检索结果-南通市图书馆

Comparison of immune profiles between hepatocellular carcinoma subtypes

在线全文

学校读者我要写书评

暂无评论

Biophysics Reports 2020年第1期6卷 19-32页

作者： Xuemin Pan Ping Lin fangyoumin feng Jia Li Yuan-Yuan Li Wentao Dai Bo Hu Xin-Rong Yang Jia Fan Hong Li Yixue Li School of Life Sciences and Biotechnology Shanghai Jiao Tong University Bio-Med Big Data Center Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational Biology Shanghai Institute of Nutrition and Health Shanghai Institutes for Biological Sciences University of Chinese Academy of Sciences Chinese Academy of Sciences University of the Chinese Academy of Sciences School of Life Science and Techonology Shanghai Tech University Shanghai Center for Bioinformation Technology Shanghai Academy of Science & Technology Shanghai Engineering Research Center of Pharmaceutical Translation Department of Liver Surgery Liver Cancer Institute Zhongshan Hospital Fudan University Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education Collaborative Innovation Center of Genetics and Development Fudan University

Immunotherapy, especially immune checkpoint inhibitors, is becoming a promising treatment for hepatocellular carcinoma(HCC). However, the response rate remains limited due to the heterogeneity of HCC samples. Molecular subtypes of HCC vary in genomic background, clinical features, and prognosis. This study aims to compare the immune profiles between HCC subtypes and find subtype-specific immune characteristics that might contribute to the prognosis and potential of immunotherapy. The immune profiles consist of immune-related genes, cytolytic activity, immune pathways, and tumorinfiltrating lymphocytes. HCC-c1 samples showed an overall higher activation level of immune genes and pathways, and this pattern was consistent in validation sets. We associated the difference in immune profiles with the activation level of cancer hallmarks and genomic mutations. There was a negative correlation between most of the metabolism pathway and immune-related pathways in HCC samples. CTNNB1/WNT signaling pathway mutation, one of the common mutations in HCC, appears to be associated with the expression of immune genes as well. These results reveal the difference of immune profiles between HCC subtypes and possible reasons and influence, which may also deepen our understanding of the carcinogenesis process.

关键词： Hepatocellular carcinoma Immune Tumor-infiltrating lymphocytes Metabolism CTNNB1 mutation

A novel method for AFRPs burrs removal:Principle of mechanochemo-induced fiber fracture

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第7期37卷 522-538页

作者： Jie XU Bo LI Pingfa feng Qiang WANG feng feng Division of Advanced Manufacturing Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Changhe Aircraft Industry(Group)Co.Ltd Jingdezhen 333000China

Burrs generated during the machining of Aramid-Fiber-Reinforced Composites(AFRPs)pose a challenge for the production efficiency of aircraft and helicopter housing *** studies have generally attempted to suppress burrs by referring to delamination suppression *** contrast to stratification,burrs are remediable machining *** such,a mechanochemical method with burrs trimming technological strategy are implemented to effectively combat ***,we clarify the mechanism by which aramid fibers cannot be cut off using analytical and numerical *** addition,the mechanism of fiber fracture with Modified Polyurethane Reactive Polymer(M-PUR),and development of anti-burr devices(thermostatic adhesive sealed generator)are ***,the experimental results show that the reduction rate in burr length is 87%-91%through the mechanochemical *** method not only opens a new avenue to solve the burr problem of aramid fibers but also builds an interdisciplinary bridge between polymer science and composite machining.

关键词： Mechanochemical method Burrs Orthogonal cutting Aramid fiber-reinforced composites Milling

Record-high efficiency perovskite LEDs achieved by accelerating radiative recombination

在线全文

学校读者我要写书评

暂无评论

Science China Materials 2024年第9期67卷 3039-3040页

作者： feng Gao Department of Physics Chemistry and BiologyLinköping UniversityLinköping58183Sweden

Light-emitting diodes(LEDs)have revolutionized the lighting and displays due to their superior energy *** increasing demand for more efficient and brighter thin-film LEDs in flat-panel displays and solid-state lighting applications has driven extensive research into perovskite materials,which show great promise for high brightness and efficiency.

