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Preoperatively predicting vessels encapsulating tumor clusters in hepatocellular carcinoma:Machine learning model based on contrast-enhanced computed tomography

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 857-874页

作者： Chao Zhang Hai Zhong fang Zhao Zhen-Yu Ma Zheng-Jun dai Guo-Dong Pang Department of Radiology The Second Hospital of Shandong UniversityJinan 250033Shandong ProvinceChina Department of Radiology Qilu Hospital of Shandong UniversityJinan 250014Shandong ProvinceChina Department of Radiology Linglong Yingcheng HospitalYantai 265499Shandong ProvinceChina Department of Scientific Research Huiying Medical Technology Co.LtdBeijing 100192China

BACKGROUND Recently,vessels encapsulating tumor clusters(VETC)was considered as a distinct pattern of tumor vascularization which can primarily facilitate the entry of the whole tumor cluster into the bloodstream in an invasion independent manner,and was regarded as an independent risk factor for poor prognosis in hepatocellular carcinoma(HCC).AIM To develop and validate a preoperative nomogram using contrast-enhanced computed tomography(CECT)to predict the presence of VETC+in *** We retrospectively evaluated 190 patients with pathologically confirmed HCC who underwent CECT scanning and immunochemical staining for cluster of differentiation 34 at two medical *** analysis was conducted on intratumoral and peritumoral regions in the portal vein *** features,essential for identifying VETC+HCC,were extracted and utilized to develop a radiomics model using machine learning algorithms in the training *** model’s performance was validated on two separate test *** operating characteristic(ROC)analysis was employed to compare the identified performance of three models in predicting the VETC status of HCC on both training and test *** most predictive model was then used to constructed a radiomics nomogram that integrated the independent clinical-radiological *** and decision curve analysis were used to assess the performance characteristics of the clinical-radiological features,the radiomics features and the radiomics *** The study included 190 individuals from two independent centers,with the majority being male(81%)and a median age of 57 years(interquartile range:51-66).The area under the curve(AUC)for the combined radiomics features selected from the intratumoral and peritumoral areas were 0.825,0.788,and 0.680 in the training set and the two test sets.A total of 13 features were selected to construct the *** nomogram,combining clinicalradiological and combined radiomics features could acc

关键词： Hepatocellular carcinoma Vessels encapsulating tumor clusters Intratumoral and peritumoral regions Radiomics features Nomog

Clinical implications of the latest advances in gastrointestinal tumor research

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4055-4059页

作者： wei dai Yuan-Qi Li You Zhou Tumor Biological Diagnosis and Treatment Center The Third Affiliated Hospital of Soochow UniversityChangzhou 213003Jiangsu ProvinceChina

In this editorial,we provide commentary on six articles recently published in the World Journal of Gastrointestinal *** articles collectively present the latest findings in the field of gastric and colorectal cancer(CRC)*** global incidence of gastric cancer varies based on geographical location,age,and *** disease predominantly affects middle-aged and elderly individuals,with a slightly higher prevalence in men than in *** is characterized by a low 5-year survival rate and high mortality *** primarily affects individuals over the age of 50,and the risk of disease increases with *** gastric and CRC pose significant health threats,thus requiring more effective diagnostic,therapeutic,and supportive care strategies to improve patient *** articles discussed in this editorial encompass topics such as screening,diagnosis,mechanisms of progression,and postoperative recovery in gastric and CRC,and the findings offer valuable insights for clinical decision-making in the diagnosis,treatment,and prognosis of gastrointestinal cancers.

关键词： Gastric cancer Colorectal cancer Screening Diagnosis Mechanisms of progression Postoperative recovery

A lipid droplets-targetable fluorescent probe for polarity detection in cells of iron death,inflammation and fatty liver tissue

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Chinese Chemical Letters 2024年第6期35卷 365-369页

作者： Xing Tian Di Wu Wanheng wei Guifu dai Zhanxian Li Benhua Wang Mingming Yu Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China School of Life Sciences Zhengzhou UniversityZhengzhou 450001China Shenzhen Research Institute of Central South University Shenzhen 518057China

Abnormal accumulation and metabolism of lipid droplets can lead to a variety of ***,a key parameter of the microenvironment,is closely associated with many diseases and dysfunctions in the *** is important to elucidate the relationship between the physiological activity of lipid droplets(LDs)and the polarity of the *** this work,based on push-pull mechanism,a fluorescent probe(E)-3-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one(PPTH)with aggregation-induced emission(AIE)properties for the detection of polarity changes in cells was *** not only visualize intracellular polarity fluctuation of iron death and inflammation but also distinguish between normal and fatty liver tissue.

