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Boosting MA-based two-dimensional Ruddlesden-Popper perovskite solar cells by incorporating a binary spacer

Journal of Energy Chemistry 2024年第8期95卷 348-356,I0008页

作者： Xue Dong Yinhao Tang Yiqun Li Xin Li Yuzhen Zhao Wenqi Song fangmin wang Shudong Xu Yipeng Zhou Chenxin Ran Zongcheng Miao Lin Song Zhongbin Wu Xi’an Key Laboratory of Advanced Photo-Electronics Materials and Energy Conversion Device Technological Institute of Materials&Energy Science(TIMES)Xijing UniversityXi’an 710123ShaanxiChina Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)Northwestern Polytechnical UniversityXi'an 710072ShaanxiChina School of Artificial Intelligence Optics and Electronics(iOPEN) Northwestern Polytechnical UniversityXi'an 710072ShaanxiChina

Two-dimensional Ruddlesden-Popper(2DRP)perovskite exhibits excellent stability in perovskite solar cells(PSCs)due to introducing hydrophobic long-chain organic ***,the poor charge transporting property of bulky organic cation spacers limits the performance of 2DRP *** by the Asite cation alloying strategy in 3D perovskites,2DRP perovskites with a binary spacer can promote charge transporting compared to the unary spacer ***,the superior MA-based 2DRP perovskite films with a binary spacer,including 3-guanidinopropanoic acid(GPA)and 4-fluorophenethylamine(FPEA)are *** films(GPA_(0.85)FPEA_(0.15))_(2)MA_(4)Pb_5I_(16)show good morphology,large grain size,decreased trap state density,and preferential orientation of the as-prepared ***,the present 2DRP-based PSC with the binary spacer achieves a remarkable efficiency of 18.37%with a V_(OC)of1.15 V,a J_(SC)of 20.13 mA cm^(-2),and an FF of 79.23%.To our knowledge,the PCE value should be the highest for binary spacer MA-based 2DRP(n≤5)PSCs to ***,owing to the hydrophobic fluorine group of FPEA and the enhanced interlayer interaction by FPEA,the unencapsulated 2DRP PSCs based on binary spacers exhibit much excellent humidity stability and thermal stability than the unary spacer counterparts.

关键词： Perovskite solar cells Two-dimensional Ruddlesden-Popper perovskite Binary spacers Stability

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山地多中心城市公园绿地生态系统文化服务供需匹配特征

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生态学报 2024年第13期44卷 5816-5827页

作者：骆畅王方民李高高杨朝现西南大学园艺园林学院重庆400715 重庆市地理信息与遥感应用中心重庆401147 西南大学资源环境学院重庆400715

城市公园绿地为居民提供了重要的生态系统文化服务,在促进居民身心健康和提高社会福祉方面发挥着关键作用。以典型山地城市重庆中心城区为例,构建供需匹配评估体系,利用多源数据量化供给与需求,识别供需平衡与协调发展关系。结果表明:(1... 详细信息

城市公园绿地为居民提供了重要的生态系统文化服务,在促进居民身心健康和提高社会福祉方面发挥着关键作用。以典型山地城市重庆中心城区为例,构建供需匹配评估体系,利用多源数据量化供给与需求,识别供需平衡与协调发展关系。结果表明:(1)重庆市中心城区城市公园绿地生态系统文化服务供需具有显著空间异质性,供给呈北高南低、分散布局的格局,需求呈中心高、外围低的格局;(2)生态系统文化服务供需失衡特征显著,其中52.38%的组团文化服务供给滞后,33.33%的组团属于供给超前状态;供需耦合协调指数平均值为0.50,协调发展程度空间分布呈“中心高、外围低”格局;(3)综合分析供需均衡与耦合协调结果发现,由于供给超前导致了外围城市组团的失调发展,而城市中心区域组团在供给滞后状态下维持了中等水平协调发展程度。总体来看,重庆市中心城区各组团存在不同程度的公园绿地生态系统文化服务供需错配,基于评估提出针对性的城市公园绿地优化策略,可为公园绿地的合理配置与规划提供重要支持。

关键词：城市公园绿地生态系统文化服务山地城市供需平衡协调发展

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A step to the decentralized real-time timekeeping network

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Chinese Physics B 2024年第1期33卷 183-191页

作者：王芳敏陈雨锋周建华蔺玉亭杨军王波王力军 State Key Laboratory of Precision Space-time Information Sensing Technology Department of Precision InstrumentTsinghua UniversityBeijing 100084China Key Laboratory of Photonic Control Technology Tsinghua UniversityBeijing 100084China Beijing Satellite Navigation Center Beijing 100094China Beijing Institute of Radio Metrology and Measurement Beijing 100854China

