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Differential Transcriptomic Landscapes of SARS-CoV-2 Variants in Multiple Organs from Infected Rhesus Macaques

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Genomics, Proteomics & Bioinformatics 2023年第5期21卷 1014-1029页

作者： Tingfu Du Chunchun Gao Shuaiyao Lu Qianlan Liu Yun Yang Wenhai Yu Wenjie Li Yong Qiao Sun Cong Tang Junbin Wang Jiahong Gao Yong Zhang fangyu luo Ying Yang Yun-Gui Yang Xiaozhong Peng National Kunming High-level Biosafety Primate Research Center Institute of Medical BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeKunming 650118China State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and BiochemistryInstitute of Basic Medical SciencesMedical Primate Research CenterNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China CAS Key Laboratory of Genomic and Precision Medicine Collaborative Innovation Center of Genetics and DevelopmentCollege of Future TechnologyBeijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 100049China Institute of Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)caused the persistent coronavirus disease 2019(COVID-19)pandemic,which has resulted in millions of deaths worldwide and brought an enormous public health and global economic burden.The recurring global wave of infections has been exacerbated by growing variants of SARS-CoV-2.In this study,the virological characteristics of the original SARS-CoV-2 strain and its variants of concern(VOCs;including Alpha,Beta,and Delta)in vitro,as well as differential transcriptomic landscapes in multiple organs(lung,right ventricle,blood,cerebral cortex,and cerebellum)from the infected rhesus macaques,were elucidated.The original strain of SARS-CoV-2 caused a stronger innate immune response in host cells,and its VOCs markedly increased the levels of subgenomic RNAs,such as N,Orf9b,Orf6,and Orf7ab,which are known as the innate immune antagonists and the inhibitors of antiviral factors.Intriguingly,the original SARS-CoV-2 strain and Alpha variant induced larger alteration of RNA abundance in tissues of rhesus monkeys than Beta and Delta variants did.Moreover,a hyperinflammatory state and active immune response were shown in the right ventricles of rhesus monkeys by the up-regulation of inflammation-and immune-related RNAs.Furthermore,peripheral blood may mediate signaling transmission among tissues to coordinate the molecular changes in the infected individuals.Collectively,these data provide insights into the pathogenesis of COVID-19 at the early stage of infection by the original SARS-CoV-2 strain and its VOCs.

关键词： SARS-CoV-2 Variant of concern Subgenomic RNA Rhesus macaque Transcriptome

动态环境下基于深度学习的视觉SLAM研究综述

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半导体光电 2024年第1期45卷 1-10页

作者：罗元沈吉祥李方宇重庆邮电大学光电工程学院重庆400065

目前的同时定位与地图构建(Simultaneous Localization and Mapping,SLAM)研究大多是基于静态场景的假设,而实际生活中动态物体是不可避免的。在视觉SLAM系统中加入深度学习,可以协同剔除场景中的动态物体,有效提升视觉SLAM在动态环境... 详细信息

目前的同时定位与地图构建(Simultaneous Localization and Mapping,SLAM)研究大多是基于静态场景的假设,而实际生活中动态物体是不可避免的。在视觉SLAM系统中加入深度学习,可以协同剔除场景中的动态物体,有效提升视觉SLAM在动态环境下的鲁棒性。文章首先介绍了动态环境下基于深度学习的视觉SLAM分类,然后详细介绍了基于目标检测、基于语义分割和基于实例分割的视觉SLAM,并对它们进行了分析比较。最后,结合近年来视觉SLAM的发展趋势,通过对动态环境下基于深度学习的视觉SLAM存在的主要问题进行分析,总结了未来可能的发展方向。

关键词：视觉同时定位与地图构建深度学习动态环境语义信息

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结合三维交互注意力与语义聚合的表情识别

计算机工程与应用 2024年第6期60卷 238-248页

作者：王广宇罗晓曙徐照兴丰芳宇许江杰广西师范大学电子与信息工程学院广西桂林541004 江西服装学院大数据学院南昌330201

针对传统卷积网络难以有效整合不同阶段人脸面部表情的特征、存在特征表征瓶颈以及无法高效利用上下文语义等问题,提出了一种结合三维交互注意力与语义聚合的面部表情识别方法。在秩扩展(ReXNet)网络的基础上对其进行优化,在消除表征瓶... 详细信息

