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Expression of interleukin-32 in bone marrow of patients with myeloma and its prognostic significance

World Journal of Clinical Cases 2019年第24期7卷 4234-4244页

作者： Gang Wang fang-ying ning Jia-Heng Wang Hai-Meng Yan Hong-Wei Kong Yu-Ting Zhang Qiang Shen Department of Hematology Quzhou People’s HospitalQuzhou 324000Zhejiang ProvinceChina Department of Hematology People’s Hospital of Hangzhou Medical CollegeZhejiang Provincial People’s HospitalHangzhou 310000Zhejiang ProvinceChina Bone Marrow Transplantation Center The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Adicon Clinical Laboratories Inc. Hangzhou 310023Zhejiang ProvinceChina

BACKGROUND The guiding effect of prognostic stratification in multiple myeloma(MM) for treatment has been increasingly emphasized in recent years. The stratification of risk factors based on the International Staging System(ISS), Durie-Salmon(DS)staging and related indicators is affected by the renal function of patients,resulting in poor performance. This study assesses the relationship between interleukin-32(IL-32) and related risk factors in 67 patients with MM and their clinical *** To investigate the feasibility of IL-32 in evaluating prognosis in patients with MM and the factors influencing *** This was a pragmatic, prospective observational study of patients with MM at a single center. According to IL-32 level, patients were divided into two *** variables under consideration included age, blood β2-microglobulin,albumin, C-reactive protein, serum calcium, serum creatinine, lactate dehydrogenase, M protein type, ISS stage, DS stage, and IL-32 levels and minimal residual disease(MRD) after induction treatment. The main outcomes were progression-free survival(PFS) and overall survival(OS).RESULTS IL-32 was an important factor affecting PFS and OS in patients with *** with patients with IL-32 levels ≥ 856.4 pg/m L, patients with IL-32 levels < 856.4 pg/m L had longer PFS(P = 0.0387) and OS(P = 0.0379);Univariate analysis showed that IL-32 level and MRD were significantly associated with OS and PFS(P < 0.05). Multivariate analysis showed that IL-32 levels ≥ 856.4 pg/m L and MRD positive were still independent risk factors for OS and PFS(P < 0.05).CONCLUSION IL-32 is valuable for assessing the prognosis of MM patients. IL-32 level combined with MRD may be a useful routine evaluation index for MM patients after treatment.

关键词： Multiple myeloma Interleukin-32 Minimal residual lesions Progression-free survival Overall survival Prognosis

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Impacts of the annual cycle of background SST in the tropical Pacific on the phase and amplitude of ENSO

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 12-17页

作者： Song Jiang Congwen Zhu ning Jiang State Key Laboratory of Severe Weather(LASW) Chinese Academy of Meteorological SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

The dominant annual cycle of sea surface temperature(SST)in the tropical Pacific exhibits an antisymmetric mode,which explains 83.4%total variance,and serves as a background of El Niño-Southern Oscillation(ENSO).However,there is no consensus yet on its anomalous impacts on the phase and amplitude of *** on data during 1982-2022,results show that anomalies of the antisymmetric mode can affect the evolution of ENSO on the interannual scale via Bjerknes feedback,in which the positive(negative)phase of the antisymmetric mode can strengthen El Niño(La Niña)in boreal winter via an earlier(delayed)seasonal cycle transition and larger(smaller)annual *** magnitude of the SST anomalies in the equatorial eastern Pacific can reach more than±0.3◦C,regulated by the changes in the antisymmetric mode based on random sensitivity *** reveal the spatial pattern of the annual cycle associated with the seasonal phase-locking of ENSO evolution and provide new insight into the impact of the annual cycle of background SST on ENSO,which possibly carries important implications for forecasting ENSO.

关键词： Annual cycle SST anomaly Antisymmetric mode ENSO

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A breakthrough of printable mesoscopic perovskite solar cells

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Science China Materials 2025年第1期 307-308页

作者： Zhiyi Yao Zhijun ning School of Physical Science and Technology Shanghai Tech University

High-performance solar cells based on low-cost wet coating methods are the much-anticipated technology for the next generation of photovoltaics. Perovskite solar cells (PSCs) provide a fascinating choice because their...

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The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing ning Shi Lv Qian Wang Yuzhen Xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

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Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En ning Chang Liu Yu-Chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

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Bioinspired Ultrasensitive Flexible Strain Sensors for Real-Time Wireless Detection of Liquid Leakage

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NANO-MICRO LETTERS 2025年第1期17卷 1-18页

作者： Zhou, Weilong Du, Yu Chen, yingying Zhang, Congyuan ning, Xiaowei Xie, Heng Wu, Ting Hu, Jinlian Qu, Jinping Huazhong Univ Sci & Technol Sch Chem & Chem Engn Key Lab Mat Chem Energy Convers & Storage Minist EducHubei Key Lab Mat Chem & Serv Failure Wuhan 430074 Peoples R China Huazhong Univ Sci & Technol Hubei Engn Res Ctr Biomat & Med Protect Mat Sch Chem & Chem Engn Wuhan 430074 Peoples R China Wuhan Inst Technol Sch Mat Sci & Engn Wuhan 430205 Peoples R China City Univ Hong Kong Dept Biomed Engn Hong Kong 999077 Peoples R China

