检索结果-南通市图书馆

血清抗菌肽37、HDAC4对急性心肌梗死患者PCI术后发生不良心血管事件的预测价值

在线全文

学校读者我要写书评

暂无评论

检验医学与临床 2024年第14期21卷 2102-2106页

作者：李永光迟京霞孙光宗苏方成山东省潍坊市人民医院急诊内科山东潍坊261041 潍坊滨海经济技术开发区人民医院急诊内科山东潍坊262737

目的探讨血清抗菌肽LL-37、组蛋白去乙酰化酶(HDAC)4对急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)术后发生主要不良心血管事件(MACE)的预测价值。方法选取2021年1月至2023年5月在潍坊市人民医院急诊内科行PCI术的AMI患者240例,... 详细信息

目的探讨血清抗菌肽LL-37、组蛋白去乙酰化酶(HDAC)4对急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)术后发生主要不良心血管事件(MACE)的预测价值。方法选取2021年1月至2023年5月在潍坊市人民医院急诊内科行PCI术的AMI患者240例,根据PCI术后3个月是否发生MACE分为MACE组和non-MACE组。采用酶联免疫吸附试验检测血清LL-37、HDAC4水平。采用多因素Logistic回归分析PCI术后AMI患者发生MACE的影响因素。采用受试者工作特征(ROC)曲线分析血清LL-37、HDAC4单项及联合检测对PCI术后AMI患者发生MACE的预测价值。结果 240例AMI患者PCI术后3个月有66例发生MACE(MACE组),其余174例纳入non-MACE组,MACE发生率为27.50%。与non-MACE组比较,MACE组血清LL-37、HDAC4水平降低(P<0.05)。年龄增加、KILLIP分级≥Ⅱ级是AMI患者PCI术后发生MACE的独立危险因素(P<0.05),左心室射血分数、LL-37和HDAC4水平升高是保护因素(P<0.05)。血清LL-37联合HDAC4预测AMI患者PCI术后发生MACE的曲线下面积为0.864,大于血清LL-37、HDAC4单独预测的0.778、0.779(P<0.05)。结论血清LL-37、HDAC4联合检测对AMI患者PCI术后发生MACE的预测价值较高。

关键词：急性心肌梗死经皮冠状动脉介入治疗抗菌肽LL-37 组蛋白去乙酰化酶4 主要不良心血管事件

Observation of chemical components of PM2.5 and secondary inorganic aerosol formation during haze and sandy haze days in Zhengzhou, China

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2020年第2期32卷 316-325页

作者： Zhangsen Dong fangcheng su Zhenya Zhang Shenbo Wang Graduate School of Life and Environmental Sciences University of TsukubaJapan Research Institute of Environmental Science College of Chemistry and Molecular EngineeringZhengzhou UniversityZhengzhou 450001China

Mineral dust particles play an important role in the formation of secondary inorganic aerosols, which largely contribute to haze pollution in *** this study, a haze episode(haze days) and a typical haze process mixed with sandstorm(sandy haze days)were observed in Zhengzhou with a series of high-time-resolution monitoring instruments from November 22 to December 8, *** of PM10 and crustal elements clearly increased in the sandy haze *** of gaseous pollutants, metallic elements emitted from anthropogenic sources, nitrate, and ammonium during sandy haze days were slightly lower than those during the haze days but still obviously higher than those during the non-haze *** sulfate concentrations, the sulfate fractions in PM2.5,and the sulfur oxidation ratios significantly increased in the sandy haze *** reactions dominated the conversion of SO2 during the haze and sandy haze *** SO2 conversion during the sandy haze days may be attributed to the high concentrations of transition metal ions from the sandstorm when the values of relative humidity(RH) were in 30%–70%, and high O3 at certain time ***-phase NO2 oxidation reactions were the main pathways for nitrate *** the sandy haze days,higher nitrogen oxidation ratio(NOR) at daytime may be associated with higher RH and lower temperature than those in the haze days, which facilitate the gas-to-particle partitioning of nitrate;higher NOR values at night may be attributed to the higher O3 concentrations, which promoted the formation of N2O5.

