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Acupuncture reduces sedative and anaesthetic consumption and improves pain tolerance in patients undergoing colonoscopy:a Meta-analysis

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Journal of Traditional Chinese Medicine 2024年第6期44卷 1091-1103页

作者： WANG Bingyu jin fangfang GAO Jiawei YANG Liuxin ZHANG Yali YUAN Xingxing ZHANG Yang School of Graduate Studies Heilongjiang University of Chinese MedicineHarbin 150040China Department of Gastroenterology Heilongjiang Academy of Traditional Chinese MedicineHarbin 150040China Department of Zhang Yali Senior Traditional Chinese Medicine Expert Studio Heilongjiang Academy of Traditional Chinese MedicineHarbin 150006China Department of Gastroenterology the First Affiliated Hospital of Heilongjiang University of Chinese MedicineHarbin 150040China

OBJECTIVE:To evaluate the effects of acupuncture anesthesia on the consumption of sedatives and anesthetics,pain,and time consumption in patients undergoing colonoscopy,thus providing evidence that acupuncture anesthesia should be extended to endoscopists and ***:Four English and four Chinese databases were searched for randomised controlled trials of acupuncture anaesthesia in patients undergoing colonoscopy,published from database inception to 1 March *** were consumption of sedatives and anaesthetics,pain tolerance,visual analog scale(VAS)score,the meantime consumption of examination,satisfaction,and adverse ***:Thirty-one randomized controlled trials with a total of 4790 participants were *** showed that acupuncture anaesthesia significantly reduced consumption of sedatives and anaesthetics[9 studies,n=944,standardized mean difference(SMD)=-0.82,95%CI(-1.31,-0.33),P=0.001],VAS score[9 studies,n=1790,mean difference(MD)=-1.13,95%CI(-1.70,-0.57),P<0.001],meantime consumption[21 studies,n=3799,MD=-2.09,95%CI(-3.15,-1.03),P<0.001]and adverse reactions of colonoscopy[7 studies,n=738,odds ratio(OR)=0.17,95%CI(0.10,0.28),P<0.001].Acupuncture also significantly improved pain tolerance[14 studies,n=1661,OR=7.05,95%CI(3.79,13.12),P<0.001],while no beneficial effects were found for satisfaction[7 studies,n=843,SMD=0.02,95%CI(-0.38,0.43),P=0.91].CONCLUSION:Acupuncture has beneficial effects on patients undergoing colonoscopy,particularly in reducing consumption of sedatives and anaesthetics,alleviating pain,shortening the time consumption of examination and preventing adverse *** an alternative,effective,inexpensive,and accessible approach,acupuncture anaesthesia should be extended to endoscopists and anaesthesiologists.

关键词： acupuncture anesthesia pain colonoscopy Meta-analysis

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The protective role of myeloid-derived suppressor cells in concanavalin A-induced hepatic injury

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Protein & Cell 2014年第9期5卷 714-724页

作者： Wenli Diao fangfang jin Bing Wang Chen-Yu Zhang Jiangning Chen Ke Zen Limin Li Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University Nanjing 210093 China People's Liberation Army 404 Hospital Weihai 264200 China

The mechanism underlying T cell-mediated fulminant hepatitis is not fully understood. In this study, we investigated whether myeloid derived suppressor cells （MDSCs） could prevent the concanavalin A （ConA）- induced hepatitis through suppressing T cell proliferation. We observed an increase in the frequencies of MDSCs in mouse spleen and liver at early stage of ConA treatment, implicating that the MDSCs might be involved in the initial resistance of mice against ConA- mediated inflammation. Subpopulation analysis showed that the MDSCs in liver of ConA-induced mice were mainly granulocytic MDSCs. Adoptive transfer of the bone marrow-derived MDSCs into ConA-treated mice showed that the MDSCs migrated into the liver and spleen where they suppressed T cell proliferation through ROS pathway. In addition, the frequencies of MDSCs in mice were also significantly increased by the treatment with immune suppressor glucocorticoids. Transfer of MDSCs into the regulatory T cell （Treg）- depleted mice showed that the protective effect of MDSCs on ConA-induced hepatitis is Treg-independent. In conclusion, our results demonstrate that MDSCs possess a direct protective role in T cell-mediated hepatitis, and increasing the frequency of MDSCs by either adoptive transfer or glucocorticoid treatment represents a potential cell-based therapeutic strategy for the acute inflammatory disease.

