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血清ORMDL3结合FeNO对哮喘稳定期急性发作的预测分析

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齐齐哈尔医学院学报 2024年第6期45卷 535-539页

作者：韩方方马朝阳郑州大学附属郑州中心医院呼吸康复科河南郑州450000

目的分析血清类黏蛋白1样蛋白3(ORMDL3)结合呼出气一氧化氮(FeNO)对哮喘稳定期急性发作的预测价值。方法选择2018年7月—2023年8月在本院门诊随访的120例哮喘稳定期患者作为疾病组,另同期选取120名健康体检者作为对照组,检测两组ORMDL... 详细信息

目的分析血清类黏蛋白1样蛋白3(ORMDL3)结合呼出气一氧化氮(FeNO)对哮喘稳定期急性发作的预测价值。方法选择2018年7月—2023年8月在本院门诊随访的120例哮喘稳定期患者作为疾病组,另同期选取120名健康体检者作为对照组,检测两组ORMDL3 mRNA表达量和FeNO浓度。依据疾病组3个月内是否出现哮喘急性发作将其分为急性发作组和非急性发作组,比较两组患者ORMDL3 mRNA表达量和FeNO浓度,采用多因素Logistic回归分析哮喘稳定期急性发作的影响因素,采用受试者工作特征(ROC)曲线分析ORMDL3 mRNA、FeNO单项及联合对哮喘稳定期急性发作的预测价值。结果疾病组ORMDL3 mRNA表达量、FeNO浓度均高于对照组(P<0.05);急性发作组ORMDL3 mRNA表达量、FeNO浓度、体质量指数(BMI)以及吸烟史占比均高于非急性发作组(P<0.05),淋巴细胞计数、用力肺活量占预计值百分比(FVC%)、第一秒用力呼气末容积占预计值百分比(FEV1%)低于非急性发作组(P<0.05);经多因素Logistic回归分析显示,高ORMDL3 mRNA、高FeNO、高BMI均为哮喘稳定期患者急性发作的危险因素(P<0.05),高FVC%、高FEVI%为其保护因素(P<0.05)。ORMDL3 mRNA、FeNO联合预测哮喘稳定期患者急性发作的灵敏度高于单独预测,联合预测的AUC高于单独预测(P<0.05),联合预测的特异度与单独预测相近。结论 ORMDL3、FeNO均在哮喘稳定期急性发作患者中存在异常高表达,均是哮喘稳定期急性发作的影响因素,且两者联合对哮喘稳定期急性发作具有较好的预测价值。

关键词：哮喘稳定期急性发作血清类黏蛋白1样蛋白3 呼出气一氧化氮预测价值

呼吸康复操联合中医延续性护理对特发性肺纤维化患者生活质量的影响

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西部中医药 2024年第5期37卷 135-138页

作者：韩芳芳陈咏青张铭上海市胸科医院/上海市交通大学附属胸科医院上海200030

目的:探讨呼吸康复操结合中医延续性护理对特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)患者生活质量的影响。方法:将88例IPF患者按随机数字表法分为研究组和对照组各44例。对照组给予常规护理,研究组在对照组基础上予呼吸康复... 详细信息

目的:探讨呼吸康复操结合中医延续性护理对特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)患者生活质量的影响。方法:将88例IPF患者按随机数字表法分为研究组和对照组各44例。对照组给予常规护理,研究组在对照组基础上予呼吸康复操联合中医延续性护理。比较两组患者护理前后肺功能指标(一氧化碳弥散量占预计值百分比、肺总量预计值占比、用力肺活量预计值占比)、呼吸力学指标(呼气末跨肺压、吸气末跨肺压,跨肺驱动压)及生活质量。结果:护理后研究组患者肺功能指标高于对照组、呼吸力学指标低于对照组(P<0.05),IPF患者生活质量特异性量表评分低于对照组(P<0.05)。结论:呼吸康复操联合中医延续性护理有助于提高IPF患者肺功能,改善其呼吸困难症状,且能提高IPF患者生活质量。

