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D-tryptophan triggered epithelial-mesenchymal transition by activating TGF-βsignaling pathway

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Food Science and Human Wellness 2022年第5期11卷 1215-1221页

作者： Chong wang fangting wang Yanbo wang Linglin Fu Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China

D-tryptophan is a special kind of nonprotein amino acid showing multiple physiological functions,but the detailed mechanisms are not fully revealed,impairing its further development and *** work was to investigate D-tryptophan physiological function and demonstrate the underlying mechanisms.D-tryptophan suppressed HaCaT cell proliferation but increased cell ***,D-tryptophan decreased E-cadherin and increased Snail,Twist,and Slug expression,resulting in the development of an epithelial-mesenchymal transitions(EMT)***,D-tryptophan promoted the expression of transforming growth factor-β(TGF-β)1,and Smad4 knockout damages D-tryptophan’s *** results indicated that D-tryptophan stimulated HaCaT cells to produce TGF-β1 and thus activated the TGF-β/Samd pathway,resulting in the triggering of *** study revealed the molecular mechanisms of D-tryptophan activity,provided D-tryptophan as a potential approach for cancer treatment,wound healing,organ development and other relevant applications.

关键词： D-tryptophan Epithelial-mesenchymal transitions Smad4 Transforming growth factor-β

An antifouling polydopamine-based fluorescent aptasensor for determination of arginine kinase

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Food Science and Human Wellness 2023年第3期12卷 737-744页

作者： Yanbo wang Huan Li Jinru Zhou fangting wang Yifan Qian Linglin Fu Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China

Simple yet efficient detection methods for food allergens are in urgent need to help people avoid the risks imposed by allergenic *** this work,a polydopamine(PDA)-based fluorescent aptasensor was developed to detect arginine kinase(AK),one of the major allergens in *** aptamer towards AK was firstly selected via systematic evolution of ligands by exponential enrichment method and labeled with fluorescein amidite(FAM)to build a fluorescence resonance energy transfer(FRET)system with PDA *** glycol(PEG)was employed to construct an antifouling surface for the aptasensor to eliminate food matrix *** the presence of AK,the PDA-based aptasensor exhibited elevated fluorescent signals as the FAM-labeled aptamer bound to AK and detached from the PDA *** aptasensor showed great stability and resistance to nonspecific interference of background proteins and had a limit of detection(LOD)of 0.298μg/*** proposed aptasensor was further proved to be feasible for quantitative analysis of AK in nine species of shrimps and five commercial processed products,which indicated its high potential in tracing the presence of AK in complex aquatic products.

关键词： Food allergy Aptasensor Antifouling Polydopamine FRET effect

Elucidate long-term changes of ozone in Shanghai based on an integrated machine learning method

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Frontiers of Environmental Science & Engineering 2023年第11期17卷 223-238页

作者： Jin Xue fangting wang Kun Zhang Hehe Zhai Dan Jin Yusen Duan Elly Yaluk Yangjun wang Ling Huang Yuewu Li Thomas Lei Qingyan Fu Joshua S.Fu Li Li School of Environmental and Chemical Engineering Shanghai UniversityShanghai 200444China Key Laboratory of Organic Compound Pollution Control Engineering(MOE) Shanghai UniversityShanghai 200444China Shanghai Environmental Monitoring Center Shanghai 200235China Institute of Science and Environment University of Saint JosephMacao 999078China Department of Civil and Environmental Engineering University of TennesseeKnoxvilleTN 37996USA

Surface ozone(O_(3))is influenced by regional background and local photochemical formation under favorable meteorological *** the contribution of these factors to changes in O_(3)is crucial to address the issue of O_(3)*** this study,we propose a novel integrated method that combines random forest,principal component analysis,and Shapley additive explanations to distinguish observed O_(3)into meteorologically affected ozone(O_(3_MET)),chemically formed from local emissions(O_(3_LC)),and regional background ozone(O_(3_RBG)).Applied to three typical stations in Shanghai during the warm season from 2013 to 2021,the results indicate that O_(3_RBG)in Shanghai was 48.8±0.3 ppb,accounting for 79.6%–89.4%at different sites,with an overall declining trend of 0.018 ppb/yr.O_(3_LC)at urban and regional sites ranged from 5.9–9.0 ppb and 8.9–14.6 ppb,respectively,which were significantly higher than the contributions of 2.5–7.4 ppb at an upwind background site.O_(3_MET)can be categorized into those affecting O_(3)photochemical generation and those changing O_(3)dispersion conditions,with absolute contributions to O_(3)ranging from 13.4–19.0 ppb and 13.1–13.7 ppb,*** found that the O_(3)rebound in 2017,compared to 2013,was primarily influenced by unfavorable O_(3)dispersion conditions and unbalanced emission reductions;while the O_(3)decline in 2021,compared to 2017,was primarily influenced by overall favorable meteorological conditions and further emissions *** findings highlight the challenge of understanding O_(3)change due to meteorology and regional background,emphasizing the need for systematic interpretation of the different components of O_(3).