The composite time scale(CTS) provides an accurate and stable time-frequency reference for modern science and technology. Conventional CTS always features a centralized network topology, which means that the CTS is accompanied by a local master clock. This largely restricts the stability and reliability of the CTS. We simulate the restriction and analyze the influence of the master clock on the CTS. It proves that the CTS's long-term stability is also positively related to that of the master clock, until the region dominated by the frequency drift of the H-maser(averaging time longer than ~10~5s).Aiming at this restriction, a real-time clock network is utilized. Based on the network, a real-time CTS referenced by a stable remote master clock is achieved. The experiment comparing two real-time CTSs referenced by a local and a remote master clock respectively reveals that under open-loop steering, the stability of the CTS is improved by referencing to a remote and more stable master clock instead of a local and less stable master clock. In this way, with the help of the proposed scheme, the CTS can be referenced to the most stable master clock within the network in real time, no matter whether it is local or remote, making democratic polycentric timekeeping possible.

关键词： frequency synchronization network composite time scale frequency stability democratic timekeeping

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药物临床研究阶段申办者和生产场地变更研究三:美国药物临床试验及临床试验期间变更管理要求对我国完善监管体系的启示

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中国药事 2024年第5期38卷 508-515页

作者：于冰吴正宇陈江鹏陈园王方敏中国外商投资企业协会药品研制和开发工作委员会北京100020 诺和诺德(上海)医药贸易有限公司上海200131 沈阳药科大学亦弘商学院北京100055 上海市药品和医疗器械不良反应监测中心上海200040

目的:研究美国药物临床研究期间变更管理的法规监管要求和实施情况,并与我国当前相关监管法规建设和实施现状进行比较,为完善我国药物临床研究期间申办者和生产场地变更管理的监管体系提供参考。方法:对美国临床研究期间申办者和生产场... 详细信息

目的:研究美国药物临床研究期间变更管理的法规监管要求和实施情况,并与我国当前相关监管法规建设和实施现状进行比较,为完善我国药物临床研究期间申办者和生产场地变更管理的监管体系提供参考。方法:对美国临床研究期间申办者和生产场地变更的监管法规进行系统的梳理研究,结合我国临床研究期间变更管理情况提出建议。结果与结论:美国药物临床试验监管体系采用审批及检查相结合的方式,通过强化申办者负责制,在风险可控的前提下允许申办者及生产场地在不同国家(跨境)的情况存在。我国近年来药品审评审批改革不断深化,在临床研究期间的变更监管体系已初步建立,未来可分阶段细化我国临床试验期间变更的相关要求,以支持产业发展。

关键词：临床试验变更管理申办者变更生产场地变更药品注册

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Time shifting deviation method enhanced laser interferometry: ultrahigh precision localizing of traffic vibration using a urban fiber link

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Photonics Research 2022年第8期10卷 433-443页

作者： Guan wang Zhongwang Pang Bohan Zhang Pangmin wang Yufeng Chen Hongfei Dai Bo wang Lijun wang State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China Key Laboratory of Photonic Control Technology(Tsinghua University) Ministry of EducationBeijing 100084China

Using a fiber network as a huge sensing system will enrich monitoring methods of public infrastructures and geological disasters. With the traditional cross-correlation method, a laser interferometer has been used to detect and localize the vibration event. However, the random error induced by the cross-correlation method limits the localization accuracy and makes it not suitable for ultrahigh precision localizing applications. We propose a novel time shifting deviation(TSDEV) method, which has advantages over the cross-correlation method in practicability and localization accuracy. Three experiments are carried out to demonstrate the novelty of the TSDEV method. In a lab test, vibration localization accuracy of;.5 m is realized. In field tests, TSDEV method enhanced interferometry is applied to monitor the urban fiber link. Traffic vibration events on the campus road and Beijing ring road have been precisely localized and analyzed, respectively. The proposed technique will extend the function of the existing urban fiber network, and better serve the future smart city.

关键词： fiber laser interferometer

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药物临床研究阶段申办者和生产场地变更研究六:临床研究阶段申办者和生产场地跨境变更的风险分析

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中国药事 2024年第5期38卷 538-548页

作者：陈震王方敏吴正宇于冰陈江鹏高丽萍杨建红郑州大学药学院郑州450001 上海市药品和医疗器械不良反应监测中心上海200040 诺和诺德(上海)医药贸易有限公司上海200131 中国外商投资企业协会药品研制和开发工作委员会北京100020 沈阳药科大学亦弘商学院北京100055 国家药品监督管理局药品审评中心北京100076

目的:通过对临床研究阶段申办者、生产场地发生跨境变更时的风险变化进行分析,为申办者和生产场地的跨境变更管理提供参考。方法:基于申办者和生产场地不同组合情形的初始风险评价结果和采取风险管控措施后的风险再评价结果,比较分析不... 详细信息

