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Journal of Materials Science & Technology 2023年第20期151卷 119-149页

作者： Kai xu Chengcheng Zhan Ming Lou xuelian Xiao Ruonan Zhou fangming Wang Xiaofei Hu Yuan Yuan Keke Chang Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Rare-earth(RE)elements,known as“industrial vitamins”,have permeated modern lives,especially in high-tech *** the RE elements possess close chemical similarities and have been treated as“one element”in the periodic table,their characteristics differ from each *** RE microalloying effect is the crux to ameliorate the physicomechanical and thermochemical properties of materials,thereby the study of RE-related phase diagrams becomes indispensable to the design and optimization of RE-containing ***,in reality,the knowledge base in this area is considerably scarce compared with that of other commonly-used *** this work,the phase equilibria,phase diagrams,phase transformations,and some recent examples of RE-containing materials design are summarized,with which one can predict the RE solubilities,the RE precipitates,as well as the corresponding service *** attainment of enhanced materials’properties suggests that the thermodynamic rules extracted from the phase diagrams could serve as fundamental criteria for the successful development of novel RE-containing materials.

关键词： Rare-earth elements Phase diagrams CALPHAD Phase transformations Materials design

晚期内含子/溶酶体适配子和促分裂原活化蛋白激酶以及哺乳动物重组雷帕霉素激活物分子2基因的RNA干扰慢病毒载体的构建及其对巨噬细胞中炎性因子分泌的影响

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中华传染病杂志 2019年第10期37卷 605-609页

作者：伍婷徐方明苏丛刘艳艳兰燕虎李家斌安徽医科大学第一附属医院感染病科合肥230000 安徽医科大学附属巢湖医院感染疾病科 238000 安徽省细菌耐药性监控中心合肥230000

目的构建针对晚期内含子/溶酶体适配子和促分裂原活化蛋白激酶以及哺乳动物重组雷帕霉素激活物分子2(late endosomal/lysosomal adaptor,mitogen-activated protein kinase and mammalian target of rapamycin activator 2,lamtor2)基因的小发夹RNA慢病毒载体,探讨RNA干扰lamtor2基因表达后对肺炎克雷伯菌感染引起的巨噬细胞中炎性因子分泌的调控作用.方法针对小鼠lamtor2基因设计2对小发夹RNA(shlamtor2),重组构建慢病毒载体pLKO.1-puro shlamtor2,并感染小鼠巨噬细胞系RAW264.7细胞.设2个实验组,pLKO.1-puro shlamtor2-1感染组(sh1组)和pLKO.1-puro shlamtor2-2感染组(sh2组),以空载pLKO.1质粒感染RAW264.7细胞为对照组.通过实时定量PCR和蛋白质印迹法检测各组细胞中lamtor2基因表达.肺炎克雷伯菌感染sh2组细胞,采用实时定量PCR方法检测细菌感染后细胞内白细胞介素(interleukin,IL)-1β、IL-6和肿瘤坏死因子(tumor necrosis factor,TNF)-α表达水平的变化.2组间比较采用t检验.结果重组慢病毒颗粒pLKO.1-shlamtor2感染RAW 264.7细胞后,对照组lamtor2基因mRNA相对表达量为1.000±0.000,sh1组为0.596±0.125,sh2组为0.120±0.080,sh2组的lamtor2表达量低于sh1组,差异有统计学意义(t=3.399,P=0.015),且sh1组和sh2组的表达量均低于对照组,差异均有统计学意义(t=3.333、9.734,均P<0.05).以肺炎克雷伯菌感染的野生RAW 264.7细胞作为对照,sh2组细胞感染肺炎克雷伯菌后,细胞中的IL-1β(t=15.20)、IL-6(t=43.30)和TNF-α(t=12.67)表达水平均高于对照组(均P<0.01).结论针对lamtor2基因的小发夹RNA可通过RNA干扰机制稳定下调巨噬细胞中lamtor2基因的表达,基因下调对感染了肺炎克雷伯菌的巨噬细胞内的炎性因子的分泌有明显的促进作用.

