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Free or fixed state of nHAP differentially regulates hBMSC morphology and osteogenesis through the valve role of ITGA7

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Bioactive Materials 2022年第12期7卷 539-551页

作者： fangyuan bao Junzhi Yi Yixiao Liu Yuliang Zhong Hui Zhang Zhonglin Wu Boon Chin Heng Ying Wang Ziyang Wang Lizi Xiao Hua Liu Hongwei Ouyang Jing Zhou Dr Li Dak Sum&Yip Yio Chin Center for Stem Cells and Regenerative Medicine and Department of Orthopedic Surgery of The Second Affiliated HospitalZhejiang University School of MedicineHangzhouPR China Department of Sports Medicine Zhejiang University School of MedicineHangzhouPR China Zhejiang University-University of Edinburgh Institute Zhejiang University School of Medicineand Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang ProvinceZhejiang University School of MedicineHangzhouPR China China Orthopedic Regenerative Medicine Group(CORMed) HangzhouPR China School of Stomatology Peking UniversityBeijingPR China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhouPR China

Nano-hydroxyapatite(nHAP)has been widely used in bone repair as an osteo-inductive and naturally-occurring ***,the optimal applied form of nHAP and the underlying mechanisms involved remain ***,to investigate into these,a range of corresponding models were designed,including three applied forms of nHAP(Free,Coating and 3D)that belong to two states(Free or fixed).The results indicate that when fixed nHAP was applied in the 3D form,optimal osteogenesis was induced in human bone marrow stem cells(hBMSCs)with increased bone volume via integrinα7(ITGA7)-mediated upregulation of the PI3K-AKT signaling pathway,while contrary results were observed with free *** osteogenesis experiments in mice subcutaneous transplantation model further confirmed the different tendencies of ITGA7 expression and osteogenesis of hBMSCs in free and fixed states of *** results revealed that the two states of nHAP play a different regulatory role in cell morphology and osteogenesis through the valve role of ITGA7,providing cues for better application of nanoparticles and a potential new molecular target in bone tissue engineering.

关键词： Applied forms nHAP Osteogenesis ITGA7

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A pathological joint-liver axis mediated by matrikine-activated CD4^(+)T cells

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2679-2693页

作者： Junzhi Yi Hui Zhang fangyuan bao Zhichu Chen Yuliang Zhong Tianning Ye Xuri Chen Jingyi Qian Mengya Tian Min Zhu Zhi Peng Zongyou Pan Jianyou Li Zihao Hu Weiliang Shen Jiaqi Xu Xianzhu Zhang Youzhi Cai Mengjie Wu Hua Liu Jing Zhou Hongwei Ouyang Department of Sports Medicine of the Second Affiliated Hospital and Liangzhu LaboratoryZhejiang University School of MedicineHangzhouChina Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cells and Regenerative Medicine Zhejiang University School of MedicineHangzhouChina Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesHangzhouChina The MOE Key Laboratory of Biosystems Homeostasis&Protection The Key Laboratory of Cancer Molecular Cell Biology of Zhejiang ProvinceLife Sciences InstituteZhejiang UniversityHangzhouChina Department of Orthopedics Huzhou Central HospitalAffiliated Huzhou HospitalZhejiang University School of MedicineHuzhouChina China Orthopedic Regenerative Medicine Group(CORMed) HangzhouChina Department of Orthopedics The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina

The knee joint has long been considered a closed *** pathological effects of joint diseases on distant organs have not been ***,our clinical data showed that post-traumatic joint damage,combined with joint bleeding(hemarthrosis),exhibits a worse liver function compared with healthy *** mouse model,hemarthrosis induces both cartilage degeneration and remote liver ***,we found that hemarthrosis induces the upregulation in ratio and differentiation towards Th17 cells of CD4^(+)T cells in peripheral blood and *** of CD4^(+)T cells reverses hemarthrosis-induced liver *** of cartilage matrix induced by hemarthrosis upregulates serological type Ⅱ collagen(COL Ⅱ),which activates CD4^(+)T *** application of a COL Ⅱ antibody blocks the ***,bulk RNAseq and single-cell qPCR analysis revealed that the cartilage Akt pathway is inhibited by blood ***-articular application of Akt activator blocks the cartilage degeneration and thus protects against the liver impairment in mouse and pig *** together,our study revealed a pathological joint-liver axis mediated by matrikine-activated CD4^(+)T cells,which refreshes the organ-crosstalk axis and provides a new treatment target for hemarthrosis-related disease.