关键词： Lipid droplets AIE Polarity Ferroptosis Fatty liver

Design, performance and application of a line-imaging velocity interferometer system for any reflector coupled with a streaked optical pyrometer system at the Shenguang-Ⅱ upgrade laser facility

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High Power Laser Science and Engineering 2024年第1期12卷 52-59页

作者： Dawei Yuan Shaojun Wang Huigang wei Haochen Gu Yu dai Jiayong Zhong Yutong Li Gang Zhao Jie Zhang Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijingChina Institute of Frontiers in Astronomy and Astrophysics of Beijing Normal University BeijingChina Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijingChina Key Laboratory for Laser Plasmas(MOE)and School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Department of Astronomy Beijing Normal UniversityBeijingChina Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghaiChina School of Physical Sciences University of Chinese Academy of SciencesBeijingChina Songshan Lake Materials Laboratory DongguanChina

The velocity interferometer system for any reflector(VISAR) coupled with a streaked optical pyrometer(SOP) system is used as a diagnostic tool in inertial confinement fusion(ICF) experiments involving equations of state and shock *** validate the process of adiabatically compressing the fuel shell through precise tuning of shocks in experimental campaigns for the double-cone ignition(DCI) scheme of ICF, a compact line-imaging VISAR with an SOP system is designed and implemented at the Shenguang-II upgrade laser facility. The temporal and spatial resolutions of the system are better than 30 ps and 7 μm, respectively. An illumination lens is used to adjust the lighting spot size matching with the target size. A polarization beam splitter and λ/4 waveplate are used to increase the transmission efficiency of our system. The VISAR and SOP work at 660 and 450 nm, respectively, to differentiate the signals from the scattered lights of the drive lasers. The VISAR can measure the shock velocity. At the same time, the SOP system can give the shock timing and relative strength. This system has been used in different DCI campaigns, where the generation and propagation processes of multi-shock are carefully diagnosed.

关键词： double-cone ignition streaked optical pyrometer velocity interferometer system for any reflector

POV-based molecular catalysts for highly efficient esterification of alcohols with aldehydes as acylating agents

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Chinese Chemical Letters 2024年第8期35卷 330-334页

作者： Zhikang Wu Guoyong dai Qi Li Zheyu wei Shi Ru Jianda Li Hongli Jia Dejin Zang Mirjana Colovic Yongge wei Key Lab of Organic Optoelectronics&Molecular Engineering of Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China Institute of Materia Medica Shandong First Medical University&Shandong Academy of Medical SciencesJi'nan 250117China University of Belgrade VincaInstitute of Nuclear Sciences-National Institute of the Republic of SerbiaDepartment of Physical ChemistryBelgrade 11351Serbia

The selective oxidative esterification of aldehydes with alcohols to the corresponding esters has been one of the hot spots in scientific research and industrial ***,the application of precious metal catalytic systems is limited by their complicated synthetic steps and high *** a highly efficient,green,recyclable selective synthesis method of esters catalyzed by polyoxovanadate(POV)-based molecu-lar catalysts has been developed in this *** results show that supramolecular interaction between POV and 1,3-dibenzylimidazolium bromide(Act_(2)Im)can efficiently convert alcohols and aldehydes to the corresponding esters in high yield under much milder *** insight is also provided based on the control experiments,single crystal X-ray diffraction and cyclic voltammetry studies.

关键词： POV Oxidation Supramolecular Esterification Catalyst

Air-Ground Collaborative Mobile Edge Computing:Architecture,Challenges,and Opportunities

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China Communications 2024年第5期21卷 1-16页

作者： Qin Zhen He Shoushuai Wang Hai Qu Yuben dai Haipeng Xiong Fei wei Zhenhua Li Hailong College of Communications Engineering Army Engineering University of PLANanjing 210000China Department of Information and Communication Noncommissioned Officer Academy of PAPHangzhou 310000China Key Laboratory of Dynamic Cognitive System of Electromagnetic Spectrum Space Ministry of Industry and Information TechnologyNanjing 211106China College of Electronic and Information Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China State Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210023China CMC Political and Law Commission Beijing100120China Xi’an Research Institute of High Technology Xi’an 710025China

By pushing computation,cache,and network control to the edge,mobile edge computing(MEC)is expected to play a leading role in fifth generation(5G)and future sixth generation(6G).Nevertheless,facing ubiquitous fast-growing computational demands,it is impossible for a single MEC paradigm to effectively support high-quality intelligent services at end user equipments(UEs).To address this issue,we propose an air-ground collaborative MEC(AGCMEC)architecture in this *** proposed AGCMEC integrates all potentially available MEC servers within air and ground in the envisioned 6G,by a variety of collaborative ways to provide computation services at their best for ***,we introduce the AGC-MEC architecture and elaborate three typical use ***,we discuss four main challenges in the AGC-MEC as well as their potential ***,we conduct a case study of collaborative service placement for AGC-MEC to validate the effectiveness of the proposed collaborative service placement ***,we highlight several potential research directions of the AGC-MEC.

