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Genes & Diseases 2023年第3期10卷 675-678页

作者： Mingshi Xu Gang Zhang Xiaofan Gu Fangqin Zhao Zhongmin Yang Xiongwen Zhang Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200241China

Chemoresistance is still one of the main obstacles to treat colorectal cancer(CRC).Substantial studies on biomarkers related to chemoresistance have emerged in recent years.Many microRNAs(miRNA)have been reported to involved in drug resistance and CRC.1 MiR-126-5p participates in malignant behaviors of numerous cancers.2,3 However,it is not known if miR-126-5p participates in multidrug resistance in CRC.Especially,the impact of miR-126-5p on drug resistance of CRC and its drug resistance mechanism have not been reported.

关键词： colorectal miR cancer

Preoperative P-wave duration as a predictor of atrial fibrillation after coronary artery bypass grafting: A prospective cohort study with meta-analysis

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International Journal of Nursing Sciences 2018年第2期5卷 151-156页

作者： fangqin Wu Ying Wu Wenyan Tao Haibo zhao Dongyan Shen School of Nursing Capital Medical UniversityBeijingChina Heart Center Beijing Chao-yang Hospital Affiliated to Capital Medical UniversityBeijingChina Heart Center Beijing Jian-gong HospitalBeijingChina

Objectives:Reported prediction rules for postoperative atrial fibrillation(AF)have suffered from inconsistent results and controversy surrounding the predictive value of a preoperative P-wave duration(PreOPWD).This study examined PreOPWD as a predictor for AF after coronary artery bypass grafting(CABG).Methods:Two-hundred-and-ninety-nine patients with sinus rhythm before off-pump CABG were recruited into the study.Patients'demographic and clinical data were evaluated prospectively.Patients were continuously monitored for the first seven postoperative days.Multiple logistic regressionwas used to determine significant predictors of AF.Findings were then combined with similar studies and a metaanalysis was performed.Results:Postoperative AF was observed in 33.1%of 299 patients.Patients with AF were older,had a prolonged PreOPWD,higher incidences of hypertension,aortic regurgitation,and mitral regurgitation.A cut-off point of PreOPWD105ms achieved a specificity of 74%,and a sensitivity of 65%for predictive of AF.Multivariate analysis showed that PreOPWD105ms(odds ratio[OR]4.63,95%confidence intervals[CI]2.66 to 8.03,P<0.001),age60 years(OR 2.72,95%CI 1.51 to 4.90,P<0.01)and hypertension(OR 2.10,95%CI 1.08 to 4.07,P<0.05)independently predicted postoperative AF.A meta-analysis of this data combined with those of ten other studies showed that PreOPWD was greater in patients with POAF,with a weighted mean difference of 3.95 ms(95%CI 1.97 to 5.92,P<0.001).Conclusion:This study confirmed,among other predictive characteristics,that PreOPWD is a powerful independent predictor of POAF.

关键词： Atrial fibrillation Coronary artery bypass Off-pump Cohort studies Meta-analysis

Experimental investigation and cost assessment of the salt production by solar assisted evaporation of saturated brine

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Chinese Journal of Chemical Engineering 2018年第4期26卷 701-707页

作者： Jing zhao Huaigang Cheng Xiao Wang Wenting Cheng fangqin Cheng Institute of Resources and Environmental Engineering State Environment Protection Key Laboratory of Efficient Utilization of Coal Waste Resources Shanxi University Taiyuan 030006 China College of Chemical Engineering Qinghai University Xining 817000 China

The technical feasibility and economy of solar heat collection-forced evaporation process are the keys to its practicality,especially its application in strong brine treatment.The operation cost of applying solar collection in salt manufacturing through depth evaporation of brine has been studied.For Na^+,K^+,Mg^(2+)//Cl^-,SO_4^(2-)-H_2O salt–water system,most of the Na Cl and all of the Carnallite were separated.The operation cost reached the optimum when the heat collection and evaporation were controlled at 75 and 55°C,respectively.When the solar radiation amount was 19557 kJ·m^(-2)·d^(-1),the solar collector area for producing Carnallite was about 34.27 m^2·(t salt)^(-1),and the operation cost was 13 USD?(t salt)^(-1).The energy consumption of salt manufacturing is at least 25%higher than that of natural evaporation.Regarding the economy,the solar assisted salt manufacturing process is recommended to be performed at a production scale of more than 20 tons per day.

