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Nano Research 2023年第1期16卷 613-623页

作者： fangfang zou Xia Liao Pengwei Song Shaozhe Shi Jia Chen Xiaohan Wang Guangxian Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China

The electrical conductivity of conductive polymer composites(CPCs)with a classical double percolated structure is highly connected to the phase morphology.However,lots of conductive fillers,which are added to guarantee CPCs’electrical conductivity,caused increased viscosity and limited phase coarsening in traditional atmosphere annealing.Herein,a novel processing method of supercritical carbon dioxide(scCO_(2)),assisted phase coarsening for polylactide acid(PLA)/polystyrene(PS)/multi-wall carbon nanotube(MWCNT)composites was explored.It was first proved that obviously coarsened conductive network of double percolation after scCO_(2) annealing was achieved,which benefited from CO_(2) plasticized polymer chains and thus decreased viscosity.Therefore,the electrical properties and electromagnetic interference(EMI)shielding performance of the composites were significantly improved.The percolation threshold of PLA/PS/MWCNT composites decreased from 0.31 wt.%to 0.16 wt.%,and EMI shielding effectiveness increased from 32.8 to 37.4 dB at 5 wt.%MWCNT loading.This work provides a simple,green,and effective way of post-processing to tailor the phase structure via varying conditions of annealing medium such as temperature,CO_(2) pressure,and time,and gains CPCs with improved electrical conductivity and EMI shielding performance.

关键词： double-percolated structure supercritical carbon dioxide annealing

LiZr_(2)(PO_(4))_(3)surface coating towards stable layer structure Li_(1.2)Mn_(0.54)Ni_(0.13)Co_(0.13)O_(2)cathode materials with long cycle performance

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Nano Research 2023年第2期16卷 2373-2382页

作者： Hao Yang Jie Wang Changsheng Xu Kewei Wu fangfang zou Xuebu Hu Zhongli Hu College of Chemistry and Chemical Engineering Chongqing University of TechnologyChongqing 400054China

Li-rich manganese-based materials are considered to be the mainstream cathode materials for next-generation lithium-ion batteries due to high discharge capacity and low cost,but poor cycle life and high temperature performance limit their development.Herein,LiZr_(2)(PO_(4))_(3)(LZPO)is coated on the surface of spherical Li_(1.2)Mn_(0.54)Ni_(0.13)Co_(0.13)O_(2)(LMNCO)material by a simple wet chemical method.The LZPO layer not only has the function of traditional coating layer to inhibit the occurrence of side reactions between electrolyte and LMNCO surface but also promotes the formation of spinel phase in the layered structure,increases the content of lattice oxygen,and reduces the content of absorbed oxygen.Thus,LZPO coated LMNCO has a more stable layered structure during cycling compared pure LMNCO,which improves effectively its long life and high temperature performance.The capacity loss rate of LZPO coated LMNCO is only 16.2%and 11.9%after 350 cycles at 25℃and 200 cycles at 50℃,respectively.Moreover,the capacity retention rate of the full cell composed of LZPO coated LMNCO and graphite is 70.7%after 200 cycles at 1.0 C.The coating layer toward stable surface structure can provide an idea for the modification of cathode materials,especially for Li-rich manganese-based materials.

关键词： Li_(1.2)Mn_(0.54)Ni_(0.13)Co_(0.13)O_(2) LiZr_(2)(PO_(4))_(3) layered structure cycle life high temperature

Edaravone-loaded poly(amino acid) nanogel inhibits ferroptosis for neuroprotection in cerebral ischemia injury

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 89-101页

作者： Yunhan Zhang Zhulin zou Shuang Liu fangfang Chen Minglu Li Haoyang zou Haiyan Liu Jianxun Ding Key Laboratory of Pathobiology Ministry of Education Department of AnatomyCollege of Basic Medical SciencesJilin UniversityChangchun 130061China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Department of Gastrointestinal Colorectaland Anal SurgeryChina-Japan Union Hospital of Jilin UniversityChangchun 130033China