关键词： air-ground architecture collaborative mobile edge computing

Genome engineering of the human gut microbiome

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Journal of Genetics and Genomics 2024年第5期51卷 479-491页

作者： Linggang Zheng Juntao Shen Ruiyue Chen Yucan Hu wei Zhao Elaine Lai-Han Leung Lei dai Dr Neher's Biophysics Laboratory for Innovative Drug Discovery/State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyTaipaMacao 999078China CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Cancer Center Faculty of Health ScienceUniversity of MacaoMacao 999078China MOE Frontiers Science Center for Precision Oncology University of MacaoMacao 999078China

The human gut microbiome,a complex ecosystem,significantly influences host health,impacting crucial aspects such as metabolism and *** enhance our comprehension and control of the molecular mechanisms orchestrating the intricate interplay between gut commensal bacteria and human health,the exploration of genome engineering for gut microbes is a promising ***,the complexities and diversities inherent in the gut microbiome pose substantial challenges to the development of effective genome engineering tools for human gut *** this comprehensive review,we provide an overview of the current progress and challenges in genome engineering of human gut commensal bacteria,whether executed in vitro or in situ.A specific focus is directed towards the advancements and prospects in cargo DNA delivery and high-throughput ***,we elucidate the immense potential of genome engineering methods to enhance our understanding of the human gut microbiome and engineer the microorganisms to enhance human health.

关键词： Non-model gut commensals Genomeediting reagents Cargo delivery High-throughput genome engineering

Bichromatically pumped artificial cnoidal wave breathers in optical microresonators

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Photonics Research 2024年第7期12卷 1464-1477页

作者： YIRAN GAO JIAN dai ZHONGHAN WU ANNI LIU TIAN ZHANG wei SUN JUNQIU LIU KUN XU State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China School of Communication Engineering Hangzhou Dianzi UniversityHangzhou 310018China International Quantum Academy Shenzhen 518048China Hefei National Laboratory University of Science and Technology of ChinaHefei 230026China

Breathers are localized structures that undergo a periodic oscillation in their duration and amplitude. Optical microresonators, benefiting from their high-quality factor, provide an ideal test bench for studying breathing phenomena. In a monochromatically pumped microresonator system, intrinsic breathing instabilities are widely observed in the form of temporal dissipative Kerr solitons which only exist in the effectively red-detuned ***, we demonstrate a novel bichromatic pumping scheme to create compulsive breathing microcombs via respectively distributing two pump lasers at the effectively blue-and red-detuned sides of a single *** experimentally discover the artificial cnoidal wave breathers and molecular crystal-like breathers in a photonic chip-based silicon nitride microresonator and theoretically describe their intriguing temporal dynamics based on the bichromatic pumping Lugiato–Lefever equation. In particular, the corresponding breathing microcombs exhibit diverse comb line spacing ranging from 2 to 17 times the free spectral range of the *** discovery not only provides a simple yet robust method to harness microcombs with reconfigurable comb line spacing but also reveals a new class of breathing waves in driven dissipative nonlinear systems.

关键词： pumped resonator pumping

Interface-induced polymerization strategy for constructing titanium dioxide embedded carbon porous framework with enhanced chemical immobilization towards lithium polysulfides

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Nano Research 2024年第3期17卷 1473-1481页

作者： Yue Ouyang Xiaoxiao Li Jiexin Zhu wei Zong Yuhang dai Xuan Gao wei Zhang Shengyuan Yang Roohollah Bagherzadeh Feili Lai Yue-E Miao Tianxi Liu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua University2999 North Renmin RoadShanghai 201620China The Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China Advanced Fibrous Materials LAB Institute for Advanced Textile Materials and Technologies(ATMT)School of Advanced Materials and ProcessesAmirkabir University of TechnologyTehran 15914Iran Christopher Ingold Laboratory Department of ChemistryUniversity College London20 Gordon StreetLondon WC1H 0AJUK Department of Chemistry KU LeuvenCelestijnenlaan 200FLeuven 3001Belgium

The shuttle effect induced by soluble lithium polysulfides(LiPSs)is known as one of the crucial issues that limit the practical applications of lithium-sulfur(Li-S)***,a titanium dioxide nanoparticle embedded in nitrogen-doped porous carbon nanofiber(TiO_(2)@NCNF)composite is constructed via an interface-induced polymerization strategy to serve as an ideal sulfur *** the protection of the nanofiber walls,the uniformly dispersed TiO_(2) nanocrystalline can act as capturing centers to constantly immobilize LiPSs towards durable sulfur ***,the mesoporous microstructure in the fibrous framework endows the TiO_(2)@NCNF host with strong physical reservation for sulfur and LiPSs,sufficient pathways for electron/ion transfer,and excellent endurance for volume *** expected,the sulfur-loaded TiO_(2)@NCNF composite electrode presents a fabulous rate performance and long cycle lifespan(capacity fading rate of 0.062%per cycle over 500 cycles)at 2.0 ***,the assembled Li-S batteries harvest superb areal capacity and cycling stability even under high sulfur loading and lean electrolyte conditions.

关键词： interface-induced polymerization electrospun porous nanofibers lithium-sulfur(Li-S)batteries high sulfur loading lithium polysulfides(LiPSs)immobilization