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鲜切果蔬酚类物质生物合成机制及抗氧化活性研究进展

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中国食品学报 2024年第2期24卷 397-406页

作者：管玉格王怡袁宁萨仁高娃冯可胡文忠浙江农林大学食品与健康学院杭州311300 大连民族大学生命科学学院辽宁大连116600 珠海科技学院药学与食品科学学院广东珠海519040 澳门科技大学医学院中国澳门999078

近年来,随着人们生活水平的提高,保健意识的增强以及生活节奏的加快,鲜切果蔬产品因具有“方便、安全、营养、新鲜”的特点而受到广大消费者的青睐。果蔬在鲜切加工过程中,不可避免地受到机械损伤,启动自身的防御体系合成酚类等次生代... 详细信息

近年来,随着人们生活水平的提高,保健意识的增强以及生活节奏的加快,鲜切果蔬产品因具有“方便、安全、营养、新鲜”的特点而受到广大消费者的青睐。果蔬在鲜切加工过程中,不可避免地受到机械损伤,启动自身的防御体系合成酚类等次生代谢产物。酚类物质的积累不仅可用于抵御和修复机械损伤,还能显著提高鲜切果蔬的抗氧化活性。对果蔬进行鲜切预处理,进而提高鲜切果蔬的抗氧化保健功效,受到采后领域学者的广泛关注。目前基于酚类物质的生物合成机制及抗氧化活性的生理、生化研究,在提高鲜切果蔬营养价值方面取得了重要进展。本文综述鲜切果蔬酚类物质的生物合成机制及其贮藏期间抗氧化活性的变化规律,为研究提高酚类物质含量和抗氧化活性的方法提供新的思路。

关键词：鲜切果蔬酚类物质生物合成机制抗氧化活性

Pain management of hemiplegic shoulder pain post stroke in patients from Nanjing,China

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Neural Regeneration Research 2013年第25期8卷 2389-2398页

作者： yi Zhu Bin Su ning Li Hongzhu jin Teaching and Research Department of Rehabilitation Treatment Second Clinical MedicineNanjing University of Traditional Chinese Medicine Wuxi Tongren International Rehabilitation Hospital Department of Rehabilitation Second Xiangya Hospital of Central South University Second Clinical Medicine Nanjing University of Traditional Chinese Medicine

We selected 106 hemiplegic patients with shoulder pain hospitalized after stroke from three hospi- tals in Nanjing, China between February 2007 and January 2012. All patients had complete clinical data sets and accounted for 45.5% of the inpatients because of stroke. Results showed that the number of patients with hemiplegic shoulder pain post stroke increased yearly, attacking mainly males 50-69 years of age. Of 106 patients, there were 60 cases （56.6%） of adhesive capsulitis, 19 （17.9%） of shoulder subluxation, 14 （13.2%） of complex regional pain syndrome, and 13 （12.6%） of central pain. The main symptoms were shoulder pain （100%）, limit of shoulder mobility （98.1%）, and adhesion of the scapula （56.6%）. MRI of the shoulder showed tendon and ligament lesions （57.1%） and rotator cuff tear （38.1%）. 53.8% of central pain was related to the thalamus, in addition to the basal ganglia, brain stem, and cerebellopontine angle. Shoulder pain, upper limb motor function, and function independence were significantly improved after comprehensive rehabilitation. In par- ticular, electroacupuncture based on basic physical therapy exhibited efficacy on shoulder subluxa- tion and complex regional pain syndrome. Multiple linear regression results showed a negative re- lationship of efficacy of pain management with the attack period of shoulder pain, involvement of the posterior limb of the internal capsule, and duration between onset and rehabilitation treatment, but a positive correlation with pain-related education, pain regression period, and pain diagnosis.