Neurological injury caused by ischemic stroke is a major cause of permanent disability and death. The currently available neuroprotective drugs fail to achieve desired therapeutic efficacy mainly due to short circulation half-life and poor blood−brain barrier (BBB) permeability. For that, an edaravone-loaded pH/glutathione (pH/GSH) dual-responsive poly(amino acid) nanogel (NG/EDA) was developed to improve the neuroprotection of EDA. The nanogel was triggered by acidic and EDA-induced high-level GSH microenvironments, which enabled the selective and sustained release of EDA at the site of ischemic injury. NG/EDA exhibited a uniform sub-spherical morphology with a mean hydrodynamic diameter of 112.3 ± 8.2 nm. NG/EDA efficiently accumulated at the cerebral ischemic injury site of permanent middle cerebral artery occlusion (pMCAO) mice, showing an efficient BBB crossing feature. Notably, NG/EDA with 50 µM EDA significantly increased neuron survival (29.3%) following oxygen and glucose deprivation by inhibiting ferroptosis. In addition, administering NG/EDA for 7 d significantly reduced infarct volume to 22.2% ± 7.2% and decreased neurobehavioral scores from 9.0 ± 0.6 to 2.0 ± 0.8. Such a pH/GSH dual-responsive nanoplatform might provide a unique and promising modality for neuroprotection in ischemic stroke and other central nervous system diseases.

关键词： Poly(amino acid)nanogel Controlled drug delivery Inhibition of ferroptosis Neuroprotection Cerebral ischenia injury therapy

COX-2 derived prostanoid promote vascular smooth muscle cell proliferation response to injury

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COX-2 derived prostanoid promote vascular smooth muscle cell...

“双减”背景下小学语文高效课堂实施策略初探

中国生物化学与分子生物学会第十届会员代表大会暨全国学术...

作者： fangfang zou Jian Zhang Yanjun Gong Bing Xiao Lixia Xiong Ying Yu Institute for Nutritional Sciences Shanghai institute of Biological Sciences CAS Medical College of Nanchang University

Background and objective:Cyclooxygenase(COX) is the key enzyme in the biosynthesis of prostanoid and it plays an important role in the development of vascular inflammation such as atherosclerosis and post-angioplasty restenosis. Although selective inhibition of COX-2 increases the risk of heart attack and stock,little is known about its effect in vascular remodeling after interventional therapy.To investigate whether COX-2 derived prostanoid mediate vascular smooth muscle cell(VSMC) proliferation,femoral arterial intima were evaluated followed by wire-induced artery injury from both COX-2 knock out(KO) and COX- 1>COX-2 mice,where the COX-1 gene was knocked-into

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科教文汇 2023年第1期 155-158页

作者：邹方方蒙城县亳州师专附属小学淝河路校区安徽亳州233500

“双减”政策的提出给语文教学提出了新的挑战,传统的小学语文课堂出现的弊端亟待解决。如何顺应教育发展,落实“双减”政策要求,构建高效的小学语文课堂,是小学语文教师需要深思的问题。该文基于“双减”政策,对目前小学语文课堂教学... 详细信息

“双减”政策的提出给语文教学提出了新的挑战,传统的小学语文课堂出现的弊端亟待解决。如何顺应教育发展,落实“双减”政策要求,构建高效的小学语文课堂,是小学语文教师需要深思的问题。该文基于“双减”政策,对目前小学语文课堂教学现状进行了思考,并提出了一系列构建高效课堂的策略,从而促进学生语文综合素养的提升。

关键词：双减小学语文教学方式

数字乡村背景下新生代农民工返乡创业职业教育路径研究

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吉林省教育学院学报 2023年第8期39卷 167-172页

作者：邹芳芳周金龙戴毅福建农林大学

新生代农民工已成为新农村建设的主力军,发展优质的农民工返乡创业职业教育势在必行。但目前新生代农民工返乡创业职业教育存在一些困境,主要来源于农民工自身、培训组织和社会支持三个方面。数字乡村政策的推广为新生代农民工返乡创业... 详细信息

