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Supramolecular polymer-based gel fracturing fluid with a double network applied in ultra-deep hydraulic fracturing

Petroleum Science 2024年第3期21卷 1875-1888页

作者： Yong-Ping Huang Yong Hu Chang-Long Liu yi-ning Wu Chen-Wei Zou Li-Yuan Zhang Ming-Wei Zhao Cai-Li Dai School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China Shandong Key Laboratory of Oilfield Chemistry China University of Petroleum(East China)Qingdao 266580ShandongPR China SINOPEC Petroleum Exploration and Production Research Institute Beijing102206PR China CNOOC China Co Ltd Tianjin BranchTianjin300459PR China

A gel based on polyacrylamide,exhibiting delayed crosslinking characteristics,emerges as the preferred solution for mitigating degradation under conditions of high temperature and extended shear in ultralong *** viscosity/viscoelasticity of the fracturing fluid was required to maintain excellent proppant suspension properties before *** into account both the cost and the potential damage to reservoirs,polymers with lower concentrations and molecular weights are generally *** this work,the supramolecular action was integrated into the polymer,resulting in significant increases in the viscosity and viscoelasticity of the synthesized supramolecular polymer *** double network gel,which is formed by the combination of the supramolecular polymer system and a small quantity of Zr-crosslinker,effectively resists temperature while minimizing permeability damage to the *** results indicate that the supramolecular polymer system with a molecular weight of(268—380)×10^(4)g/mol can achieve the same viscosity and viscoelasticity at 0.4 wt%due to the supramolecular interaction between polymers,compared to the 0.6 wt%traditional polymer(hydrolyzed polyacrylamide,molecular weight of 1078×10^(4)g/mol).The supramolecular polymer system possessed excellent proppant suspension properties with a 0.55 cm/min sedimentation rate at 0.4 wt%,whereas the0.6 wt%traditional polymer had a rate of 0.57 cm/*** comparison to the traditional gel with a Zrcrosslinker concentration of 0.6 wt%and an elastic modulus of 7.77 Pa,the double network gel with a higher elastic modulus(9.00 Pa)could be formed only at 0.1 wt%Zr-crosslinker,which greatly reduced the amount of residue of the fluid after *** viscosity of the double network gel was66 m Pa s after 2 h shearing,whereas the traditional gel only reached 27 m Pa s.

关键词： Ultra-deep reservoir Gel fracturing fluid Double network Supramolecular polymer system Proppant suspension property

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TRPM2 Mediates Hepatic Ischemia–Reperfusion Injury via Ca^(2+) -Induced Mitochondrial Lipid Peroxidation through Increasing ALOX12 Expression

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Research 2024年第1期2023卷 351-368页

作者： Cheng Zhong jing Yang yiyin Zhang Xiaoxiao Fan Yang Fan ning Hua Duguang Li Shengxi jin yirun Li Peng Chen Yongle Chen Xiaobo Cai yi Zhang Linhua Jiang Wei Yang Peilin Yu Hui Lin Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouP.R.China Department of Biophysics and Department of Neurology of the Fourth Affiliated Hospital Zhejiang University School of MedicineHangzhou 310000P.R.China Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province Xinxiang Medical University453003 XinxiangHenanP.R.China School of Biomedical Sciences Faculty of Biological SciencesUniversity of LeedsLS29JT LeedsUK Department of Toxicology and Department of Medical Oncology of Second Affiliated Hospital Zhejiang University School of MedicineHangzhouP.R.China Zhejiang Engineering Research Center of Cognitive Healthcare Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310020P.R.China College of Biomedical Engineering and Instrument Science Zhejiang UniversityHangzhou 310058P.R.China