关键词： lighting radiative high

Derivation of Expanded Isospectral-Nonisospectral Integrable Hierarchies via the Column-vector Loop Algebra

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2024年第3期40卷 778-800页

作者： Hai-feng WANG Yu-feng ZHANG School of Science Jimei UniversityXiamen 361021China School of Mathematics China University of Mining and TechnologyXuzhou 221116China

A scheme for generating nonisospectral integrable hierarchies is *** on the method,we deduce a nonisospectral hierarchy of soliton equations by considering a linear spectral *** follows that the corresponding expanded isospectral and nonisospectral integrable hierarchies are deduced based on a 6 dimensional complex linear space ■.By reducing these integrable hierarchies,we obtain the expanded isospectral and nonisospectral derivative nonlinear Schr?dinger *** using the trace identity,the biHamiltonian structure of these two hierarchies are also ***,some symmetries and conserved quantities of the resulting hierarchy are discussed.

关键词： expanded isospectral-nonisospectral integrable hierarchies column-vector loop algebra bi-Hamiltonian structure symmetry

Carbon-based materials with combined functions of thermal management and electromagnetic protection: Preparation, mechanisms, properties, and applications

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第3期17卷 883-903页

作者： Junwei Yue Yiyu feng Mengmeng Qin Wei feng School of Materials Science and Engineering and Tianjin Key Laboratory of Composite and Functional Materials Tianjin UniversityTianjin 300350China

The proliferation of high-power,highly informationized,and highly integrated electronic devices and weapons equipment has given rise to increasingly conspicuous issues about electromagnetic(EM)pollution and thermal *** issues,in turn,impose constraints on the performance of such equipment and jeopardize personnel *** materials,owing to their diverse and modifiable structures,offer adjustable thermal and electric conductivity,rendering them highly promising for applications in fields such as thermal management and EM protection which have garnered extensive research and *** pursuit of integrated device and equipment development has elevated the demand for multifunctional materials,prompting significant research into carbon-based composite materials that include both thermal management and EM protection ***,there are no relevant reviews on this topic at ***,this work consolidates research findings from recent years on carbon matrix composites exhibiting dual attributes of thermal management and EM *** attributes include thermally conductive electromagnetic interference(EMI)shielding materials,thermally insulating EMI shielding materials,thermally conductive EM wave(EMW)absorbing materials,and thermally insulating EMW absorbing *** paper elucidates the fundamental principles underpinning thermal conduction,thermal insulation,EMW absorbing,and EMI ***,it engages in discussions surrounding areas of contention,design strategies,and the functional properties of various material ***,the paper concludes by presenting the challenges encountered and potential research strategies about composites endowed with both thermal management and EM protection functionalities,while also envisaging the development of novel multifunctional EM protection materials.

关键词： carbon-based composites electromagnetic interference shielding microwave absorption thermal conduction thermal insulation

Design and identification of a double-acting piezoelectric-hydraulic hybrid actuator

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第3期37卷 456-467页

作者： Junjian ZHANG Zhihua feng Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes University of Science and Technology of ChinaHefei 230026China

Traditional single-acting piezoelectric-hydraulic hybrid actuators usually have the problem of inertial force caused by flow pulsation of the liquid,which degrades their output *** suppress or solve the associated inertial force and enhance its output capabilities,this paper proposes a new type of double-acting piezoelectric-hydraulic hybrid actuator with four check valves acting as mechanical *** new hybrid actuator was fabricated and its output performance was *** the voltage is 700 Vp-pand the bias pressure is 2 MPa,the pulsation ratesδof the new actuator at 400 Hz,500 Hz and 600 Hz are 2.29,2.08 and 1.78,respectively,whileδof the single-acting hybrid actuator under the same conditions are 10.98,11.05 and ***,the liquid pulsation rate of the new hybrid actuator is significantly reduced,which is beneficial for improving the flow uniformity and weakening the influence of inertial force on the hybrid *** strategy ultimately leads to a maximum no-load velocity of 168.1 mm/s at 600 Hz and a maximum blocking force of 141 N at 450 Hz for the new hybrid *** addition,this strategy has the potential to be used in other electrohydrostatic actuators to improve their performance.

