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Food Science and Human Wellness 2024年第3期13卷 1475-1484页

作者： fangfang yan Qun Lu Chengming Wang Rui Liu College of Food Science and Technology Huazhong Agricultural UniversityWuhan 430070China Key Laboratory of Environment Correlative Dietology(Huazhong Agricultural University) Ministry of EducationWuhan 430070China Key Laboratory of Urban Agriculture in Central China Ministry of Agriculture and Rural AffairsWuhan 430070China

Our previous study has revealed that procyanidin A_(1)(A_(1))and its simulated digestive product(D-A,)can alleviate acrylamide(ACR)-induced intestine cell ***,the underlying mechanism remains *** this study,we elucidated the molecular mechanism for and D-A_(1) to alleviate ACR-stimulated IPEC-J2 cell *** slightly activated nuclear factor erythroid 2-related factor 2(Nrf2)signaling and its target genes,but this activation could not reduce intestine cell damage.A_(1) and D-A_(1) could alleviate ACR-induced cell damage,but the effect was abrogated in cells transiently transfected with Nrf2 small interfering RNA(siRNA).Further investigation confirmed that A_(1) and D-A_(1) interacted with Ketch-like ECH-associated protein 1(Keapl),which boosted the stabilization of Nrf2,subsequently promoted the translocation of Nrf2 into the nucleus,and further increased the expression of antioxidant proteins,thereby inhibiting glutathione(GSH)consumption,maintaining redox balance and eventually alleviating ACR-induced cell ***,there was no difference between A_(1) and D-A_(1) treated groups,indicating that A_(1) can tolerate gastrointestinal digestion and may be a potential compound to limit the toxicity of ACR.

关键词： Procyanidin A_1 Digestive products Acrylamide Nuclear factor erythroid 2-related factor 2(Nrf2) Intestinal cell damage

Sonochemical synthesis and characterization of magnetic separable Fe_(3)O_(4)-TiO_(2)nanocomposites and their catalytic properties

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International Journal of Smart and Nano Materials 2010年第4期1卷 278-287页

作者： Wanquan Jiang Xueping Zhang Xinglong Gong fangfang yan Zhong Zhang Department of Chemistry University of Science and Technology of China(USTC)Hefei 230026PR China CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern MechanicsUSTCHefei 230027PR China National Center for Nanoscience and Technology Beijing 100080PR China

A novel sonochemical method is described for the preparation of Fe_(3)O_(4)–TiO_(2)photocatalysts in which nanocrystalline titanium dioxide particles are directly coated onto a magnetic *** Fe_(3)O_(4)nanoparticles were partially embedded in TiO_(2)***_(2)nanocrystallites were obtained by hydrolysis and condensation of titanium tetraisopropyl in the presence of ethanol and water under high-intensity ultrasound *** method is attractive since it eliminated the high-temperature heat treatment required in the conventional sol–gel method,which is important in transforming amorphous titanium dioxide into a photoactive crystalline *** comparison to other methods,the developed method is simple,mild,green and *** magnetization hysteresis loop for Fe_(3)O_(4)–TiO_(2)nanocomposites indicates that the hybrid catalyst shows superparamagnetic characteristics at room *** activity studies confirmed that the as-prepared nanocomposites have high photocatalytic ability toward the photodegradation of RhB ***,the photodecomposition rate decreases only slightly after six cycles of the photocatalysis ***,these Fe_(3)O_(4)–TiO_(2)nanocomposites can be served as an effective and conveniently recyclable photocatalyst.

关键词： sonochemical synthesis recyclable photocatalyst TiO_(2)nanocomposite rhodamine B degradation

deCS:A Tool for Systematic Cell Type Annotations of Single-cell RNA Sequencing Data among Human Tissues

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Genomics, Proteomics & Bioinformatics 2023年第2期21卷 370-384页

作者： Guangsheng Pei fangfang yan Lukas M.Simon Yulin Dai Peilin Jia Zhongming Zhao Center for Precision Health School of Biomedical InformaticsThe University of Texas Health Science Center at HoustonHoustonTX 77030USA Therapeutic Innovation Center Baylor College of MedicineHoustonTX 77030USA Human Genetics Center School of Public HealthThe University of Texas Health Science Center at HoustonHoustonTX 77030USA MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences HoustonTX 77030USA Department of Biomedical Informatics Vanderbilt University Medical CenterNashvilleTN 37203USA CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China

Single-cell RNA sequencing(scRNA-seq)is revolutionizing the study of complex and dynamic cellular ***,cell type annotation remains a main challenge as it largely relies on a priori knowledge and manual curation,which is cumbersome and *** increasing number of scRNA-seq datasets,as well as numerous published genetic studies,has motivated us to build a comprehensive human cell type reference ***,we present decoding Cell type Specificity(deCS),an automatic cell type annotation method augmented by a comprehensive collection of human cell type expression profiles and marker *** used deCS to annotate scRNAseq data from various tissue types and systematically evaluated the annotation accuracy under different conditions,including reference panels,sequencing depth,and feature selection *** results demonstrate that expanding the references is critical for improving annotation *** to many existing state-of-the-art annotation tools,deCS significantly reduced computation time and increased *** can be integrated into the standard scRNA-seq analytical pipeline to enhance cell type ***,we demonstrated the broad utility of deCS to identify trait-cell type associations in 51 human complex traits,providing deep insights into the cellular mechanisms underlying disease pathogenesis.