关键词： Sandstorm Haze sulfate Aqueous-phase reactions Transition metal ions

血清sOSCAR对急性非ST段抬高型急性心肌梗死患者PCI术后心血管不良事件的预测价值

在线全文

学校读者我要写书评

暂无评论

国际检验医学杂志 2024年第17期45卷 2108-2112页

作者：马文超王琨王小龙谢地成刘磊孙胜苏方成潍坊市人民医院急诊内科山东潍坊261000 潍坊市人民医院呼吸与危重症医学科山东潍坊261000

目的探讨血清可溶性破骨细胞相关受体(sOSCAR)对急性非ST段抬高型急性心肌梗死(NSTEMI)患者经皮冠状动脉介入治疗(PCI)术后心血管不良事件的预测价值。方法选取2020年1月至2022年1月潍坊市人民医院收治的接受PCI术的124例NSTEMI患者为NS... 详细信息

目的探讨血清可溶性破骨细胞相关受体(sOSCAR)对急性非ST段抬高型急性心肌梗死(NSTEMI)患者经皮冠状动脉介入治疗(PCI)术后心血管不良事件的预测价值。方法选取2020年1月至2022年1月潍坊市人民医院收治的接受PCI术的124例NSTEMI患者为NSTEMI组,根据术后是否发生主要不良心血管事件分为预后不良组(n=31)和预后良好组(n=93),另选取同期100体检健康的志愿者为对照组。构建多因素Logistic回归模型分析影响NSTEMI患者PCI术后预后的因素,绘制受试者工作特征(ROC)曲线分析sOSCAR水平对NSTEMI患者PCI术后预后的预测价值。结果与对照组比较,NSTEMI组血清血管生成素-2(Ang-2)水平升高,sOSCAR水平降低(P<0.05)。随访1年,124例NSTEMI患者PCI术后预后不良发生率为25.00%(31/124)。多因素Logistic回归分析结果显示,年龄增加和Ang-2升高为NSTEMI患者PCI术后预后的独立危险因素(P<0.05),左心室射血分数升高和sOSCAR升高为独立保护因素(P<0.05)。ROC曲线分析显示,血清Ang-2、sOSCAR水平联合预测NSTEMI患者PCI术后预后的曲线下面积为0.865,大于血清Ang-2、sOSCAR水平单独预测的0.791、0.786(P<0.05)。结论NSTEMI患者血清sOSCAR水平与患者PCI术后预后不良密切相关,血清sOSCAR联合Ang-2对NSTEMI患者PCI术后预后不良有较高的预测价值。

关键词：急性非ST段抬高型心肌梗死血管生成素-2 可溶性破骨细胞相关受体经皮冠状动脉介入治疗预后

Spatiotemporal characterization and regional contributions of O3 and NO2:An investigation of two years of monitoring data in Henan,China

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2020年第4期32卷 29-40页

作者： Shijie Yu Shasha Yin Ruiqin Zhang Lingling Wang fangcheng su Yixiang Zhang Jian Yang Research Institute of Environmental Science College of Chemistry and Molecular EngineeringZhengzhou UniversityZhengzhou450001China Henan Environment Monitoring Centre Zhengzhou450004China

To investigate the characteristics of ground level ozone(O3)for Henan Province,the ambient air quality monitoring data of 2015 and 2016 were *** result showed that the 8 h-max-O3 concentrations displayed a distinct seasonality,where the maximum and minimum values,averaging 140.41,54.19μg/m3,occurred in summer and winter,*** is a significant correlation between meteorological factors and O3 *** Voronoi neighborhood averaging analysis indic ated that O3,temperature,and ultraviolet radiation in Henan province were decreased from northwest to southeast,while relative humidity and precipitation displayed the opposite *** meteorological factors,the chemical processes play an essential role in ozone *** of NO,NO2 and O3 form a closed system,and the partitioning point of the OX-component(O3+NO2)was at 40 and 80μg/m3 for nitrogen oxide(NOx)in winter and summer,respectively,with NO2 dominating at higher NOx pollution and O3 being the m ajor component at lower *** relationship between oxidant(OX=O3+NO2)and NOx concentrations were evaluated to understand the regional and local contribution of *** showed that high regional contribution occurred in the spring,whereas the highest local contribution lead to the summer peak of O3 observed in *** present study reveals important environment impacts from the photochemical process and the meteorological conditions in the region with better understanding on the O3 characterization.