关键词： neural regeneration brain injury hemiplegia post stroke shoulder pain adhesive capsulitis shoulder subluxation complex regional pain syndrome grants-supported paper neuroregeneration

XELOX(capecitabine plus oxaliplatin)plus bevacizumab(anti-VEGF-A antibody)with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer:a multicenter,open-label,randomized,controlled,phase 3 trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2104-2113页

作者： Qiu-Zhong Pan jing-jing Zhao Liang Liu Dong-Sheng Zhang Li-Ping Wang Wen-Wei Hu De-Sheng Weng Xiang Xu yi-Zhuo Li Yan Tang Wei-Hong Zhang Jie-Yao Li Xiao Zheng Qi-jing Wang Yong-Qiang Li Tong Xiang Li Zhou Shuang-ning Yang Chen Wu Rong-Xing Huang Jia He Wei-Jiao Du Lu-Jun Chen Yue-Na Wu Bin Xu Qiong Shen yi Zhang jing-Ting Jiang Xiu-Bao Ren Jian-Chuan Xia State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Department of Biotherapy Sun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerTianjin 300060PR China Key Laboratory of Cancer Immunology and Biotherapy Tianjin 300060PR China Department of Biotherapy/Immunology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060PR China Department of Oncology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052PR China Department of Tumor Biological Treatment the Third Affiliated Hospital of Soochow UniversityChangzhouJiangsu 213003PR China Jiangsu Engineering Research Center for Tumor Immunotherapy ChangzhouJiangsu 213003PR China Institute for Cell Therapy of Soochow University ChangzhouJiangsu 213003PR China Department of Stem Cell&Regenerative Medicine State Key Laboratory of TraumaBurn and Combined InjuryDaping HospitalArmy Medical UniversityChongqing 400042PR China Imaging Diagnosis and Interventional Center Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060PR China

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer(mCRC),but the prognosis remains *** phase 3 trial(***:NCT03950154)assessed the efficacy and adverse events(AEs)of the combination of PD-1 blockade-activated DC-CIK(PD1-T)cells with XELOX plus bevacizumab as a first-line therapy in patients with mCRC.A total of 202 participants were enrolled and randomly assigned in a 1:1 ratio to receive either first-line XELOX plus bevacizumab(the control group,n=102)or the same regimen plus autologous PD1-T cell immunotherapy(the immunotherapy group,n=100)every 21 days for up to 6 cycles,followed by maintenance treatment with capecitabine and *** main endpoint of the trial was progression-free survival(PFS).The median follow-up was 19.5 *** PFS was 14.8 months(95%CI,11.6-18.0)for the immunotherapy group compared with 9.9 months(8.0-11.8)for the control group(hazard ratio[HR],0.60[95%CI,0.40-0.88];p=0.009).Median overall survival(OS)was not reached for the immunotherapy group and 25.6 months(95%CI,18.3-32.8)for the control group(HR,0.57[95%CI,0.33-0.98];p=0.043).Grade 3 or higher AEs occurred in 20.0%of patients in the immunotherapy group and 23.5%in the control groups,with no toxicity-associated deaths *** addition of PD1-T cells to first-line XELOX plus bevacizumab demonstrates significant clinical improvement of PFS and OS with well tolerability in patients with previously untreated mCRC.

关键词： PD1 immunotherapy bevacizumab

World Federation of Acupuncture-Moxibustion Societies(WFAS)Technical Benchmark of Acupuncture and Moxibustion:Cupping

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World Journal of Acupuncture-Moxibustion 2024年第3期34卷 222-226页

作者： Dan LI Yu-Jia LI yi GUO Xue ZHAO Xiao-Dong WU Xiao-ning YuaN Ono YASUO Jia-yin ZHANG Yu-Fan ZHOU yi YANG Tian-yi ZHAO Bo CHEN Zi-Qi WANG Hao-Yang WEN Tian-Cong FU Ze-Lin CHEN Jun jin Tianjin University of Traditional Chinese Medicine Tianjin 301617China International Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin300381China Tianjin Institute of Traditional Chinese Medicine standardization Tianjin 301617China Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBejing 100700China College of Traditional Chinese Medicine and Pharmacology Canada Toronto M1T3J3Canada Kounandia CARE Nigata-shi951-8106Japan Tung Shin Hospital Kuala Lumpur 55100Malaysia Harmony TCM Studio Queensland 4113Australia

World Federation of Acupuncture-Moxibustion Societies(WFAS)Technical Benchmark of Acupuncture and Moxibustion:Cupping,developed under the leadership of Tianjin University of Traditional Chinese Medicine,was approved by *** technical benchmark was issued on October 9,2023,and implemented on December 31,*** main contents include the scope,normative references,terms and definitions,procedures and rules,and *** article focuses on the above contents,an outlook on the application,popularization,and update plan of this technical benchmark is proposed.

