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One-pot synthesis of salicylaldehyde containing biaryl frameworks via an aminocatalytic Diels-Alder-retro-Diels-Alder cascade reaction of ynals with 2-pyrones

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Green Synthesis and Catalysis 2020年第1期1卷 66-69页

作者： Xixi Song Yueteng Zhang Peng Ji Fanxun Zeng fangchao Bi Wei Wang College of Chemistry Zhengzhou UniversityNo.100 Science AvenueZhengzhou 450001China Departments of Pharmacology and Toxicology and Chemistry and Biochemistry And BIO5 InstituteUniversity of ArizonaArizona 85721United States School of Pharmacy East China University of Science and TechnologyShanghai 200237China

Salicylaldehyde containing biaryls are efficiently synthesized via an unprecedented amine promoted Diels-Alderretro-Diels-Alder cascade reaction of ynals with 2-pyrones in good *** reaction is instrumentally metalfree... 详细信息

关键词： Aminocatalysis Biaryls Cascade reactions Diels-Alder reaction Organocatalysis Ynals

浅埋煤层过沟开采覆岩破坏特征及水害防治技术研究

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煤炭技术 2024年第1期43卷 148-152页

作者：李民峰雷方超侯恩科杜超杰冯栋刘凡凡陕西涌鑫矿业有限责任公司陕西府谷719400 西安科技大学地质与环境学院西安710054

黄土沟壑区溃水水害是浅埋煤层开采的主要灾害之一。安山煤矿煤层埋藏浅、局部沟道所在区域5-2煤层顶板距离地表不足30 m,为了解决黄土沟壑区工作面过沟开采可能遇到的水害问题,通过数值模拟的手段研究了工作面过沟开采时的覆岩破坏特征... 详细信息

黄土沟壑区溃水水害是浅埋煤层开采的主要灾害之一。安山煤矿煤层埋藏浅、局部沟道所在区域5-2煤层顶板距离地表不足30 m,为了解决黄土沟壑区工作面过沟开采可能遇到的水害问题,通过数值模拟的手段研究了工作面过沟开采时的覆岩破坏特征,提出了研究区过沟开采时冒裂安全性分区标准,并基于分区结果提出了预防工作面过沟开采发生溃水水害事故的防治技术,过沟开采防治技术包括采前筑坝截流引流,采后工作面地表裂缝修复等,并在工作面过沟开采区域成功地进行了防治应用,应用结果表明,防治技术能够有效预防工作面过沟开采溃水水害。研究成果对榆神矿区工作面安全、绿色高效过沟开采具有一定的借鉴意义。

关键词：过沟开采黄土沟壑区地裂缝修复截流引流

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水产品货架期质量预测模型的研究进展

渔业研究 2024年第5期46卷 547-562页

作者：董浩郑诗伟崔方超王当丰李婷婷励建荣渤海大学食品科学与工程学院辽宁省食品安全重点实验室大连民族大学生命科学学院

【背景】全球每年约有35%的水产品在从捕捞到消费的过程中遭到损失或浪费，这不仅对经济造成巨大损失，还对环境带来不利影响。【目的】为减少这些不利影响，制造商需要在每个阶段提供关于食品货架期的准确信息。准确的货架期信息对于... 详细信息

【背景】全球每年约有35%的水产品在从捕捞到消费的过程中遭到损失或浪费，这不仅对经济造成巨大损失，还对环境带来不利影响。【目的】为减少这些不利影响，制造商需要在每个阶段提供关于食品货架期的准确信息。准确的货架期信息对于优化供应链管理、提高食品安全性和减少浪费至关重要。本文旨在对现有的货架期模型进行分类和分析，详述这些模型在水产品领域的应用，以帮助行业更好地了解和使用这些模型，从而提升水产品质量监测和管理水平。【方法】通过文献回顾和案例分析，详细介绍了常用模型的应用背景和特点。特别关注这些模型在水产品领域的具体应用，重点介绍了预测食品新鲜度指数和货架期的模型。通过比较不同模型的优缺点，探讨其在实际应用中的效果和潜力。【结论】研究发现，目前用于监测食品质量的模型种类繁多，每种模型都有其独特的应用背景和特点。常用的货架期模型包括动力学模型、神经网络、加速有效期测试和偏最小二乘回归模型。在水产品领域，这些模型被广泛应用于预测鱼类、贝类和甲壳类等产品的货架期，帮助企业优化供应链管理和减少损失。未来的研究应关注货架期模型在水产品领域的进一步推广，特别是新模型的发展和多元分析方法的应用。【展望】通过实时食品质量监测，可以筛选出更可靠的运输、加工和包装方法，从而减少损失、提高效益。结合物联网和人工智能技术，以实现实时监测和预测。通过这些努力，可以大大减少水产品在供应链各环节的损失和浪费，提高整个行业的经济效益和可持续发展水平。

