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Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization

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Acta Pharmaceutica Sinica B 2022年第7期12卷 3124-3138页

作者： Siyue Zhang fangyuan xie Kaichun Li He Zhang You Yin Yuan Yu Guangzhao Lu Shihao Zhang Yan Wei Ke Xu Yan Wu Hong Jin Lan Xiao Leilei Bao Can Xu Yulin Li Ying Lu Jie Gao Department of Pharmacy Naval Medical UniversityShanghai 200433China Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghai 200433China Institute of Translational Medicine Shanghai UniversityShanghai 200444China Department of Pharmacy Shanghai Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghai 200433China Department of Oncology Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China Unit for Drug and Instrument Supervision and Inspection of Wuxi Joint Logistic Support Center Nanjing 210000China Key Laboratory for Ultrafine Materials of Ministry of Education Engineering Research Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Gastroenterology Shanghai Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Neurology Changzheng HospitalNaval Medical UniversityShanghai 200003China Department of Biomaterial College of Life SciencesMudanjiang Medical UniversityMudanjiang 157011China Department of Laboratory Medicine Hongqi HospitalMudanjiang Medical CollegeMudanjiang 157011China Centre for Biomedical Technologies Queensland University of TechnologyBrisbane QLD 4000Australia mWenzhou Institute of Shanghai UniversityWenzhou 325000China

Tumor-associated macrophages(TAMs),one of the dominating constituents of tumor microenvironment,are important contributors to cancer progression and treatment ***,regulation of TAMs polarization from M2 phenotype towards M1 phenotype has emerged as a new strategy for tumor ***,we successfully initiated antitumor immunotherapy by inhibiting TAMs M2 polarization via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles(PEG-Au NPs).PEG-Au NPs suppressed TAMs M2 polarization in both in vitro and in vivo models,elicited antitumor immunotherapy and inhibited subcutaneous tumor growth in *** demonstrated by the m RFP-GFP-LC3 assay and analyzing the autophagy-related proteins(LC3,beclin1 and P62),PEGAu NPs induced autophagic flux inhibition in TAMs,which is attributed to the PEG-Au NPs induced lysosome alkalization and membrane ***,TAMs were prone to polarize towards M2phenotype following autophagy activation,whereas inhibition of autophagic flux could reduce the M2polarization of *** results revealed a mechanism underlying PEG-Au NPs induced antitumor immunotherapy,where PEG-Au NPs reduce TAMs M2 polarization via induction of lysosome dysfunction and autophagic flux *** study elucidated the biological effects of nanomaterials on TAMs polarization and provided insight into harnessing the intrinsic immunomodulation capacity of nanomaterials for effective cancer treatment.

关键词： Macrophage polarization Tumor-associated macrophages Nanomaterials Autophagy flux Lysosomal damage Gold nanoparticles M2 macrophage Cancer therapy

Amorphous Iridium Oxide-Integrated Anode Electrodes with Ultrahigh Material Utilization for Hydrogen Production at Industrial Current Densities

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Nano-Micro Letters 2024年第10期16卷 225-239页

作者： Lei Ding Kui Li Weitian Wang Zhiqiang xie Shule Yu Haoran Yu David ACullen Alex Keane Kathy Ayers Christopher BCapuano fangyuan Liu Pu-Xian Gao Feng-Yuan Zhang Department of Mechanical Aerospace and Biomedical EngineeringUniversity of TennesseeKnoxvilleTN 37996USA Oak Ridge National Lab Center for Nanophase Materials SciencesOak RidgeTN 37831USA Nel Hydrogen WallingfordCT 06492USA Institute of Materials Science University of ConnecticutStorrsCT 06269USA Department of Materials Science and Engineering University of ConnecticutStorrsCT 06269USA

Herein,ionomer-free amorphous iridium oxide(IrO_(x))thin electrodes are first developed as highly active anodes for proton exchange membrane electrolyzer cells(PEMECs)via low-cost,environmentally friendly,and easily scalable electrodeposition at room *** with a Nafion 117 membrane,the IrO_(x)-integrated electrode with an ultralow loading of 0.075 mg cm^(-2)delivers a high cell efficiency of about 90%,achieving more than 96%catalyst savings and 42-fold higher catalyst utilization compared to commercial catalyst-coated membrane(2 mg cm^(-2)).Additionally,the IrO_(x)electrode demonstrates superior performance,higher catalyst utilization and significantly simplified fabrication with easy scalability compared with the most previously reported ***,the remarkable performance could be mainly due to the amorphous phase property,sufficient Ir^(3+)content,and rich surface hydroxide groups in ***,due to the high activity,high cell efficiency,an economical,greatly simplified and easily scalable fabrication process,and ultrahigh material utilization,the IrO_(x)electrode shows great potential to be applied in industry and accelerates the commercialization of PEMECs and renewable energy evolution.