关键词： myeloid derived suppressor cells T cell-mediated hepatitis ROS glucocorticoids concanavalin A(ConA) adoptive transfer glucocorticoid treatment

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Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis

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Frontiers of Medicine 2022年第2期16卷 216-226页

作者： Shoubin Zhan Ping Yang Shengkai Zhou Ye Xu Rui Xu Gaoli Liang Chenyu Zhang Xi Chen Liuqing Yang fangfang jin Yanbo Wang Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy State Key Laboratory of Pharmaceutical Biotechnology and Department of PhysiologyJiangsu Engineering Research Center for MicroRNA Biology and BiotechnologyNJU Advanced Institute of Life Sciences(NAILS)School of Life SciencesNanjing UniversityNanjing 210023China Department of Clinical Laboratory The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210023China School of Medicine&Holistic Integrative Medicine Nanjing University of Chinese MedicineNanjing 210023China Department of Infectious Diseases The First People's Hospital of LianyungangThe First Affiliated Hospital of Kangda College of Nanjing Medical UniversityLianyungang 222000China

Hepatocellular carcinoma(HCC),which makes up the majority of liver cancer,is induced by the infection of hepatitis B/C *** are needed to facilitate the early detection of HCC,which is often diagnosed too late for effective *** tRNA-derived small RNAs(tsRNAs)play vital roles in tumorigenesis and are stable in ***,the diagnostic values and biological functions of circulating tsRNAs,especially for HCC,are still *** this study,we first utilized RNA sequencing followed by quantitative reverse-transcription PCR to analyze tsRNA signatures in HCC *** identified tRF-Gln-TTG-006,which was remarkably upregulated in HCC serum(training cohort:24 HCC patients vs.24 healthy controls).In the validation stage,we found that tRF-Gln-TTG-006 signature could distinguish HCC cases from healthy subjects with high sensitivity(80.4%)and specificity(79.4%)even in the early stage(Stage I:sensitivity,79.0%;specificity,74.8%;155 healthy controls vs.153 HCC patients from two cohorts).Moreover,in vitro studies indicated that circulating tRF-Gln-TTG-006 was released from tumor cells,and its biological function was predicted by bioinformatics assay and validated by colony formation and apoptosis *** summary,our study demonstrated that serum tsRNA signature may serve as a novel biomarker of HCC.

关键词： tsRNA biomarker hepatocarcinoma

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PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1α

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Genes & Diseases 2024年第4期11卷 353-367页

作者： Yu Wei Dian Zhang He Shi Husun Qian Hongling Chen Qian Zeng fangfang jin Yan Ye Zuli Ou Minkang Guo Bianqin Guo Tingmei Chen Key Laboratory of Clinical Laboratory Diagnostics(Ministry of Education) College of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer HospitalChongqing 400030China

Pyruvate dehydrogenase kinase 1(PDK1)phosphorylates the pyruvate dehydroge-nase complex,which inhibits its *** pyruvate dehydrogenase complex inhibits the tricarboxylic acid cycle and the reprogramming of tumor cell metabolism to glycolysis,which plays an important role in tumor *** study aims to elucidate how PDK1 pro-motes breast cancer *** found that PDK1 was highly expressed in breast cancer tissues,and PDK1 knockdown reduced the proliferation,migration,and tumorigenicity of breast cancer cells and inhibited the HIF-1α(hypoxia-inducible factor 1α)*** investigation showed that PDK1 promoted the protein stability of HIF-1αby reducing the level of ubiquitination of HIF-1α.The HIF-1αprotein levels were dependent on PDK1 kinase ***,HIF-1αphosphorylation at serine 451 was detected in wild-type breast cancer cells but not in PDK1 knockout breast cancer *** phosphorylation of HIF-1αat Ser 451 stabilized its protein levels by inhibiting the interaction of HIF-1αwith von Hippel-Lindau and prolyl hydroxylase *** also found that PDK1 enhanced HIF-1αtranscriptional *** summary,PDK1 enhances HIF-1αprotein stability by phosphorylating HIF-1αat Ser451 and promotes HIF-1αtranscriptional activity by enhancing the binding of HIF-1αto ***1 and HIF-1αform a positive feedback loop to promote breast cancer progression.

