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Derivation of Plastic Specific Work Rate for Equal Area Yield Criterion and Its Application to Rolling

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Journal of Iron and Steel Research International 2010年第4期17卷 34-38页

作者： ZHAO De-wen fang qi li Can-ming liU Xiang-hua WANG Guo-dong State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

On the basis of the analysis of the hexagons inscribed and circumscribed of the Mises yield circle on the π- plane in Haigh Westergaard stress space, a new equation called equal area linear yield criterion or EA criterion was proposed, and its plastic specific work rate was derived. Then, a generalized worked example of plate rolling was analyzed by the criterion and its corresponding plastic specific work rate. Finally, the precision of the solution was compared with measured roll separation force in plate finish rolling process. It indicates that the calculated results by EA criterion are slightly higher than the measured ones.

关键词： EA yield criterion specific work rate finish rolling analytical solution

The first catalytic asymmetric addition of diethylzinc to aldehyde promoted by chiral thiourea

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Chinese Chemical Letters 2011年第11期22卷 1265-1268页

作者： Zhi Guo qiao Tian Hua Shen Zhen fang Fu Jun qi li Hong Wang qing Bao Song The State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology College of Chemical Engineering and Materials Science Zhejiang University of Technology Hangzhou 310032 China

A series of C_2-symmetric and asymmetric chiral thiourea derivatives were synthesized from commercial *** of the new compounds have been fully characterized by IR,~1H NMR,^（13）C NMR,MS spectra and elemental *** chiral thioureas were used as chiral ligands in the catalytic enantioselective ethylation of aldehydes with diethylzinc,the corresponding sec-alcohols were gained with excellent enantioselectivities（up to 87.1%ee） and high yields（up to 76.7%） after the conditions were optimized.

关键词： Chiral thiourea Diethylzinc Amino alcohol C_2-symmetric Enantioselective addition

High Incidence of Venous Thromboembolism Due to Immune Checkpoint Inhibitors:an Immunotherapy-related Toxicity

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Journal of Nutritional Oncology 2021年第3期6卷 101-108页

作者： fang qi li Jiu Wei Cui Cancer Center The First Hospital of Jilin UniversityChangchun130021China

The incidence of venous thromboembolism(VTE)in cancer patients is 4-7 times higher than that in the general *** is a common complication in clinical practice,and is the second leading cause of death in cancer patients,severely affects the prognosis of cancer *** chemotherapy can result in higher incidence of VTE in cancer patients,a new class of treatments,immune checkpoint inhibitors(ICIs),can reduce the immune escape of tumors and have greatly improved patient survival,become a hot issue at ***,recent reports of high rate of VTE have raised concerns about these agents,suggests that VTE was a new type of toxicity associated with these *** order to make a preliminary exploration,we analyzed the results of 14 retrospective studies and two phaseⅡclinical trials,and herein discuss the incidence of VTE in patients receiving ICIs,as well as the postulated mechanisms and risk factors for *** also analyzed the effects of these VTE on the prognosis of patients receiving ICIs and evaluated the predictive value of the Khorana score to evaluate the adverse reaction to ICIs.

关键词： Cancer Venous thromboembolism Immunotherapy Immune checkpoint inhibitors Mortality Khorana

Transforming Growth Factor-β1 Induces Transdifferentiation of Fibroblasts into Myofibroblasts in Hyp0Xic Pulmonary Vascular Remodeling

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Acta Biochimica et Biophysica Sinica 2006年第1期38卷 29-36页

作者： Yong-liang JIANG Ai-Guo DAI qi-fang li Rui-Cheng HU Department of Respiratory Medicine,Hunan Institute of Gerontology,Hunan Province Geriatric Hospital,Changsha 410001,China Department of Respiratory Medicine Hunan Institute of Gerontology Hunan Province Geriatric Hospital Changsha 410001 China

