检索结果-南通市图书馆

Correlation of adsorbent cavity structure with adsorption behavior and interaction of long-chainα-olefin/paraffin on microporous adsorbents

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第4期16卷 5721-5732页

作者： Ruihan Yang fangyu zhao Shafqat Ullah Xiao Chen Junxiang Ma Yuan Gao Yujun Wang Guangsheng Luo State Key Lab of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Lu’an Chemical Group CO. LTD.Changzhi 046299China

Long-chainα-olefins have a high added value as important raw materials for many highly marketable ***-Tropsch synthesis products contain ultrahigh-contentα-olefins,which are of great value if the challenging separation ofα-olefin/paraffin is achieved through energy-saving ways,for which adsorption separation is an attractive *** of the most significant differences between the adsorption separation of long-chain and light hydrocarbons is the steric hindrance of the molecular ***,we propose a combination of window size,metal node spacing,and bending degree to quantitatively describe the adsorption cavity structure for the separation of long-chainα-olefin/*** general cavity structural characteristics of microporous materials with good separation performance for long-chainα-olefin/paraffin are *** selective adsorption of liquid C6 and C_(8)α-olefin/paraffin mixtures on CuBTC(BTC=benzene-1,3,5-tricarboxylate)was studied in detail to reveal the influence of the cavity structure on the adsorption and interaction using a combination of batch adsorption experiments and molecular simulation *** exhibited 360 and 366 mg/g olefin adsorption capacities for C6 and C8 linearα-olefins,*** adsorption energies were−0.540 and−0.338 eV for C8 linearα-olefin and paraffin,*** contributions of different types of interactions to the overall adsorption energy were quantified to illustrate the adsorption energy difference betweenα-olefin/paraffin and *** work provides a new understanding of the long-chain hydrocarbon adsorption behavior different from ethylene/ethane and propylene/propane,which guides the design of adsorbents forα-olefin/paraffin separation.

关键词： linearα-olefin adsorption cavity structure metal-organic framework liquid-phase adsorption molecular simulations principal orbital interaction

Synthesis of alumina-nitrogen-doped carbon support for CoMo catalysts in hydrodesulfurization process

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2022年第1期35卷 392-402页

作者： Zhentao Chen Yaxin Liu Jian Chen Yang zhao Tao Jiang fangyu zhao Jiahuan Yu Haoxuan Yang Fan Yang Chunming Xu State Key Laboratory of Heavy Oil Proceeing China University of PetroleumChangpingBeijing 102249China

More stringent environmental legislation imposes severe requirements to reduce the sulfur content in diesel to ultra-low levels with high efficient *** this paper,a series of CoMo/NDC@alumina catalysts were synthesized by combination of the chemical vapor deposition of nitrogen-doped carbon(NDC)using 1,10-phenanthroline and co-impregnation of Mo and Co active *** optimal catalyst with additive of 25%1,10-phenanthroline was screened by a series of property characterization and the hydrodesulfrization(HDS)active *** amount of“CoMoS”active phase of the optimal CoMo/C3 catalyst increased 5.3%as compared with the CoMo/c-Al_(2)O_(3).The introduction of NDC improved the sulfidation degree of Mo by 21.8%as compared to the CoMo/c-Al_(2)O_(3) catalyst,which was beneficial to form more active *** HDS conversion of the NDC supported catalysts are higher than CoMo/c-Al_(2)O_(3) whether for the dibenzothiophene(DBT)or 4,6-dimethyl dibenzothiophene(4,6-DMDBT).Further hydroprocessing evaluation with Dagang diesel revealed that the CoMo/C3 catalyst possessed higher HDS property and the removal rate of DBTs in the diesel increased by 4%–11%as compared to the CoMo/c-Al_(2)O_(3) catalyst.