目的:通过对临床研究阶段申办者、生产场地发生跨境变更时的风险变化进行分析,为申办者和生产场地的跨境变更管理提供参考。方法:基于申办者和生产场地不同组合情形的初始风险评价结果和采取风险管控措施后的风险再评价结果,比较分析不同组合情形之间发生变更时变更前后的“风险指数水平”变化。结果与结论:基于初始风险评价结果,有两种变更情形的风险指数水平在变更后较变更前降低;基于风险再评价结果,有四种变更情形的风险指数水平在变更后较变更前降低。

关键词：临床研究阶段申办者生产场地跨境变更风险分析

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Highly efficient catalyst for 1,1,2-trichloroethane dehydrochlorination via BN_(3) frustrated Lewis acid-base pairs

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Nano Research 2024年第6期17卷 4773-4781页

作者： Yuxue Yue fangmin Zuo Bolin wang Xiaoling Xian Jun Tang Haifeng Zhang Zilong Zhang Qingping Ke Wei Chen School of Chemical Engineering Northeast Electric Power UniversityJilin 132012China Industrial Catalysis Institute of Zhejiang University of Technology Hangzhou 310014China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China College of Chemistry and Chemical Engineering Anhui University of TechnologyMaanshan 243002China

In this study,a novel non-metallic carbon-based catalyst co-doped with boron and nitrogen(B,N)was successfully *** precisely controlling the carbonization temperature of a binary mixed ionic liquid,we selectively modified the doping site structure,ultimately constructing a B,N co-doped frustrated Lewis acid-base pair *** catalyst exhibited remarkable catalytic activity,selectivity,and stability in the dehydrochlorination reaction of 1,1,2-trichloroethane(TCE).Detailed characterization and theoretical calculations revealed that the primary active center of this catalyst was the BN_(3)*** to conventional graphitic N structures,the BN_(3)structure had a higher p-band center,ensuring superior adsorption and activation capabilities for TCE during the *** the BN_(3)site,three negatively charged nitrogen atoms acted as Lewis bases,while positively charged boron atoms acted as Lewis *** synergistic interaction facilitated the specific dissociation of chlorine and hydrogen atoms from TCE,significantly enhancing the 1,1-dichloroethene *** this research,we not only explored the active site structure and catalytic mechanism of B,N co-doped catalysts in depth but also provided an efficient,selective,and stable catalyst for the dehydrochlorination of TCE,contributing significantly to the development of non-metallic catalysts.

关键词： B N co-doped sites dehydrochlorination frustrated Lewis acid-base pairs catalytic mechanism

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Activation of the complement C3/C3aR pathway in the prefrontal cortex mediates methamphetamine addiction in rats

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中国药理学与毒理学杂志 2023年第7期37卷 525-526页

作者： wang fangmin CHEN Shanshan LIU Huizhen HUANG Xiaolei ZHOU Yiying WU Manqing LAI Miaojun ZHUANG Dingding LIU Huifen ZHOU Wenhua Zhejiang Provincial Key Lab of Addiction Ningbo Kangning Hospital School of Medicine Ningbo University

OBJECTIVE To investigate the role of the complement C3/C3aR signaling pathway in the prefrontal cortex and colon neuroglia cell interactions during methamphetamine(METH) addiction, to observe the effects of TLR4 inhibitors as well as complement C3 elimination on METH reward and relapse behavior, and to explore the neuroinflammatory mechanisms of complement C3 activation in METH addiction. METHODS(1) A 14 d and 28 d rat METH addiction model was established to observe the effects of TLR4 antagonist ibudilast 3 mg · kg-1and10 mg · kg-1on self-administration, reward motivation,relapse, and natural reward behavior in METH-trained 14 d rats and the effects of 0.02 mg·kg-1complement C3 antagonist on self-administration behavior in METH-trained 28 d rats.(2) Differences in the expression of TLR4, NF-κB,GRP94, C3, cathepsin L, CD68, and GFAP in the prefrontal cortex of each group were examined using Western blotting.(3) In addition, the expression of ATF6 in the prefrontal cortex of each group and the effects on neuronal and microglia/macrophage INOS, CD206 GRP94,and complement C3/C3aR. RESULTS(1) Endoplasmic reticulum stress occurred in neurons and microglia after METH exposure depending on GRP94 and unfolded protein responses to the ATF6 pathway. In addition, it activates the TLR4-NF-κB pathway.(2) Microglia with high complement C3/C3aR expression in the prefrontal cortex were recruited to synaptic pruning and phagocytic responses around neurons with high GRP94, complement C3/C3aR expression and these effects were blocked by complement C3 antagonists.(3) In the rectum, GRP94 functions as a molecular chaperone for complement C3 and cathepsin L. Crosstalk occurs between enteric neurons high in GRP94, complement C3, and macrophages high in C3aR, located in the submucosa,lamina propria, and muscular, respectively, and all of these effects are blocked by complement C3 antagonists.(4) Treatment with the TLR4 antagonist ibudilast inhibits self-administration, reward motivation, a