关键词： Cell type-specific enrichment analysis scRNA-seq Cell type annotation Trait-cell type association Cell typemarkergene

Procyanidin A1 and its digestive products inhibit acrylamide-induced IPEC-J2 cell damage: apoptosis and cell cycle arrest

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Food Science and Human Wellness 2024年

作者： fangfang yan Si Qin Chengming Wang Wolfram Weckwerth Qun Lu Rui Liu Lab of Food Function and Nutrigenomics， College of Food Science and Technology， Hunan Agricultural University College of Food Science and Technology， Huazhong Agricultural University Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University)， Ministry of Education Molecular Systems Biology， Department of Functional and Evolutionary Ecology， University of Vienna

Our previous study has demonstrated that procyanidin A1(A1) and its simulated digestive product (D-A1) can prevent acrylamide （ACR）-induced cytotoxicity in small intestine cells. However， the potential mechanism remains poorly understood. In this study， ACR treatment was found to increase the levels of 8-hydroxy-deoxyguanine （8-OHdG） and phosphorated histone H2AX (γH2AX)， two DNA damage markers， thereby resulting in cell cycle arrest in the G2/M phase; whereas both A1and D-A1could prevent the phosphorylation of ataxia telangiectasia mutated （ATM） and checkpoint kinase 2 （Chk2）， and then regulate the expression of G2/M phase-related proteins， finally maintaining normal cell cycle progression. Moreover， A1and D-A1could increase the B cell lymphoma 2 （Bcl-2）/Bcl2-associated X （Bax） ratio and decrease the expression of cleaved caspase-3 and cleaved caspase-9 proteins to alleviate ACR-induced cell apoptosis， which might be related to the inhibition of the mitogen-activated protein kinase （MAPK） pathway. More importantly， A1showed no remarkable variation in inhibitory effect before and after digestion， indicating that it can endure gastrointestinal digestion and may be a promising phytochemical to alleviate ACR-induced intestinal cell damage.

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Preparation and Photocatalytic Ability of Magnetic Nanosized Titania/Expanded Graphite Light Catalyst

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矿物学报 2013年第S1期33卷 120-120页

作者： yan fangfang XIE Peng FENG Qiming Key Laboratory of Waste Solid Treatment and Resource Recycle of Ministry of Education

By using hydrothermal synthesis method, successively adding tetrabutyl titanate and expandable flake graphite in 40 mL 0.95% NH4Cl solution prepared the nano TiO2/expandable flake graphite, which was then settled in muffle furnace in the expansion of 10 s under 800 ℃ and got nanosized TiO2/expanded graphite. Synthesized that with CoFe2O4 by chemical coprecipitation method finally prepared magnetic nanosized photocatalyst TiO2/expanded graphite. Magnetic nanosized TiO2/expanded graphite was studied on the photodegradation performance of methyl orange solution and the magnetic recovery after the degradation of methyl orange solution. The experiment result showed that in 50 mL 25 mg/L methyl orange solution joined 120 mg loading 50% TiO2 of the expanded graphite, exposed to ultraviolet irradiation for 1 h, the methyl orange decolorization ratio was 90%. When the load of CoFe2O4 in nanosized TiO2/expanded graphite reached 40%, its magnetic recovery efficiency reached 94.3%.

关键词： nanosized titania cobalt ferrite nanoparticles expanded graphite photodegradation magnetic recovery

场面调度的现象学--高尔基戏剧《在底层》的电影改编

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南京师范大学文学院学报 2020年第2期 110-116页

作者：严芳芳中国传媒大学戏剧影视学院北京100024

高尔基的剧作《在底层》在世界电影史中有多部经典的电影改编。让·雷诺阿、黑泽明和黄佐临导演的版本是其中最具代表性的几部。文章从场面调度的视角考察电影与戏剧的异同。黑泽明的《低下层》最忠实于原作,他用摄影机镜头复刻了一个... 详细信息

高尔基的剧作《在底层》在世界电影史中有多部经典的电影改编。让·雷诺阿、黑泽明和黄佐临导演的版本是其中最具代表性的几部。文章从场面调度的视角考察电影与戏剧的异同。黑泽明的《低下层》最忠实于原作,他用摄影机镜头复刻了一个封闭、隔绝、不再有任何希望的空间;让·雷诺阿的场面调度是最为电影化的,通过景框构图来探索属于人物也属于电影本身的一种自由;黄佐临的《夜店》是最具症候性的,他用情节剧的形式保留了对这个黑暗世界中的小人物的某种同情,同时又通过女性人物的重影形象来尝试让她们从高度固化的现实中解脱。