新生代农民工已成为新农村建设的主力军,发展优质的农民工返乡创业职业教育势在必行。但目前新生代农民工返乡创业职业教育存在一些困境,主要来源于农民工自身、培训组织和社会支持三个方面。数字乡村政策的推广为新生代农民工返乡创业职业教育带来了新的发展机遇。只有及时掌握数字技术,利用数字技术带来的便利条件,才能助推新生代农民工返乡创业,提高农民工职业教育的教学效果。基于此,本文从政府、社会、农民三个角度提出了相应的对策,以期推动新生代农民工返乡创业职业教育事业的顺利推进。

关键词：数字乡村新生代农民工返乡创业职业教育

“后扶贫时代”森林旅游地农户生计适应行为研究

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林业经济问题 2022年第3期42卷 262-268页

作者：邹芳芳陈少镪许国辉彭蝶林炜铃福建农林大学安溪茶学院泉州362400

基于社会-生态系统和可持续发展分析框架,通过对福建省泉州市安溪县芦田镇福岭村农户的实地调查,运用扎根理论分析农户生计适应行为的影响因素及其作用机理。结果表明:农户生计适应行为受农户自身、农户生计资本、脆弱性背景和政策制度... 详细信息

基于社会-生态系统和可持续发展分析框架,通过对福建省泉州市安溪县芦田镇福岭村农户的实地调查,运用扎根理论分析农户生计适应行为的影响因素及其作用机理。结果表明:农户生计适应行为受农户自身、农户生计资本、脆弱性背景和政策制度等因素的综合影响;农户生计适应行为因兼业形式、适应意愿和旅游发展阶段呈现不同模式。因此,在“后扶贫时代”,提出森林旅游地应优化农户旅游认知、完善人才培育政策、保障改善民生等意见。

关键词： “后扶贫时代” 森林旅游地生计适应行为扎根理论福岭村

大黄、芒硝外敷联合瓜蒌牛蒡汤治疗乳痈的疗效研究

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药品评价 2022年第13期19卷 790-792页

作者：邹芳芳李伟廖朝青新余市中医院江西新余338000

目的:分析大黄、芒硝外敷联合瓜蒌牛蒡汤治疗乳痈的疗效。方法:选择2019年3月至2021年11月在新余市中医院进行治疗的乳痈患者80例为研究对象,按照随机数字表法分为对照组和治疗组,每组各40例,对照组主要给予青霉素治疗,治疗组瓜蒌牛蒡... 详细信息

目的:分析大黄、芒硝外敷联合瓜蒌牛蒡汤治疗乳痈的疗效。方法:选择2019年3月至2021年11月在新余市中医院进行治疗的乳痈患者80例为研究对象,按照随机数字表法分为对照组和治疗组,每组各40例,对照组主要给予青霉素治疗,治疗组瓜蒌牛蒡汤联合大黄、芒硝贴敷进行治疗。比较两组的临床有效率、治疗前后肿块面积评分、治疗前后的乳房疼痛评分。结果:连续治疗6 d后,治疗组临床总有效率高于对照组(P0.05),治疗后治疗组评分低于对照组(P<0.05);治疗后两组患者乳房疼痛评分均下降,且治疗组低于对照组(P<0.05)。结论:大黄、芒硝外敷联合瓜蒌牛蒡汤治疗乳痈减小肿块和改善患者疼痛感,具有临床可行性。

关键词：乳腺炎乳痈大黄芒硝瓜蒌牛蒡汤疗效研究

从“滋阴补肾论”中药方六味地黄汤对细菌性阴道炎(阴虚内热型)疗效、阴道菌群、免疫功能影响探究

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中华中医药学刊 2022年第8期40卷 248-251页