关键词： degeneration damage inhibited

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Systemic and single cell level responses to 1 nm size biomaterials demonstrate distinct biological effects revealed by multi-omics atlas

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Bioactive Materials 2022年第12期7卷 199-212页

作者： Tao Zhang Tingyun Lei Ruojin Yan Bo Zhou Chunmei Fan Yanyan Zhao Shasha Yao Haihua Pan Yangwu Chen Bingbing Wu Yuwei Yang Lijuan Hu Shen Gu Xiaoyi Chen fangyuan bao Yu Li Hanqi Xie Ruikang Tang Xiao Chen Zi Yin Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cells and Regenerative Medicine and Department of Orthopedic Surgery of Sir Run Shaw HospitalZhejiang University School of MedicineHangzhou310058PR China Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province School of MedicineZhejiang UniversityHangzhou310058PR China China Orthopedic Regenerative Medicine Group CORMed Hangzhou310058PR China Department of Orthopaedic Surgery of Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou310058PR China Qiushi Academy for Advanced Studies Zhejiang UniversityHangzhou310058PR China Department of Pathology of the First Affiliated Hospital Anhui University of Chinese MedicineHefei230031PR China chool of Biomedical Sciences The Chinese University of Hong KongShatinN.THKSARChina

Although ultra-small nanoclusters(USNCs,<2 nm)have immense application capabilities in biomedicine,the investigation on body-wide organ responses towards USNCs is ***,applying a novel strategy of single-cell mass cytometry combined with Nano Genome Atlas of multi-tissues,we systematically evaluate the interactions between the host and calcium phosphate(CaP)USNCs at the organism *** single-cell mass cytometry,and magnetic luminex assay results,we identify dynamic immune responses to CaP USNCs at the single cell *** innate immune is initially activated and followed by adaptive immune activation,as evidenced by dynamic immune cells ***,using Nano Genome Atlas of multi-tissues,we uncover CaP USNCs induce stronger activation of the immune responses in the cartilage and subchondral bone among the five local tissues while promote metabolic activities in the liver and ***,based on the immunological response profiles,histological evaluation of major organs and local tissue,and a body-wide transcriptomics,we demonstrate that CaP USNCs are not more hazardous than the Food and Drug Administration-approved CaP nanoparticles after 14 days of *** findings provide valuable information on the future clinical applications of USNCs and introduce an innovative strategy to decipher the whole body response to implants.

关键词： Nanoparticle Nanocluster Single-cell mass cytometry RNA-Seq Multi-omics

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Ultrathin 3 V Spinel Clothed Layered Lithium-Rich Oxides as Heterostructured Cathode for High-Energy and High-Power Li-ion Batteries

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Chinese Journal of Chemistry 2021年第2期39卷 345-352页

作者： Liqin Dai Ning Li Lai Chen Yuefeng Su Cheng-Meng Chen fangyuan Su Liying bao Shi Chen Feng Wu Beijing Key Laboratory of Environmental Science and Engineering School of Material Science and EngineeringBeijing Institute of TechnologyBeijing100081 China Key Laboratory of Carbon Materials Institute of Coal ChemistryChinese Academy of SciencesTaiyuanShanxi030001 China Beijing Institute of Technology Chongqing Innovation Center Chongqing401120 China

In an attempt to overcome the drawbacks of high-capacity layered lithium-rich cathodes xLi2MnO3·(1–x)LiMO2(0 详细信息