关键词：《在底层》场面调度让·雷诺阿黑泽明黄佐临

Research on Kaolinite Type Pyrite Slag as Activity of Cement Mixed Material

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矿物学报 2013年第S1期33卷 115-115页

作者： XIE Peng HUANG yang yan fangfang FENG Qiming Key Laboratory of Solid Waste Treatment and Resource Recycle SWUSTMinistry of Education

Produced by the production of sulfuric acid from kaolinite type when the Fe2O3 and metakaolin together constitute the kaolinite type pyrite cinder is a typical industrial solid waste. Only in southern Sichuan China storage capacity has reached millions of tons, that caused serious impact on ecology and environment in this area. It also caused serious waste of resources. The magnetite concentrate and given priority to with partial kaolinite pyrite cinder tailings that were obtained by grinding and magnetic separation. This experiment studied the relationship composition and particle size with its activity when cinder tailings as cement mixed material. The results show that the particle size of D90 were 88 micron, 56 micron, 40 micron, the activity index were 1.036, 1.068, 1.102. The slag after magnetic separation is a kind of very good activity of cement mixed material. It can make good use of the industrial solid waste.

关键词： kaolinite type pyrite cinder magnetic separation activity of cement admixture activity index

Used for the Study of Nitrogen Fertilizer Slow-Release Carrier Life Sludge

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矿物学报 2013年第S1期33卷 46-46页

作者： LI Junlong XIE Peng yan fangfang QIU Qing FENG Qiming Key Laboratory of Solid Waste Treatment and Resource Recycle SWUSTMinistry of Education

After the sewage treatment, putting the wet sludge in which the heavy metal content is extremely low, corrupt and broken straw, bentonite, urea in proportioning according to the certain ratio, mixing well-distributed, taking the shape of Nitrogen slow-release fertilizers, doing the dynamic bioleaching test by the method of Artificial rainfall simulation, researching the slow-release characteristic, water retention. When the mass ratio of the wet sludge whose water content is 82.5%: bentonite: corrupt and broken straw: urea is 62.5: 12.5: 12.5: 12.5, drip washing the 10g Nitrogen slow-release fertilizers by the 80ml distilled water after 48h, the residue rate of urea is 29.63%; Under the room temperature of 25 ℃, 77%RH, moisture evaporate 46.32% after 60 h. The results demonstrate that the slow-release fertilizer has a good release-effect of nitrogen and water conservation effect. It provides the basic for the development and application of the sewage in the aspect of Nitrogen slow-release fertilizers.

关键词： life sludge bentonite corrupt and broken straw urea nitrogen slow-release fertilizers

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《东北虎》的电影语法:名词、动词、形容词

电影艺术 2022年第2期 104-106页

作者：孙柏严芳芳中国人民大学文学院中国劳动关系学院

《东北虎》在最大程度上搁置视听语言成规惯例的同时,对一种新的电影表达进行探索。其出发点在于名词化的固定镜头,以此表现凋敝的东北工业旧城中人们的生存境况,人与人之间关系的凝固、缺乏流动性借助大量标准化但无意义的双人镜头加... 详细信息

《东北虎》在最大程度上搁置视听语言成规惯例的同时,对一种新的电影表达进行探索。其出发点在于名词化的固定镜头,以此表现凋敝的东北工业旧城中人们的生存境况,人与人之间关系的凝固、缺乏流动性借助大量标准化但无意义的双人镜头加以表现,由此人物的行动或动作才能作为动词活化、生动起来,通过制造摩擦、剥离和裂隙来寻求人们之间情感的再度连接。影片结尾,一些常规电影语言以形容词的姿态重新介入,以营造恰到好处的情绪效果。

关键词：耿军《东北虎》电影语言双人镜头剪辑

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《我和我的祖国》：历史的提喻法

电影艺术 2019年第6期 44-47页

作者：孙柏严芳芳中国人民大学文学院中国劳动关系学院文化传播学院中国传媒大学戏剧影视学院

《我和我的祖国》完成了为庆祝中华人民共和国成立70周年献礼的任务。本文以“历史的提喻法”之叙事策略切入本片,讨论其如何将知识分子主体和科学技术的现代化作为一个贯穿始终的主题,从而组织起不同年代各个段落的历史叙述,以及这样... 详细信息

《我和我的祖国》完成了为庆祝中华人民共和国成立70周年献礼的任务。本文以“历史的提喻法”之叙事策略切入本片,讨论其如何将知识分子主体和科学技术的现代化作为一个贯穿始终的主题,从而组织起不同年代各个段落的历史叙述,以及这样的叙事策略带来的问题和它所遭遇的难题。本文最终立足于关于“中国电影”自我定位的讨论,中国电影是民族国家工业系统中的一部分,它的形式动机在钟表机芯或国防科技的画面内容中获得了对应的呈现。

关键词：《我和我的祖国》共和国史提喻法知识分子科学技术