关键词：水产品质量监测货架期预测数学模型综述

Programmable dual responsive system reconstructing nerve interaction with small-diameter tissue-engineered vascular grafts and inhibiting intimal hyperplasia in diabetes

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Bioactive Materials 2022年第1期7卷 466-477页

作者： Yanzhao Li Yeqin Wang fangchao Xue Xuli Feng Zhaojing Ba Junjie Chen Zhenhua Zhou Yanhong Wang Ge Guan Guanyuan yang Ziwei Xi Hao Tian Yong Liu Ju Tan Gang Li Xiewan Chen Mingcan yang Wen Chen Chuhong Zhu Wen Zeng Department of Anatomy National and Regional Engineering Laboratory of Tissue EngineeringState and Local Joint Engineering Laboratory for Vascular ImplantsKey Lab for Biomechanics and Tissue Engineering of ChongqingThird Military Medical UniversityChongqing400038China Department of Cell Biology Third Military Army Medical UniversityChongqing400038China Innovative Drug Research Centre of Chongqing University Chongqing401331China Departments of Neurology Southwest HospitalThird Military Medical UniversityChongqingChina Medical English Department Third Military Medical UniversityChongqing400038China The 8th Medical Center of Chinese PLA General Hospital Beijing100091China Department of Plastic and Aesthetic Surgery Southwest HospitalThird Military Medical UniversityChongqingChina State Key Laboratory of Trauma Burn and Combined InjuryChongqingChina

Small-diameter tissue-engineered vascular grafts(sdTEVGs)with hyperglycemia resistance have not been *** intimal hyperplasia caused by hyperglycemia remains problem to hinder the patency of ***,inspired by bionic regulation of nerve on vascular,we found the released neural exosomes could inhibit the abnormal phenotype transformation of vascular smooth muscle cells(VSMCs).The transformation was a prime culprit causing the intimal hyperplasia of *** address this concern,sdTEVGs were modified with an on-demand programmable dual-responsive system of ultrathin *** external primary Reactive Oxygen Species(ROS)-responsive Netrin-1 system was initially triggered by local inflammation to induce nerve remolding of the sdTEVGs overcoming the difficulty of nerve regeneration under ***,the internal secondary ATP-responsive DENND1A(guanine nucleotide exchange factor)system was turned on by the neurotransmitter ATP from the immigrated nerve fibers to stimulate effective release of neural *** results showed nerve fibers grow into the sdTEVGs in diabetic rats 30 days after *** day 90,the abnormal VSMCs phenotype was not detected in the sdTEVGs,which maintained long-time patency without intima *** study provides new insights to construct vascular grafts resisting hyperglycemia damage.

关键词： sdTEVGs On-demand programmed responsive systems Neural exosomes Nerve reconstruction Intimal hyperplasia

Fruit and vegetable consumption,cardiovascular disease,and all-cause mortality in China

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Science China(Life Sciences) 2022年第1期65卷 119-128页

作者： Jun Wang fangchao Liu Jianxin Li Keyong Huang Xueli yang Jichun Chen Xiaoqing Liu Jie Cao Shufeng Chen Chong Shen Ling Yu Fanghong Lu Xianping Wu Liancheng Zhao Ying Li Dongsheng Hu Jianfeng Huang Dongfeng Gu Xiangfeng Lu Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBeijing 100037China Tianjin Key Laboratory of Environment Nutrition and Public Health/Department of Occupational and Environmental HealthSchool of Public HealthTianjin Medical UniversityTianjin 300070China Division of Epidemiology Guangdong Provincial People’s Hospital and Cardiovascular InstituteGuangzhou 510080China Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjing 211166China Department of Cardiology Fujian Provincial HospitalFuzhou 350014China Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong Academy of Medical SciencesJinan 250062China Sichuan Center for Disease Control and Prevention Chengdu 610041China Department of Epidemiology and Health Statistics College of Public HealthZhengzhou UniversityZhengzhou 450001China Department of Epidemiology and Health Statistics School of Public HealthShenzhen University Health Science CentreShenzhen 518060China School of Medicine Southern University of Science and TechnologyShenzhen 518055China