Hepatic ischemia–reperfusion(IR)injury is a serious clinical problem that complicates liver resection and *** recent advances in understanding of the pathophysiology of hepatic IR injury,effective interventions and therapeutics are still ***,we examined the role of transient receptor potential melastatin 2(TRPM2),a Ca^(2+)-permeable,non-selective cation channel,in mediating hepatic IR *** data showed that TRPM2 deficiency attenuated IR-induced liver dysfunction,inflammation,and cell death in ***,RNA sequencing analysis indicated that TRPM2-induced IR injury occurs via ferroptosis-related ***,as a ferroptosis inducer,(1S,3R)-RSL3 treatment induced mitochondrial dysfunction in hepatocytes and a TRPM2 inhibitor suppressed ***,TRPM2-mediated calcium influx caused mitochondrial calcium accumulation via the mitochondrial Ca^(2+)-selective uniporter and increased the expression level of arachidonate 12-lipoxygenase(ALOX12),which results in mitochondrial lipid peroxidation during hepatic IR ***,hepatic IR injury-induced ferroptosis was obviously relieved by a TRPM2 inhibitor or calcium depletion,both in vitro and in ***,these findings demonstrate a crucial role for TRPM2-mediated ferroptosis in hepatic IR injury via increased Ca^(2+)-induced ALOX12 expression,indicating that pharmacological inhibition of TRPM2 may provide an effective therapeutic strategy for hepatic IR injury-related diseases,such as during liver resection and transplantation.

关键词： TRPM2 Lipid Hepatic

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Prediction of hepatic artery occlusion after liver transplantation by ultrasound characteristics and clinical risk factors

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World Journal of Radiology 2024年第6期16卷 196-202页

作者： Yu-Ting Lai yi Chen Tai-Shi fang Zhi-Yan Li ning-Bo Zhao Department of Ultrasound National Clinical Research Centre for Infectious DiseasesThe Third People’s Hospital of ShenzhenThe Second Hospital Affiliated with the Southern University of Science and TechnologyShenzhen 518112Guangdong ProvinceChina Department of Liver Surgery National Clinical Research Centre for Infectious DiseasesThe Third People’s Hospital of ShenzhenThe Second Hospital Affiliated with the Southern University of Science and TechnologyShenzhen 518112Guangdong ProvinceChina

BACKGROUND Hepatic artery occlusion(HAO)after liver transplantation(LT)is a devastating complication,resulting in early graft loss and reduced overall ***-sound is an established assessment method for HAO in patients following LT,especially those with complex hepatic artery *** We retrospectively analyzed the ultrasound characteristics and the clinic risk factors associated with HAO in 400 adult LT patients who were enrolled and treated at the Third People's Hospital of Shenzhen between November 2016 and July *** patients diagnosed with acute HAO(A-HAO)by surgery and fifteen diagnosed with chronic HAO(C-HAO)were included.A control group of 33 patients without HAO complications during the same period were randomly selected using a random number *** patients underwent an ultrasono-graphy *** including resistance index(RI),peak systolic velocity(PSV),and portal vein velocity(PVV)were compared across the ***,basic clinical data were collected for all patients,including gender,age,primary diagnosis,D-dimer concentration,total operation time,cold ischemia time,hot ischemia time,intraoperative blood loss and transfusion,intraoperative urine volume,infusion,model for end-stage liver disease(MELD)score,and whether complex hepatic artery reconstructions were ***,risk factors influencing HAO formation after LT were *** Compared to the non-HAO group,PVV and RI were higher in the A-HAO group,while PSV was ***,both PSV and RI were lower in the C-HAO group compared to the non-HAO *** proportion of patients undergoing complex hepatic artery reconstructions and the gamma-glutamyltransferase(GGT)level before occlusion were significantly higher in the A-HAO group compared to the non-HAO ***,there were no distinct differences between the two groups in D-dimer,MELD score,pre-occlusion alanine transaminase and aspartate transaminase levels,or intrao

关键词： Hepatic artery occlusion Ultrasonography Diagnostic performance Risk factors Liver transplantation

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Appendiceal intussusception complicated by adenocarcinoma of the cecum:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1461-1466页

作者： Yu Long yi-ning Xiang Fei Huang Lei Xu Xiao-Yun Li Yun-Huan Zhen Department of Colorectal Surgery The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550001Guzihou ProvinceChina Department of Colorectal Surgery Guizhou Medical UniversityGuiyang 550001Guizhou ProvinceChina Department of Pathology The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550001Guizhou ProvinceChina