针对传统卷积网络难以有效整合不同阶段人脸面部表情的特征、存在特征表征瓶颈以及无法高效利用上下文语义等问题,提出了一种结合三维交互注意力与语义聚合的面部表情识别方法。在秩扩展(ReXNet)网络的基础上对其进行优化,在消除表征瓶颈的情况下,融合上下文特征,使其更适配表情识别任务。为捕获判别性人脸表情细粒度特征,结合非本地块与跨维度信息交互理论构建了三维交互注意力。为充分利用表情的浅中层底层特征与高层语义特征,设计了语义聚合模块,将多级全局上下文特征与高级语义信息进行聚合,达到同一类别的表情语义相互增益、增强类内一致性的目的。实验表明,该方法在公开数据集RAF-DB、FERPlus和AffectNet-8上的准确率分别为88.89%、89.53%与62.22%,展现了该方法的先进性。

关键词：人脸表情识别表征瓶颈三维交互注意力上下文语义

Correlation of adsorbent cavity structure with adsorption behavior and interaction of long-chainα-olefin/paraffin on microporous adsorbents

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Nano Research 2023年第4期16卷 5721-5732页

作者： Ruihan Yang fangyu Zhao Shafqat Ullah Xiao Chen Junxiang Ma Yuan Gao Yujun Wang Guangsheng luo State Key Lab of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Lu’an Chemical Group CO. LTD.Changzhi 046299China

Long-chainα-olefins have a high added value as important raw materials for many highly marketable products.Fishcher-Tropsch synthesis products contain ultrahigh-contentα-olefins,which are of great value if the challenging separation ofα-olefin/paraffin is achieved through energy-saving ways,for which adsorption separation is an attractive technology.One of the most significant differences between the adsorption separation of long-chain and light hydrocarbons is the steric hindrance of the molecular chain.Herein,we propose a combination of window size,metal node spacing,and bending degree to quantitatively describe the adsorption cavity structure for the separation of long-chainα-olefin/paraffin.The general cavity structural characteristics of microporous materials with good separation performance for long-chainα-olefin/paraffin are revealed.The selective adsorption of liquid C6 and C_(8)α-olefin/paraffin mixtures on CuBTC(BTC=benzene-1,3,5-tricarboxylate)was studied in detail to reveal the influence of the cavity structure on the adsorption and interaction using a combination of batch adsorption experiments and molecular simulation techniques.CuBTC exhibited 360 and 366 mg/g olefin adsorption capacities for C6 and C8 linearα-olefins,respectively.The adsorption energies were−0.540 and−0.338 eV for C8 linearα-olefin and paraffin,respectively.The contributions of different types of interactions to the overall adsorption energy were quantified to illustrate the adsorption energy difference betweenα-olefin/paraffin and CuBTC.This work provides a new understanding of the long-chain hydrocarbon adsorption behavior different from ethylene/ethane and propylene/propane,which guides the design of adsorbents forα-olefin/paraffin separation.

关键词： linearα-olefin adsorption cavity structure metal-organic framework liquid-phase adsorption molecular simulations principal orbital interaction

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中医药调节铁死亡防治缺血缺氧性疾病的研究

中国中医基础医学杂志 2024年第1期30卷 162-167页

作者：肖孟勇骆亚莉齐晓风周雯周世琴刘凯安方玉刘永琦甘肃中医药大学兰州730000 甘肃省高校重大疾病分子医学与中医药防治研究省级重点实验室兰州730000 甘肃省中医药防治慢性疾病重点实验室兰州730000

缺血缺氧是广泛存在于多种临床疾病中的病理过程。研究显示铁死亡以铁依赖性脂质过氧化为主要特征,在缺血缺氧性疾病中常伴有铁死亡发生,铁死亡抑制剂的应用可减轻缺血缺氧导致的损害。近年来,中医药调节铁死亡成为防治缺血缺氧疾病的... 详细信息