Evidence about the response patterns of fruit and vegetable consumption with the risk of cardiovascular disease(CVD)and allcause mortality was *** associations were examined using a large-scale,population-based Chinese cohort comprising 100,728 participants.A food-frequency questionnaire was used to assess fruit and vegetable *** were ascertained by interviewing individuals or their proxies and checking hospital records or death *** proportional hazards regression was used to calculate hazard ratios(HRs)with 95% confidence intervals(CIs).At the 736,668 person-years of follow-up,3,677 CVD cases and 5,466 deaths were *** multivariable-adjusted HRs for CVD across increasing quartiles of total fruit and vegetable consumption were 1(reference),0.94(95%CI=0.85-1.04),0.89(95%CI=0.80-0.98),and 0.85(95%CI=0.77-0.95).Moreover,participants in the highest quartile displayed a 13% lower risk of all-cause mortality(HR=0.87;95%CI=0.80-0.95).A nonlinear dose-response relation was found for CVD,without additional benefits beyond a consumption of600 g d-1,whereas the all-cause mortality risk decreased along with higher consumption,with a linear *** associations remained significant for fruit consumption but not for vegetable *** findings indicated that greater fruit and vegetable consumption was significantly associated with a lower risk of CVD and all-cause *** fruit and vegetable consumption,especially fruit,in the general population would prevent CVD and premature mortality.

关键词： fruit vegetable cardiovascular disease mortality

Impacts of PM_(2.5) on Ambulatory Blood Pressure Monitoring Indicators Attenuated by Blood Pressure Control Status and Treatment-Two Cities and Two Municipalities,China,2017−2019

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China CDC weekly 2021年第45期3卷 948-953页

作者： fangchao Liu Zhennan Lin Xinyan Wang Xueli yang Qiong Liu Xiaolong Xing Jie Cao Jianxin Li Keyong Huang Weli Yan Tingting Liu Wei Li Shufeng Chen Xiangfeng Lu Dongfeng Gu Jianfeng Huang Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBeijingChina Center for Reproductive Medicine Tianjin Central Hospital of Gynecology ObstetricsTianjinChina Tianjin Key Laboratory of Environment Nutrition and Public HealthDepartment of Occupational and Environmental HealthSchool of Public HealthTianjin Medical UniversityTianjinChina Department of Clinical Epidemiology&Clinical Trial Unit Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Cardiology Renmin Hospital of Wuhan UniversityWuhanHubeiChina Function Test Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medicine Southern University of Science and TechnologyShenzhenGuangdongChina

Summary What is already known about this topic?Short-term PM_(2.5) exposure has been associated with hourly,24-hour,daytime,and nighttime blood pressure(BP)levels,and further studies focusing whether and how the assoc... 详细信息

关键词： Blood monitoring indicators

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黄芪提取物对鲫鱼抗氧化功能的影响

农业技术与装备 2024年第6期 137-139页

作者：孙万辉姜芳超姜亚男刘圣龙陈荣杰莱州市海洋发展和渔业服务中心山东莱州261400

为研究黄芪提取物对鲫鱼机体抗氧化功能的影响,探讨了黄芪提取物在鲫鱼养殖中最适添加水平。按照单因素试验设计原则,以饲料中添加黄芪提取物为变量,将试验鲫鱼分成5个处理组,养殖试验鲫鱼8周。试验结束后,采集各组鲫鱼的血液,收集血清... 详细信息

为研究黄芪提取物对鲫鱼机体抗氧化功能的影响,探讨了黄芪提取物在鲫鱼养殖中最适添加水平。按照单因素试验设计原则,以饲料中添加黄芪提取物为变量,将试验鲫鱼分成5个处理组,养殖试验鲫鱼8周。试验结束后,采集各组鲫鱼的血液,收集血清检测血清抗氧化指标。结果显示,试验组2和试验组3鲫鱼血清丙二醛水平显著降低(P<0.05),谷胱甘肽过氧化物酶和过氧化氢酶活力显著提高(P<0.05);试验组2、试验组3和试验组4血清超氧化物歧化酶活力显著提高(P<0.05)。研究表明,在鲫鱼生产中添加适量的黄芪提取物可以显著增强机体的抗氧化功能,综合各项指标数据,黄芪提取物的最适添加量为500~1000 mg/kg。

关键词：黄芪提取物鲫鱼抗氧化功能最适添加量

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Temporal trend in mortality of cardiovascular diseases and its contribution to life expectancy increase in China, 2013 to 2018

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Chinese Medical Journal 2022年第17期135卷 2066-2075页

