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3-脱氮腺苷(3-DAA)加速小鼠及仓鼠细胞日本脑炎病毒复制并下调炎症因子水平

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细胞与分子免疫学杂志 2024年第3期40卷 235-243页

作者：李雪云姚敏李越香程治蓉张世哲张芳琳吕欣延安大学医学院陕西延安716000 空军军医大学基础医学院微生物与病原生物学教研室陕西西安710032 空军军医大学基础医学院学员五大队十八队陕西西安710032

目的利用N_(6)-甲基腺苷酸(m^(6)A)甲基化修饰抑制剂3-脱氮腺苷(3-DAA)初步明确其对日本脑炎病毒(JEV)复制的影响。方法JEV分别感染Neuro2a小鼠神经母细胞瘤细胞、N9小鼠小胶质细胞和BHK幼仓鼠肾传代细胞,然后用3-DAA处理;在C57BL/6成... 详细信息

目的利用N_(6)-甲基腺苷酸(m^(6)A)甲基化修饰抑制剂3-脱氮腺苷(3-DAA)初步明确其对日本脑炎病毒(JEV)复制的影响。方法JEV分别感染Neuro2a小鼠神经母细胞瘤细胞、N9小鼠小胶质细胞和BHK幼仓鼠肾传代细胞,然后用3-DAA处理;在C57BL/6成年小鼠足底接种JEV,腹腔注射3-DAA。实时定量PCR检测细胞与小鼠脑组织中JEV,白细胞介素1.(IL-1.)、IL-6、肿瘤坏死因子α(TNF-α)、单核细胞趋化蛋白1.MCP-1.、诱导型一氧化氮合酶(iNOS)、精氨酸酶1.Arg1.、α干扰素(IFN-α)、IFN-β、IFN-γ、CXC趋化因子配体1.(CXCL1.)的mRNA表达,Western blot法检测细胞及小鼠脑组织中JEV蛋白表达,观察小鼠生存情况,并通过HE染色检测小鼠脑部病理变化。结果3-DAA可剂量依赖性的促进JEV在小鼠和仓鼠细胞及小鼠脑组织的核酸复制与蛋白表达,显著加速JEV感染小鼠的发病进程,降低小鼠生存率。3-DAA的处理下调IL-6、TNF-α、CXCL1.、IL-1.、iNOS多种炎症因子的表达,免疫反应减弱。结论3-DAA促进JEV感染,加速被感染细胞及小鼠死亡,提示m^(6)A修饰可能对JEV复制起负向调控作用。

关键词： 3-脱氮腺苷(3-DAA) N^(6)-甲基腺苷酸(m^(6)A) 日本脑炎病毒(JEV) 复制

基于同态加密的电力调度数据抗泄露加密系统设计

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电子设计工程 2024年第8期32卷 87-91页

作者：赵麟祥郭芳琳王华寇小霞国网甘肃省电力公司甘肃兰州730050

电力调度数据需满足端到端转发的高转发率和低延迟要求,面对海量调度数据,在电力内网和外网的复杂体系中,各层数据易出现丢失、篡改等问题。为避免信息泄露事件的出现,设计一种基于同态加密的电力调度数据抗泄露加密系统。通过建立密码... 详细信息

电力调度数据需满足端到端转发的高转发率和低延迟要求,面对海量调度数据,在电力内网和外网的复杂体系中,各层数据易出现丢失、篡改等问题。为避免信息泄露事件的出现,设计一种基于同态加密的电力调度数据抗泄露加密系统。通过建立密码模板,联合获取明文样本,求解边缘加密系数取值范围,完成电力调度数据同态加密方案的制定。将File设备中存储的电力调度数据按需分配至上机位、下机位布局环境中,调节各级设备模块的运行状态,完成电力调度数据抗泄露加密系统设计。实验结果表明,该设计系统可有效保证明文样本与密文样本之间的对应编译关系,其对应编译关系准确率达到1.0%。在解决信息泄露问题方面具有突出价值。