关键词：特发性肺纤维化肺功能生活质量呼吸康复操中医延续性护理

药品不良反应数据挖掘技术在药物警戒中的应用

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中国现代应用药学 2024年第6期41卷 864-870页

作者：周瑞珊卢佩雯陈君恒石艺杨何明秀韩芳芳蔡永铭广东药科大学广州510006 国家药监局药物警戒技术研究与评价重点实验室广州510006 广东省中医药精准医学大数据工程技术研究中心广州510006

随着信息技术的发展,医药电子数据海量增长,药品不良事件报告大幅增加,给药物警戒研究带来了巨大的挑战。而数据挖掘技术可以自动从真实世界数据中撷取药品不良反应风险信号。因此,对海量不良事件报告数据进行高效数据挖掘是实现药品不... 详细信息

随着信息技术的发展,医药电子数据海量增长,药品不良事件报告大幅增加,给药物警戒研究带来了巨大的挑战。而数据挖掘技术可以自动从真实世界数据中撷取药品不良反应风险信号。因此,对海量不良事件报告数据进行高效数据挖掘是实现药品不良反应自动检测的必要措施。本研究通过介绍当前主要的大型药品不良事件报告数据库和相关数据挖掘方法,对药品不良反应数据挖掘技术在药物警戒中的应用及其局限性进行综述,为药物警戒相关机构和科研人员提供参考。

关键词：数据挖掘不良事件报告药物警戒药品不良反应自动检测

Hypoxic microenvironment in cancer:molecular mechanisms and therapeutic interventions

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1047-1069页

作者： Zhou Chen fangfang han Yan Du Huaqing Shi Wence Zhou The First Clinical Medical College Lanzhou UniversityLanzhouGansuChina The First Hospital of Lanzhou University LanzhouGansuChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansuChina Lanzhou University Sencond Hospital LanzhouGansuChina

Having a hypoxic microenvironment is a common and salient feature of most solid *** has a profound effect on the biological behavior and malignant phenotype of cancer cells,mediates the effects of cancer chemotherapy,radiotherapy,and immunotherapy through complex mechanisms,and is closely associated with poor prognosis in various cancer *** studies have demonstrated that through normalization of the tumor vasculature,nanoparticle carriers and biocarriers can effectively increase the oxygen concentration in the tumor microenvironment,improve drug delivery and the efficacy of *** also increase infiltration of innate and adaptive anti-tumor immune cells to enhance the efficacy of ***,drugs targeting key genes associated with hypoxia,including hypoxia tracers,hypoxia-activated prodrugs,and drugs targeting hypoxia-inducible factors and downstream targets,can be used for visualization and quantitative analysis of tumor hypoxia and antitumor ***,the relationship between hypoxia and cancer is an area of research that requires further ***,we investigated the potential factors in the development of hypoxia in cancer,changes in signaling pathways that occur in cancer cells to adapt to hypoxic environments,the mechanisms of hypoxia-induced cancer immune tolerance,chemotherapeutic tolerance,and enhanced radiation tolerance,as well as the insights and applications of hypoxia in cancer therapy.

关键词： drugs therapeutic microenvironment

Self-assembled amphiphilic NIR-Ⅱ emissive nano-micelles for imaging-guided photothermal therapy of colorectal cancer

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Science China Chemistry 2024年第8期67卷 2767-2774页

作者： Axin He fangfang Xia Da han Qinglai Yang Weihong Tan Institute of Molecular Medicine(IMM) Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200240China Center for Molecular Imaging Probe Hunan Province Key Laboratory of Cancer Cellular and Molecular PathologyCancer Research InstituteHengyang Medical SchoolUniversity of South ChinaHengyang 421001China The Key Laboratory of Zhejiang Province for Aptamers and Theranostics Zhejiang Cancer Hospital Hangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhou 310022China Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyAptamer Engineering Center of Hunan ProvinceHunan UniversityChangsha 410082China