作者： Xue Xia Yue Cai Xiang Cui Ruixian Wu fangchao Liu Keyong Huang Xueli yang Xiangfeng Lu Shiyong Wu Dongfeng Gui Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBejing 100037China Center for Health Statistics and Information National Health CommissionBejing 100044China Department of Occupational and Environmental Health Tianjn Key Laboratory of EnvironmentNutrtion and Public HealthSchool of Public HealthTianjin Medical UniversityTianjin 300070China School of Medicine Southern University of Science and TechnologyShenzhenGuangdong 518055China

Backgrounds::Cardiovascular disease(CVD)remains the leading cause of deaths ***,little is understood about its temporal trend and corresponding influence on longevity *** aimed to describe the updated tendency in CVD mortality and to quantify its impact on life expectancy(LE)increase in ***::All-cause mortality rates were calculated with population sizes from the National Bureau of Statistics and death counts from the National Health *** estimated CVD mortality rates by allocating age-and sex-based mortality envelopes to each CVD subtype based on its proportion derived from the Disease Surveillance Points *** probability of CVD premature deaths and LE were calculated with life tables and we adopted Arriaga’s method to quantitate age-and cause-specific contributions to LE ***::During 2013 to 2018,the age-standardized mortality rate of CVD decreased from 289.69(95%confidence interval[CI]:289.03,290.35)/100,000 to 272.37(95%CI:271.81,272.94)/100,000,along with a decline in probability of CVD premature deaths from 9.05%(95%CI:9.02%,9.09%)to 8.13%(95%CI:8.10%,8.16%).The gap in CVD mortality across sexes expanded with more remarkable declines in females,especially for those aged 15 to 64 *** major subtypes,the probability of premature deaths from hemorrhage stroke declined fastest,while improvements of ischemic stroke and ischemic heart disease were limited,and there was an increase in stroke *** in China reached 77.04(95%CI:76.96,77.12)years in 2018 with an increase of 1.38 years from *** the total LE gains,21.15%(0.29 years)were attributed to reductions of CVD mortality in the overall population,mostly driven by those aged>65 ***::The general process in reducing CVD mortality has contributed to longevity improvements in *** attention should be paid to prevention and control of atherosclerotic CVD and stroke sequelae,especially for the ***-age males also d

关键词： Aged Cardiovascular diseases Causes of death Hemorrhagic stroke Ischemic stroke Longevity Mortality,premature Myocardial ischemia Life expectancy China

东北传统酱腌菜中耐盐乳酸菌的筛选、鉴定及其发酵特性研究

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中国酿造 2024年第8期43卷 31-37页

作者：顾娜泥武文玉刘水琳白凤翎吕欣然励建荣檀茜倩崔方超俞张富沈荣虎渤海大学食品科学与工程学院生鲜农产品贮藏加工及安全控制技术国家地方联合工程研究中心辽宁省食品安全重点实验室辽宁锦州121013 大连海关技术中心辽宁大连116000 杭州萧山农业发展有限公司浙江杭州311215

该研究利用溶钙圈法及耐盐性能分析从东北传统酱腌菜中分离筛选耐盐乳酸菌,采用形态学观察、生理生化试验及16S rRNA序列分析对筛选菌株进行鉴定,并进一步通过测定菌株的产酸、降解亚硝酸盐、抗氧化、抑菌、产香及产β-葡萄糖苷酶等能力... 详细信息

该研究利用溶钙圈法及耐盐性能分析从东北传统酱腌菜中分离筛选耐盐乳酸菌,采用形态学观察、生理生化试验及16S rRNA序列分析对筛选菌株进行鉴定,并进一步通过测定菌株的产酸、降解亚硝酸盐、抗氧化、抑菌、产香及产β-葡萄糖苷酶等能力,评价耐盐乳酸菌的发酵特性。结果表明,从7种酱腌菜中分离到6株乳酸菌,其中菌株GNL2和GNL3在16.0%NaCl条件下生长良好,具有良好的耐盐性,经鉴定均为植物乳植杆菌(Lactiplantibacillus plantarum)。与菌株GNL2相比,菌株GNL3具有较好的发酵特性,其产酸性能较好,发酵液的pH为3.75,亚硝酸盐降解率为99.80%,β-葡萄糖苷酶活力为0.76 U/mL,完整细胞提取物的1,1-二苯基-2-三硝基苯肼(DPPH)自由基清除率为80.60%,无细胞提取物的超氧阴离子自由基清除率为78.70%,丁二酮和乙醛合成能力分别为11.13 mg/L和16.02 mg/L。结果表明,菌株GNL3可应用于东北传统酱腌菜生产中,为实现传统酱腌菜高品质规模化生产提供优质菌种资源。

关键词：乳酸菌筛选鉴定耐盐性发酵性能