关键词：同态加密电力调度数据密码模板抗泄露加密边缘加密系数编译关系

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载脂蛋白CⅢ与相关疾病的研究进展

实用检验医师杂志 2024年第3期16卷 285-288页

作者：牛小芳李洋王丽君何芳林兰州大学第一医院检验科甘肃兰州730000

载脂蛋白是脂蛋白中的蛋白部分,目前已明确有五大种类(ApoA、ApoB、ApoC、ApoD、ApoE)。其中ApoC由于相对分子质量较小,很容易在高密度脂蛋白(HDL)和含载脂蛋白之间转移,是可交换的载脂蛋白,可以调节血浆三酰甘油(TG)和胆固醇(CHO)水平... 详细信息

载脂蛋白是脂蛋白中的蛋白部分,目前已明确有五大种类(ApoA、ApoB、ApoC、ApoD、ApoE)。其中ApoC由于相对分子质量较小,很容易在高密度脂蛋白(HDL)和含载脂蛋白之间转移,是可交换的载脂蛋白,可以调节血浆三酰甘油(TG)和胆固醇(CHO)水平。ApoCⅢ作为ApoC家族中含量最丰富的载脂蛋白,在富含三酰甘油脂蛋白(TRL)的分解代谢中具有重要的调节作用,与多种疾病的发生密切相关,值得临床关注。该文从ApoCⅢ的结构和功能、与疾病的关系、发病机制以及药物使用研究等方面进行阐述。

关键词：载脂蛋白CⅢ 结构疾病发病机制

The structure of Crimean-Congo hemorrhagic fever virus Gc is revealed;many more still need an answer

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Virologica Sinica 2022年第4期37卷 634-636页

作者： Wei Ye Chuantao Ye Yongliang Hu Yangchao Dong Yingfeng Lei fanglin Zhang Department of Microbiology School of Preclinical MedicineAirforce Medical University:Fourth Military Medical UniversityXi'an710032China Department of Infectious Diseases Tangdu HospitalAirforce Medical University:Fourth Military Medical UniversityXi'an710038China Department of Dermatology The Eighth Medical Center of PLA General HospitalBeijing100091China

Crimean-Congo hemorrhagic fever virus(CCHFV)is regarded as one of the most deadly viruses,with mortality of up to 40%.Currently,no licensed vaccine with validated efficacy against CCHFV is *** uses Gn and Gc glycoproteins to bind and penetrate the cell,like other bunyaviruses(Hulswit et al.,2021..Thus,the desired vaccines are needed,to elicit a potent neutralizing antibody(NAb)response to counteract this process.

关键词： hemorrhagic fever Gc

Porous Hafnium-Containing Acid/Base Bifunctional Catalysts for Efficient Upgrading of Bio-Derived Aldehydes

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Journal of Bioresources and Bioproducts 2021年第3期6卷 243-253页

作者： fanglin Dai Junrong Luo Shenghui Zhou Xingzhen Qin Detao Liu Haisong Qi School of Chemistry and Chemical Engineering Guangxi UniversityNanning 530004China State Key Laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhou 510640China

Novel organic-inorganic hybrids were synthesized by using HfCl 4 and organic ligand 1.-pyrrole-2,5-dicarboxylic acid(PDCA)via a simple hydrothermal *** as-prepared Hf-PDCA were characterized by various techniques,such as electron microscope,N_(2) adsorption/desorption,and X-ray photoelectron *** them,the porous and nitrogen-containing Hf-PDCA as heterogeneous acid/base bifunctional catalyst was then applied to the catalytic hydrogenation of furfural to produce furfuryl alcohol(FFA).It exhibited excellent catalytic performance,with high conversion(98.8%)and selectivity(98.5%)by using 2-propanol as hydrogen source under a relatively mild ***,the Hf-PDCA has strong stability and durability,and can be recovered after the catalyst *** addition,the Hf-PDCA as catalyst can be extended to fabricate corresponding alcohols by catalytic conversion of other biomass derived aldehydes.