In an attempt to overcome the drawbacks of high-capacity layered lithium-rich cathodes xLi2MnO3·(1–x)LiMO2(0

关键词： Li-ion batteries Heterostructure Layered compounds Spinel phases Electrochemistry

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Novel compound FLZ alleviates rotenoneinduced PD mouse model by suppressing TLR4/MyD88/NF-kB pathway through microbiotaegutebrain axis

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2859-2879页

作者： Zhe Zhao fangyuan Li Jingwen Ning Ran Peng Junmei Shang Hui Liu Meiyu Shang Xiu-Qi bao Dan Zhang State Key Laboratory of Bioactive Substrate and Function of Natural Medicine Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Parkinson’s disease(PD)is the second most common neurodegenerative disease,but none of the current treatments for PD can halt the progress of the disease due to the limited understanding of the *** PD development,the communication between the brain and the gastrointestinal system influenced by gut microbiota is known as microbiota-gut-brain ***,the explicit mechanisms of microbiota dysbiosis in PD development have not been well elucidated ***,a novel squamosamide derivative,has been proved to be effective in many PD models and is undergoing the phase I clinical trial to treat PD in ***,our previous pharmacokinetic study revealed that gut microbiota could regulate the absorption of FLZ in *** aims of our study were to assess the protective effects of FLZ treatment on PD and to further explore the underlying microbiota-related mechanisms of PD by using FLZ as a *** the current study,chronic oral administration of rotenone was utilized to induce a mouse model to mimic the pathological process of *** we revealed that FLZ treatment alleviated gastrointestinal dysfunctions,motor symptoms,and dopaminergic neuron death in rotenone-challenged mice.16 S rRNA sequencing found that PD-related microbiota alterations induced by rotenone were reversed by FLZ ***,FLZ administration attenuated intestinal inflammation and gut barrier destruction,which subsequently inhibited systemic ***,FLZ treatment restored blood-brain barrier structure and suppressed neuroinflammation by inhibiting the activation of astrocytes and microglia in the substantia nigra(SN).Further mechanistic research demonstrated that FLZ treatment suppressed the TLR4/MyD88/NF-κB pathway both in the SN and ***,FLZ treatment ameliorates microbiota dysbiosis to protect the PD model via inhibiting TLR4 pathway,which contributes to one of the underlying mechanisms beneath its neuroprotective *** research also suppo

关键词： FLZ Microbiota-gut-brain axis Parkinson’s disease Rotenone mouse model TLR4/MyD88/NF-kB pathway Gastrointestinal dysfunction Systemic inflammation Neuroinflammation

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Barite in omphacite-hosted K-feldspar + quartz poly-crystalline aggregates from the Sulu eclogites and its implications

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Chinese Science Bulletin 2007年第21期52卷 2995-3001页

作者： ZENG LingSen LIU FuLai LIANG FengHua CHEN fangyuan Institute of Geology Chinese Academy of Geological Sciences Beijing 100037 China

K-feldspar + quartz polycrystalline aggregates were found as sub-millimeter-size inclusions with a pseudomorph after coesite (?) in omphacites from a number of Sulu eclogites. In these aggregates, round or subhedral barites occur as tiny inclusions in either K-feldspar or quartz. Energy dispersive spectroscopy (EDS) analyses show that these barites have (1) 33.86%―41.12% SO3, 0%―34.65% SrO, and 24.12%―63.55% bao, (2) seemingly negative linear correlations between SrO and bao, indicating that they are ideal solid solutions of barite (BaSO4) and celestite (SrSO4), and (3) highly variable Sr/Ba molar ratios ranging from 0 to 2.1. Presence of barites in the Sulu eclogites not only indicates oxidation of the subducting continental crust, but also very limited and restricted fluids pre- sented during exhumation of the Sulu UHP eclogites.

