM Mean pooling MLP Semantic checking

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Evaluating Parameterizations for Turbulent Fluxes over the Landfast Sea-Ice Surface in Prydz Bay, Antarctica

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Advances in Atmospheric Sciences 2023年第10期40卷 1816-1832页

作者： fangyuan cheng Qinghua YANG Changwei LIU Bo HAN Shijie PENG Guanghua HAO School of Atmospheric Sciences Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519080China National Marine Environmental Forecasting Center Beijing 100081China

It is crucial to appropriately determine turbulent fluxes in numerical *** data collected in East Antarctica from 8 April to 26 November 2016,this study evaluates parameterization schemes for turbulent fluxes over the landfast seaice surface in five numerical *** Community Noah Land Surface Model with Multi-Parameterizations Options(Noah_mp)best replicates the turbulent momentum flux,while the Beijing Climate System Model(BCC_CSM)produces the optimum sensible and latent heat *** particular,two critical issues of parameterization schemes,stability functions and roughness lengths,are *** tests indicate that roughness lengths play a decisive role in model *** on the observed turbulent fluxes,roughness lengths over the landfast sea-ice surface are *** results,which can provide a basis for setting up model parameters,reveal that the dynamic roughness length(z0m)increases with the increase of frictional velocity(u*)when u*≤0.4 m s^(−1) and fluctuates around 10^(−3 )m when u*>0.4 m s^(−1);thermal roughness length(z0t)is linearly related to the temperature gradient between air and sea-ice surface(ΔT)with a relation of lg(z0t)=−0.29ΔT−3.86;and the mean water vapor roughness length(z0q)in the specific humidity gradient(Δq)range ofΔq≤−0.6 g kg^(−1) is 10^(−6) m,3.5 times smaller than that in the range ofΔq˃−0.6 g kg^(−1).

关键词： turbulent fluxes Antarctica landfast sea-ice surface parameterization evaluating numerical models

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Unraveling the incompatibility mechanism of ethylene carbonate-based electrolytes in sodium metal anodes

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Journal of Energy Chemistry 2024年第7期94卷 560-567页

作者： Daomin Qin fangyuan cheng Meilian Cao Feiyang Yan Qian Wang Chun Fang Jiantao Han State Key Laboratory of Material Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan430074HubeiChina

Ethylene carbonate(EC)is widely used in lithium-ion batteries due to its optimal overall performance with satisfactory conductivity,relatively stable solid electrolyte interphase(SEI),and wide electrochemical *** is also the most widely used electrolyte solvent in sodium ion ***,compared to lithium metal,sodium metal(Na)shows higher activity and reacts violently with EC-based electrolyte(NaPF_(6)as solute),which leads to the failure of sodium metal batteries(SMBs).Herein,we reveal the electrochemical instability mechanism of EC on sodium metal battery,and find that the com-bination of EC and NaPF_(6) is electrically reduced in sodium metal anode during charging,resulting in the reduction of the first coulombic efficiency,and the continuous consumption of electrolyte leads to the cell *** address the above issues,an additive modified linear carbonate-based electrolyte is provided as a substitute for EC based ***,ethyl methyl carbonate(EMC)and dimethyl carbon-ate(DMC)as solvents and fluoroethylene carbonate(FEC)as SEI-forming additive have been identified as the optimal solvent for NaFP_(6)based electrolyte and used in Na_(4)Fe_(3)(PO_(4))_(2)(P_(2)O_(7))/Na *** batter-ies exhibit excellent capacity retention rate of about 80%over 1000 cycles at a cut-off voltage of 4.3 V.

关键词： Na metal batteries Ethylene carbonate decomposition Na_(4)Fe_(3)(PO_(4))_(2)(P_(2)O_(7))cathode Interface engineering Ethylene carbonate-free electrolyte

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地下变电站复合墙体受力分析与设计

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电力勘测设计 2025年第1期 38-43页

作者：陈轩彭益成刘伟亮程方圆上海电力设计院有限公司上海200001

地下变电站一般建于用地紧张、周边建筑密集的市区,埋深较深,防水要求高,外围护多采用地下连续墙与内衬墙相结合的叠合墙或复合墙。叠合墙技术虽然在已建地下变电站工程中广泛应用,但由于其本身局限,无法满足《建筑与市政工程防水通用... 详细信息

地下变电站一般建于用地紧张、周边建筑密集的市区,埋深较深,防水要求高,外围护多采用地下连续墙与内衬墙相结合的叠合墙或复合墙。叠合墙技术虽然在已建地下变电站工程中广泛应用,但由于其本身局限,无法满足《建筑与市政工程防水通用规范》对一级防水的要求。本文结合上海110 kV甘肃地下变电站,对复合墙、叠合墙方案进行对比分析,对不同内衬墙、地下连续墙厚度组合进行受力分析与经济性分析,结果表明:采用复合墙方案时,内衬墙弯矩更小,从而可以获得更经济的配筋,在满足结构安全和裂缝控制要求下,具备更优的经济性。