关键词： Ozone Integrated method Machine learning

Regulating^(*)COOH intermediate via amino alkylation engineering for exceptionally effective photocatalytic CO_(2) reduction

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Journal of Energy Chemistry 2024年第5期92卷 282-291页

作者： Chengcheng Chen Qiaoyu Zhang fangting Liu Zhengguo Zhang Qiong Liu Xiaoming Fang Key Laboratory of Enhanced Heat Transfer and Energy Conservation The Ministry of EducationSchool of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640GuangdongChina Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology(China) Institute of AnalysisGuangdong Academy of Sciences(China National Analytical CenterGuangzhou)Guangzhou 510070GuangdongChina Guangdong Engineering Technology Research Center of Efficient Heat Storage and Application South China University of TechnologyGuangzhou 510640GuangdongChina Guangdong Provincial Key Laboratory of Fuel Cell Technology South China University of TechnologyGuangzhou 510640GuangdongChina

Photocatalytic reduction of CO_(2) into fuel represents a promising approach for achieving carbon neutrality,while realizing high selectivity in this process is challenging due to uncontrollable reaction intermediate and retarded desorption of target *** the interface microenvironment of catalysts has been proposed as a strategy to exert a significant influence on reaction outcomes,yet it remains a significant *** this study,amino alkylation was successfully integrated into the melem unit of polymeric carbon nitrides(PCN),which could efficiently drive the photocatalytic CO_(2) *** characterization and theoretical calculations revealed that the introduction of amino alkylation lowers the energy barrier for CO_(2) reduction into^(*)COOH intermediate,transforming the adsorption of^(*)COOH intermediate from the endothermic to an exothermic ***,the as-prepared materials demonstrated outstanding performance in photocatalytic CO_(2) reduction,yielding CO_(2)at a rate of 152.8μmol h^(-1) with a high selectivity of 95.4%and a quantum efficiency of 6.6%.

关键词： Polymeric carbonnitride Regulate intermediate Photocatalytic CO_(2)reduction Amino alkylation ^(*)COOH adsorption

Marketing Strategies for Reading Promotion Activities in Academic Libraries:A Case Study of the University of Shanghai for Science and Technology

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Journal of Contemporary Educational Research 2024年第4期8卷 16-22页

作者： fangting Ye University of Shanghai for Science and Technology Shanghai 200093China

In the contemporary digital age,traditional reading habits have been compromised by digital media,a situation that has forced academic libraries to adopt proactive marketing approaches to promote reading among students and *** article investigates the implementation of marketing strategies in promoting reading activities within academic libraries,taking the University of Shanghai for Science and Technology as a case *** paper explores various marketing strategies employed by academic libraries,including market segmentation,utilization of new media platforms,and the creation of personalized content for *** from an extensive literature review and real-world examples,the study establishes a framework for marketing reading promotion activities tailored to academic *** findings underscore how effective marketing strategies can enhance user participation,expand library influence,and optimize resource utilization.

关键词： University libraries Reading promotion Marketing strategies Library services Case study

The Optimization Path of Research Support Services in University Libraries from the Perspective of Affordance Theory

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Journal of Contemporary Educational Research 2024年第6期8卷 64-70页

作者： fangting Ye University of Shanghai for Science and Technology Shanghai 200093China

University libraries,as an integral component of university research capabilities,are tasked with serving education by providing research support to faculty and *** study adopts an affordance research perspective originating from ecological psychology to explore the optimization path of research support services in libraries in the new media *** on the characteristics of university library services,this research analyzes three aspects:production affordance,mobile affordance,and social affordance,and proposes practical recommendations to guide future research service practices of university libraries.

