检索结果-南通市图书馆

尼妥珠单抗联合同期放化疗用于局部晚期鼻咽癌患者的效果

在线全文

学校读者我要写书评

暂无评论

中国民康医学 2024年第6期36卷 48-50页

作者：肖家骠刘良胜戴芳芳泰和县人民医院肿瘤血液科江西吉安343700

目的:观察尼妥珠单抗联合同期放化疗用于局部晚期鼻咽癌患者的效果。方法:选取2022年1月至2023年1月该院收治的60例局部晚期鼻咽癌患者进行前瞻性研究,按随机数字表法将其分为对照组与观察组各30例。对照组采用同期放化疗,观察组在对照... 详细信息

目的:观察尼妥珠单抗联合同期放化疗用于局部晚期鼻咽癌患者的效果。方法:选取2022年1月至2023年1月该院收治的60例局部晚期鼻咽癌患者进行前瞻性研究,按随机数字表法将其分为对照组与观察组各30例。对照组采用同期放化疗,观察组在对照组基础上联合尼妥珠单抗治疗,比较两组临床疗效,治疗前后肿瘤标志物指标[鳞状细胞癌相关抗原(SCCAg)、细胞角蛋白19片段抗原21-1(CYFRA21-1)]水平,不良反应发生率、疾病复发率和远处转移率。结果:观察组客观缓解率(ORR)为83.33%(25/30),高于对照组的60.00%(18/30),差异有统计学意义(P0.05)。结论:尼妥珠单抗联合同期放化疗用于局部晚期鼻咽癌患者可提高ORR,降低肿瘤标志物指标水平,其效果优于单纯同期放化疗。

关键词：局部晚期鼻咽癌尼妥珠单抗同期放化疗肿瘤标志物不良反应

Physical structure and vertical distribution of chlorophyll a in winter sea ice from the northwestern Weddell Sea, Antarctica

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2010年第3期29卷 97-105页

作者： dai fangfang WANG Zipan YAN Xiaojun LI Zhijun ALLHUSEN Erika DIECKMANN Gerhard Ningbo University Ningbo 315211 China Zhejiang Wanli University Ningbo 315100 China Dalian University of Technology Dalian 116024 China Alfred Wegener Institute for Marine and Polar Research Bremerhaven 27570 Germany

The investigation on sea-ice biology in combination with physics, chemistry and ecology was carried out in the northwestern Weddell Sea, Antarctica, during the cruise ANT/XX III-7 on board POLARSTERN in the austral winter （August-October） in 2006. The distribution of chlorophyll a was measured and related to sea ice texture. The mean concentrations of chlorophyll a in the sea ice varied considerably with ice texture. The concentration of chlorophyll a per core ranged from 2.10– 84.40 μg/dm ^3 with a mean of 16.56 μg/dm ^3 . And the value of R （chlorophyll a / gross chlorophyll） ranged from 0.79–0.83. These high winter chlorophyll values indicate that primary production is considerable and confirms that there is significant primary production in Antarctic sea ice during winter. Thus this constitutes a major proportion of southern ocean primary production and carbon flux before the sea ice retreats.

关键词： physical structure chlorophyll a Antarctica winter sea-ice

基于网络药理学和细胞实验探讨艾迪注射液治疗卵巢癌的机制研究

在线全文

学校读者我要写书评

暂无评论

医学研究杂志 2024年第2期53卷 40-50,61页

作者：邓志敏吴玛丽代芳芳程艳香武汉大学人民医院 430060

目的利用网络药理学和细胞实验探讨艾迪注射液治疗卵巢癌的关键分子靶点及可能的作用机制。方法通过中药系统药理学数据库与分析平台(Troditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)数据库... 详细信息

目的利用网络药理学和细胞实验探讨艾迪注射液治疗卵巢癌的关键分子靶点及可能的作用机制。方法通过中药系统药理学数据库与分析平台(Troditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)数据库筛选艾迪注射液中中药的活性成分及作用靶点,并筛选卵巢癌异常表达的基因,取交集后获得艾迪注射液作用于卵巢癌的可能靶点。接着对可能靶点进行蛋白质互作网络分析、构建药物-化合物-靶点网络和富集分析。进一步筛选靶点,对与卵巢癌预后相关的关键基因进行实验验证,用50mg/ml艾迪注射液处理卵巢癌细胞后利用CCK-8实验观察细胞增殖能力,实时荧光定量聚合酶链反应技术检测核心靶基因的表达。结果筛选到艾迪注射液作用于卵巢癌的可能靶点共13个。这些靶点主要富集于细胞凋亡、铂耐药和白细胞介素-17等肿瘤发生、发展密切相关的信号通路。13个基因中,与卵巢癌预后相关的关键基因为细胞间紧密连接蛋白4(claudin 4,CLDN4)、分泌性白细胞蛋白酶抑制因子(secretory leukocyte peptidase inhibitor,SLPI)和杆状病毒IAP重复序列包含5(baculoviral IAP repeat containing 5,BIRC5)。细胞实验发现,艾迪注射液能显著抑制卵巢癌细胞增殖,促进卵巢癌保护性靶点BIRC5的表达,并显著下降卵巢癌危险因素CLDN4和SLPI的水平。结论艾迪注射液可能是通过影响CLDN4、SLPI、BIRC5这3个核心靶点的表达来实现多成分、多靶点、多途径的抗卵巢癌和联合化疗的增效减毒作用。