关键词：重晶石集料变质作用石英石

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Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization

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Acta Pharmaceutica Sinica B 2022年第7期12卷 3124-3138页

作者： Siyue Zhang fangyuan Xie Kaichun Li He Zhang You Yin Yuan Yu Guangzhao Lu Shihao Zhang Yan Wei Ke Xu Yan Wu Hong Jin Lan Xiao Leilei bao Can Xu Yulin Li Ying Lu Jie Gao Department of Pharmacy Naval Medical UniversityShanghai 200433China Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghai 200433China Institute of Translational Medicine Shanghai UniversityShanghai 200444China Department of Pharmacy Shanghai Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghai 200433China Department of Oncology Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China Unit for Drug and Instrument Supervision and Inspection of Wuxi Joint Logistic Support Center Nanjing 210000China Key Laboratory for Ultrafine Materials of Ministry of Education Engineering Research Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Gastroenterology Shanghai Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Neurology Changzheng HospitalNaval Medical UniversityShanghai 200003China Department of Biomaterial College of Life SciencesMudanjiang Medical UniversityMudanjiang 157011China Department of Laboratory Medicine Hongqi HospitalMudanjiang Medical CollegeMudanjiang 157011China Centre for Biomedical Technologies Queensland University of TechnologyBrisbane QLD 4000Australia mWenzhou Institute of Shanghai UniversityWenzhou 325000China

Tumor-associated macrophages(TAMs),one of the dominating constituents of tumor microenvironment,are important contributors to cancer progression and treatment ***,regulation of TAMs polarization from M2 phenotype towards M1 phenotype has emerged as a new strategy for tumor ***,we successfully initiated antitumor immunotherapy by inhibiting TAMs M2 polarization via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles(PEG-Au NPs).PEG-Au NPs suppressed TAMs M2 polarization in both in vitro and in vivo models,elicited antitumor immunotherapy and inhibited subcutaneous tumor growth in *** demonstrated by the m RFP-GFP-LC3 assay and analyzing the autophagy-related proteins(LC3,beclin1 and P62),PEGAu NPs induced autophagic flux inhibition in TAMs,which is attributed to the PEG-Au NPs induced lysosome alkalization and membrane ***,TAMs were prone to polarize towards M2phenotype following autophagy activation,whereas inhibition of autophagic flux could reduce the M2polarization of *** results revealed a mechanism underlying PEG-Au NPs induced antitumor immunotherapy,where PEG-Au NPs reduce TAMs M2 polarization via induction of lysosome dysfunction and autophagic flux *** study elucidated the biological effects of nanomaterials on TAMs polarization and provided insight into harnessing the intrinsic immunomodulation capacity of nanomaterials for effective cancer treatment.

关键词： Macrophage polarization Tumor-associated macrophages Nanomaterials Autophagy flux Lysosomal damage Gold nanoparticles M2 macrophage Cancer therapy

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幽门螺杆菌根除方案和影响因素

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胃肠病学 2013年第9期18卷 565-568页

作者：董方元黄一沁保志军复旦大学附属华东医院消化科 200040

随着抗菌药物耐药性的不断上升,经典三联疗法对幽门螺杆菌(Hp)的根除率明显降低。近年出现的新治疗策略可替代三联疗法作为一线疗法,包括序贯疗法、含铋剂的四联疗法、伴同疗法、混合疗法等,以左氧氟沙星、利福布丁和呋喃唑酮为基础的... 详细信息

随着抗菌药物耐药性的不断上升,经典三联疗法对幽门螺杆菌(Hp)的根除率明显降低。近年出现的新治疗策略可替代三联疗法作为一线疗法,包括序贯疗法、含铋剂的四联疗法、伴同疗法、混合疗法等,以左氧氟沙星、利福布丁和呋喃唑酮为基础的疗法可作为补救治疗。此外,中药和益生菌亦可作为补充治疗。考虑到Hp的耐药性、CYP2C19基因表型、吸烟等诸多因素对根除效果的影响,临床医师应根据具体情况选择合理的治疗方案。本文就近年Hp根除治疗方案和影响因素作一综述。

