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PARP1-DNA co-condensation:the driver of broken DNA repair

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2351-2353页

作者： Xiang Wei fangfang zhou Long Zhang Life Sciences Institute The Second Affiliated Hospital of the Zhejiang University School of MedicineThe MOE Key Laboratory of Biosystems Homeostasis&Protection and Zhejiang Provincial Key Laboratory for Cancer Molecular Cell BiologyZhejiang UniversityHangzhouChina The First Affiliated Hospital the Institutes of Biology and Medical SciencesSuzhou Medical CollegeSoochow UniversitySuzhouJiangsu 215123China

A recent study published by Simon Alberti1 in Cell has revealed that DNA double-strand break(DSB)sites that prevent the disjunction of broken DNA ends are formed through poly(ADPribose)(PAR)polymerase 1(PARP1)-DNA co-condensation.1(Fig.1).Here,a comprehensive and novel model was provided for the ordered assembly of PARP1-DNA condensates,which can rationally make clear broken DNA end synapses and how repair effectors are recruited to repair DSB.

关键词： PARP1 repair rational

社交媒体关注、监管问询与公司并购——基于东方财富“股吧”论坛文本分析的经验证据

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管理工程学报 2024年第4期38卷 104-121页

作者：傅祥斐周芳芳赵立彬赵妍南京审计大学会计学院/智能管理会计与内部控制研究院江苏南京211815 武汉纺织大学会计学院湖北武汉430200 北京物资学院会计学院北京101149

本文基于2014—2018年中国A股上市公司重大资产重组数据,借助文本分析,考察了社交媒体关注对企业并购决策的影响。结果发现,并购活动受到社交媒体讨论越负面,公司越有可能终止并购交易,且这种关系在交易所监管问询介入后更为显著。通过... 详细信息

本文基于2014—2018年中国A股上市公司重大资产重组数据,借助文本分析,考察了社交媒体关注对企业并购决策的影响。结果发现,并购活动受到社交媒体讨论越负面,公司越有可能终止并购交易,且这种关系在交易所监管问询介入后更为显著。通过异质性分析发现,在同一控制下和非现金支付的并购活动中,社交媒体负面讨论对并购交易终止的影响作用更显著,且交易所问询能在其中发挥更好的治理效应。进一步研究发现,受社交媒体讨论越负面的并购,其市场公告效应越差,未来股价崩盘风险越大;交易所问询后,可以改善企业市场表现和缓解股价崩盘风险。本文研究结论表明,社交媒体借助交易所监管问询这一路径,可以更好地发挥外部治理功能。

关键词：社交媒体监管问询并购终止市场反应股价崩盘风险

STING,a critical contributor to SARS-CoV-2 immunopathology

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Signal Transduction and Targeted Therapy 2022年第4期7卷 958-960页

作者： Heyu Li fangfang zhou Long Zhang School of Medicine Zhejiang University City College310015 HangzhouZhejiangChina Institutes of Biology and Medical Science Soochow University215123 SuzhouChina MOE Laboratory of Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network Life Sciences InstituteZhejiang University310058 HangzhouChina

Recently,a study published in Nature by Domizio et al.1 revealed the underlying mechanism of aberrant immunopathology during the late phase of infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The authors provided evidence demonstrating that stimulator of interferon genes(STING)plays a unique role in the alveolus-capillary cytokine storm induced by mitochondrial DNA(mtDNA)during coronavirus disease 2019(COVID-19)(Fig.1).Some studies stressed that the STING agonists block the SARS-CoV-2 infection via triggering the type I interferons(IFNs)response,2,3 while others revealed that SARS-CoV-2 induces the chromatin DNA traveling to cytosol by promoting the cell-tocell fusion,resulting in the activation of cGAS-STING signaling.

关键词： interferon stimulator acute

Novel pyroptosis-independent functions of gasdermins

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1366-1368页

作者： Ziran Qin fangfang zhou Long Zhang Zhejiang University City College HangzhouChina Institutes of Biology and Medical Science Soochow University215123SuzhouChina MOE Laboratory of Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network Life Sciences InstituteZhejiang University310058HangzhouChina

Recently,Rana et *** Zhang et *** two studies illustrating the important regulatory roles of gasdermin B(GSDMB)and-D(GSDMD)in inflammatory bowel disease(IBD)and intestinal immune homeostasis maintenance,respectively.1,2 Their findings collectively indicate that the gasdermins(GSDMs)can play a crucial role in restoring epithelial barrier function and shaping gut mucosal ***,neither of the functions of GSDMs revealed by these two studies are related to pyroptosis,which may provide new insights into the non-pyroptosis-dependent functions of GSDM proteins.

关键词： homeostasis collective

The fungal mycobiome:a new hallmark of cancer revealed by pan-cancer analyses

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Signal Transduction and Targeted Therapy 2023年第3期8卷 872-873页

作者： Zhi Zong fangfang zhou Long Zhang International Biomed-X Research Center Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang University310058 HangzhouChina Institute of Biology and Medical Science Soochow University215123 SuzhouChina MOE Key Laboratory of Biosystems Homeostasis&Protection and Innovation Center for Cell Signaling Network Life Sciences InstituteZhejiang University310058 HangzhouChina Cancer Center Zhejiang University310058 HangzhouChina

In a recent study published in Cell,1 a group led by Ravid Straussman and Rob Knight characterized fungi across multiple types of cancer and revealed their distribution,relationships with immune cells,and possible prognostic ***,another study led by Anders *** and Iliyan ***2 reported a similar pan-cancer mycobiome analysis of diverse body sites and identified tumor-associated fungi.

