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p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells

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Protein & Cell 2024年第11期15卷 840-857页

作者： Nini Wang Shangda Yang Yu Li fanglin Gou Yanling Lv Xiangnan Zhao Yifei Wang Chang Xu Bin Zhou Fang Dong Zhenyu Ju Tao Cheng Hui Cheng State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China CAMS Center for Stem Cell Medicine PUMC Department of Stem Cell and Regenerative MedicineTianjin 300020China The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease(Ministry of Education)Department of Cell BiologyTianjin Medical UniversityTianjin 300270China State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative MedicineCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China

The maintenance of hematopoietic stem cells(HSCs)is a complex process involving numerous cell-extrinsic and-intrinsic *** first member of the cyclin-dependent kinase family of inhibitors to be identified,p21,has been reported to perform a wide range of critical biological functions,including cell cycle regulation,transcription,differentiation,and so *** the previous inconsistent results regarding the functions of p21 in HSCs in a p21-knockout mouse model,we employed p21-tdTomato(tdT)mice to further elucidate its role in HSCs during *** results showed that p21-tdT+HSCs exhibited increased self-renewal capacity compared to p21-tdT−***18,a transcriptional repressor,was upregulated in p21-tdT+HSCs,and its knockdown significantly impaired the reconstitution capability of ***,p21 interacted with ZBTB18 to co-repress the expression of cKit in HSCs and thus regulated the self-renewal of *** data provide novel insights into the physiological role and mechanisms of p21 in HSCs during homeostasis independent of its conventional role as a cell cycle inhibitor.

关键词： hematopoietic stem cells self-renewal p21 Zbtb18 cKit

Consolidated Lightning Protection Methods of Landfill and Incineration Plants and Its Application Technology Investigation

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Meteorological and Environmental Research 2017年第5期8卷 100-104页

作者： Jia Pei Qi Jiuhan Zhu fanglin Hubei Lightning Protection Center Wuhan 430074China Nanjing University of Information Science&Technology Nanjing 210044China Wuhan Leiguang Lightning Protection Co. Ltd.Wuhan 430074China

Taking lightning-protection engineering of Wuhan Changshankou landfill and incineration plants for the example,in this article,we have discussed the integrated technology of direct lightning protection by early streamer emission lightning rod,lifting lightning rod and mobile lightning rod. Additionally,lightning protection methods and measures of landfill with large receiving area of lightning strike and landfill gas and incineration plant with irregular landfill cell are explored.

关键词： Landfill and incineration plants Landfill gas Consolidated direct lightning protection technology

Asymmetric Total Synthesis of (+)-21-epi-Eburnamonine Via a Photocatalytic Radical Cascade Reaction

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Natural Products and Bioprospecting 2021年第1期11卷 99-103页

作者： Yuan Huang fanglin Xue Hengmao Liu Fei Xue Xiao-Yu Liu Hao Song Yong Qin Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041SichuanChina

An asymmetric total synthesis of(+)-21-epi-eburnamonine has been *** features of the synthesis include a visible-light photocatalytic intra-/intramolecular radical cascade reaction to assemble the tetracyclic ABCD ring system,and a highly diastereoselective Johnson-Claisen rearrangement to establish the C20 all-carbon quaternary stereocenter.

关键词： Eburnamine-vincamine alkaloids Photochemistry Radical cascade reaction Johnson-claisen rearrangement

Particulate Amines in the Background Atmosphere of the Yangtze River Delta,China:Concentration,Size Distribution,and Sources

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Advances in Atmospheric Sciences 2021年第7期38卷 1128-1140页

作者： Wei DU Xinpei WANG Fengqin YANG Kaixu BAI Can WU Shijie LIU fanglin WANG Shaojun LV Yubao CHEN Jinze WANG Wenliang LIU Lujun WANG Xiaoyong CHEN Gehui WANG Key Laboratory of Geographic Information Science of the Ministry of Education School of Geographic SciencesEast China Normal UniversityShanghai 200241China School of Ecological and Environmental Sciences East China Normal UniversityShanghai 200241China Institute of Eco-Chongming Shanghai 200062China