关键词： Cupping Technical benchmark World Federation of Acupuncture-Moxibustion Societies(WFAS) Standard

A homopolymolybdate-supported plate-like 2D cobalt network constructed from a new pyrazole-amide-pyridyl ligand: highly electrochemical activity in both capacitive performance and the detection of Cr(Ⅵ)

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Tungsten 2024年第2期6卷 422-427页

作者： Xiu-Li Wang Yong-Zhen Chen Zhi-Han Chang Yu-Chun Lin jing-yi Ma College of Chemistry and Materials Engineering Bohai UniversityJinzhou 121013China Professional Technology Innovation Center of Liaoning Province for Conversion Materials of Solar Cell Jinzhou 121013China

By employing a new semi-rigid pyrazole-amide-derived bis(pyridyl)ligand[N,N'-bis(4-picolylamine)-1-hydropyrazole(4-dpap)],a new homopolymolybdate-based two-dimensional(2D)plate-like complex[Co(4-dpap)(H_(2)O)(β-Mo_(8)O_(2)6)1/2](1)has been prepared under solvothermal condition and structurally ***β-Mo_(8)anions are fi xed between the 2D metal–organic networks[Co(4-dpap)(H_(2)O)]n 2n+via hydrogen-bonding *** 1 possesses satisfactory specifi c capacitance of 1512.4 F·g^(−1)(current density:1 A·g^(−1))and good cycling stability(90.8%after 1000 cycles).Moreover,1 represents a promising amperometric sensor for measurement of Cr(Ⅵ)with low detection limit(0.042μmol·L^(−1))and high *** insertion ofβ-Mo_(8)anions between the unique 2D metal−organic networks improves the active area of polyoxometalates,which further promotes electrochemical performance.

关键词： Homopolymolybdate Metal–organic network Pyrazole-amide-derived bis(pyridyl)ligand Supercapacitor Electrochemical sensor

双重信息引导的蚁群算法求解绿色多舱车辆路径问题

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控制理论与应用 2024年第6期41卷 1067-1078页

作者：郭宁申秋义钱斌那靖胡蓉毛剑琳昆明理工大学信息工程与自动化学院云南昆明650500 昆明理工大学机电工程学院云南昆明650500 昆明理工大学云南省人工智能重点实验室云南昆明650500

针对当前实际运输中广泛存在的绿色多舱车辆路径问题(GMCVRP),文章提出一种双重信息引导的蚁群优化算法(DIACO)进行求解.首先,在DIACO的全局搜索阶段,重新构建传统蚁群优化算法(TACO)中的信息素浓度矩阵(PCM),使其同时包含客户块信息和... 详细信息

针对当前实际运输中广泛存在的绿色多舱车辆路径问题(GMCVRP),文章提出一种双重信息引导的蚁群优化算法(DIACO)进行求解.首先,在DIACO的全局搜索阶段,重新构建传统蚁群优化算法(TACO)中的信息素浓度矩阵(PCM),使其同时包含客户块信息和客户序列信息,即建立具有双重信息的PCM(DIPCM),从而更全面学习和累积优质解的信息;采用3种启发式方法生成较高质量个体,用于初始化DIPCM,可快速引导算法朝向解空间中优质区域进行搜索.其次,在DIACO的局部搜索阶段,设计结合自适应策略的多种变邻域操作,用于对解空间的优质区域执行深入搜索.再次,提出信息素浓度平衡机制,以防止搜索陷入停滞.最后,使用不同规模的算例进行仿真测试和算法对比,结果验证了DIACO是求解GMCVRP的有效算法.