Colorectal cancer(CRC) is one of the major causes of cancer-related mortality worldwide. Most near-infrared(NIR) agents used in clinical CRC treatment are at NIR-I(700–900 nm) window, which has limitations on deep tissue, and fluorescent probes in the second NIR(1,000–1,700 nm) allow high-resolution bioimaging with deep tissue penetration. However, existing NIR-II fluorophores used in clinical are still rare. Herein, based on shielding-donor-acceptor-donor-shielding(S-D-A-D-S) scaffold, we developed an organic small-molecule fluorophore IR-BTGP with NIR-II emission for imaging-guided photothermal therapy(PTT) in CRC mice model. Amphiphilic IR-BTGP can be self-assembled into spherical nano-micelles, which presents reliable water solubility and photothermal conversion efficiency(30.2%). In vitro experiments indicate that cancer cells treated with IRBTGP were significantly killed upon 808 nm light irradiation. Furthermore, in vivo NIR-II fluorescence imaging confirms that IR-BTGP accumulates in the tumor region. Remarkably, a significant tumor inhibition rate(78.5%) was observed in tumorbearing mice when treated with IR-BTGP plus 808 nm irradiation. Therefore, this work shows that IR-BTGP holds great promise as an NIR-II fluorescence imaging-guided PTT platform for CRC in the future.

关键词： photothermal therapy(PTT) second near-infrared(NIR-Ⅱ)imaging organic molecule

A novel silver-doped nickel oxide hole-selective contact for crystalline silicon heterojunction solar cells

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Frontiers of Chemical Science and Engineering 2024年第2期18卷 93-101页

作者： Junfeng Zhao Xudong Yang Zhongqing Zhang Shengpeng Xie fangfang Liu Anjun han Zhengxin Liu Yun Sun Wei Liu Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Engineering Research Center of Thin Film Photoelectronic TechnologyInstitute of Photoelectronic Thin Film Devices and Technology of Nankai University(Ministry of Education)Tianjin 300350China Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghai 201800China

Based on its band alignment,p-type nickel oxide(NiO_(x))is an excellent candidate material for hole transport layers in crystalline silicon heterojunction solar cells,as it has a smallΔEV and largeΔEC with crystalline ***,to overcome the poor hole selectivity of stoichiometric NiO_(x) due to its low carrier concentration and conductivity,silver-doped nickel oxide(NiO_(x):Ag)hole transport layers with high carrier concentrations were prepared by co-sputtering high-purity silver sheets and pure NiO_(x) *** improved electrical conductivity of NiO_(x) was attributed to the holes generated by the Ag^(+)substituents for Ni^(2+),and moreover,the introduction of Ag^(+)also increased the amount of Ni^(3+)present,both of which increased the carrier concentration in NiO_(x).Ag^(+)doping also reduced the c-Si/NiO_(x) contact resistivity and improved the hole-selective contact with NiO_(x).Furthermore,the problems of particle clusters and interfacial defects on the surfaces of NiO_(x):Ag films were solved by UV-ozone oxidation and high-temperature annealing,which facilitated separation and transport of carriers at the c-Si/NiO_(x) *** constructed c-Si/NiO_(x):Ag solar cell exhibited an increase in open-circuit voltage from 490 to 596 mV and achieved a conversion efficiency of 14.4%.

关键词： band alignment nickel oxide hole transport layer silver-doped nickel oxide UV-ozone

Optical sensor array for the discrimination of liquors

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未来食品学报(英文) 2024年第1期4卷 48-60页

作者： Yang Yu fangfang Shi Yi Zhang Fei Li Jinsong han State Key Laboratory of Natural Medicines National R&D Center for Chinese Herbal Medicine ProcessingDepartment of Food Quality and SafetyCollege of EngineeringChina Pharmaceutical UniversityNanjing 210009China

The discrimination of liquors plays a vital role in our daily life as a large amount of cheap alcoholic beverages and low-quality counterfeits greatly damage the health of ***-based optical sensors have been developed as a fast and effective tool to discriminate multi-analytes or complex mixtures with similar structures,such as acids,esters,aldehydes and *** the past decades,optical sensor arrays have demonstrated remarkable capabilities in fast and accurate detection of diverse types,qualities,and authentic *** identification strategy mainly focuses on the specific/non-specific interactions of flavor compounds in liquors with sensor *** cross-reactive optical signal readouts from the combination of sensor elements with liquors and multiple machine learning algorithms are essential to ensure the discriminatory capability of sensing *** this review,we discuss the advantages and recent advances in pattern recognition of liquors in terms of the design of various types of sensing materials and the construction strategies of sensor arrays.