BACKGROUND Appendiceal intussusception is a pathological condition in which the appendix is inverted into the cecum,which may cause symptoms that resemble those of other gastrointestinal disorders and may induce intestinal *** rarity of this case presentation is the co-occurrence of appendiceal intussusception and cecal adenocarcinoma,a combination that to our knowledge has not previously been reported in the medical *** case provides new insights into the complexities of diagnosing and managing overlapping *** SUMMARY A 25-year-old woman presented with persistent periumbilical pain and bloody *** initial biopsy showed cecal cancer;however,subsequent colonoscopy and computed tomography findings raised the suspicion of appendiceal intussus-ception,which was later confirmed *** unique case was charac-terized by a combination of intussusception and adenocarcinoma of the *** intervention included a laparoscopic right hemicolectomy,which led to the histopathological diagnosis of mucinous adenocarcinoma with appendiceal *** patient recovered well postoperatively and was advised to initiate adjuvant *** case highlights not only the importance of considering appendiceal intussusception in the differential diagnosis,but also the possibility of appendicitis and the atypical presentation of neoplastic *** Physicians should consider the possibility of appendiceal intussusception in cases of atypical appendicitis,particularly when associated with neoplastic presentation.

关键词： Appendiceal intussusception Appendicitis Cecal cancer Target signs Misdiagnosis Case report

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Primary pulmonary meningioma and minute pulmonary meningothelial-like nodules: Rare pulmonary nodular lesions requiring more awareness in clinical practice

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World Journal of Clinical Cases 2024年第11期12卷 1857-1862页

作者： Li-Dan Liu Ke-Xin Zhang Hai-ning Zhang yi-Wen Zheng Hong-Tao Xu Department of Pathology The First Hospital and College of Basic Medical Sciences of China Medical UniversityShenyang 110001Liaoning ProvinceChina

In this editorial,we comment on an article by Ruan et al published in a recent issue of the World Journal of Clinical *** meningothelial proliferative lesions,including primary pulmonary meningiomas,minute pulmonary meningothelial-like nodules,and metastatic pulmonary meningiomas are rare pulmonary *** lesions are difficult to differentiate from lung cancers based on clinical and imaging ***,we briefly introduce the clinical,imaging,and pathological characteristics of these lesions and discuss their pathogenesis to strengthen the current understanding of pulmonary meningothelial proliferative lesions in clinical diagnosis and therapy.

关键词： Pulmonary meningothelial proliferation Primary pulmonary meningioma Minute pulmonary meningothelial-like nodule Lung neoplasm Rare pulmonary nodular lesion

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基于联合方向梯度和均值对比度的红外弱小目标检测方法

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红外与毫米波学报 2024年第1期43卷 106-115页

作者：李宁郭义放焦继超逄敏徐威北京邮电大学电子工程学院北京100876 中国电波传播研究所第三研究部山东青岛266108

针对小目标在整幅图像中占比很低,且目标周围存在大量杂波,提出了一种基于联合方向梯度(Associated Directional Gradient,ADG)和均值对比度(Mean Contrast,MC)的红外弱小目标检测算法。该算法由两个模块组成:ADG利用红外弱小目标的高... 详细信息

针对小目标在整幅图像中占比很低,且目标周围存在大量杂波,提出了一种基于联合方向梯度(Associated Directional Gradient,ADG)和均值对比度(Mean Contrast,MC)的红外弱小目标检测算法。该算法由两个模块组成:ADG利用红外弱小目标的高斯分布模型,将单一方向的梯度与一个相邻方向上的梯度相加组成新的联合梯度特征,增强真实目标、抑制背景杂波的同时能够消除高亮边缘对目标检测效果的影响;MC融入方向信息来计算目标的多方向对比度,选用多方向对比度的最小值抑制结构噪声,并将均值滤波的思想引入对比度的计算,抑制背景中的孤立噪声,进一步降低检测的虚警率。在实际红外图像上的实验结果表明,该算法在增强目标信噪比和抑制背景噪声方面,能够取得较好效果。