关键词：巨噬细胞克雷伯菌,肺炎基因沉默 shRNA

Memory access integrity:detecting fine-grained memory access errors in binary code

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Cybersecurity 2019年第1期2卷 286-303页

作者： Wenjie Li Dongpeng xu WeiWu Xiaorui Gong Xiaobo Xiang Yan Wang fangming gu Qianxiang Zeng School of Cyber Security University of Chinese Academy of SciencesBeijingChina University of New Hampshire BeijingChina Key Laboratory of Network Assessment Technology CASBeijingChina Beijing Key Laboratory of Network Security and Protection Technology BeijingChina Institute of Information Engineering Chinese Academy of SciencesBeijingChina

As one of the most notorious programming errors,memory access errors still hurt modern software ***,they are hidden deeply in important software systems written in memory unsafe languages like C/C++.Plenty of work have been proposed to detect bugs leading to memory access ***,all existing works lack the ability to handle two ***,they are not able to tackle fine-grained memory access errors,e.g.,data overflow inside one data *** errors are usually overlooked for a long time since they happen inside one memory block and do not lead to program ***,most existing works rely on source code or debugging information to recover memory boundary information,so they cannot be directly applied to detection of memory access errors in binary ***,searching memory access errors in binary code is a very common scenario in software vulnerability detection and *** order to overcome these challenges,we propose Memory Access Integrity(MAI),a dynamic method to detect finegrained memory access errors in off-the-shelf binary *** core idea is to recover fine-grained accessing policy between memory access behaviors and memory ranges,and then detect memory access errors based on the *** key insight in our work is that memory accessing patterns reveal information for recovering the boundary of memory objects and the accessing *** on these recovered information,our method maintains a new memory model to simulate the life cycle of memory objects and report errors when any accessing policy is *** evaluate our tool on popular CTF datasets and real world *** with the state of the art detection tool,the evaluation result demonstrates that our tool can detect fine-grained memory access errors effectively and *** the practical impact,our tool has detected three 0-day memory access errors in an audio decoder.

关键词： Binary analysis Fine-grained Memory access error Detection

中药灌肠联合塌渍法对慢性肾衰瘙痒指数、肾功能指标的影响

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长春中医药大学学报 2024年第9期40卷 986-989页

作者：徐毅周波罗斗前陈方明宋小丽达州市中西医结合医院肾内科四川达州635000 达州市万源市中医院肾内科四川达州635000

目的探讨中药灌肠联合中药塌渍法在慢性肾衰竭(CKD3 ~5期)、皮肤瘙痒(血虚风湿瘀毒证)的临床有效性及安全性。方法本研究采用多中心、随机对照原则,共纳入病例90例,疗程4周。根据随机表法分为对照组和试验组,各45例。对照组维持西医... 详细信息

目的探讨中药灌肠联合中药塌渍法在慢性肾衰竭(CKD3 ~5期)、皮肤瘙痒(血虚风湿瘀毒证)的临床有效性及安全性。方法本研究采用多中心、随机对照原则,共纳入病例90例,疗程4周。根据随机表法分为对照组和试验组,各45例。对照组维持西医基础治疗,试验组为西医基础治疗加中药灌肠联合中药塌渍法治疗。观察2组治疗前后皮肤瘙痒情况、肾功能、睡眠质量,以及血常规、谷丙转氨酶、钙磷、甲状旁腺激素等指标,评估临床疗效和安全性。结果试验组总有效率为88.8%。对照组总有效率为44.4%。治疗后试验组血红蛋白、血肌酐、尿素氮、β2微球蛋白、血磷指标改善明显。2组未出现血小板、谷丙转氨酶、血钙等安全性指标异常。结论中药灌肠联合中药塌渍法治疗慢性肾衰竭患者皮肤瘙痒的治疗方法有效,安全性好,能有效改善患者皮肤瘙痒及肾功能。