关键词： Double-acting Flow pulsation Inertial force Piezoelectric actuators Piezoelectric devices Piezoelectric hydraulic actuation Piezoelectric pump

Rational Solutions of First Order Algebraic Ordinary Differential Equations

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2024年第2期37卷 567-580页

作者： feng Shuang SHEN Liyong School of Physical and Mathematical Sciences Nanjing Tech UniversityNanjing 211816China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

Let f(t,y,y')=∑ _(i=0)^(n )a_(i)(t,y)y'^(i)=0 be an irreducible first order ordinary differential equation with polynomial *** in 1998 proved that there exists a constant C such that every rational solution of f(t,y,y')=0 is of degree not greater than *** show that this degree bound C depends not only on the degrees of f in t,y,y' but also on the coefficients of f viewed as the polynomial in t,y,y'.In this paper,the authors show that if f satisfies deg(f,y)0,then the degree bound C only depends on the degrees of f in t,y,y',and furthermore we present an explicit expression for C in terms of the degrees of f in t,y,y'.

关键词： Degree bound first order AODE height rational solution

How can technology and efficiency alleviate the dilemma of economic growth and carbon emissions in China's industrial economy? A metafrontier decoupling decomposition analysis

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第2期21卷 1415-1428页

作者： Miao Wang Chao feng School of Business Zhengzhou UniversityZhengzhou450001HenanChina School of Economics and Business Administration Chongqing UniversityChongqing400030China

This paper attempts to explore the decoupling relationship and its drivers between industrial economic increase and energy-related CO_(2) emissions(ICE). Firstly, the decoupling relationship was evaluated by Tapio index. Then, based on the DEA meta-frontier theory framework which taking into account the regional and industrial heterogeneity and index decomposition method, the driving factors of decoupling process were explored mainly from the view of technology and efficiency. The results show that during2000-2019, weak decoupling was the primary state. Investment scale expansion was the largest reason hindering decoupling process of industrial increase from ICE. Both energy saving and production technology achieved significant progress, which facilitated the decoupling process. Simultaneously, the energy technology gap and production technology gap among regions have been narrowed, and played a role in promoting decoupling process. On the contrary, both scale economy efficiency and pure technical efficiency have inhibiting effects on decoupling process. The former indicates that the scale economy of China's industry was not conducive to improve energy efficiency and production efficiency, while the latter indicates that resource misallocation problem may exist in both energy market and product market.

关键词： China's industrial sector Decoupling process Meta-frontier DEA Index decomposition method Driving factors

H-and J-aggregation of conjugated small molecules in organic solar cells

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第6期93卷 174-192,I0005页

作者： Qiaoqiao Zhao feng He State Key Laboratory of Biobased Material and Green Papermaking Qilu University of TechnologyShandong Academy of SciencesJinan 250353ShangdongChina Shenzhen Grubbs Institute and Department of Chemistry Southern University of Science and TechnologyShenzhen 518055GuangdongChina Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and TechnologyShenzhen 518055GuangdongChina

As H-and J-aggregation receive more and more attention in the research of organic solar cells(OSCs),especially in small molecular systems,deep understanding of aggregation behavior is needed to guide the design of conjugated small molecular structure and the fabrication process of OSC *** this end,this review is ***,the review firstly introduced the basic information about H-and J-aggregation of conjugated small molecules in ***,the characteristics of H-and J-aggregation and the methods to identify them were ***,it reviewed the research progress of H-and J-aggregation of conjugated small molecules in OSCs,including the factors influencing H-and J-aggregation in thin film and the effects of H-and J-aggregation on OPV performance.

关键词： H-aggregation J-aggregation Organic solar cells Small molecules Efficiency Stability