关键词： Ground-level ozone Meteorological parameter Photochemical oxidant Voronoi neighborhood averaging(VNA) Seasonal variation

Chemical characteristics and source apportionment of PM_(2.5) between heavily polluted days and other days in Zhengzhou, China

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2018年第4期30卷 188-198页

作者： Nan Jiang Qiang Li fangcheng su Qun Wang Xue Yu Panru Kang Ruiqin Zhang Xiaoyan Tang Research Institute of Environmental Science College of Chemistry and Molecular Engineering Zhengzhou University

PM（2.5） samples were collected in Zhengzhou during 3 years of observation, and chemical characteristics and source contribution were analyzed. Approximately 96% of the daily PM（2.5） concentrations and annual average values exceeded the Chinese National Ambient Air Quality Daily and Annual Standards, indicating serious PM（2.5） pollution. The average concentration of water-soluble inorganic ions was 2.4 times higher in heavily polluted days（daily PM32.5 concentrations ＆gt; 250 μg/mand visibility ＆lt; 3 km） than that in other days, with sulfate, nitrate, and ammonium as major ions. According to the ratio of NO-3/SO2-4,stationary sources are still the dominant source of PM（2.5） and vehicle emission could not be ignored. The ratio of secondary organic carbon to organic carbon indicated that photochemical reactivity in heavily polluted days was more intense than in other *** elements were the most abundant elements, accounting for more than 60% of 23 elements. Chemical Mass Balance results indicated that the contributions of major sources（i.e., nitrate, sulfate, biomass, carbon and refractory material, coal combustion, soil dust,vehicle, and industry） of PM（2.5） were 13%, 16%, 12%, 2%, 14%, 8%, 7%, and 8% in heavily polluted days and 20%, 18%, 9%, 2%, 27%, 14%, 15%, and 9% in other days, *** combustion activities were the main sources of polycyclic aromatic hydrocarbons during the episode（Jan 1-9, 2015） and the total benzo[a]pyrene equivalency concentrations in heavily polluted days present significant health threat. Because of the effect of regional transport, the pollution level of PM（2.5） in the study area was aggravated.

关键词： PM2.5 Water soluble inorganic ions Secondary organic carbon CMB Back trajectory analysis

Dynamic propagation velocity of a positive streamer in a 3 m air gap under lightning impulse voltage

在线全文

学校读者我要写书评

暂无评论

Plasma Science and Technology 2024年第4期26卷 114-121页

作者：李志伟雷挺苏宇姚修远杨冰雪刘德龙律方成丁玉剑 North China Electric Power University Beijing 102206People’s Republic of China China Electric Power Research Institute Beijing 100192People’s Republic of China

Streamers represent an important stage in the initiation of gap discharge. In this work, we used an eight-frame intensified charge-coupled device camera to capture the streamer development process when a lightning impulse voltage of 95%–100% U50% was applied in a 3 m rod–plate gap and the streamer velocity was analyzed. Analysis of the observations shows that streamer velocity can be defined by three stages: rapid velocity decline(stage 1), rapid velocity rise(stage 2)and slow velocity decline(stage 3). The effects of electrode shape, applied voltage and gap breakdown or withstanding on streamer velocity were analyzed. The electrode with a larger radius of curvature will result in a higher initial velocity, and a higher voltage amplitude will cause the streamer to propagate faster at stage 3. Gap withstanding or breakdown has no obvious effect on streamer velocity. In addition, the experimental results are compared with previous results and the statistical characteristics of the primary streamer discharge are discussed.

关键词： lightning impulse 3 m air gap development process streamer velocity

替格瑞洛配合急诊PCI治疗急性心肌梗死的临床疗效和安全性探讨

在线全文

学校读者我要写书评

暂无评论

临床心血管病杂志 2015年第1期31卷 27-30页

作者：苏方成赵芳山东省潍坊市人民医院急诊部山东潍坊261041 武汉大学中南医院心血管内科武汉430071

目的:探讨替格瑞洛配合急诊PCI在急性ST段抬高心肌梗死(STEMI)围手术期内的临床疗效和安全性,为急性ST段抬高心肌梗死的临床急救治疗和替格瑞洛的临床推广应用提供参考。方法:以107例使用替格瑞洛配合急诊PCI治疗的STEMI患者为研究组,以... 详细信息

目的:探讨替格瑞洛配合急诊PCI在急性ST段抬高心肌梗死(STEMI)围手术期内的临床疗效和安全性,为急性ST段抬高心肌梗死的临床急救治疗和替格瑞洛的临床推广应用提供参考。方法:以107例使用替格瑞洛配合急诊PCI治疗的STEMI患者为研究组,以127例接受氯吡格雷配合急诊PCI治疗的STEMI患者为对照组,回顾两组患者的临床治疗情况,对比分析两组的临床疗效。结果:术后研究组患者的TIMI血流分级、LVEF均高于对照组,且差异具有统计学意义(P0.05)。研究组和对照组患者的慢血流/无复流发生率分别为0.00%和3.74%,组间差异无统计学意义(P>0.05)。结论:替格瑞洛在STEMI急诊PCI手术中具有较好的临床疗效,且较氯吡格雷具有一定临床优势,值得临床推广和进一步研究。