关键词：中药灌肠中药塌渍法慢性肾功能衰竭皮肤瘙痒临床研究

发热伴血小板减少综合征和恙虫病患者临床特征和器官损害的差异

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中华传染病杂志 2019年第2期37卷 82-87页

作者：胡立芬徐方明夏玲玲马雪娇常啸伍婷李家斌安徽医科大学第一附属医院感染科合肥230022

目的分析发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome, SFTS)和恙虫病患者临床表现和器官损害的差异,探讨影响预后的因素。方法2014年10月至2017年6月安徽医科大学第一附属医院收治的SFTS患者49例,恙虫病患者1... 详细信息

目的分析发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome, SFTS)和恙虫病患者临床表现和器官损害的差异,探讨影响预后的因素。方法2014年10月至2017年6月安徽医科大学第一附属医院收治的SFTS患者49例,恙虫病患者16例。评估患者的一般资料(地区、年龄、性别和各种临床表现)。病程中连续监测血常规、肝肾功能、心肌酶谱、脂肪酶、淀粉酶、电解质、C反应蛋白、降钙素原、PT和活化部分凝血活酶时间(activated partial thromboplastin time,APTT)。正态分布的计量资料采用t检验,非正态分布的计量资料采用非参数检验,计数资料采用卡方检验进行统计学分析。结果SFTS患者年龄(62.1±15.5)岁,范围17~87岁;恙虫病患者年龄(56.1±9.2)岁,范围47~73岁;两组年龄差异无统计学意义(t=1.47,P=0.147)。SFTS患者中男性25例(51%),恙虫病患者中男性8例(50%),两组性别构成差异无统计学意义(χ^2=0.005,P=0.943)。SFTS和恙虫病患者头痛呕吐、体表淋巴结肿大、意识障碍、蛋白尿、血尿、肺部感染、多器官功能损伤和急性胰腺炎发生率比较差异均有统计学意义(χ^2值分别为8.82、4.38、8.71、11.17、7.88、5.56、4.35、9.43和8.13,P<0.05或0.01)。SFTS患者白细胞计数(Z=2.73)、中性粒细胞计数(Z=2.46)、淋巴细胞计数(Z=3.15)、血小板计数(Z=4.25)、白蛋白(Z=2.65)和血钠水平(t=2.10)低于恙虫病患者,比较差异均有统计学意义(P<0.05或0.01);AST(Z=2.94)、乳酸脱氢酶[lactate dehydrogenase,LDH(Z=3.42)]、肌酸激酶[creatine kinase,CK(Z=2.88)]、淀粉酶(Z=2.77)、脂肪酶(Z=2.82)、肌酐(Z=2.07)和尿素氮(Z=2.50)较恙虫病患者明显升高,比较差异均有统计学意义(P<0.05或0.01)。SFTS死亡16例,生存33例。死亡组与生存组年龄(t=3.33)、血小板计数(Z=2.55)、ALT(Z=2.10)、AST (Z=2.22)、LDH(Z=2.26)、CK(Z=3.50)、CK-MB (Z=3.10)、肌酐(Z=2.17)、尿素氮(Z=2.36)、血钠(t=2.65)比较差异均有统计学意义(P<0.05或0.01)。结论SFTS病情危重,病死率高,恙虫病预后较好,早期鉴别诊断并给予合理治疗是降低患者病死率的关键。

关键词：丛林斑疹伤寒发热伴血小板减少综合征新型布尼亚病毒器官损害

医教协同创新高职中药学专业人才培养模式研究

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药学教育 2020年第4期36卷 12-14,29页

作者：申海进李勇刘倩刘产明刘辉朱月琴徐方铭凡杭包莉常州卫生高等职业技术学校常州市中医医院常州市武进中医医院常州213000

基层中药人才的供给问题严重制约常州中医药事业的传承与发展。作为常州地区唯一开办中药学教育的学校,人才培养必须综合考虑常州社会民生的需要,充分体现常州地区特色。通过组建校院联盟,聘请具备相应资格的专业技术人员遵循传统方式... 详细信息