关键词：红外图像目标检测联合方向梯度均值对比度

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Unveiling the next generation of MRI contrast agents:current insights and perspectives on ferumoxytol-enhanced MRI

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National Science Review 2024年第5期11卷 385-404页

作者： Guangxiang Si Yue Du Peng Tang Gao Ma Zhaochen Jia Xiaoyue Zhou Dan Mu Yan Shen yi Lu Yu Mao Chuan Chen Yan Li ning Gu Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical EngineeringSoutheast University Key Laboratory for Bio-Electromagnetic Environment and Advanced Medical Theranostics School of Biomedical Engineering and InformaticsNanjing Medical University Department of Radiology the First Affiliated Hospital of Nanjing Medical University MR Collaboration Siemens Healthineers Ltd. Department of Radiology Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School School of Mathematical Sciences Capital Normal University Nanjing Key Laboratory for Cardiovascular Information and Health Engineering Medicine Institute of Clinical Medicine Nanjing Drum Tower HospitalMedical SchoolNanjing University

Contrast-enhanced magnetic resonance imaging(CE-MRI) is a pivotal tool for global disease diagnosis and management. Since its clinical availability in 2009, the off-label use of ferumoxytol for ferumoxytol-enhanced MRI(FE-MRI) has significantly reshaped CE-MRI practices. Unlike MRI that is enhanced by gadolinium-based contrast agents, FE-MRI offers advantages such as reduced contrast agent dosage, extended imaging windows, no nephrotoxicity, higher MRI time efficiency and the capability for molecular imaging. As a leading superparamagnetic iron oxide contrast agent, ferumoxytol is heralded as the next generation of contrast agents. This review delineates the pivotal clinical applications and inherent technical superiority of FE-MRI, providing an avant-garde medical-engineering interdisciplinary lens, thus bridging the gap between clinical demands and engineering innovations. Concurrently, we spotlight the emerging imaging themes and new technical breakthroughs. Lastly, we share our own insights on the potential trajectory of FE-MRI, shedding light on its future within the medical imaging realm.

关键词： ferumoxytol contrast agent contrast-enhanced MRI ferumoxytol-enhanced MRI

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To explore the mechanism of yigong San anti-gastric cancer and immune regulation

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1965-1994页

作者： Dou-Dou Lu Ling Yuan Zhao-Zhao Wang Jian-Jun Zhao Yu-Hua Du Na ning Guo-Qing Chen Shi-Cong Huang yi Yang Zhe Zhang yi Nan School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Chinese Medical Gastrointestinal China-Japan Friendship HospitalBeijing 100029China Key Laboratory of ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND yigong San(YGS)is a representative prescription for the treatment of digestive disorders,which has been used in clinic for more than 1000 ***,the mechanism of its anti-gastric cancer and regulate immunity are still remains *** To explore the mechanism of YGS anti-gastric cancer and immune *** Firstly,collect the active ingredients and targets of YGS,and the differentially expressed genes of gastric ***,constructed a protein-protein interaction network between the targets of drugs and diseases,and screened hub *** the clinical relevance,mutation and repair,tumor microenvironment and drug sensitivity of the hub gene were ***,molecular docking was used to verify the binding ability of YGS active ingredient and hub *** Firstly,obtained 55 common targets of gastric cancer and *** Kyoto Encyclopedia of Genes and Genomes screened the microtubule-associated protein kinase signaling axis as the key pathway and IL6,EGFR,MMP2,MMP9 and TGFB1 as the hub *** 5 hub genes were involved in gastric carcinogenesis,staging,typing and prognosis,and their mutations promote gastric cancer ***,molecular docking results confirmed that the components of YGS can effectively bind to therapeutic *** YGS has the effect of anti-gastric cancer and immune regulation.