关键词： Breast cancer HIF-1α PDK1 Protein phosphorylation Transcriptional activity

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B掺杂制备Li_(1+2x)Mn_(0.8)Fe_(0.2)P_(1-x)B_xO_4锂电池正极材料

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硅酸盐学报 2017年第1期45卷 1-8页

作者：赵德任丽靳芳芳河北工业大学高分子科学与工程研究所天津300130

采用水热法制备富锂相正极材料Li_(1+2x)Mn_(0.8)Fe_(0.2)P_(1-x)B_xO_4(x≤0.10),通过X射线衍射、激光粒度仪、扫描电子显微镜对所得样品进行表征。将所得正极材料组装成电池,采用恒流充放电、循环伏安和交流阻抗测试其电化学性能。结... 详细信息

采用水热法制备富锂相正极材料Li_(1+2x)Mn_(0.8)Fe_(0.2)P_(1-x)B_xO_4(x≤0.10),通过X射线衍射、激光粒度仪、扫描电子显微镜对所得样品进行表征。将所得正极材料组装成电池,采用恒流充放电、循环伏安和交流阻抗测试其电化学性能。结果表明:B原子进入晶格,取代P原子位置,形成固溶体。当B的取代量x=0.02时,富锂相正极材料Li_(1.04)Mn_(0.8)Fe_(0.2)P_(0.98)B_(0.02)O_4的电化学性能最好,0.1C时放电比容量为157.9 mA·h/g、5C时为102.7 mA·h/g,分别优于未经B掺杂的LiMn_(0.8)Fe_(0.2)PO_4的149.7和85.3 mA·h/g。

关键词：磷酸锰锂水热法硼掺杂锂二次电池

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The Relationship Between Maternal Serum Vitamin D Levels and Infant Neurodevelopment and Anthropometry:an Observational Prospective Study

The Relationship Between Maternal Serum Vitamin D Levels and...

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2018年浙江省医学会儿科学分会学术年会

作者： meizhu chi Lin Zhu fangfang jin The First Affiliated Hospital of Wenzhou Medical College

Background:Vitamin D deficiency is common during *** vitamin D levels have been reported to contribute to bone homeostasis and brain *** aim was to determine whether there is a relationship between serum vitamin D levels,neurodevelopment and anthropometry in Chinese ***:A total of 160 women gave birth to 160 healthy full term infants who were followed up for 6 *** serum Vitamin D levels were assayed by electrochemical luminescence immunoassay at 28 weeks *** outcome measures were cognitive,motor,socio-emotional and language scores using the Bayley Scales of Infant Development and infant growth at 6 months of age.

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现代物流业对进出口贸易影响的实证研究

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科技管理研究 2012年第8期32卷 124-127页

作者：金芳芳中国计量学院经济与管理学院浙江杭州310018

基于浙江省1986—2009年货物周转量与进出口贸易的相关数据进行回归分析,以验证现代物流业对进出口贸易是否有影响。接着,根据弹性理论建立计算模型,定量测算物流产业对进出口贸易增长的促进程度。结果表明:物流业发展对进出口贸易增长... 详细信息

基于浙江省1986—2009年货物周转量与进出口贸易的相关数据进行回归分析,以验证现代物流业对进出口贸易是否有影响。接着,根据弹性理论建立计算模型,定量测算物流产业对进出口贸易增长的促进程度。结果表明:物流业发展对进出口贸易增长具有显著的促进作用;就浙江而言,物流业发展水平每提高1%,进出口贸易额平均提高2.90%;物流发展对进出口贸易的促进程度随时间变化有所差异。最后,提出若干建议。