关键词：地下变电站复合墙叠合墙内衬墙

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Cytochrome P450s in algae:Bioactive natural product biosynthesis and light-driven bioproduction

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Acta Pharmaceutica Sinica B 2022年第6期12卷 2832-2844页

作者： Shanmin Zheng Jiawei Guo fangyuan cheng Zhengquan Gao Lei Du Chunxiao Meng Shengying Li Xingwang Zhang School of Life Sciences Shandong University of TechnologyZibo 255000China State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266237China School of Pharmacy Binzhou Medical UniversityYantai 264003China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China

Algae are a large group of photo synthetic organisms responsible for approximately half of the earth’s total *** addition to their fundamental ecological roles as oxygen producers and as the food base for almost all aquatic life,algae are also a rich source of bioactive natural products,including several clinical *** P450 enzymes(P450s) are a superfamily of biocatalysts that are extensively involved in natural product biosynthesis by mediating various types of *** the post-genome era,a growing number of P450 genes have been discovered from algae,indicating their important roles in algal ***,the functional studies of algal P450s remain *** from the recent technical advances in algae cultivation and genetic manipulation,the researches on P450s in algal natural product biosynthesis have been approaching to a new ***,some photoauto trophic algae have been developed into "photo-bioreactors" for heterologous P450s to produce high-value added pharmaceuticals and chemicals in a carbon-neutral or carbon-negative ***,we comprehensively review these advances of P450 studies in algae from 2000 to 2021.

关键词： Natural product biosynthesis Algal pharmaceuticals Cytochrome P450 enzymes Algae Light-driven bioproduction

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甘油二酯的降血脂及控制体质量作用机制研究进展

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中国油脂 2025年第2期50卷 80-86页

作者：施丽娜王亚群王明星王月华程芳园金俊金青哲吴港城王兴国江南大学食品学院江苏无锡214122 长寿花食品股份有限公司山东滨州256209

甘油二酯(DAG)是甘油三酯中一个脂肪酸被羟基取代形成的酯,是膳食油脂中的天然成分之一。旨在为DAG油作为降脂减重功能性油脂的应用提供理论参考,介绍了DAG的降血脂及控制体质量功效,并综述了其作用机制。DAG因其自身的特异性结构而具有... 详细信息

甘油二酯(DAG)是甘油三酯中一个脂肪酸被羟基取代形成的酯,是膳食油脂中的天然成分之一。旨在为DAG油作为降脂减重功能性油脂的应用提供理论参考,介绍了DAG的降血脂及控制体质量功效,并综述了其作用机制。DAG因其自身的特异性结构而具有与TAG不同的消化特性,且DAG可以上调小肠中脂肪氧化、产热基因的表达,上调肝脏中β-氧化相关基因表达,抑制脂质转运和增强血浆脂质清除作用。综上,基于DAG本身结构的特异性消化代谢途径以及DAG摄入后对脂质代谢相关基因的调控,DAG可有效降低餐后血脂水平并减少体内脂肪积累,达到控制体质量的效果,改善或预防肥胖的发生。

关键词：甘油二酯降血脂控制体质量减肥机制

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Enabling stable 4.6 V LiCoO_(2) cathode through oxygen charge regulation strategy

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Journal of Energy Chemistry 2023年第1期76卷 557-565,I0014页

作者： Wen Zhang Xiaoyu Zhang fangyuan cheng Meng Wang Jing Wan Yuyu Li Jia Xu Yi Liu Shixiong Sun Yue Xu Chun Fang Qing Li Jiantao Han Yunhui Huang State Key Laboratory of Material Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiChina Department of Applied Physics Chongqing UniversityChongqing 401331China Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education Jianghan UniversityWuhan 430056HubeiChina

LiCoO_(2) is the preferred cathode material for consumer electronic products due to its high volumetric energy density. However, the unfavorable phase transition and surface oxygen release limits the practical application of LiCoO_(2)at a high-voltage of 4.6 V to achieve a higher energy density demanded by the market. Herein, both bulk and surface structures of LiCoO_(2)are stabilized at 4.6 V through oxygen charge regulation by Gd-gradient doping. The enrichment of highly electropositive Gd on LiCoO_(2) surface will increase the effective charge on oxygen and improve the oxygen framework stability against oxygen *** the other hand, Gd ions occupy the Co-sites and suppress the unfavorable phase transition and microcrack. The modified LiCoO_(2) exhibits superior cycling stability with capacity retention of 90.1% over 200 cycles at 4.6 V, and also obtains a high capacity of 145.7 m Ah/g at 5 C. This work shows great promise for developing high-voltage LiCoO_(2) at 4.6 V and the strategy could also contribute to optimizing other cathode materials with high voltage and large capacity, such as cobalt-free high-nickel and lithiumrich manganese-based cathode materials.

关键词： Li-ion batteries 4.6 V LiCoO_(2) Gd-gradient doping Oxygen charge Cycle stability

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