Amines are important for new particle formation and subsequent growth in the ***,the processes involved are receiving more attention in recent ***,we conduct a field observation in order to investigate the atmospheric particulate amines at a background site in the Yangtze River Delta(YRD)during the summer of *** amines in PM_(2.5),i.e.,methylamine(MA),dimethylamine(DMA),diethylamine(DEA),and trimethylamine(TMA),were collected,twice daily and *** the campaign,our measurements found the concentrations of MA,DMA,DEA,and TMA of 15.0±15.0,6.3±6.9,20.4±30.1,and 4.0±5.9 ng m^-(3),respectively,and the four amines correlated well with each *** concentration of amines appear to be independent of whether they were collected during the day or *** MA and DMA exhibited a bimodal size distribution that had peaks at 0.67 and 1.1μm,suggesting amines preferably distribute on submicron *** layer height(BLH),relative humidity,and pH of aerosols were found have a negative relationship with amines,while aerosol liquid water content(ALWC)was found to have a positive relationship with *** PMF(positive matrix factorization)source apportionment results showed that the main source of amines in Chongming Island was of anthropogenic origin such as industrial and biomass emission,followed by marine sources including sea salt and marine biogenic *** that the YRD region is still suffering from complex atmospheric pollution and that the knowledge on aerosol amines is still limited,more field studies are in urgent need for a better understanding of the pollution characteristics of amines.

关键词： particulate amines Yangtze River Delta PM_(2.5) size distribution source

Insight into the nitrogen-vacancy center formation in type-Ib diamond by irradiation and annealing approach

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Materials Futures 2024年第4期3卷 181-191页

作者： Taiqiao Liu fanglin Lyu Tian Shao Diwei Zou Wei Shen Yuzheng Guo Yuan Zhong Chaoyang Chen Liangchen Yi Zhaofu Zhang Andy H Shen The Institute of Technological Sciences Wuhan UniversityWuhan 430072People’s Republic of China Gemmological Institute China University of GeosciencesWuhan 430074People’s Republic of China School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072People’s Republic of China Zhongnan Diamond Company Nanyang 473264People’s Republic of China Hubei Key Laboratory of Electronic Manufacturing and Packaging Integration Wuhan UniversityWuhan 430072People’s Republic of China

Comprehending the microscopic formation of nitrogen vacancy(NV)centers in nitrogen-doped diamonds is crucial for enhancing the controllable preparation of NV centers and quantum *** followed by annealing simulations for a type-Ib diamond with a 900 ppm concentration of isolated nitrogen is conducted along different orientations and at different annealing *** these simulations,molecular dynamics(MD)with smoothly connected potential functions are *** simulations revealed the dynamic formation process of the NV center,which was subsequently verified by first-principles calculations and *** results indicate that vacancies undergo one or multiple migrations by exchanging sites with neighboring *** are three mechanisms for the formation of NV centers:direct irradiation-induced NV formation,irradiation with further annealing to form NV and vacancy migration(VM)during the annealing ***,the results show that both VM and NV center formations are affected by *** study clarifies the formation of NV centers across multiple scales and provides a solid foundation for the targeted preparation of NV centers.

关键词： diamond NV center irradiation annealing molecular dynamics

The Association Between H3K4me3 and Antisense Transcription

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Genomics, Proteomics & Bioinformatics 2012年第2期10卷 74-81页

作者： Peng Cui Wanfei Liu Yuhui Zhao Qiang Lin Feng Ding Chengqi Xin Jianing Geng Shuhui Song fanglin Sun Songnian Hu Jun Yu CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100029China Institute of Epigenetics and Cancer Research School of MedicineTsinghua UniversityBeijing 100080China Graduate University of Chinese Academy of Sciences Beijing 100049China

Histone H3 lysine 4 trimethylation （H3K4me3） is well known to occur in the promoter region of genes for transcription activation. How- ever, when investigating the H3K4me3 profiles in the mouse cerebrum and testis, we discovered that H3K4me3 also has a significant enrichment at the 3＇ end of actively transcribed （sense） genes, named as 3＇-H3K4me3. 3＇-H3K4me3 is associated with ~15% of pro- tein-coding genes in both tissues. In addition, we examined the transcriptional initiation signals including RNA polymerase II （RNAPII） binding sites and Y-CAGE-tag that marks transcriptional start sites. Interestingly, we found that 3＇-H3K4me3 is associated with the ini- tiation of antisense transcription. Furthermore, 3＇-H3K4me3 modification levels correlate positively with the antisense expression levels of the associated sense genes, implying that 3＇-H3K4me3 is involved in the activation of antisense transcription. Taken together, our findings suggest that H3K4me3 may be involved in the regulation of antisense transcription that initiates from the 3＇ end of sense genes. In addition, a positive correlation was also observed between the expression of antisense and the associated sense genes with 3＇-H3K4me3 modification. More importantly, we observed the 3＇-H3K4me3 enrichment among genes in human, fruitfly and Arabidopsis, and found that the sequences of 3＇-H3K4me3-marked regions are highly conserved and essentially indistinguishable from known promoters in ver- tebrate. Therefore, we speculate that these 3＇-H3K4me3-marked regions may serve as potential promoters for antisense transcription and 3＇-H3K4me3 appear to be a universal epigenetic feature in eukaryotes. Our results provide a novel insight into the epigenetic roles of H3K4me3 and the regulatory mechanism of antisense transcription.