关键词：现代物流进出口贸易相关分析弹性分析

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中国闲置耕地的区域分布及影响因素研究

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资源科学 2018年第4期40卷 719-728页

作者：金芳芳辛良杰中国科学院地理科学与资源研究所陆地表层格局与模拟重点实验室北京100101 河南大学环境与规划学院开封475004

耕地闲置已经成为中国的普遍现象,这与中国政府耕地集约利用的主张相违背,也直接影响到农业产量。本文利用中国家庭收入调查(CHIP)数据分析了2002—2013年中国闲置耕地的时空变化特征,采用Tobit模型探讨了影响耕地闲置的主要因素。结果... 详细信息

耕地闲置已经成为中国的普遍现象,这与中国政府耕地集约利用的主张相违背,也直接影响到农业产量。本文利用中国家庭收入调查(CHIP)数据分析了2002—2013年中国闲置耕地的时空变化特征,采用Tobit模型探讨了影响耕地闲置的主要因素。结果表明:(1)2002—2013年间,中国闲置耕地比例从0.32%上升到5.72%,可能无法避免"森林转型"引致的耕地在空间上收缩现象,从区域上看,东中西部闲置耕地占耕地总面积的比例分别为0.81%、6.91%与7.65%;(2)全国层面上,户主的健康状况、家庭耕地总面积、家庭农业收入成为农户耕地闲置与否的最关键因素。户主健康恶化与较多的耕地面积均会促使农户闲置耕地,而家庭农业总收入的增加能起到促进农户充分利用耕地的作用;(3)平原地区的土地流转能有效利用耕地资源,防止土地闲置,而在山区土地流转对耕地闲置的影响不明显。建议积极建立基层的土地流转中介平台,以推动平原地区的土地流转与全国层面的农业规模经营。

关键词：闲置耕地区域分布影响因素土地流转中国家庭收入调查(CHIP)

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X100管线钢的CCT曲线

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金属热处理 2014年第4期39卷 49-52页

作者：刘守显靳芳芳李钧正河北钢铁集团邯钢公司技术中心河北邯郸056015

用Gleeble-3500热/力模拟试验机对X100管线钢进行热模拟试验,研究X100管线钢经轧制变形后连续冷却过程中的相变规律,采用膨胀法和金相法建立动态CCT曲线。结果表明,随着冷却速率的增大,X100管线钢的组织由铁素体逐步转变为贝氏体组织,... 详细信息

用Gleeble-3500热/力模拟试验机对X100管线钢进行热模拟试验,研究X100管线钢经轧制变形后连续冷却过程中的相变规律,采用膨胀法和金相法建立动态CCT曲线。结果表明,随着冷却速率的增大,X100管线钢的组织由铁素体逐步转变为贝氏体组织,硬度呈上升趋势。

关键词： X100管线钢冷却速率动态CCT曲线热模拟

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非负不可约矩阵最大特征值的估计法

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济南大学学报（自然科学版） 2017年第4期31卷 334-338页

作者：王芳芳杨晋太原理工大学数学学院山西太原030024

为了估计非负不可约矩阵最大特征值的界,构造2个新矩阵,利用Perron-Frobenius定理和新构造矩阵的行和与列和的性质,估计非负不可约矩阵最大特征值的上、下界,并推导极限估计式。结果表明,这种基于PerronFrobenius定理的估计非负不可约... 详细信息

为了估计非负不可约矩阵最大特征值的界,构造2个新矩阵,利用Perron-Frobenius定理和新构造矩阵的行和与列和的性质,估计非负不可约矩阵最大特征值的上、下界,并推导极限估计式。结果表明,这种基于PerronFrobenius定理的估计非负不可约矩阵最大特征值的方法的估计范围比已有结论更精确。

关键词：非负不可约矩阵最大特征值估计

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