基层中药人才的供给问题严重制约常州中医药事业的传承与发展。作为常州地区唯一开办中药学教育的学校,人才培养必须综合考虑常州社会民生的需要,充分体现常州地区特色。通过组建校院联盟,聘请具备相应资格的专业技术人员遵循传统方式带徒授业,将师承教育全面融入院校教育,构建以服务能力提升为主线的医教协同培养新模式。

关键词：医教协同高职中药学专业院校教育师承教育人才培养模式

Interface microstructure and properties of submerged arc brazing tin-based babbit

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China Welding 2019年第2期28卷 45-49页

作者： Zhou fangming Li Jing xu Donghao Shi Mingxiao Jiangsu Province Key Laboratory of Advanced Welding Technology Jiangsu University of Science and TechnologyZhenjiang 212003China School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

The submerged arc brazing method was used to connect the tin-based babbit alloy with the steel *** microstructure of the submerged arc brazed Babbitt interface layer on the surface of Q235 B steel was analyzed by OM,SEM and EDS and the hardness properties of the joint interface layer were tested by MH-5 microhardness *** result of research shows that a layer of canine-shaped intermetallic compound with uneven thickness is formed at the interface,and the thickness is 10-20 μ*** interface layer includes two kinds of compound layers,namely the Fe Sn layer near the side of the steel substrate and FeSn layer near the side of the *** the interfacial reaction process,Fe atoms in the steel matrix dissolve into the liquid babbit alloy and form a certain concentration gradient at the *** farther from the interface,the lower the Fe atom *** growth of Gibbs free energy of Fe Sn is lower when the temperature is above 780.15 K,and the temperature during the welding process is much higher than 780.15 K,moreover the precipitation temperature of Fe Sn is ***,in the subsequent cooling process,Fe Sn is first precipitated from the interface near the side of steel matrix and then FeSn is precipitated from the interface near the side of babbit *** test showed that the intermetallic compound at the interface layer significantly improved the hardness properties.

关键词： tin-based babbitt alloy submerged arc brazing interfacial structure intermetallic compound hardness

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青海省5岁儿童龋齿患病状况及影响因素分析

中国妇幼健康研究 2024年第5期35卷 21-28页

作者：段锐许志华郭方明景强史雪莹魏迎玲周敏茹徐莉立青海大学医学部公共卫生系青海西宁810007 青海省疾病预防控制中心慢性非传染病预防控制所青海西宁810000

目的分析青海省2017年5岁儿童龋齿患病状况及影响因素。方法依据2017年第四次全国口腔健康流行病学抽样调查结果中青海省的数据,按地区、性别分别计算5岁儿童患龋指标,按地区分析5岁儿童家长对口腔健康的知识与态度、儿童饮食习惯及... 详细信息

目的分析青海省2017年5岁儿童龋齿患病状况及影响因素。方法依据2017年第四次全国口腔健康流行病学抽样调查结果中青海省的数据,按地区、性别分别计算5岁儿童患龋指标,按地区分析5岁儿童家长对口腔健康的知识与态度、儿童饮食习惯及儿童口腔卫生服务利用情况,并与2007年第三次全国口腔流行病学调查结果中青海省的数据进行比较;采用多因素Logistic回归分析儿童龋齿的影响因素。结果 2017年青海省5岁儿童患龋率为77.75%,较2007年上升了6.34个百分点(χ^(2)=5.818,P<0.05);其中城市地区儿童患龋率上升了10.81个百分点(χ^(2)=7.880,P<0.05),女童患龋率上升了14.00个百分点(χ^(2)=13.530,P<0.05)。2017年青海省5岁儿童龋齿填充率为1.76%,较2007年下降了0.14个百分点,其中城市地区儿童龋齿填充率高于农村地区儿童(χ^(2)=12.859,P<0.05)。2017年青海省5岁儿童龋均为4.69,较2007年增加了1.39。2017年青海省5岁儿童家长口腔健康知晓率为36.47%,较2007年上升了20.58个百分点;儿童家长对口腔健康持积极态度的比例为60.78%,较2007年下降了17.57个百分点。2017年青海省5岁儿童在过去12个月内出现牙痛或不适的比例为35.78%,而有就医经历者仅占19.27%,城市地区儿童有就医经历的比例高于农村地区儿童(χ^(2)=10.795,P<0.05)。多因素Logistic回归分析显示,从来没去医院看过牙(OR=0.374,95%CI:0.141~0.993)是儿童发生龋齿的保护因素(P<0.05);对孩子牙齿和口腔状况评价为一般(OR=2.006,95%CI:1.174~3.425)或差(OR=8.236,95%CI:2.326~29.166)、儿童家长认为刷牙预防牙龈出血不正确/不知道(OR=1.648,95%CI:1.120~2.424)均是儿童发生龋齿的危险因素(P<0.05)。结论 2017年青海省5岁儿童患龋率仍较高,应重点关注城市地区及女童的龋齿状况。实施有效的口腔综合干预措施,定期开展儿童口腔检查及对儿童的父母进行口腔知识宣教,能促使儿童树立正确的口腔健康观,养成良好的口腔健康行为,降低儿童患龋率。