关键词：多舱车辆路径问题绿色蚁群优化算法双重信息引导信息素浓度平衡机制

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艺术青年“城乡两栖化”介入乡村振兴:特征、机理及对策建议

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南京理工大学学报（社会科学版） 2024年第5期37卷 47-55页

作者：邵宁张轶南京理工大学设计艺术与传媒学院江苏南京210094

在国家政策推动文化产业赋能乡村振兴的背景下,艺术青年是艺术介入乡村振兴人才中的中坚力量。本文以艺术青年为研究对象,对艺术青年“城乡两栖化”介入乡村振兴的流动现象进行理论阐释,勾勒艺术青年“城乡两栖化”介入乡村振兴的主要特... 详细信息

在国家政策推动文化产业赋能乡村振兴的背景下,艺术青年是艺术介入乡村振兴人才中的中坚力量。本文以艺术青年为研究对象,对艺术青年“城乡两栖化”介入乡村振兴的流动现象进行理论阐释,勾勒艺术青年“城乡两栖化”介入乡村振兴的主要特征,归纳艺术青年“城乡两栖化”介入乡村振兴的内在机理,为探讨艺术介入乡村振兴提供新的理论视角。此外,本文探索性地提出通过进阶式艺术青年驻村计划促进艺术青年“城乡两栖化”介入乡村振兴,为进一步探索乡村如何引进艺术青年人才,优化艺术人才配置与培育本土化艺术人才提出对策建议。

关键词：艺术青年城乡两栖化乡村振兴艺术介入乡村

10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： Qiang Li Li‑Jiao Wang jing‑Yu Tang Xiang‑Biao Qiu Zhen Chen Mao‑Yuan Zhao Chang‑Jun ning Kai Pan Wei Xu Tao Li Su‑Peng Lu Han yi Rui‑Rui Fan Chang‑Qing Feng Rong Zhang Xiao‑Yang Sun Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping Chen Yong‑Hao Chen Zeng‑Qi Cui An‑Chuan Fan Fan‑Zhen Feng Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He Yang Hong yi‑Wei Hu Han‑Xiong Huang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao jin Ling Kang Bo Li Gong Li Xiao Li Yang Li Jie Liu Rong Liu Shu‑Bin Liu yi‑Na Liu Guang‑Yuan Luan Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Kang Sun Zhi‑Xin Tan Sheng‑Da Tang jin‑Cheng Wang Peng‑Cheng Wang Zhao‑Hui Wang Zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu Cong Xia Yong‑Ji Yu Guo‑Hui Zhang Hang‑Chang Zhang Lin‑Hao Zhang Qi‑Wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang Zhi‑Yong Zhang Zhi‑Hao Zhou Ke‑Jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

数智驱动营销下企业网络平台供应链的绿色产品营销策略研究

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中国管理科学 2024年第5期32卷 81-92页

作者：陈翼孙晓曼张宁蔡双立牟宗玉天津财经大学商学院天津300222 青岛大学商学院山东青岛266071

网络平台具有的数智驱动营销技术和在线销售服务功能有助于绿色产品的生产和销售。因此,本文构建了由一个制造商和一个平台所组成的网络平台供应链模型,考虑了制造商投资绿色技术生产产品,网络平台利用消费者在线购物数据开展数智驱动... 详细信息

网络平台具有的数智驱动营销技术和在线销售服务功能有助于绿色产品的生产和销售。因此,本文构建了由一个制造商和一个平台所组成的网络平台供应链模型,考虑了制造商投资绿色技术生产产品,网络平台利用消费者在线购物数据开展数智驱动营销活动,研究了制造商和平台合作营销绿色产品的营销策略,以及考虑制造商利用成本共担契约协同网络平台开展数智驱动营销绿色产品的问题。研究发现:(1)优化绿色投资和数智驱动营销成本,以及提升消费者对绿色产品和数智驱动营销的敏感度,均有利于提升网络平台供应链成员的获利水平和产品的绿色水平;(2)在代售策略下,网络平台收取的佣金率是影响制造商和平台销售策略选择的主要因素,存在一个佣金率阈值,使得制造商和平台均可获取相较转售策略更多的利润;(3)在代售和转售策略下,制造商可利用成本共担契约有效激励网络平台销售绿色产品,且存在一个成本共担的阈值,使得制造商和网络平台均有机会获得帕累托改进的利润,网络平台收取较少的佣金、制造商分担较大的营销成本均有利于实现经济和生态效益的共赢。

关键词：数智驱动营销绿色生产网络平台供应链在线销售成本共担契约