关键词： Antisense initiation and activation Antisense transcription H3K4me3

Effects of temperature on hydrostatic pressure-induced FE-AFE phase transition in PbLa(Zr,Sn,Ti)O_3 ceramics

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Chinese Science Bulletin 2001年第18期46卷 1574-1578页

作者： XU Zhuo, FENG Yujun, ZHENG Shuguang, JIN An, WANG fanglin & YAO XiElectronic Materials Research Laboratory (EMRL), Xi’an Jiaotong University, Xi’an 710049, China Electronic Materials Research Laboratory (EMRL) Xi’an Jiaotong University Xi’an China

Hydrostatic pressure-induced ferroelectric-antiferroelectric (FE-AFE) phase transition and the pressure dependence of dielectric properties in La-doped Pb(Zr,Sn, Ti)O3 ceramics were researched; the effects of temperature on hydrostatic pressure-induced FE-AFE phase transition and dielectric properties of the samples were studied. It was found that the temperature made the FE-AFE phase transition pressure decrease, and there existed the behavior of dielectric frequency dispersion and phase transition diffusion in the dielectric-pressure spectrum. These phenomena were very useful to enrich and develop the knowledge on the diffused phase transition behavior of polycomponent relaxor ferroelectric.

关键词： hydrostatic pressure pressure-induced phase transition FE-AFE phase transition dielectric-pressure spectrum.

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论市场主体退出权

重庆大学学报（社会科学版） 2013年第2期19卷 48-57页

作者：葛方林西南政法大学经济法学院重庆401120

随着中国市场经济制度的确立和不断完善,中国经济正由数量上的扩张转向质量上的提升。在这种情况下,市场主体是否拥有完整的市场退出权并且能够自由行使,就成为反映市场经济质量提升和发育成熟的标志之一。从学理维度看,关于市场主体退... 详细信息

随着中国市场经济制度的确立和不断完善,中国经济正由数量上的扩张转向质量上的提升。在这种情况下,市场主体是否拥有完整的市场退出权并且能够自由行使,就成为反映市场经济质量提升和发育成熟的标志之一。从学理维度看,关于市场主体退出权理论的一般性、基础性研究有助于完善市场主体退出权制度,修补其整个制度中的法律漏洞,减少法律冲突。从实践层面看,一个完善的市场退出权制度,一方面可以维持市场主体正常的新陈代谢,保持市场经济的动态平衡,另一方面可以实现宪政秩序下的制度竞争。

关键词：市场主体退出权公共利益制度竞争宪政秩序

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区间桁架结构动力特性分析的区间因子法

应用力学学报 2007年第3期24卷 477-481页

作者：王芳林高伟西安电子科技大学西安710071

对于具有区间参数的桁架结构的动力特性分析问题,提出了一种新的分析方法即区间因子法。利用区间因子法,结构材料物理参数、几何尺寸均可表达为其区间因子和确定性量的乘积,进而结构的固有频率和振型也可显式表达成区间因子们的函数。... 详细信息

对于具有区间参数的桁架结构的动力特性分析问题,提出了一种新的分析方法即区间因子法。利用区间因子法,结构材料物理参数、几何尺寸均可表达为其区间因子和确定性量的乘积,进而结构的固有频率和振型也可显式表达成区间因子们的函数。利用区间算法,推导出了结构固有频率和振型的上、下限与均值的计算表达式。通过算例,分析了结构参数的不确定性对结构动力特性的影响,并验证了本文模型和方法的合理性与可行性。本文方法的优点是能够反映结构某一参数的不确定性对结构动力特性的影响。

关键词：区间因子法区间参数桁架结构动力特性