关键词： Nitrogen-doped carbonmaterials Catalyst hydrodesulfurization(HDS) Diesel Dibenzothiophene(DBT)

Establishment of NOD/SCID mouse models of human hepatocellular carcinoma via subcutaneous transplantation of histologically intact tumor tissue

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2013年第3期25卷 289-298页

作者： Mingxia Yan Hong Li fangyu zhao Lixing Zhang Chao Ge Ming Yao Jinjun Li State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital Shanghai Jiaotong University School of Medicine

Hepatocellular carcinoma （HCC） is one of the most deadly human cancers, but it is very difficult to establish an animal model by using surgical specimens. In the present experiment, histologically intact fresh surgical specimens of HCC were subcutaneously transplanted in non-obese diabetic/severe combined immunodeficienccy （NOD/SCID） mice. The biological characteristics of the original and the corresponding transplanted tumors and cell lines were investigated. The results showed that 5 new animal models and 2 primary cell lines were successfully established f^om surgical specimens. Hematoxylin-eosin staining showed that xenografts retained major histological features of the original surgical specimens. The two new cell lines had been cultivated for 3 years and successively passaged for more than 100 passages in vitro. The morphological characteristics and biologic features of the two cell lines were genetically similar to the original tumor. The subcutaneous transplant animal models with histologically intact tumor tissue and primary cell lines could be useful for in vivo and in vitro testing of anti-cancer drugs and be ideal models to study various biologic features of HCC.

关键词： Animal model hepatocellular carcinoma subcutaneous transplantation surgical specimens

Protective and Adverse Roles of DDX3X in Different Cell Types in Nonalcoholic Steatohepatitis Progression

在线全文

学校读者我要写书评

暂无评论

Research 2024年第3期6卷 561-574页

作者： Suzhen Yang Lin Zhou Tianming zhao Hanlong Zhu Tingting Luo Kang Jiang Xiaoxiao Shi Chunyan Chen Han Zhang Si zhao Xiaoping Zou Yuzheng Zhuge fangyu Wang Lei Wang Mingzuo Jiang Bing Xu Department of Gastroenterology the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolJiangsuNanjing210002China. Department of Gastroenterology and Hepatology the Affiliated Jinling Hospital of Nanjing University Medical SchoolJiangsuNanjing210002China School of Medicine Northwest UniversityShaanxiXi’an710069China. Department of Gastroenterology Nanjing Drum Tower HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeJiangsuNanjing210008China.

Persistent hepatic cellular metabolic stress and liver inflammatory stimuli are key signatures of nonalcoholic steatohepatitis(NASH).DDX3X is a vital molecule involved in cell fate decisions in both pro-survival stress granule(SG)and pro-death NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome assembly in response to stress ***,the role of DDX3X in NASH remains *** characterized the cell type-specific roles of DDX3X in *** liver tissues from NASH patients and normal control subjects were collected to assess DDX3X expression and *** steatohepatitis models were constructed by feeding macrophage-specific DDX3X knockout(DDX3^(XΔMφ)),hepatocyte-specific DDX3X knockout(DDX3X^(Δhep)),and wild-type control(DDX3X^(fl/fl))mice a high-fat and high-cholesterol(HFHC)diet,a methionine-and choline-deficient(MCD)diet,and a high-fat/high-iron/high-fructose/high-cholesterol,low-methionine,and choline-deficient(HFHIHFHC-MCD)*** study demonstrated that DDX3X was predominantly expressed in macrophages and hepatocytes in control liver tissues,and its expression was down-regulated in patients or mice with *** to DDX3X^(fl/fl) littermates,DDX3^(XΔMφ)mice showed improved liver histology in nutritional steatohepatitis *** of macrophage DDX3X inhibited NLRP3 inflammasome-mediated pyroptosis,causing anti-inflammatory M2 polarization and alleviating hepatocyte steatohepatitic ***3X^(Δhep) mice developed marked steatohepatitis in multiple nutritional steatohepatitis models compared to DDX3X^(fl/fl) ***3X-deleted hepatocytes showed impaired SG assembly,leading to increased sensitivity and intolerance to metabolic stimulation and resultant *** conclusion,DDX3X plays opposite roles in different cell types during the progression of NASH.A better understanding of the cell-specific differences in the crosstalk between SG formation and NLRP3 activation is crucial for developing pr

关键词： NLRP3 impaired inhibited

Research Progress on Extraction Technology of Polysaccharides from Polygonatum spp.