关键词： Furfural furfuryl alcohol catalytic transfer hydrogenation bifunctional catalyst organic-inorganic hybrid

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成人骨型Ⅲ类矫治前后前牙区变化的临床研究

中国卫生标准管理 2024年第9期15卷 106-109页

作者：何方林蒋立辉宋思吟吴萍中山市小榄人民医院口腔科广东中山528415

目的探讨成人骨型Ⅲ类患者矫治前后上下前牙区牙槽高度和宽度变化以及前牙区牙根位置变化。方法选取2020年5月—2022年1.月在中山市小榄人民医院口腔科正畸掩饰治疗的成人骨型Ⅲ类患者50例,比较正畸治疗前后患者上下颌前牙牙槽骨厚度和... 详细信息

目的探讨成人骨型Ⅲ类患者矫治前后上下前牙区牙槽高度和宽度变化以及前牙区牙根位置变化。方法选取2020年5月—2022年1.月在中山市小榄人民医院口腔科正畸掩饰治疗的成人骨型Ⅲ类患者50例,比较正畸治疗前后患者上下颌前牙牙槽骨厚度和高度,其中包括上前牙槽骨厚度(upper anterior alveolar bonethickness,UA)、上后牙槽骨厚度(upper posterior alveolar bone thickness,UP)、上牙槽骨总厚度(upper alveolar bone width,UW)、下前牙槽骨厚度(lower anterior alveolar bone thickness,LA)、下后牙槽骨厚度(lower posterior alveolar bone thickness,LP)、下牙槽骨总厚度(lower alveolar bone width,LW)、根中水平上前牙槽骨厚度(upper anterior alveolar bone thickness at the mid-root level,UA-m)、根中水平上后牙槽骨厚度(upper posterior alveolar bone thickness at the mid-root level,UP-m)、根中水平上牙槽骨总厚度(upper alveolar bone thickness at the mid-root level,UW-m)、根中水平下前牙槽骨厚度(lower anterior alveolar bone thickness at the mid-root level,LA-m)、根中水平下后牙槽骨厚度(lower posterior alveolar bone thickness at the mid-root level,LP-m)、根中水平下牙槽骨总厚度(lower alveolar bone thickness at the mid-root level,LW-m)以及上前牙槽骨高度(upper anterior alveolar bone height,UAH)和下前牙槽骨高度(lower anterior alveolarbone height,LAH)。结果正畸治疗前后患者UA、UP-m测量值比较,差异无统计学意义(P>0.05)。与正畸治疗前比较,正畸治疗后患者UP、UW、UA-m、UW-m测量值均显著降低(P0.05)。与正畸治疗前比较,正畸治疗后患者LA、LW、LP-m、LW-m测量值均降低(P1..62±0.57)mm、(9.65±0.48)mm,正畸治疗前患者上下颌前牙解剖牙根长度分别为(1..01.0.58)mm、(1..37±0.48)mm,与正畸治疗前比较,患者上下颌前牙解剖牙根长度明显减小(P<0.05)。结论成人骨型Ⅲ类患者进行正畸掩饰治疗后,牙槽形态会发生相应改变,患者上下前牙牙槽骨厚度和高度会一定程度地减少。因此,在矫治过程中应当对患者牙槽形态的变化给予密切关注,尽量避免上下前牙发生代偿性移动,从而降低不良反应情况发生的风险。

关键词：成人骨型Ⅲ类正畸掩饰治疗前牙区牙槽形态牙槽高度牙槽宽度代偿性移动

研究生现代药物分析及药物质量控制课程思政改革初探

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江西化工 2024年第3期40卷 114-117页

作者：迟宝珠郭芳林庹浔戴延凤胡昱南昌大学化学化工学院江西南昌330031

高校要落实“立德树人”的根本任务,就需对教学进行思政改革,将思政教育和课程教学合理融合。本文在此背景下概述了研究生现代药物分析及药物质量控制课程的思政目标,结合教学内容,从培养爱国情怀和文化自信,增强法治观念,提高职业素养... 详细信息

高校要落实“立德树人”的根本任务,就需对教学进行思政改革,将思政教育和课程教学合理融合。本文在此背景下概述了研究生现代药物分析及药物质量控制课程的思政目标,结合教学内容,从培养爱国情怀和文化自信,增强法治观念,提高职业素养,培养辩证唯物主义精神,培养科学发展观和培养创新精神共六个方面挖掘思政案例,并以线上线下相结合,设置学习小组,实施翻转课堂,充分发挥科研讲座的作用,定期在教学团队中采取课程思政课堂效果交流和优化课程考核评价体系的方式探讨并改进教学模式,以提高学生主动学习意识的若干方法,更好地发挥课程思政的育才功能,培养适应新时代的优质复合型人才。