缺血缺氧是广泛存在于多种临床疾病中的病理过程。研究显示铁死亡以铁依赖性脂质过氧化为主要特征,在缺血缺氧性疾病中常伴有铁死亡发生,铁死亡抑制剂的应用可减轻缺血缺氧导致的损害。近年来,中医药调节铁死亡成为防治缺血缺氧疾病的研究热点。中药及其活性成分对铁死亡的调节具有多点起效、稳定安全及廉价易得的优势,笔者基于中医“气血理论”,阐述了中医对铁死亡的认识并归纳了中药调节铁死亡防治缺血缺氧性疾病的报道文献,以期为缺血缺氧相关疾病的临床治疗提供新的思路和策略,并加快相关中药的研发进程。

关键词：缺血缺氧铁死亡分子机制气血

Highly-selective Pt/PAA@MIL-125 Catalyst for Hydrosilylation of γ-(2,3-Epoxypropoxy) Trimethoxysilane

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Chemical Research in Chinese Universities 2023年第6期39卷 1077-1083页

作者： ZHU Yahui luo Yanping ZHU fangyu LIANG Qiuhong YUAN Mingwei ZHANG Bingzhen SHI Shunli WANG Shuhua CHEN Chao State Key Laboratory of Jiangxi Province for Environment and Energy Catalysis College of Chemistry and Chemical EngineeringNanchang UniversityNanchang 330031P.R.China Jiangxi Chenguang New Materials Co. Ltd.Nanchang 332500P.R

γ-(2,3-Epoxypropoxy)trimethoxysilane is a crucial silicone product synthesized by hydrosilylation.Its derived downstream silicone products have galvanized the development of silicone industry.However,the Speier's or Karstedt's catalysts commonly utilized in its industrial process are homogeneous,leading to complications,such as low catalytic selectivity and recycling difficulty.Herein,a new heterogeneous platinum catalyst was developed by using a titanium-based metal organic framework(MIL-125)composite with polylactic acid(PAA)as the support.The as-synthesized Pt/PAA-2@MIL-125 catalyst exhibited impressive catalytic performance,producing a 97%yield inβ-product,and maintained recyclability for the synthesis ofγ-(2,3-epoxypropoxy)trimethoxysilane.Further characterization analyses revealed that the introduction of PAA resulted in the formation of a defective mesoporous MIL-125,which accelerated the transmission efficiency of reactants.Moreover,the abundant carboxylic acid groups in the MIL-125/PAA composite could interact strongly with Pt active species,thereby enhancing the catalytic performance and minimizing the loss of Pt,ultimately improving its cycling performance.The comprehensive experiments demonstrated the potential of this catalyst as an effective and versatile heterogeneous catalyst not only for the hydrosilylation of various olefins,but also for the hydrosilyation of silanes.

关键词： γ-(2 3-Epoxypropoxy)trimethoxysilane Hydrosilylation Metal-organic framework

The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1614-1624页

作者： Li Jiao Yun Yang Wenhai Yu Yuan Zhao Haiting Long Jiahong Gao Kaiyun Ding Chunxia Ma Jingmei Li Siwen Zhao Haixuan Wang Haiyan Li Mengli Yang Jingwen Xu Junbin Wang Jing Yang Dexuan Kuang fangyu luo Xingli Qian Longjiang Xu Bin Yin Wei Liu Hongqi Liu Shuaiyao Lu Xiaozhong Peng National Kunming High-Level Biosafety Primate Research Center Institute of Medical BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeKunmingYunnanChina State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and BiochemistryInstitute of Basic Medical SciencesMedical Primate Research CenterNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijingChina Department of Anatomy Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijingChina

Neurological manifestations are frequently reported in the COVID-19 patients.Neuromechanism of SARS-CoV-2 remains to be elucidated.In this study,we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of COVID-19.In rhesus monkey,SARS-CoV-2 invades the CNS primarily via the olfactory bulb.Thereafter,viruses rapidly spread to functional areas of the central nervous system,such as hippocampus,thalamus,and medulla oblongata.The infection of SARS-CoV-2 induces the inflammation possibly by targeting neurons,microglia,and astrocytes in the CNS.Consistently,SARS-CoV-2 infects neuro-derived SK-N-SH,glial-derived U251,and brain microvascular endothelial cells in vitro.To our knowledge,this is the first experimental evidence of SARS-CoV-2 neuroinvasion in the NHP model,which provides important insights into the CNS-related pathogenesis of SARS-CoV-2.