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Medicinal Plant 2018年第6期9卷 7-10,14页

作者： Jiang LIU Yuanjiang XU fangyu zhao Hong QUAN Xiaozhong LAN Food Science College Tibet Agriculture & Animal Husbandry University Research Institute of Tibet Plateau Ecology Tibet Agriculture & Animal Husbandry University

In this paper,the extraction methods of polysaccharides from Polygonatum *** recent years are reviewed to provide reference for further development and utilization of Polygonatum *** addition,the prospects of the extr... 详细信息

关键词： Polygonatum polysaccharides Extraction process Research progress

Loss of interactions between p53 and survivin gene in mesenchymal stem cells after spontaneous transformation in vitro

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Loss of interactions between p53 and survivin gene in mesenc...

Auxiliary ligand-induced assembly of atomically precise silver clusters

石河子大学2017年“一带一路”核心区创新驱动发展博士论坛医学分论坛

作者： Liu He fangyu zhao Yong Zheng Yu Wan Jian Song Department of Anatomy and Embryology Wuhan University School of Medicine Department of Physiology Wuhan University School of Medicine

Mesenchymal stem cells(MSC) from various animals undergo a spontaneous transformation in longterm culture. The transformed MSCs are highly tumorigenic and are likely to be the tumor-initiating cells of sarcoma. To explain why the transformed MSCs become tumorigenic, the present study investigated the characteristics of rat MSCs before and after spontaneous transformation. It was shown that although the transformed MSCs maintained typical surface markers of MSC, they exhibited some cancer stem celllike characteristics such as loss of contact inhibition and multi-potency to mesenchymal lineages, and acquirement of ability of anchorage-independent growth. The expression of a key senescence regulator p16 almost disappeared, but the other one, p53 abnormally increased in the transformed MSCs. Ch IP assay demonstrated that a normal negative regulation of p53 on survivin gene disappeared in the transformed cells due to a lack of p53 binding to the promoter of survivin gene. DNA sequencing revealed that the p53 gene in transformed MSCs was not a wild-type, but a 942 C > T mutant with the mutation located in the sequence coding p53 protein’s DNA-binding domain. These findings indicate that the transformed MSCs express high levels of a p53 mutant that loses the ability to bind survivin gene, leading to an abnormally upregulated expression of survivin, which is a key reason for the cell’s unlimited proliferation.

关键词： Mesenchymal stem cells Cell transformation p53 Survivin

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Science China Chemistry 2024年

作者： Yeqin Feng Xuemeng Jing fangyu Fu Mengyun zhao Manzhou Chi Hongjin Lü Guoyu Yang MOE Key Laboratory of Cluster Science Beijing Key Laboratory of Photoelectroic/Electrophotonic Conversion MaterialsSchool of Chemistry and Chemical Engineering Beijing Institute of Technology

Establishing the correlation between inter-cluster assembly and auxiliary ligands at the atomic level is crucial for the development of metal cluster *** this work,we report the successful preparation and characterization of three Ag clusters,discrete 0-D Ag51S6Cl3（iPrS）21（TsO）15CH3CN(0-D Ag51,iPrS-=isopropanethiolate,TsO-=toluenesulfonate),1-D {Ag38S4（iPrS）18（PhCOO）12}_n(1-D Ag38,PHCOO-=benzoate),and 2-D {Ag20（SO4）Cl2（iPrS）10（NO3）6}_n(2-D Ag20),using a delicate auxiliary-ligand-induced *** analyses reveal that the types of auxiliary ligands can readily affect the structure and dimensionality of resulting Ag *** addition of different surface auxiliary ligands from TsO-to PhCOO-and then to NO3-leads to the formation of 0-D Ag51to 1-D Ag38and then to 2-D Ag20clusters under otherwise identical reaction conditions,*** resulting Ag clusters exhibited structure-related optical/luminescence properties and distinct bathochromic shifts as revealed by the temperature-dependent luminescence and single-crystal X-ray diffraction studies.