关键词： Ionomer-free Amorphous IrOx electrodes Ultrahigh material utilization Scalable electrodeposition Hydrogen production

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过驱动卫星姿态动态控制分配研究

航天控制 2023年第1期41卷 53-59页

作者：谢方圆张爱民中国人民解放军63766部队西双版纳666200 西安交通大学电子与信息学部西安710049

针对受干扰、飞轮故障、安装偏差和饱和影响的过驱动卫星的姿态控制问题提出了一种控制器设计方法。首先建立了过驱动卫星的姿态方程,给出了飞轮安装偏差、故障和饱和的数学描述。随后设计了存在外界不确定干扰和飞轮安装偏差时的滑模... 详细信息

针对受干扰、飞轮故障、安装偏差和饱和影响的过驱动卫星的姿态控制问题提出了一种控制器设计方法。首先建立了过驱动卫星的姿态方程,给出了飞轮安装偏差、故障和饱和的数学描述。随后设计了存在外界不确定干扰和飞轮安装偏差时的滑模控制律,再应用动态控制分配解决过驱动卫星飞轮故障问题,最后考虑飞轮存在饱和时,使用零空间法使飞轮力矩指令保持在可行区间之内。设计的控制方法避免了复杂的控制器设计过程,控制器更为简单,适应性更广,更容易理解且更易于工程应用。

关键词：卫星姿态滑模动态控制分配零空间法

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土的击实试验指标的线性回归分析

黄河水利职业技术学院学报 2022年第2期34卷 31-35页

作者：谢方媛河北省水利规划设计研究院有限公司河北石家庄050021

为了简化击实试验的过程、缩短试验周期、提高工作效率,选择河北省内高碑店、邢台、石家庄等地水利水电工程项目中123组土的击实试验数据进行统计分析,得到了土的液限与最优含水率、最优含水率与最大干密度的线性回归方程,并应用实例证... 详细信息

为了简化击实试验的过程、缩短试验周期、提高工作效率,选择河北省内高碑店、邢台、石家庄等地水利水电工程项目中123组土的击实试验数据进行统计分析,得到了土的液限与最优含水率、最优含水率与最大干密度的线性回归方程,并应用实例证明线性回归方程的适用性。

关键词：击实试验土样制备液限最优含水率最大干密度线性回归分析

全球极端降水对不同外强迫的敏感性响应:基于PDRMIP模拟试验

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科学通报 2024年第15期69卷 2093-2106页

作者：武洁石正国解小宁杨永恒刘方圆中国科学院地球环境研究所黄土与第四纪地质国家重点实验室西安710061 中国科学院大学北京100049 西安交通大学全球环境变化研究院西安710049 中国科学院西北生态环境资源研究院兰州730000

全球增暖背景下极端降水变化受到了温室气体、太阳辐射、气溶胶等自然与人为强迫因素的共同影响.本文基于“降水驱动与响应模式间比较计划”(A Precipitation Driver and Response Model Intercomparison Project,PDRMIP)提供的9个全球... 详细信息

全球增暖背景下极端降水变化受到了温室气体、太阳辐射、气溶胶等自然与人为强迫因素的共同影响.本文基于“降水驱动与响应模式间比较计划”(A Precipitation Driver and Response Model Intercomparison Project,PDRMIP)提供的9个全球气候模式模拟的针对5种不同因子(加倍二氧化碳、增加2%的太阳辐射、10倍黑碳、5倍硫酸盐、3倍甲烷)高强迫情景下的理想试验,利用气候变化检测和指数专家组(Expert Team on Climate Change Detection and Indices,ETCCDI)定义的4个降水指数,详细分析了不同外部强迫因子作用下全球极端降水的响应.结果表明,相比于平均降水,在5种强迫因子作用下极端降水指数均表现出更大的变化.与加倍二氧化碳相比,增加2%的太阳辐射、5倍硫酸盐气溶胶和3倍甲烷强迫下全球极端降水对温度变化的响应更加强烈,而10倍黑碳气溶胶强迫下的降水变化则表现出较强的模式间差异.在加倍二氧化碳、增加2%的太阳辐射和3倍甲烷强迫下,极端降水的变化表现相似的纬向分布特征,最强的降水响应出现在赤道地区;10倍黑碳、5倍硫酸盐气溶胶强迫下则表现出明显的南北半球差异.水汽收支诊断结果揭示了在高强迫情景下,二氧化碳、太阳辐射和甲烷强迫下热带地区更强烈的降水变化主要与热力作用有关,而动力作用可能是导致黑碳、硫酸盐气溶胶强迫下降水变化的主要原因.