关键词：课程思政制药工程教学模式改革研究生教育

Efficiently coupled glucose oxidation for high-value D-glucaric acid with ultradurable hydrogen via Mn(III)in acidic solution

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Nano Research 2023年第8期16卷 10748-10755页

作者： Junhua Li Yi Jiang Xu Zhang Yidan Huo fanglin Du Yongxiao Tuo Zhiyan Guo Dawei Chen Shenghua Chen College of Material Science and Engineering Qingdao University of Science and TechnologyQingdao 266042China National Innovation Platform(Center)for Industry-Education Integration of Energy Storage Technology Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Heavy Oil Processing College of New EnergyChina University of Petroleum(East China)Qingdao 266580China

The electrooxidation of the alcohol and aldehyde molecules instead of water coupled with H2 production has been proven to be effective for producing high-value fine chemicals under alkaline *** is also noteworthy that under acidic conditions,the stability of non-noble metal water oxidation catalysts remains a great challenge due to the lattice oxygen ***,we coupled the biomass-derived glucose oxidation for high-value D-glucaric acid(GRA)with ultra-durable hydrogen in acid solution over a Yb-MnO_(2)*** Mn^(3+)regulated by Yb atoms doped in MnO_(2)can effectively optimize the adsorption and desorption processes of the alcohol and aldehyde group and improve the intrinsic activity but cannot for *** catalyst exhibited extremely high activity and stability after 50 h for glucose oxidation,inhibiting the lattice oxygen process and MnO4−formation,while the activity was quickly lost within 0.5 h for water *** functional theory(DFT)calculations further demonstrated that glucose oxidation reaction proceeds preferentially due to the oxidation of aldehyde group with lower adsorption-free energy(−0.4 eV)than water(ΔG>0 eV),avoiding the lattice oxygen *** work suggests that biomass-derived glucose oxidation not only provides a cost-effective approach for high-value chemicals,but also shows an extremely potential as an alternative to acidic oxygen evolution reaction(OER)for ultradurable H2 production.

关键词： acidic water oxidation lattice oxygen mechanism(LOM) non-noble metal catalyst stability D-glucaric acid(GRA)

Spatial heterogeneity of soil water content in the reversion process of desertification in arid areas

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Journal of Arid Land 2011年第4期3卷 268-277页

作者： QuanLin MA Fang CHENG YouJun LIU fanglin Wang DeKuai ZHANG HuJia JIN Gansu Key Laboratory of Desertification Combating ＆ Minqin National Studies Station for Desert Steppe Ecosystem Gansu Desert Control Research Institute Lanzhou 730070 China Institute of Desertification Studies Chinese Academy of Forestry Beijing 100091 China

Sandy soils in arid,rain-fed environments have low and limited water content,which is a principal factor limiting vegetation development,and a key constraint controlling the structure and functions of the ecological systems in arid *** spatial heterogeneity of soil water content is a major soil property,and a focus of soil science and *** the southern edge of the Tengger Desert,sample plots were selected from mobile sand dunes in desertified lands that had been enclosed for 5,1. and 25 years,*** study explored the dynamic and spatial heterogeneity of soil water content in these different layers of soil that were also in the reversion process of *** results showed that the soil water content of the mobile sand dunes was highest when in the initial stages of the reversion process of desertification,while the soil water content in the 0-20 cm,20-40 cm and 40-60 cm layers of soil was 1.769%,3.01.%,and 2.967% respectively,presenting a restoring tendency after 25 years of *** were significant differences,as a whole,in the soil water content among different restoration stages and different soil layers,*** in soil water content,in different soil layers,at different restoration stages,exhibited exponential or spherical *** spatial distribution of soil water content exhibited a mosaic patch pattern with obvious spatial *** ratio of the heterogeneity of spatial autocorrelation to gross spatial heterogeneity was greater than 50%.The gross spatial heterogeneity of the 0-20 cm layer of soil improved gradually,while those of the 20-40 cm and 40-60 cm layers improved initially,then weakened in the reversion process of *** study revealed that restoration with sand-binding vegetation reduced soil water content,and increased its spatial heterogeneity in arid ***,after 25 years of vegetation-soil system restoration,the soil water content started to increase and it

关键词： Tengger Desert reversion process of desertification soil water content sand-binding vegetation geostatistical analysis