关键词： cancer fungal value.

FXR inhibition: an innovative prophylactic strategy against SARS-CoV-2 infection

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1346-1347页

作者： Zhe Li Shuai Wang fangfang zhou Institutes of Biology and Medical Science Soochow UniversitySuzhou 215123China

A recent study by Brevini et *** published in Nature and proposed a critical role of farnesoid X receptor(FXR)signaling in controlling ACE2 *** of FXR signaling,ursodeoxycholic acid(UDCA)and z-guggulsterone(ZGG),have been proven to reduce ACE2 expression and susceptibility to SARS-CoV-2 infection in human tissues,providing an innovative strategy for SARS-CoV-2 treatment and prevention.

关键词： ACE2 expression. infection

The loss of epigenetic information:not only consequences but a cause of mammalian aging

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1348-1350页

作者： Chen Pan fangfang zhou Long Zhang International Biomed-X Research Center Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhou 310058China Institutes of Biology and Medical Science Soochow UniversitySuzhou 215123China Present address:MOE Laboratory of Biosystems Homeostasis&Protection and Innovation Center for Cell Signaling Network Life Sciences InstituteZhejiang UniversityHangzhou 310058China

In a recent study published in Cell,Yang et *** that changes in epigenetic landscapes caused by faithful DNA repair are key drivers accelerating aging of mammalian organs or tissues.1 Impressively,changes in H3K27ac landscape during aging process influence cell identity maintenance,and this aging process can be reversed by the inducible expression of pioneer transcription factors,Oct4,Sox2,and Klf4(OSK)in the living *** mammals,global and local changes of DNA methylation occur in the genome during ***,general loss of histones and global chromatin remodeling have been observed in all aging models,while in reverse reprograming of cell fate can lead to global changes in the epigenetic and rejuvenated epigenome,suggesting the potential of reprogramming for the reversal of aging.2 However,as no systematic studies revealed the characteristics of epigenomic changes during aging,it remains unclear whether the changes in epigenetic landscape are the consequences(marks)or direct cause of aging.

关键词： epigenetic organs aging

烧伤后创面瘙痒患者非药物干预的最佳证据总结

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中华护理杂志 2024年第5期59卷 610-617页

作者：严雪芹柏素萍刘巧艳周芳芳阎蕾曹云包磊高婷朱梦雪江苏大学附属医院烧伤科江苏省镇江市212001 江苏大学附属医院内分泌代谢科江苏省镇江市212001 江苏大学附属医院护理部江苏省镇江市212001 江苏大学附属医院手术室江苏省镇江市212001

目的检索、评价和总结烧伤后创面瘙痒患者非药物干预的最佳证据。方法计算机检索UpToDate、BMJ Best Practice、澳大利亚乔安娜布里格斯研究所循证卫生保健中心数据库、英国国家卫生与临床优化研究所网站、加拿大安大略省注册护士协会... 详细信息

目的检索、评价和总结烧伤后创面瘙痒患者非药物干预的最佳证据。方法计算机检索UpToDate、BMJ Best Practice、澳大利亚乔安娜布里格斯研究所循证卫生保健中心数据库、英国国家卫生与临床优化研究所网站、加拿大安大略省注册护士协会网站、国际指南协作网、医脉通指南网、Cochrane Library、PubMed、中国知网、万方数据库、国际烧伤协会网站、欧洲烧伤协会网站、美国烧伤协会网站、国际伤口网站和中华医学会烧伤外科学分会网站中关于烧伤后创面瘙痒患者非药物干预的证据,包括临床决策、指南、证据总结、系统评价、专家共识。检索时限为建库至2022年12月1日。指南文献由4名研究人员进行评价,其他文献由2名研究人员进行评价,并根据主题对文献内容进行提取、汇总。结果共纳入10篇文献,包括临床决策4篇、指南3篇、证据总结3篇,总结出评估、保湿润肤、按摩、压力治疗、皮肤降温、其他措施及健康教育7个方面的22条最佳证据。结论该研究总结的烧伤后创面瘙痒患者非药物干预的最佳证据,为临床应用提供循证依据。医护人员可结合临床情境、伤口愈合情况及患者意愿,合理应用证据,制订干预方案,减轻患者的瘙痒症状,提升护理质量。

关键词：烧伤瘙痒非药物干预证据总结循证护理学

近端肾小管上皮细胞代谢重编程在急性肾损伤中的研究进展

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肾脏病与透析肾移植杂志 2024年第1期33卷 59-63页

作者：郑星月周芳芳(综述) 罗群(审校) 宁波大学医学部宁波315211 宁波市第二医院肾内科

肾脏是一个高代谢器官,尤其是近端肾小管上皮细胞,在生理情况下主要依赖脂肪酸氧化供能,但是在急性肾损伤(AKI)期间,线粒体和过氧化物酶体功能障碍,近端肾小管上皮细胞发生代谢重编程,能量供应转向糖酵解,生成乳酸,并伴脂肪酸氧化紊乱... 详细信息

肾脏是一个高代谢器官,尤其是近端肾小管上皮细胞,在生理情况下主要依赖脂肪酸氧化供能,但是在急性肾损伤(AKI)期间,线粒体和过氧化物酶体功能障碍,近端肾小管上皮细胞发生代谢重编程,能量供应转向糖酵解,生成乳酸,并伴脂肪酸氧化紊乱及糖异生受损,短期内代谢重编程可能是对肾脏有益的能量代偿,但是该过程中也会加重肾损伤。本文就近端肾小管上皮细胞代谢重编程在AKI中的作用进行综述。

关键词：急性肾损伤代谢重编程近端肾小管上皮细胞