Micro-extrusion compression molding and surface modification were proposed for the mass fabrication of a superhydrophobic thermoplastic polyurethane sensor (TCGS).Inspired by scorpions, TCGS features Archimedean spiral crack arrays and micropores, achieving 218.13 sensitivity at 2% strain, a 4300% increase, and over 5000 usage cycles of *** robust superhydrophobicity of TCGS improves sensitivity and stability for detecting small-scale liquid leakage, allowing precise monitoring across various sizes and compositions while providing early warnings in various scenarios. Liquid leakage of pipeline networks not only results in considerable resource wastage but also leads to environmental pollution and ecological imbalance. In response to this global issue, a bioinspired superhydrophobic thermoplastic polyurethane/carbon nanotubes/graphene nanosheets flexible strain sensor (TCGS) has been developed using a combination of micro-extrusion compression molding and surface modification for real-time wireless detection of liquid leakage. The TCGS utilizes the synergistic effects of Archimedean spiral crack arrays and micropores, which are inspired by the remarkable sensory capabilities of scorpions. This design achieves a sensitivity of 218.13 at a strain of 2%, which is an increase of 4300%. Additionally, it demonstrates exceptional durability by withstanding over 5000 usage cycles. The robust superhydrophobicity of the TCGS significantly enhances sensitivity and stability in detecting small-scale liquid leakage, enabling precise monitoring of liquid leakage across a wide range of sizes, velocities, and compositions while issuing prompt alerts. This provides critical early warnings for both industrial pipelines and potential liquid leakage scenarios in everyday life. The development and utilization of bioinspired ultrasensitive flexible strain sensors offer an innovative and effective solution for the early wireless detection of liquid leakage.

关键词： Thermoplastic polyurethane Bioinspired Cracks Liquid leakage Flexible strain sensor

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长链非编码RNA在儿童脓毒症中表达的初步研究

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中国小儿急救医学 2018年第5期25卷 356-361页

作者：张芳王莹宁铂涛李璧如钱娟任宏张建项龙上海交通大学医学院附属上海儿童医学中心重症医学科 200127

目的探讨长链非编码RNA（long non-coding RNA，lncRNA）在脓毒症患儿的表达及临床应用价值。方法2014年1月至2014年7月收集上海交通大学医学院附属上海儿童医学中心重症医学科的15例一般脓毒症患儿、7例脓毒性休克患儿及21例儿童保健... 详细信息

目的探讨长链非编码RNA（long non-coding RNA，lncRNA）在脓毒症患儿的表达及临床应用价值。方法2014年1月至2014年7月收集上海交通大学医学院附属上海儿童医学中心重症医学科的15例一般脓毒症患儿、7例脓毒性休克患儿及21例儿童保健科健康体检儿童（健康对照组）的外周血标本。通过实时定量聚合酶链式反应（real time-polymerase chain reaction，RT-PCR）方法检测核因子-κB通路中，与脓毒症密切相关的9个lncRNA（AK092960、LOC100192426、VHDJH、AC006230.3、AC019097.7、RP4-652L8.2、RP11-108A15.2、NKILA及AK023660）的表达情况。并进一步分析一般脓毒症组、脓毒性休克组及健康对照组患儿lncRNA表达量的差异，比较lncRNA与C-反应蛋白、降钙素原、WBC诊断脓毒症和脓毒性休克的特异性和敏感性。结果VHDJH、AC019097.7、RP4-652L8.2、RP11-108A15.2、NKILA及AK023660在脓毒症组表达较健康对照组明显升高，差异有统计学意义（P〈0.01）。其中，VHDJH、AC019097.7、RP4-652L8.2、NKILA及AK023660在脓毒性休克患儿表达量较一般脓毒症组高，差异有统计学意义（P〈0.01）。虽然VHDJH、AC019097.7、RP4-652L8.2、NKILA、AK023660诊断脓毒性休克与脓毒症的特异性及敏感性均高于C-反应蛋白、降钙素原、WBC，但差异无统计学意义（P〉0.05）。结论lncRNA中的VHDJH、AC019097.7、RP4-652L8.2、RP11-108A15.2、NKILA、AK023660可作为诊断脓毒症的潜在标记物，并可能与脓毒症的严重程度相关。

关键词：脓毒症休克长链非编码RNA 儿童

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Influence of Tempering Process on Mechanical Properties of 00Cr13Ni4Mo Supermartensitic Stainless Steel

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Journal of Iron and Steel Research International 2010年第8期17卷 50-54页

作者： ZOU De-ning HAN ying ZHANG Wei fang Xu-dong School of Metallurgy and Engineering Xi'an University of Architecture and TechnologyXi'an 710055ShaanxiChina State Key Laboratory of Advanced Stainless Steel Materials Taiyuan 030003ShanxiChina

To investigate the influence of tempering process on microstructural evolutions and mechanical properties of 00Cr13Ni4Mo supermartensitic stainless steel（SMSS）,specimens were tempered in the temperature range of 520-720 ℃ for 3 h followed by air cooling and an optimized tempering temperature was chosen to prolong holding time from 3 to 12 *** heat treatments,microstructure examination was conducted by scanning electron microscope,X-ray diffraction examinations,hardness measurements and tensile *** results revealed that the superior mechanical properties were achieved by quenching at 1040 ℃ for 1 h＋water cooling and tempering at 600 ℃ for 3 h＋air *** isothermal tempering time could improve the toughness *** was believed that the property was correlated with the microstructure of tempered lath martensite and retained *** retained austenite content is beneficial to the higher toughness of the SMSS.