作者：廖朝青钟海英邹芳芳肖孝凤夏淑芳新余市中医院江西新余338000

目的观察细菌性阴道炎(阴虚内热型)采取从“滋阴补肾论”中药方六味地黄汤治疗效果。方法纳入细菌性阴道炎(阴虚内热型)患者107例(2019年5月—2021年7月收治),将纳入的107例患者以随机数字表法分成参照组与治疗组,参照组53例患者,采... 详细信息

目的观察细菌性阴道炎(阴虚内热型)采取从“滋阴补肾论”中药方六味地黄汤治疗效果。方法纳入细菌性阴道炎(阴虚内热型)患者107例(2019年5月—2021年7月收治),将纳入的107例患者以随机数字表法分成参照组与治疗组,参照组53例患者,采取甲硝唑片+苯扎溴铵溶液外阴清洗治疗,治疗组54例患者甲硝唑片+苯扎溴铵溶液外阴清洗+中药方六味地黄汤治疗,数据观察:疗效、细菌学效果、治疗前后中医证候积分(阴道灼感、白带量少、外阴瘙痒、心烦易怒、头晕眼花、口干尿赤等)变化、症状消失时间(白带减少、外阴瘙痒、阴道疼痛等)、血清C反应蛋白(CRP)及白介素4(IL-4)、白介素6(IL-6)水平变化、阴道微生态情况及阴道菌群分布情况、阴道免疫细胞功能变化、性生活质量(FSFI)评分变化、不良反应。结果参照组患者治疗总有效率为96.30%(52/54),治疗组患者治疗总有效率为83.02%(44/53)(P0.05),治疗后两组患者中医证候积分(阴道灼感、白带量少、外阴瘙痒、心烦易怒、头晕眼花、口干尿赤等)、CRP及IL-4、IL-6水平、阴道微生态情况及阴道菌群分布情况、阴道免疫细胞功能指标、FSFI评分等指标均改善,与参照组比较,治疗组治疗后中医证候积分(阴道灼感、白带量少、外阴瘙痒、心烦易怒、头晕眼花、口干尿赤等)、CRP及IL-4、IL-6水平、阴道微生态情况及阴道菌群分布情况、阴道免疫细胞功能指标、FSFI评分等指标更佳(P<0.05)。治疗组见1例恶心,参照组见1例头晕,1例呕吐(P<0.05)。结论细菌性阴道炎(阴虚内热型)采取从“滋阴补肾论”中药方六味地黄汤治疗效果佳,安全可靠,患者阴道菌群情况及阴道免疫功能改善,值得应用。

关键词：滋阴补肾论六味地黄汤阴虚内热细菌性阴道炎阴道菌群阴道免疫功能

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用于温室降温的透明辐射薄膜研究

制冷学报 2024年第1期45卷 63-69页

作者：王晨曦邓芳芳邹豪杨荣贵王如竹上海交通大学制冷与低温工程研究所上海200240 华中科技大学能源与动力工程学院武汉430047

为了缓解夏季温室内高温导致的作物减产、绝产问题,本文给出了一种适用于夏季温室降温的辐射制冷薄膜。通过在常规近红外反射材料表面结合透明辐射层,可强化薄膜自身的天空辐射制冷效果。实验测试确定了该薄膜在不同波段的光学属性,其... 详细信息

为了缓解夏季温室内高温导致的作物减产、绝产问题,本文给出了一种适用于夏季温室降温的辐射制冷薄膜。通过在常规近红外反射材料表面结合透明辐射层,可强化薄膜自身的天空辐射制冷效果。实验测试确定了该薄膜在不同波段的光学属性,其中光合有效辐射波段透射率为65.9%,近红外波段透射率为20.9%,中红外波段反射率为88.1%。利用温室环境模型对比不同材料覆盖下的温室气温与降温能耗。模拟结果表明:该薄膜可使上海地区密闭温室内部温度降低11.4℃,选择反射层与透明辐射层的降温贡献分别为6.8℃与4.6℃。使用该薄膜,可使主动降温温室的热泵能耗降低26.9%,节能增产效果显著。

关键词：辐射制冷数值模拟光谱选择性红外辐射