关键词：幽门螺杆菌治疗影响因素

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辛伐他汀联合地尔硫卓治疗糖尿病肾病的疗效及其对蛋白尿的影响

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中国现代应用药学 2018年第7期35卷 1086-1088页

作者：张怡沈芳媛刘婷包蓓艳宁波市鄞州第二医院肾内科浙江宁波315192

目的探讨辛伐他汀联合地尔硫卓治疗糖尿病肾病的临床疗效及其对蛋白尿的影响。方法选取128例糖尿病肾病患者作为研究对象,将其随机均分为观察组和对照组,对照组64例在饮食控制以及锻炼的基础上使用辛伐他汀进行治疗,观察组64例在饮食控... 详细信息

目的探讨辛伐他汀联合地尔硫卓治疗糖尿病肾病的临床疗效及其对蛋白尿的影响。方法选取128例糖尿病肾病患者作为研究对象,将其随机均分为观察组和对照组,对照组64例在饮食控制以及锻炼的基础上使用辛伐他汀进行治疗,观察组64例在饮食控制以及锻炼基础上使用辛伐他汀联合地尔硫卓进行治疗。结果治疗后2组患者的病情均有所好转,且观察组患者通过治疗后,空腹血糖、餐后2 h血糖、糖化血红蛋白、UAER、UACR显著优于对照组患者,差异有统计学意义(P<0.05);2组患者治疗后24 h蛋白尿定量比较差异有统计学意义(P<0.05)。结论辛伐他汀联合地尔硫卓治疗糖尿病肾病患者的临床疗效好,可延缓疾病进展,提高患者生活质量。

关键词：辛伐他汀地尔硫卓糖尿病肾病蛋白尿

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矫正手术治疗拇外翻合并转移性跖骨痛的疗效分析

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中华医学杂志 2017年第35期97卷 2737-2741页

作者：王显军包贝西魏芳远张建中首都医科大学附属北京同仁医院骨科足踝外科矫形中心 100730

目的分析行拇外翻矫正手术治疗拇外翻合并转移性跖骨痛的临床效果。方法回顾分析2011年9月至11月首都医科大学附属北京同仁医院骨科足踝外科矫形中心21例（30足）拇外翻合并转移性跖骨痛的患者，采用单纯拇外翻矫正手术，不同时进行外... 详细信息

目的分析行拇外翻矫正手术治疗拇外翻合并转移性跖骨痛的临床效果。方法回顾分析2011年9月至11月首都医科大学附属北京同仁医院骨科足踝外科矫形中心21例（30足）拇外翻合并转移性跖骨痛的患者，采用单纯拇外翻矫正手术，不同时进行外侧跖骨短缩手术。足负重正位X线片测量术前，术后半年，1、2年时的拇外翻角和第1、2跖骨间夹角，同时进行依据美国矫形足踝协会（AOFAS）评分，视觉模拟评分（VAS），以重复测量资料的方差分析进行统计学分析。结果所随访的患者中，26足术前，术后半年，1、2年时，拇外翻角分别为（39．6±9．7）、（14．2±7．9）、（14．8±7．9）、（13．2±6．5）°，第1、2跖骨间夹角分别为（13．8±4．0）、（4．5±4．3）、（5．8±3．9）、（5．4±4．9）°，均P〈0．001。术后2年跖骨痛的治愈率为65．3％，疼痛及胼胝改善率为73．1％。所有患者无需再次手术。术前和术后2年，拇趾AOFAS评分分别为（59．0±17．6）、（95．4±6．6）分，外侧足趾AOFAS评分分别为（84．4±8．1）、（92．0±12．5）分，VAS视觉模拟评分分别为（7．5±2．0）、（1．3±2．0）分，均较术前明显改善（均P〈0．001）。结论单纯拇外翻矫正手术治疗拇外翻合并转移性跖骨痛可获得较好的临床疗效，可避免外侧跖骨截骨手术所引起的相关并发症。

关键词：跖骨疼痛拇外翻

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