关键词：

Pectin Oligosaccharides Glycosylation Modification Reduced the Sensitization of Shrimp Tropomyosin by Regulating Cytokines Expression and Th1/Th2 Immune Balance

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Mengya zhao Chunyu Wu Jing Liu Xinian Li Zhenpeng Gao Xin Yang Di Liu fangyu Long College of Food Science and Engineering， Northwest A&F University Institute of Animal Husbandry and Veterinary Medicine， Guizhou Academy of Agricultural Sciences College of Animal Science and Technology， Northwest A&F University

Tropomyosin (TM) is the predominant allergenic protein in shrimp， which has induced IgE-mediated food allergy reactions. In this study， Lit v 1 was purified from Penaeus vannamei muscles， which were glycosylated by pectic oligosaccharides. The results showed that Di-Galacturonic acid (DGA) and galacturonic acid (GA) induced the unfolding of the primary protein structure of TM， and changed alpha-helical structure， and IgE binding capacity. In addition， compared with TM-sensitized BALB/c mice， galacturonic acid-modified TM (GA-TM) and Di-Galacturonic acid-modified TM (DGA-TM) were insufficient to stimulate sensitization， and significantly reduced the hypersecretion of IgE， IgG1， HIS， and IL-4， up-regulated IgG2a and IFN-γ levels to improve imbalanced Th1/Th2， Treg/Th17 immunity， and promoted mRNA expression of tight junction proteins. Together， this study confirmed that glycosylation modification alleviated sensitization by altering TM structure， reducing IgE binding allergic inflammatory response， and regulating cytokine immune balance. Overall， these results indicated that glycosylation modification was a promising method for decreasing the allergenic reactivity of allergic proteins.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

西藏兰科植物2新记录属

浙江大学学报（理学版） 2016年第4期43卷 502-504页

作者：罗建赵芳玉兰小中西藏大学农牧学院西藏农牧特色资源研发协同创新中心西藏林芝860000 西藏大学农牧学院西南大学药用植物联合研发中心西藏林芝860000

报道了西藏兰科植物的2个新记录属——美冠兰属（Eulophia *** Lindl.）和铠兰属（Corybas Salisb.）,以及2个新记录种——无叶美冠兰（Eulophia zollingeri（Rchb.f.）***）和大理铠兰（Corybas taliensis *** et ***）.凭证标本保存... 详细信息

报道了西藏兰科植物的2个新记录属——美冠兰属（Eulophia *** Lindl.）和铠兰属（Corybas Salisb.）,以及2个新记录种——无叶美冠兰（Eulophia zollingeri（Rchb.f.）***）和大理铠兰（Corybas taliensis *** et ***）.凭证标本保存于西藏大学农牧学院-西南大学药用植物联合研发中心药用植物标本室（TAAHC-SWU）.这2个种的分布生境与记载基本相同,而居群分布海拔则高出约500~700m;此外,西藏采集的无叶美冠兰的花期比植物志记载的花期晚;大理铠兰花期比植物志记载的明显要早,反映了这2种植物具有更强的生态适应性和更宽的分布生态幅.美冠兰属和铠兰属植物在西藏境内的首次发现,进一步完善了兰科植物的地理分布信息和兰科系统演化的资料,丰富了西藏兰科植物属种的多样性组成.

关键词：兰科铠兰属美冠兰属新记录西藏