关键词： supermartensitic stainless steel tempering mechanical property retained austenite

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Numerical Investigations on Hydrodynamic Performance of An Open Comb-Type Breakwater Under Medium Water Levels

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China Ocean Engineering 2021年第6期35卷 866-877页

作者： fang Zhuo CHENG Liang ZANG Zhi-peng SHEN Chen TIAN ying-hui CHENG ning Transport planning and Research Institute Ministry of TransportBeijing 100028China Laboratory for Traffic and Transport Planning Digitalization Beijing 100028China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116023China State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China Melbourne School of Engineering The University of MelbourneParkvilleVIC 3010Australia China Harbor Engineering Company Limited Beijing 100027China

The comb-type breakwater(CTB)has been proposed and investigated in recent years due to its advantages in terms of deep-water adaptability,material saving and water *** existing empirical formulae for CTBs have been so far restricted to the water level above the bottom of the superstructure,which mainly occurs under the high tides or storm ***,based on recent engineering applications and experimental observations,the most severe conditions for CTBs are more likely to occur under a medium water level,because impulsive wave pressure may occur due to interactions between waves and the special chamber in ***,during the most of construction and operation periods,the CTBs are mainly working under the medium water levels,i.e.,water levels below the bottom of the *** this study,the effects of main influence parameters on the horizontal wave force coefficient and wave transmission coefficient for open CTBs(with partially immersed side plates)under medium water levels were investigated based on a 3D numerical wave flume and corresponding empirical formulae were *** is indicated that the location of the side plate related to the main caisson has significant influence on the hydrodynamic performance of *** engineering applications,the location of the side plate can be designed at b/L≤0.15 or b/L≥0.3(where b is the distance between the side plate and the front face of the main caisson and L is the incident wave length)for efficiently lowering the horizontal wave force and wave *** flow mechanism of impulsive wave force on CTBs was revealed based on synchronous analyses of flow fields and pressure *** appropriate design of the height of the superstructure according to H/hD≤1.0 or H/hD≥1.5(where H is the incident wave height and hD is the distance between the still water level and the bottom of the superstructure),the likely impulsive wave pressure on the side plate can also be diminished.

关键词： numerical wave flume open comb-type breakwater horizontal wave force coefficient transmission coefficient medium water level

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Integrated Au-Nanoroded Biosensing and Regulating Platform for Photothermal Therapy of Bradyarrhythmia

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Research 2022年第3期2022卷 31-44页

作者： Jiaru fang Dong Liu Dongxin Xu Qianni Wu Hongbo Li ying Li ning Hu State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and TechnologySchool of Electronics and Information TechnologyState Key Laboratory of OphthalmologyZhongshan Ophthalmic CenterGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceSun Yatsen UniversityGuangzhou 510006China Stoddart Institute of Molecular Science Department of ChemistryZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 310058China Molecular Cancer Research Center School of MedicineSun Yat-sen UniversityShenzhen 518107China State Key Laboratory of Transducer Technology Chinese Academy of SciencesShanghai 200050China

Bradyarrhythmia is a kind of cardiovascular disease caused by dysregulation of cardiomyocytes,which seriously threatens human ***,treatment strategies of bradyarrhythmia mainly include drug therapy,surgery,or implantable cardioverter defibrillators,but these strategies are limited by drug side effect,surgical trauma,and instability of implanted ***,we developed an integrated Au-nanoroded biosensing and regulating platform to investigate the photothermal therapy of cardiac bradyarrhythmia in ***-nanoroded electrode array can simultaneously accumulate energy from the photothermal regulation and monitor the electrophsiological state to restore normal rhythm of cardiomyocytes in real *** treat the cardiomyocytes cultured on Au-nanoroded device by near-infrared(NIR)laser irradiation,cardiomyocytes return to normal for long term after irradiation of suitable NIR energy and *** with the conventional strategies,the photothermal strategy is more effective and convenient to regulate the ***,mRNA sequencing shows that the differential expression genes in cardiomyocytes are significantly increased after photothermal strategy,which are involved in the regulation of the heart rate,cardiac conduction,and ion *** work establishes a promising integrated biosensing and regulating platform for photothermal therapy of bradyarrhythmia in vitro and provides reliable evidence of photothermal regulation on cardiomyocytes for cardiological clinical studies.

关键词： arrhythmia return conduction

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