关键词： invasion inflammation system

The Relationship Between Physical Activity and All-Cause Mortality Among Older Adults--China, 1998–2018

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China CDC weekly 2023年第39期5卷 866-871,I0004页

作者： Lanjing Xu Jun Wang Yang Li Xinwei Li Chen Chen Zinan Xu Min Zhang Yidan Qiu Zhuchun Zhong Zheng Zhang fangyu Li Yufei luo Yuebin Lyu Guangdi Chen Xiaoming Shi School of Public Health Zhejiang UniversityHangzhou CityZhejiang ProvinceChina China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina School of Public Health Nanjing Medical UniversityNanjing CityJiangsu ProvinceChina Department of Epidemiology and Biostatistics School of Public HealthJilin UniversityChangchun CityJilin ProvinceChina Department of Epidemiology School of Public HealthSouthern Medical UniversityGuangzhou CityGuangdong ProvinceChina School of Public Health China Medical UniversityShenyang CityLiaoning ProvinceChina Department of Occupational Health and Environment Health School of Public HealthAnhui Medical UniversityHefei CityAnhui ProvinceChina.

Summary What is already known about this topic?Previous research indicates that non-occupational physical activity can reduce mortality risk.Nevertheless,the relationship between occupational physical activity and health improvements has not been consistently established.What is added by this report?The study found that regular exercise and leisure activities reduced the risk of all-cause mortality.However,the combination of exercise and leisure activities demonstrated more substantial benefits.Additionally,no meaningful association was identified between physical work and mortality risk within the older population.

关键词： mortality occupational meaningful

中国80岁及以上老年人睡眠时长及体育锻炼与血脂异常的关联

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中华流行病学杂志 2024年第1期45卷 48-55页

作者：吴兵李阳徐岚静章正周锦辉魏源陈晨王君吴昌恣李峥胡子雨龙范晔吴玉栋胡雪华李可馨李方玙罗宇菲刘迎春吕跃斌施小明南京医科大学公共卫生学院全球健康中心南京211166 中国疾病预防控制中心环境与人群健康重点实验室/环境与健康相关产品安全所北京100021 浙江大学公共卫生学院杭州310058 吉林大学公共卫生学院长春130012

目的探讨中国≥80岁老年人(高龄老人)睡眠时长、体育锻炼及其交互作用对血脂异常发生风险的影响。方法调查对象为老年健康生物标志物队列研究项目四轮调查(2008-2009年、2011-2012年、2014年和2017-2018年)中的高龄老人。收集人口学特... 详细信息

目的探讨中国≥80岁老年人(高龄老人)睡眠时长、体育锻炼及其交互作用对血脂异常发生风险的影响。方法调查对象为老年健康生物标志物队列研究项目四轮调查(2008-2009年、2011-2012年、2014年和2017-2018年)中的高龄老人。收集人口学特征、生活方式、体格检查等资料,收集空腹静脉血进行血脂检测。采用竞争风险模型探索睡眠时长及体育锻炼与血脂异常发生风险之间的因果关联。应用限制性立方样条(RCS)函数分析睡眠时长与血脂异常发生风险的剂量-反应关系,采用相加及相乘交互作用模型探索睡眠时长和体育锻炼对血脂异常发生风险的交互作用。结果1809名研究对象的年龄为(93.1±7.7)岁,女性占65.1%。基线调查睡眠时长为(8.0±2.5)h/d,睡眠时长9 h/d者占27.2%。累积随访6150.6人年(人均随访3.4年),血脂异常新发病例304名,发病密度为4942.6/10万人年。竞争风险模型结果表明,与睡眠时长为7~h/d者相比,>9 h/d者血脂异常发生风险增加22%(HR=1.22,95%CI:1.07~1.39);与不进行体育锻炼的高龄老人相比,进行体育锻炼的高龄老人血脂异常发生风险降低33%(HR=0.67,95%CI:0.57~0.78)。RCS函数分析显示,在高龄老人中睡眠时长与血脂异常发生风险具有正向线性的剂量-反应关系。交互作用分析显示,体育锻炼与睡眠时长对血脂异常发生风险存在拮抗作用。结论体育锻炼可能会改善睡眠时长过长对高龄老人血脂的不良影响。

关键词：高龄老人睡眠时长体育锻炼血脂异常队列研究