关键词：儿童龋齿影响因素青海

Improved two-step hydrothermal process for acetic acid production from carbohydrate biomass

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Journal of Energy Chemistry 2015年第2期24卷 207-212页

作者： Zhibao Huo Yan Fang Guodong Yao xu Zeng Dezhang Ren fangming Jin School of Environmental Science and Engineering the State Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong University State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji University

An improved two-step process for converting carbohydrate biomass to acetic acid under hydrothermal conditions is proposed. The first step consists of the production of lactic acid from carbohydrate biomass, and the second step consists of conversion of the lactic acid obtained in the first step to acetic acid using CuO as an oxidant. The results indicated that CuO as an oxidant in the second step can significantly improve the production of high-purity acetic acid from lactic acid, and the maximum yield of acetic acid was 61%, with a purity of 90%. The yield of acetic acid obtained using the improved two-step hydrothermal process from carbohydrate biomass, such as glucose, cellulose and starch, was greater than that obtained using traditional two-step process with H_2O_2 or O_2. In addition, a proposed pathway for the production of acetic acid from lactic acid in the second step with CuO was also discussed. The present study provides a useful two-step process for the production of acetic acid from carbohydrate biomass.

关键词： carbohydrate biomass lactic acid CuO acetic acid hydrothermal reactions

基于液体射流破碎法制备粒径可控的聚乙烯醇微球

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生物医学工程研究 2024年第2期43卷 159-165页

作者：赵培许珂吴迪黄琳静杨志强邹方明赵成如夏毅然赛克赛斯生物科技股份有限公司济南250101 生物医用材料山东省工程研究中心济南250101

在工业生产中,聚乙烯醇(polyvinyl alcohol,PVA)微球多采用机械搅拌法制备,得到的微球粒径不可控、粒径分布宽、小粒径(100~300μm)微球产率低。为改善上述问题,本研究将液体射流破碎法应用于油包水(W/O)微球制备体系,制备了粒径可控、... 详细信息

在工业生产中,聚乙烯醇(polyvinyl alcohol,PVA)微球多采用机械搅拌法制备,得到的微球粒径不可控、粒径分布宽、小粒径(100~300μm)微球产率低。为改善上述问题,本研究将液体射流破碎法应用于油包水(W/O)微球制备体系,制备了粒径可控、粒径分布窄的PVA水凝胶微球。本研究系统研究了分散相流速、PVA浓度、加料装置内径及稳定剂浓度对微球粒径和粒径分布的影响。最终,采用分散相流速为40 mL/min、PVA浓度为7.0%、加料装置内径为400μm及稳定剂浓度为11.5%的条件,制备了平均粒径为146.00μm,粒径分布为1.63的PVA微球。该方法得到的小粒径微球产率高、批次间重复性良好、装置简单,可实现微球的规模化生产。

关键词：介入栓塞液体射流破碎法聚乙烯醇微球加料装置粒径分布