关键词：艾迪注射液卵巢癌细胞增殖网络药理学

Extracorporeal membrane oxygenation as a bridging therapy for patients with thiamine deficiency-induced pulmonary arterial hypertension

在线全文

学校读者我要写书评

暂无评论

World Journal of Emergency Medicine 2024年第2期15卷 147-149页

作者： fangfang Qiu Weixing dai Tengyue Huang Min Li Department of Intensive Care Unit the Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000China Department of Intensive Care Unit the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China

Thiamine deficiency is characterized by a deficiency of thiamine(vitamin B1),lactic acidosis,pulmonary arterial hypertension(PAH),right-sided heart failure,and peripheral nerve *** deficiency is easily misdiagnosed and missed during clinical practice and is associated with death in severe cases.[1,2]Here we reported a patient who was admitted to the hospital with severe metabolic acidosis and pulmonary hypertension and finally diagnosed with thiamine deficiency by detecting plasma vitamin B1 *** clinically obvious thiamine deficiency is rare,and cases of thiamine deficiency requiring extracorporeal membrane oxygenation(ECMO)treatment are rarer,we believe that our case will be helpful for emergency clinicians.

关键词： vitamin hypertension arterial

正常范围内不同促甲状腺激素水平对行IVF⁃ET不孕妇女妊娠结局的影响

在线全文

学校读者我要写书评

暂无评论

中国计划生育和妇产科 2024年第2期16卷 38-41页

作者：贺春周均霞赵玲玲戴芳芳郑波邢台不孕不育专科医院检验科河北邢台054000

目的观察正常范围的低四分位数和高四分位数促甲状腺激素(thyroid stimulating hormone,TSH)水平对行体外受精⁃胚胎移植(in vitro fertilization⁃embryo transfer,IVF⁃ET)不孕妇女妊娠结局的影响。方法回顾性分析2020年1月至2022年6月... 详细信息

目的观察正常范围的低四分位数和高四分位数促甲状腺激素(thyroid stimulating hormone,TSH)水平对行体外受精⁃胚胎移植(in vitro fertilization⁃embryo transfer,IVF⁃ET)不孕妇女妊娠结局的影响。方法回顾性分析2020年1月至2022年6月在邢台不孕不育专科医院就诊的858例行长方案IVF⁃ET并行新鲜胚胎移植的不孕妇女的临床资料,根据TSH进行四分位数分组:Ⅰ组(TSH 0.40~1.46 mIU/L,215例);Ⅱ组(TSH 1.47~2.02 mIU/L,214例);Ⅲ组(TSH 2.03~2.71 mIU/L,215例);Ⅳ组(TSH 2.72~4.00 mIU/L,214例)。比较各组患者的一般资料、实验室指标及移植后妊娠结局的差异。结果基本资料分析显示,各组年龄、体质量指数、血清基础性激素水平、抗苗勒管激素、窦卵泡数、促性腺激素(Gn)使用剂量、Gn使用天数方面比较,差异均无统计学意义(P>0.05);TSH高四分位数组的自身免疫抗体阳性率较高(P0.05);各组间临床妊娠率、流产率、早产率和活产率差异均无统计学意义(P>0.05);以妊娠结局为因变量,以TSH组为预测因子,采用Logistic回归分析比较各组妊娠结局的差异,发现TSH水平与妊娠结局差异无统计学意义(P>0.05)。结论促甲状腺激素在正常范围内不影响IVF⁃ET的妊娠结局。

关键词：促甲状腺激素体外受精⁃胚胎移植妊娠结局

The role of a drug-loaded poly(lactic co-glycolic acid)(PLGA) copolymer stent in the treatment of ovarian cancer

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2020年第1期17卷 237-250页

作者： Yanqing Wang Xiaoyin Qiao Xiao Yang Mengqin Yuan Shu Xian Li Zhang Dongyong Yang Shiyi Liu fangfang dai Zhikai Tan Yanxiang Cheng Department of Obstetrics and Gynecology Renmin Hospital of Wuhan UniversityWuhan 430060China College of Biology Hunan UniversityChangsha 410082China Department of Obstetrics and Gynecology Renmin Hospital of Peking UniversityBeijing 100044China Department of Obstetrics and Gynecology Taihe HospitalHubei University of MedicineShiyan 442000China