关键词：极端降水敏感性 PDRMIP 气候强迫

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糖尿病患者视网膜动脉及静脉对心血管疾病风险的预测价值

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临床心血管病杂志 2011年第8期27卷 589-593页

作者：董昕谢芳元田刚西安交通大学第一附属医院心内科西安710061 西安市第四医院心内科

目的:探讨糖尿病患者视网膜动脉、视网膜静脉直径对心血管疾病发生的预测价值。方法:纳入72例糖尿病患者,其中23例为心肌梗死组,其余49例未发生心肌梗死的为对照组。对所有患者计算视网膜中央动脉直径等效值(central retinal arteriolar... 详细信息

目的:探讨糖尿病患者视网膜动脉、视网膜静脉直径对心血管疾病发生的预测价值。方法:纳入72例糖尿病患者,其中23例为心肌梗死组,其余49例未发生心肌梗死的为对照组。对所有患者计算视网膜中央动脉直径等效值(central retinal arteriolar equivalents,CRAE)和视网膜中央静脉直径等效值(central retinal venular e-quivalents,CRVE),以此分别代表视网膜动脉和视网膜静脉的平均直径。通过问卷调查和抽取静脉血获取其他心血管危险因素。研究2组患者CRAE和CRVE的差异性,以及其他心血管危险因素对视网膜血管直径的影响。结果:心肌梗死组患者CRAE、CRVE均较对照组缩窄;与CRAE有相关性的其他指标有年龄、性别、血压、体质指数、吸烟史、高血压史和LDL-C、HDL-C;与CRVE有相关性的有糖尿病病程、吸烟史、高血压史和糖化血红蛋白。结论:视网膜血管直径可在一定程度上预测糖尿病患者心血管疾病发生风险,但需考虑到其他心血管危险因素对于视网膜血管直径的影响。

关键词：糖尿病心肌梗死视网膜

基于干扰观测器的受扰卫星姿态控制器设计与优化

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航天控制 2019年第5期37卷 31-39页

作者：谢方圆张爱民西安交通大学

对复杂环境下的卫星姿态控制进行了研究,针对存在外界干扰和转动惯量不确定的卫星姿态控制,建立了基于误差四元数卫星姿态动力学与运动学方程,在此基础上设计了反演滑模控制器,构造Lyapunov函数并从理论上证明了闭环系统的稳定性;设计... 详细信息

对复杂环境下的卫星姿态控制进行了研究,针对存在外界干扰和转动惯量不确定的卫星姿态控制,建立了基于误差四元数卫星姿态动力学与运动学方程,在此基础上设计了反演滑模控制器,构造Lyapunov函数并从理论上证明了闭环系统的稳定性;设计非线性干扰观测器(NDO)对等效干扰进行估计,使控制器输出力矩减小,有效降低了输出饱和的风险,同时抑制了滑模控制带来的抖振;为了获得更好的控制效果,以控制器参数为优化变量,综合考虑了控制器的动态性能和被控对象的输入受限条件,建立了评价函数,利用改进的粒子群算法对控制器参数进行优化。仿真结果表明设计的控制器可行且有效,得到了较好的控制效果。

关键词：卫星姿态反演滑模控制非线性干扰观测器粒子群算法

Porous Single-Crystalline Monolith to Enhance Catalytic Activity and Stability

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Research 2022年第4期2022卷 347-358页

作者： Xiaoyan Yu fangyuan Cheng Xiuyun Duan Kui xie Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002China University of Chinese Academy of Sciences Bejing 100049China Fujian Science Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108 FujianChina Key Laboratory of Design e Assembly of Functional Nanostructures Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002China

Engineering the catalytic activity and stability of materials would require the identification of the structural features that can tailor active sites at *** single crystals combine the ordered lattice structures and disordered interconnected pores,and they would therefore provide the advantages of precise structure features to identify and engineer the active sites at ***,we fabricate porous single-crystalline vanadium nitride(VN)at centimeter scale and further dope Fe(Fe0.1V0.9N)and Co(Co0.1V0.9N)in lattice to engineer the active sites at *** demonstrate that the active surface is composed of unsaturated coordination of V-N,Fe-N,and Co-N structures which lead to the generation of high-density active sites at the porous single-crystalline monolith *** interconnected pores aid the pore-enhanced fluxion to facilitate species diffusion in the porous *** the nonoxidative dehydrogenation of ethane to ethylene,we demonstrate the outstanding performance with ethane conversion of 36%and ethylene selectivity of 99%at 660°*** stability as a result of their single-crystalline structure,the monoliths achieve the outstanding performance without degradation being observed even after 200 hours of a continuous operation in a monolithic *** work not only demonstrates the effective structural engineering to simultaneously enhance the stability and overall performance for practically useful catalytic materials but also provide a new route for the element doping of porous single crystals at large scale for the potential application in other fields.

关键词： surface crystalline stability

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应用型院校学前教育专业教育实习的优化策略

阜阳职业技术学院学报 2021年第3期32卷 51-53页

作者：谢方圆南京审计大学金审学院江苏南京210023

应用型院校学前教育专业旨在培养应用型幼教专门人才,实践性是其主要特点之一。教育实习是提升幼师生实践教学能力最直接有效的途径。准备不充分、实习园参差不齐、管理不到位、指导不深入、评价针对性不强等是目前应用型院校学前教育... 详细信息

应用型院校学前教育专业旨在培养应用型幼教专门人才,实践性是其主要特点之一。教育实习是提升幼师生实践教学能力最直接有效的途径。准备不充分、实习园参差不齐、管理不到位、指导不深入、评价针对性不强等是目前应用型院校学前教育专业教育实习普遍存在的问题。学校应针对这些问题,从多方面着手,改进优化学前教育专业教育实习,确保教育实习能够顺利且高质量地完成。

关键词：应用型院校学前教育专业教育实习