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The m^(6)A regulator KIAA1429 stabilizes RAB27B mRNA and promotes the progression of chronic myeloid leukemia and resistance to targeted therapy

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Genes & Diseases 2024年第2期11卷 993-1008页

作者： Fangyi Yao fangmin Zhong Junyao Jiang Ying Cheng Shuai Xu Jing Liu Jin Lin Jing Zhang Shuqi Li Meiyong Li Yanmei Xu Bo Huang Xiaozhong wang Jiangxi Province Key Laboratory of Laboratory Medicine Jiangxi Provincial Clinical Research Center for Laboratory MedicineDepartment of Clinical LaboratoryThe Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China

Chronic myeloid leukemia(CML)is a common adult *** the acute phase of the disease and the adverse effects of anti-cancer treatments can lead to a poor *** N6-methyladenine(m^(6)A)modification plays an important regulatory role in various physiological and pathological ***1429 is a known m^(6)A regulator,but the biological role of KIAA1429 in CML is *** this study,we observed that the m^(6)A levels and KIAA1429 expression were significantly up-regulated in patients with blast phase ***,KIAA1429 regulated the total level of RNA m^(6)A modification in the CML cells and promoted the malignant biological behaviors of CML cells,including proliferation,migration,and imatinib *** KIAA1429 in CML cells reduced the stability of RAB27B mRNA through the m^(6)A/YTHDF1 axis,consequently inhibiting CML proliferation and drug efflux,ultimately increasing the sensitivity of CML cells to ***,the knockdown of RAB27B also inhibited the proliferation and drug resistance of CML cells and promoted their ***,a recently developed anti-cancer agent,suppressed the expression of KIAA1429 and CML cell proliferation and promoted cell *** also inhibited the tumorigenesis of CML cells in *** combined use of rucaparib and imatinib enhanced the sensitivity of CML cells to *** study provides evidence that elevated KIAA1429 expression in the blast phase of CML enhances the stability of RAB27B mRNA through the m^(6)A/YTHDF1 axis to up-regulate RAB27B expression,thereby promoting CML *** exerts inhibitory effects on KIAA1429 expression and thus reduces CML progression.

关键词： Chronic myeloid leukemia KIAA1429 N6-methyladenine RAB27B Rucaparib YTHDF1

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药物临床研究阶段申办者和生产场地变更研究七:我国新药临床研究阶段申办者和生产场地及其变更的管理对策研究

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中国药事 2024年第5期38卷 549-557页

作者：杨建红王方敏吴正宇陈震顾瑶华连志荣芦臣书于冰夏雨李圆圆王宏扬武志昂张伟国家药品监督管理局药品审评中心北京100076 上海市药品和医疗器械不良反应监测中心上海200040 诺和诺德(上海)医药贸易有限公司上海200131 郑州大学药学院郑州450001 沈阳药科大学亦弘商学院北京100055 苏州工业园区药品管理中心苏州215127 阿斯利康全球研发中国中心北京100176 百济神州(北京)生物科技有限公司北京100022 中国外商投资企业协会药品研制和开发工作委员会北京100020 扬子江药业集团上海海路生物技术有限公司上海201203 再鼎医药(上海)有限公司北京100022 中国药品监督管理研究会北京100082

目的:提出我国新药临床研究阶段申办者和生产场地及其变更的管理对策,为适应药品研发新形势发展和完善我国药品监管政策提供参考。方法:对当前国内临床研究阶段申办者和生产场地管理中的问题进行分析,借鉴国外监管机构的管理经验,基于... 详细信息

目的:提出我国新药临床研究阶段申办者和生产场地及其变更的管理对策,为适应药品研发新形势发展和完善我国药品监管政策提供参考。方法:对当前国内临床研究阶段申办者和生产场地管理中的问题进行分析,借鉴国外监管机构的管理经验,基于风险原则进行综合评估研判,提出适合我国国情的相关管理对策。结果与结论:以确保受试者安全为核心,以鼓励创新、改善公众用药的可及性和可获得性为目标,提出关于强化申办者作为主体的责任、加强临床试验药物制备的质量管理、适度放开申请人/申办者与生产场地的跨境及跨境变更的试点情形的管理建议。

关键词：新药临床研究阶段申办者生产场地注册管理变更管理

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