Objectives:Cisplatin(CDDP)is a widely used and effective basic chemotherapeutic drug for the treatment of a variety of tumors,including ovarian ***,adverse side effects and acquired drug resistance are observed in the clinical application of *** a mode of administration that can alleviate side effects and reduce drug resistance has become a promising strategy to solve this ***:In this study,3 D printing technology was used to prepare a CDDP-poly(lactic-co-glycolic acid)(CDDP-PLGA)polymer compound stent,and its physicochemical properties and cytotoxicity were evaluated both in vitro and in ***:The CDDP-PLGA stent had a significant effect on cell proliferation and apoptosis and clearly decreased the size of subcutaneous tumors in nude mice,whereas the systemic side effects were mild compared with those of intraperitoneal CDDP *** with the control group,CDDP-PLGA significantly increased the mRNA and protein levels of p-glycoprotein(P<0.01;P<0.01)and decreased vascular endothelial growth factor mRNA(P<0.05)and protein levels(P<0.01),however,CDDP-PLGA significantly decreased the mR NA and protein levels of p-glycoprotein(P<0.01;P<0.01)and vascular endothelial growth factor(P<0.01;P<0.01),which are associated with chemoresistance,in subcutaneous tumor *** assay results revealed that,in the CDDP-PLGA group,the staining of the proliferation-related genes Ki67 and PCNA were lightly,and the apoptosis-related gene caspase-3 stained ***:PLGA biomaterials loaded with CDDP,as compared with the same amount of free CDDP,showed good efficacy in terms of cytotoxicity,as evidenced by changes in *** local CDDP release can decrease the systemic side effects of this drug and the occurrence of drug resistance and angiogenesis,and improve the therapeutic *** new approach may be an effective strategy for the local treatment of epithelial ovarian cancer.

关键词： 3D printing drug-loaded stent local treatment cisplatin ovarian cancer

肝病患者合并隐球菌感染的临床和菌株特征分析

在线全文

学校读者我要写书评

暂无评论

标记免疫分析与临床 2024年第7期31卷 1207-1210页

作者：代芳芳陈铭康艳芳孙桂珍娄金丽于艳华首都医科大学附属北京佑安医院检验科北京100069

目的分析肝病患者合并隐球菌感染的临床和菌株特征,为该类患者的诊治和预防提供依据。方法分析2013年至2023年就诊于我院的肝病合并隐球菌感染患者的病例信息,对从患者分离出的隐球菌菌株通过基质辅助激光解吸电离飞行时间质谱法进行鉴... 详细信息

目的分析肝病患者合并隐球菌感染的临床和菌株特征,为该类患者的诊治和预防提供依据。方法分析2013年至2023年就诊于我院的肝病合并隐球菌感染患者的病例信息,对从患者分离出的隐球菌菌株通过基质辅助激光解吸电离飞行时间质谱法进行鉴定并用ITS测序法进行确认,采用多位点序列分型(multi-locus sequence typing,MLST)法对菌株进行分型分析,使用FUNGUS 3对菌株进行抗真菌药物敏感性试验。结果6例肝病合并隐球菌感染的患者中,男性3例,女性3例;年龄48~71岁,平均年龄61.0±8.0岁;肝癌、肝衰竭和肝硬化失代偿期患者各2例;除1例为皮肤软组织感染外,其余为血流、胸腹水、脑脊液和尿液感染。6例患者合并感染的隐球菌均为新型隐球菌格鲁比变种(Cryptococcus neoformans ***),MLST分型均为ST5型。抗真菌药敏实验结果显示6株菌对抗隐球菌一线药物两性霉素B和5-氟胞嘧啶的敏感性为100%,对氟康唑的敏感性为33.3%,中介率为66.7%;6株菌除1株对伊曲康唑为非野生型(non-wild type,NWT)外,其余均为野生型(wild type,WT)菌株,6例患者隐球菌感染后均死亡。结论合并隐球菌感染的肝病患者多为免疫功能严重受损的肝病晚期中老年患者,其感染的隐球菌以新型隐球菌格鲁比变种ST5型为主,对常用抗隐球菌一线药物氟康唑的敏感性较低,单用氟康唑治疗效果差。此类患者合并侵袭性隐球菌感染的情况需引起临床医生重视,对此类患者可进行常规隐球菌感染的筛查,以便及早诊治隐球相关感染。