关键词：急性心肌梗死替格瑞洛氯吡格雷急诊围手术期

基于CFD模型的新密市餐厨油烟减排效果评估

在线全文

学校读者我要写书评

暂无评论

环境工程 2023年第S2期41卷 313-320页

作者：高恒飞苏方成张云鹏刘永刚张长森徐起翔河南博联慧绿科技集团有限公司郑州450000 郑州大学生态与环境学院郑州450000

近年来,居民源排放的餐饮油烟对大气环境影响逐渐凸显。以新密市武装部站点为研究对象,分析了站点处空气质量变化趋势、污染特征及其主要影响来源,在该监测站点周围安置餐厨油烟净化装置并设置不同气象条件下的污染物控制情景,采用计算... 详细信息

近年来,居民源排放的餐饮油烟对大气环境影响逐渐凸显。以新密市武装部站点为研究对象,分析了站点处空气质量变化趋势、污染特征及其主要影响来源,在该监测站点周围安置餐厨油烟净化装置并设置不同气象条件下的污染物控制情景,采用计算流体动力学方法对不同控制情景下的空气质量进行模拟,评估了不同气象条件下净化装置对该站点处空气质量的改善效果。结果显示:2019年新密市空气质量相比2018年总体上有所改善,但2019年大气颗粒物浓度仍明显高于现行空气质量标准,颗粒物污染形势较为严峻。在加装净化装置后,不同气象条件下净化装置对污染物的减排均有正面效果,尤其是在不利扩散的静稳天气下,污染物净化装置能有效减轻污染状况,在持续运行的前提下可实现年均颗粒物浓度3~5μg的降低。

关键词： CFD 餐厨油烟新密空气质量

PCI术后应用益气复脉(冻干)对青少年急性心肌梗死患者左心室重构及miR-23a水平的影响

在线全文

学校读者我要写书评

暂无评论

中国中医急症 2023年第1期32卷 100-103页

作者：赵新祥苏方成房师荣李永光山东省潍坊市人民医院山东潍坊261041

目的观察青少年急性心肌梗死患者经冠状动脉介入术(PCI)后辅助应用益气复脉(冻干)对其左心室重构以及miR-23a水平的影响。方法选取急诊PCI治疗的13~40岁急性心肌梗死患者52例,随机分为观察组与对照组各26例,均PCI手术后结合常规西医治疗... 详细信息

目的观察青少年急性心肌梗死患者经冠状动脉介入术(PCI)后辅助应用益气复脉(冻干)对其左心室重构以及miR-23a水平的影响。方法选取急诊PCI治疗的13~40岁急性心肌梗死患者52例,随机分为观察组与对照组各26例,均PCI手术后结合常规西医治疗,观察组在此基础上加用益气复脉(冻干)静滴,通过酶联免疫吸附法(ELISA)、心动超声仪和RT-PCR检测两组患者治疗前后外周血中白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶-9(MMP-9)的表达水平,左心室舒张末期内径(LVEDD)、后壁厚度(LVPWT)、舒张末期室间隔厚度(IVST)、重量指数(LVMI)、射血分数(LVEF)、舒张末期容积(LVEDV)和收缩末期容积(LVESV)及血清miR-23a水平。同时记录比较两组治疗前后的不良心血管事件发生率。结果治疗后观察组IL-6、TNF-α、MMP-9、LVEDD、LVPWT、IVST、LVMI、LVEDV、LVESV、miR-23a相对表达水平均显著低于对照组(P<0.05),LVEF明显高于对照组(P<0.05),不良心血管事件发生率低于对照组。结论在常规手术和西医治疗基础上加用益气复脉(冻干)能有效抑制青少年急性心肌梗死后炎症反应、心肌细胞外基质降解以及心室重构,改善心功能,降低miR-23a水平,且明显降低不良心血管事件发生率,安全且有较高的临床应用价值。

关键词：急性心肌梗死 PCI术青少年益气复脉(冻干) 左心室重构 miR-23a