关键词：盐水系统蒸发过程操作费用蒸发生产太阳试验性评价浸透

Hybrid microbial electrolytic/UV system for highly efficient organic pollutants removal

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Journal of Environmental Sciences 2019年第9期31卷 39-45页

作者： Yingying You Shaobin Huang Xuesong zhao Han Li fangqin Cheng Jinhua Wu Yongqing Zhang Shaofeng Zhou School of Environment and Energy South China University of Technology Guangzhou 510006 China School cf Environmental Science and Engineering Guangdong University of Technology Guangzhou 510006 China Department of Environmental Engineering Technical University cf Denmark DK-2800 Lyngby Denma Institute of Resources and Environmental Engineering Shanxi University Taiyuan 030006 China Guangzhou Taihe Water Ecology Technology Co. Ltd. Guangzhou 510220 China

This study for the first time proposed an efficient microbial electrolyte/UV system for Methyl Orange decomposition. With an external applied voltage of 0.2 V and cathode aeration of20 mL/min, H2O2 could be in-situ generated from two-electron reduction of oxygen in cathode, reaching to 8.1 mg/L in 2 hr and continued to increase. The pollutant removal efficiency of approximate 94.7% was achieved at initial neutral pH, with the activation of ·OH in the presence of UV illumination. Although the nature of its guiding principles remain on the vista of practical exploration, this proof-of-concept study provides an alternative operation pattern of solar–microbial hybrid technology for future wastewater treatment from a basic but multidisciplinary view.

关键词： Microbial electrolytic cell Hydrogen peroxide production Photo-Fenton reaction Organic pollutants removal Advanced oxidation process

Influence of Modified Medical Stone on Behavior of Sulfur during Pyrolysis of Longma Coal

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中国炼油与石油化工：英文版 2017年第1期19卷 81-91页

作者： Li Jingkuan zhao Shuguang Wang Baofeng Jin Yan Zhang Jinjun Cheng fangqin College of Electrical and Power Engineering Taiyuan University of Technology Taiyuan 030024 School of Chemistry & Material Science Shanxi Normal University Linfen 041004 Research Institute of Resources and Environment Engineering Shanxi University State Environmental Protection Key Laboratory of Efficient Utilization of Waste Coal Resources Taiyuan 030006

The influence of Co Mo P/medical stone and SO_4^(2-)/medical stone on sulfur behavior during the Longma coal pyrolysis was investigated in a fixed bed reactor. Moreover, the kinetics was also studied. It is found that adding SO_4^(2-)/medical stone was favorable to removal of volatile matter, while adding Co Mo P/medical stone could inhibit the emission of volatiles. Moreover, the results also showed that adding Co Mo P/medical stone made the total sulfur retention higher, while adding SO_4^(2-)/medical stone made the total sulfur retention lower. Adding modified medical stone was beneficial to removal of sulfate sulfur and pyritic sulfur, while it was beneficial to retaining organic sulfur in the residue. Furthermore, adding Co Mo P/medical stone and SO_4^(2-)/medical stone all could increase the emission of H_2S when the temperature was higher than 450℃. Judging from the kinetics study, it also can be known that addition of the natural minerals could result in a decrease of the pre-exponential factor and also change the apparent activation energy upon comparing the apparent activation energy and the pre-exponential factor of raw Longma coal at 435—537℃.

关键词： coal modified medical stone sulfur behavior pyrolysis kinetics

Effect of aluminum on microstructure and magnetic properties of sintered Nd-Fe-B magnets processed by grain boundary diffusion of Tb-Al

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Journal of Rare Earths 2023年第5期41卷 705-712,I0003页

作者： Tinghui Wang zhaokun Ma Qihang Zhu Lijing Yang Baosheng Liu Yu zhao Cheng Xu Bizhang Zheng fangqin Hu Jianzhong Li Qingfang Huang Zhenlun Song CAS Key Laboratory of Magnetic Materials and Devices Zhejiang Province Key Laboratory of Magnetic Materials and Application TechnologyNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Baotou Hidyree Technology Co. Ltd.Baotou 014030China Hangzhou Permanent Magnet Group Co. Ltd.Hangzhou 311231China Ningbo Permanent Magnetics Co. Ltd.Ningbo 315201China Fujian Key Laboratory for Rare Earth Functional Materials Longyan 366300China

The grain boundary diffusion process(GBDP)of Tb can improve the coercivity of sintered Nd-Fe-B magnets.In this study,the effect of AI on the diffusion of Tb in the GBDP was investigated.The content of diffused Tb-Al was precisely controlled by adjusting the magnetron sputtering process.The Tb equivalent of Al was also studied.Results show that AI promotes the diffusion of Tb deeper into the magnet,reducing the thickness of the shell in the core-shell structure.This study is helpful for further developing the process,reducing the consumption of heavy rare earth elements(Tb),and improving the coercivity of sintered Nd-Fe-B magnets.