关键词：肝病隐球菌感染多位点序列分型抗真菌药物敏感性

冻融周期中不同子宫内膜转化时间移植囊胚的妊娠结局分析

在线全文

学校读者我要写书评

暂无评论

中国计划生育和妇产科 2024年第2期16卷 29-32页

作者：霍志欣戴芳芳王寅刘乾文田秀珍程书清刘红邢台不孕不育专科医院/邢台生殖与遗传专科医院生殖医学中心河北邢台054000

目的比较冻融周期中不同子宫内膜转化时间移植囊胚的临床结局,探讨冻融移植周期中囊胚移植策略。方法回顾性分析2021年5月至2021年12月于邢台不孕不育专科医院生殖医学中心采用激素替代周期或降调节⁃激素替代周期准备子宫内膜进行囊胚... 详细信息

目的比较冻融周期中不同子宫内膜转化时间移植囊胚的临床结局,探讨冻融移植周期中囊胚移植策略。方法回顾性分析2021年5月至2021年12月于邢台不孕不育专科医院生殖医学中心采用激素替代周期或降调节⁃激素替代周期准备子宫内膜进行囊胚冻融移植245个周期的妊娠结局。根据孕酮转化子宫内膜时间及移植不同发育天数囊胚的情况分为4组:D6⁃5组(100个周期,孕酮转化子宫内膜第6天移植第5天囊胚),D7⁃5组(48个周期,孕酮转化子宫内膜第7天移植第5天囊胚),D6⁃6组(71个周期,孕酮转化子宫内膜第6天移植第6天囊胚),D7⁃6组(26个周期,孕酮转化子宫内膜第7天移植第6天囊胚),比较各组的临床妊娠率、种植率、异位妊娠率、流产率、活产率。结果4组患者的年龄、不孕年限、不孕类型、治疗方式、体质量指数、AMH、不孕因素、移植日内膜厚度、胚胎移植个数、胚胎评价比较,差异均无统计学意义(P>0.05);与D6⁃5组相比,D7⁃5组的胚胎着床率、临床妊娠率、活产率均有升高趋势;与D6⁃6组相比,D7⁃6组的胚胎着床率、临床妊娠率、活产率均有下降趋势;第6天囊胚与第5天囊胚相比,无论在转化子宫内膜的第6天还是第7天移植,妊娠率均有下降趋势。结论冻融周期中子宫内膜转化D6、D7移植囊胚妊娠结局无明显差异,临床工作可灵活安排,但是优选第5天囊胚进行移植可获得较满意的结果。

关键词：冻融周期子宫内膜囊胚移植孕酮妊娠结局

Effectiveness of colorectal cancer screening integrating non-genetic and genetic risk: a prospective study based on UK Biobank data

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2024年第8期21卷 712-723页

作者： Yu Zhang Chao Sheng Zhangyan Lyu Hongji dai fangfang Song Fengju Song Yubei Huang Kexin Chen Department of Epidemiology and Biostatistics Key Laboratory of Molecular Cancer EpidemiologyKey Laboratory of Prevention and Control of Human Major DiseasesMinistry of EducationNational Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjin Medical UniversityTianjin 300060China

Objective: Few studies have evaluated the benefits of colorectal cancer(CRC) screening integrating both non-genetic and genetic risk factors. Here, we aimed to integrate an existing non-genetic risk model(QCancer-10) and a 139-variant polygenic risk score to evaluate the effectiveness of screening on CRC incidence and ***: We applied the integrated model to calculate 10-year CRC risk for 430,908 participants in the UK Biobank, and divided the participants into low-, intermediate-, and high-risk groups. We calculated the screening-associated hazard ratios(HRs) and absolute risk reductions(ARRs) for CRC incidence and mortality according to risk ***: During a median follow-up of 11.03 years and 12.60 years, we observed 5,158 CRC cases and 1,487 CRC deaths, respectively. CRC incidence and mortality were significantly lower among screened than non-screened participants in both the intermediateand high-risk groups [incidence: HR: 0.87, 95% confidence interval(CI): 0.81±0.94;0.81, 0.73±0.90;mortality: 0.75, 0.64±0.87;0.70, 0.58±0.85], which composed approximately 60% of the study population. The ARRs(95% CI) were 0.17(0.11±0.24) and 0.43(0.24±0.61), respectively, for CRC incidence, and 0.08(0.05±0.11) and 0.24(0.15±0.33), respectively, for mortality. Screening did not significantly reduce the relative or absolute risk of CRC incidence and mortality in the low-risk group. Further analysis revealed that screening was most effective for men and individuals with distal CRC among the intermediate to high-risk ***: After integrating both genetic and non-genetic factors, our findings provided priority evidence of risk-stratified CRC screening and valuable insights for the rational allocation of health resources.

关键词： Colorectal cancer screening polygenic risk score incidence mortality