关键词： Sensor array Chemical tongue Chemical nose Liquors Fluorescent Colorimetric Pattern recognition Machine learning algorithm

Self-assembled amphiphilic NIR-II emissive nano-micelles for imaging-guided photothermal therapy of colorectal cancer

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Science China Chemistry 2024年

作者： Axin He fangfang Xia Da han Qinglai Yang Weihong Tan Institute of Molecular Medicine (IMM) Renji Hospital School of Medicine Shanghai Jiao Tong University Center for Molecular Imaging Probe Hunan Province Key Laboratory of Cancer Cellular and Molecular Pathology Cancer Research Institute Hengyang Medical School University of South China The Key Laboratory of Zhejiang Province for Aptamers and Theranostics Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM)Chinese Academy of Sciences Molecular Science and Biomedicine Laboratory (MBL) State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering College of Biology Aptamer Engineering Center of Hunan Province Hunan University

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Unique double-layer solid electrolyte interphase formed with fluorinated ether-based electrolytes for high-voltage lithium metal batteries

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Journal of Energy Chemistry 2024年第1期88卷 532-542,I0012页

作者： Ruo Wang Jiawei Li Bing han Qingrong Wang Ruohong Ke Tong Zhang Xiaohu Ao Guangzhao Zhang Zhongbo Liu Yunxian Qian fangfang Pan Iseult Lynch Jun Wang Yonghong Deng Department of Materials Science&Engineering School of Innovation and EntrepreneurshipSouthern University of Science and TechnologyShenzhen 518055GuangdongChina School of Geography Earth and Environmental SciencesUniversity of BirminghamEdgbastonBirmingham B152TTUK Key Laboratory of Marine Environmental Corrosion and Bio-Fouling Institute of OceanologyChinese Academy of SciencesQingdao 266071ShandongChina Shenzhen CAPCHEM Technology Co. Ltd.Shenzhen 518118GuangdongChina CALB Group Co. Ltd.Changzhou 213200JiangsuChina

Li metal batteries using high-voltage layered oxides cathodes are of particular interest due to their high energy ***,they suffer from short lifespan and extreme safety concerns,which are attributed to the degradation of layered oxides and the decomposition of electrolyte at high voltage,as well as the high reactivity of metallic *** key is the development of stable electrolytes against both highvoltage cathodes and Li with the formation of robust interphase films on the ***,we report a highly fluorinated ether,1,1,1-trifluoro-2-[(2,2,2-trifluoroethoxy)methoxy]ethane(TTME),as a cosolvent,which not only functions as a diluent forming a localized high concentration electrolyte(LHCE),but also participates in the construction of the inner solvation *** TTME-based electrolyte is stable itself at high voltage and induces the formation of a unique double-layer solid electrolyte interphase(SEI)film,which is embodied as one layer rich in crystalline structural components for enhanced mechanical strength and another amorphous layer with a higher concentration of organic components for enhanced *** Li||Cu cells display a noticeably high Coulombic efficiency of 99.28%after 300 cycles and Li symmetric cells maintain stable cycling more than 3200 h at 0.5 mA/cm^(2) and 1.0m Ah/cm^(2).In addition,lithium metal cells using LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) and Li CoO_(2) cathodes(both loadings~3.0 m Ah/cm^(2))realize capacity retentions of>85%over 240 cycles with a charge cut-off voltage of 4.4 V and 90%for 170 cycles with a charge cut-off voltage of 4.5 V,*** study offers a bifunctional ether-based electrolyte solvent beneficial for high-voltage Li metal batteries.

关键词： Lithium metal batteries High-voltage layered oxides Fluorinated ether-based electrolytes Solid electrolyte interphase Cathode electrolyte interphase