关键词： Sintered Nd-Fe-Bmagnet Heavy rare earth elements Grain boundary diffusion process Coercivity

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基于贝叶斯网络的城市交通规划辅助决策模型

山东交通学院学报 2021年第3期29卷 32-38,49页

作者：赵芳琴安徽省公安教育研究院安徽合肥230031

为解决传统模型定位跟踪能力较差、交通规划决策线路覆盖不均衡的问题,构建基于贝叶斯网络的城市交通规划辅助决策模型。根据城市交通特征提取机动车的分布状态,得到城市某一随机路段的交通流量,利用贝叶斯网络定位跟踪交通移动目标,实... 详细信息

为解决传统模型定位跟踪能力较差、交通规划决策线路覆盖不均衡的问题,构建基于贝叶斯网络的城市交通规划辅助决策模型。根据城市交通特征提取机动车的分布状态,得到城市某一随机路段的交通流量,利用贝叶斯网络定位跟踪交通移动目标,实现交通流量和通行状态的实时追踪、结合跟踪结果,依据平衡分配规划指标构建城市交通规划辅助决策模型。结果表明:所建模型在不同移动速度下的跟踪误差小于2组传统模型;在城市交通线路规划决策上,该模型反馈的交通线路覆盖更加均衡,能够为整个城市区域的交通线路提供更加多样化的选择,模型的综合性能更优。

关键词：贝叶斯网络城市交通规划交通流量辅助决策模型

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桩基静载试验自平衡测试技术研究

萍乡学院学报 2017年第6期34卷 37-41页

作者：赵芳琴安徽公安职业学院交通管理系安徽合肥230011

介绍了桩基静载试验自平衡测试技术的理论依据,并结合实际静载试验,对佛山市和北公路主干线平胜大桥北引桥工程的某单桩进行自平衡法静载试验,通过检测桩的竖向承载力,得到了Q-S曲线分布、分层岩土的摩擦阻力、桩基端部阻力等,从而检验... 详细信息

介绍了桩基静载试验自平衡测试技术的理论依据,并结合实际静载试验,对佛山市和北公路主干线平胜大桥北引桥工程的某单桩进行自平衡法静载试验,通过检测桩的竖向承载力,得到了Q-S曲线分布、分层岩土的摩擦阻力、桩基端部阻力等,从而检验桩基承载的安全性。结论表明,基桩承载力自平衡测试法能测出基桩承载力,更加快捷、方便且不受施工场地条件的限制。研究课题能为同类基桩检测工程问题提供借鉴经验和参考依据。

关键词：桩基静载试验自平衡测试侧摩阻力

血管内皮生长因子-D在乳腺癌淋巴转移中的临床意义

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中国组织化学与细胞化学杂志 2016年第5期25卷 437-441页

作者：赵云霞崔芳芹蚌埠医学院病理生理学教研室蚌埠233030

目的探讨乳腺癌中血管内皮生长因子-D(VEGF-D)对淋巴管生成的作用及其与临床病理指标和预后的关系。方法应用免疫组织化学S-P法检测120例乳腺癌组织中VEGF-D的免疫反应性,同时以D2-40、podoplanin标记微淋巴管,计数微淋巴管密度(LVD),... 详细信息

目的探讨乳腺癌中血管内皮生长因子-D(VEGF-D)对淋巴管生成的作用及其与临床病理指标和预后的关系。方法应用免疫组织化学S-P法检测120例乳腺癌组织中VEGF-D的免疫反应性,同时以D2-40、podoplanin标记微淋巴管,计数微淋巴管密度(LVD),分析其与临床病理指标及预后的关系。结果乳腺癌组织中VEGF-D蛋白免疫反应阳性率、LVD值均明显高于乳腺纤维腺瘤组织;乳腺癌组织中VEGF-D蛋白免疫反应与淋巴结转移呈正相关,且LVD值与VEGF-D表达呈线性相关。结论 VEGF-D参与乳腺癌淋巴管生成,影响乳腺癌的预后。

关键词：乳腺癌微淋巴管密度

基于数字孪生的裂纹扩展结构健康管理方法研究

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振动与冲击 2023年第9期42卷 253-260,303页

作者：常琦陈乐乐赵恒谢方勤高鹤明西安理工大学机械与精密仪器工程学院西安710048

疲劳裂纹是金属结构常见的损伤之一,提出了一种构建数字孪生模型对裂纹扩展结构进行健康管理的方法。在数字孪生模型的建立过程中,首先建立裂纹结构的有限元模型,并结合Paris公式构建裂纹扩展模型;其次基于动态贝叶斯网络表示裂纹状态... 详细信息

疲劳裂纹是金属结构常见的损伤之一,提出了一种构建数字孪生模型对裂纹扩展结构进行健康管理的方法。在数字孪生模型的建立过程中,首先建立裂纹结构的有限元模型,并结合Paris公式构建裂纹扩展模型;其次基于动态贝叶斯网络表示裂纹状态随时间演化的规律;最后采用粒子滤波算法作为模型的推理算法,从而在数字空间中完成对裂纹扩展行为的描述。通过应变传感器实时在线监测裂纹状态,驱动孪生模型动态更新,实现裂纹扩展状态和剩余使用寿命更准确的预测。通过试验验证了该方法在裂纹扩展结构健康管理上的有效性与实用性。

关键词：数字孪生疲劳裂纹扩展健康管理动态贝叶斯网络粒子滤波算法