关键词： Academic libraries Affordance theory Research support services Social media Media integration

长江流域武汉段典型湖泊中微塑料的赋存特征及生态风险评估

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环境工程学报 2023年第12期17卷 3953-3959页

作者：王芳婷包科齐信中国地质调查局武汉地质调查中心武汉430205 长江水利委员会河湖保护与建设运行安全中心武汉430010

塑料污染在环境中具有普遍性,对生态系统具有潜在的风险性,为新兴的全球性环境问题。武汉境内江河纵横、百湖密布,是全球同纬度地区和长江中下游湖泊型湿地的典型代表。调查了武汉湖泊表层水体中微塑料的分布特征,并采用生态风险指数(RI... 详细信息

塑料污染在环境中具有普遍性,对生态系统具有潜在的风险性,为新兴的全球性环境问题。武汉境内江河纵横、百湖密布,是全球同纬度地区和长江中下游湖泊型湿地的典型代表。调查了武汉湖泊表层水体中微塑料的分布特征,并采用生态风险指数(RI)评估了微塑料的生态风险。结果表明,微塑料丰度为2 000~7 733 items·m^(-3),远城区湖泊表层水体微塑料丰度通常高于城乡结合区湖泊,中心城区微塑料丰度具有显著差异。湖泊中微塑料以纤维状为主,其次是碎片状,大小以<1 mm的小颗粒为主,主要颜色为透明和蓝色,主要成分为聚乙烯(PE)、聚丙烯(PP)和聚对苯二甲酸乙二醇酯(PET)。武汉市典型湖泊表层水体中MPs生态风险指数为601.5~8 954,均属于危险或高危等级,且PE、PP和PET的生态风险指数普遍较高。该研究结果可为城市湖泊中微塑料污染治理提供参考。

关键词：微塑料空间分布湖泊生态风险评估武汉

The Study on the Evolution of Urban Spatial Structure in Zhuhai City Based on Spatial Syntax

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Journal of Architectural Research and Development 2024年第4期8卷 40-44页

作者： Weiqiang Zhou fangting Liang School of Architecture and Urban Planning Zhuhai College of Science and TechnologyZhuhai 519000Guangdong ProvinceChina School of Architecture South China University of TechnologyGuangzhou 510641Guangdong ProvinceChina

With the deepening of the Guangdong-Hong Kong-Macao Greater Bay Area strategy and the accelerated integration and development of the east and west sides of the Pearl River Estuary,Zhuhai’s hub position is becoming more and more *** city of Zhuhai has a dense water network and is divided into two urban areas,the east and the west,under the influence of the Mordor Gate *** on the theory of spatial syntax,this paper carries out an analytical study on the urban spatial structure of Zhuhai,identifies the distribution characteristics of urban POIs,and provides theoretical support for the urban development of Zhuhai.

关键词： Spatial syntax POI data Transport network Urban spatial structure

Genome Mining and Biosynthesis Study of a Type B Linaridin Reveals a Highly Versatileα-N-Methyltransferase

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CCS Chemistry 2021年第3期3卷 1049-1057页

作者： fangting wang Wanqing Wei Junfeng Zhao Tianlu Mo Xin wang Xuedong Huang Suze Ma Shu wang Zixin Deng Wei Ding Yong Liang Qi Zhang Department of Chemistry Fudan UniversityShanghai 200433 State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic MaterialsChemistry and Biomedicine Innovation CenterSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023 State Key Laboratory of Microbial Metabolism School of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai 200240

Linaridins are a small but growing family of natural products belonging to the ribosomally synthesized and post-translationally modified peptide(RiPP)*** this study,a genome mining approach led to the identification of a novel linaridin,mononaridin(MON),from Streptomyces ***-frame deletion genetic knockout studies showed that,in addition to many genes essential for MON biosynthesis,monM encodes an S-adenosyl methionine(SAM)-dependentα-N-methyltransferase that is responsible for installing two methyl groups in the MON *** SAM,MonM also accepts ethyl-SAM and allyl-SAM,in which the methyl of SAM is replaced by an ethyl and an allyl,*** showed that ethyl-SAM and allyl-SAM have distinct reactivities in MonM catalysis,and this observation was further investigated in detail by density functional theory(DFT)***,MonM acts efficiently on nisin,a prototypic lantibiotic that is structurally very different from the native substrate,and the ability of MonM to transfer an allyl group to the nisin N-terminus allowed production of a fluorescently labeled nisin,which can be further used in microscopic cell *** studies provide new insights into linaridin biosynthesis and demonstrate the potential of linaridin methyltransferases in bioengineering applications.

关键词： substrate promiscuity SAM analogue dehydrobutyrine biosynthesis lanthipeptide