关键词： Gastric cancer yigong San Mechanism Immune

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CircMYBL2 facilitates hepatocellular carcinoma progression by regulating E2F1 expression

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Oncology Research 2024年第6期32卷 1129-1139页

作者： JUNZHE yi BINBIN LI XIAOMIN yiN LINGRUI LIU CAILU SONG yiNG ZHAO MANBO CAI HAILIN TANG DONG CHEN ning LYU State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou510060China Department of Medical Oncology The Third People’s Hospital of YongzhouYongzhou425000China Department of Radiotherapy The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang421001China Center of Hepato-Pancreato-Biliary Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China

Circular RNAs(circRNAs)have been recognized as pivotal regulators in tumorigenesis,yet the biological functions as well as molecular mechanisms of the majority of circRNAs in hepatocellular carcinoma(HCC)remain *** sought to unveil the expression profile and biological role of circMYBL2 in *** microarray analyses were conducted to probe the expression profile of circMYBL2 in HCC cells,and qRT‒PCR analysis was then performed in HCC cell lines and tissues,revealing significant upregulation of *** experiments were conducted to evaluate the biological function of circMYBL2 in HCC ***,bioinformatics analysis,qRT‒PCR analysis,luciferase reporter assays,and western blot analysis were employed to investigate the interplay among circMYBL2,miR-1205,and ***2 was found to exhibit marked upregulation in tumor tissues as well as HCC cell *** expression of circMYBL2 increased the proliferation and migration of HCC cells,whereas circMYBL2 knockdown elicited contrasting ***,our results indicated that circMYBL2 promoted E2F1 expression and facilitated HCC progression by sponging *** findings revealed that circMYBL2 contributed to HCC progression through the circMYBL2/miR-1205/E2F1 axis,suggesting the potential of circMYBL2 as a novel target for HCC treatment or a prognostic biomarker for HCC.

关键词： Circular RNAs circMYBL2 miR-1205 E2F1 Hepatocellular carcinoma

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Feasibility of compacted attapulgite/diatomite amended clayey soils as gas barrier materials

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3707-3717页

作者： Heng Zhuang Wei-yi Xia Jia-Ming Wen Min Wang ying-Zhen Li ning-Jun Jiang Konstantin S.Rodygin Yan-Jun Du Jiangsu Key Laboratory of Low Carbon and Sustainable Geotechnical Engineering Institute of Geotechnical EngineeringSoutheast UniversityNanjing211189China Jiangsu Province Ecology and Environment Protection Engineering Research Center of Groundwater Pollution Prevention and Control Jiangsu Environmental Engineering Technology Co.Ltd.Nanjing210036China Zijin(Changsha)Engineering Technology Co. Ltd.Changsha410006China Institute of Chemistry Saint Petersburg State UniversityStary Petergof198504Russia

Compacted clay liners are extensively used as barriers to control the upward diffusion of vapors of volatile or semi-volatile organic contaminants released from unsaturated contaminated soils at industrycontaminated *** study aimed to investigate the gas diffusion barrier performance of compacted clayey soils amended with three agents including attapulgite and diatomite individually,and attapulgite/diatomite *** properties including water retention,volumetric shrinkage,gas diffusion,and unconfined compressive strength were evaluated through a series of laboratory tests of amended compacted clayey *** results demonstrate that the decrease in volume proportions of interaggregate pores leads to an increase in unconfined compressive strength(qu).Both hydrophilic groups and microstructures of attapulgite and diatomite result in an increase in water retention percent(Wt)of compacted clayey soil specimens after amendment regardless of the type of agent or initial water content(w0).Furthermore,the ratio of the gas diffusion coefficient(De)to the gas diffusion coefficient in the air(Da)was significantly reduced owing to a decrease in volume proportions of inter-aggregate pores,hydrophilic group,and microstructures of attapulgite and *** electron microscope analyses revealed that rod-shaped attapulgite filled the inter-aggregate pores formed by clay particles,whereas the disc-shaped diatomite particles,characterized by micropores,failed to obstruct the interaggregate pores due to their larger particle *** intrusion porosimetry(MIP)analyses showed a reduction in pore volume in the inter-aggregate pores,leading to a reduction in the total pore volume for both the attapulgite and attapulgite/diatomite mixture amended clays,which is in accordance with the scanning electron microscope(SEM)*** findings are pertinent to the practical application of compacted clay liners as gas barriers against the upward migration of volatile or s

关键词： Compacted clay liner Attapulgite/diatomite mixture Diffusion barrier Water retention

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