The muscularization of non-muscular pulmonary arterioles is an important pathological featureof hypoxic pulmonary vascular ***,the origin of the cells involved in this process is stillnot well *** present study was undertaken to test the hypothesis that transforming growthfactor-β1 (TGF-β1) can induce transdifferentiation of fibroblasts into myofibroblasts,which might play akey role in the muscularization of non-muscular pulmonary *** was found that mean pulmonaryarterial pressure increased significantly after 7 d of *** artery remodeling index and rightventricular hypertrophy became evident after 14 d of *** distribution of nonmuscular,partiallymuscular,and muscular vessels was significantly different after 7 d of *** demonstrated that the expression of co-smooth muscle actin was increased in intra-acinar pulmonaryarteries with increasing hypoxic ***-β1 mRNA expression in pulmonary arterial walls was increasedsignificantly after 14 d of hypoxia,but showed no obvious changes after 3 or 7 d of *** pulmonarytunica adventitia and tunica media,TGF-β1 protein staining was poorly positive in control rats,but wasmarkedly enhanced after 3 d of hypoxia,reaching its peak after 7 d Of *** myofibroblast phenotypewas confirmed by electron microscopy,which revealed microfilaments and a well-developed rough endo-plasmic *** together,our results suggested that TGF-β1 induces transdifferentiation of fibro-blasts into myofibroblasts,which is important in hypoxic pulmonary vascular remodeling.

关键词： transforming growth factor-β1 fibroblast myofibroblast hypertension lung

Study on static characteristics of a novel prestress-reinforced railway subgrade

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RAILWAY ENGINEERING SCIENCE 2025年第1期33卷 108-126页

作者： Dong, Junli Xu, fang Zhang, qishu Leng, Wuming li, Yafeng Yang, qi Cent South Univ Sch Civil Engn Changsha 410075 Peoples R China Cent South Univ MOE Key Lab Engn Struct Heavy Haul Railway Changsha 410075 Peoples R China Cent South Univ Forestry & Technol Sch Civil Engn Changsha 410004 Peoples R China Anhui Univ Sci & Technol Sch Civil Engn & Architecture Huainan 232001 Peoples R China

Understanding the reinforcement effect of the newly developed prestressed reinforcement components (PRCs) (a system composed of prestressed steel bars (PSBs), protective sleeves, lateral pressure plates (LPPs), and anchoring elements) is technically significant for the rational design of prestressed subgrade. A three-dimensional finite element model was established and verified based on a novel static model test and utilized to systematically analyze the influence of prestress levels and reinforcement modes on the reinforcement effect of the subgrade. The results show that the PRCs provide additional confining pressure to the subgrade through the diffusion effect of the prestress, which can therefore effectively improve the service performance of the subgrade. Compared to the unreinforced conventional subgrades, the settlements of prestress-reinforced subgrades are reduced. The settlement attenuation rate (Rs) near the LPPs is larger than that at the subgrade center, and increasing the prestress positively contributes to the stability of the subgrade structure. In the multi-row reinforcement mode, the reinforcement effect of PRCs can extend from the reinforced area to the unreinforced area. In addition, as the horizontal distance from the LPPs increases, the additional confining pressure converted by the PSBs and LPPs gradually diminishes when spreading to the core load bearing area of the subgrade, resulting in a decrease in the Rs. Under the single-row reinforcement mode, PRCs can be strategically arranged according to the local areas where subgrade defects readily occurred or observed, to obtain the desired reinforcement effect. Moreover, excessive prestress should not be applied near the subgrade shoulder line to avoid the shear failure of the subgrade shoulder. PRCs can be flexibly used for preventing and treating various subgrade defects of newly constructed or existing railway lines, achieving targeted and classified prevention, and effectively improving the

关键词： Prestressed subgrade Static characteristic Reinforcement effect Reinforcement mode Settlement Numerical simulation

Bone marrow mesenchymal stem cell-derived exosomal microRNAs target PI3K/Akt signaling pathway to promote the activation of fibroblasts

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World Journal of Stem Cells 2023年第4期15卷 248-267页

作者： fang-qi li Wen-Bo Chen Zhi-Wen Luo Yi-Sheng Chen Ya-Ying Sun Xiao-Ping Su Jun-Ming Sun Shi-Yi Chen Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Laboratory Animal Center Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Fibroblast plays a major role in tendon-bone *** derived from bone marrow mesenchymal stem cells(BMSCs)can activate fibroblasts and promote tendon-bone healing via the contained microRNAs(miRNAs).However,the underlying mechanism is not comprehensively ***,this study aimed to identify overlapped BMSC-derived exosomal miRNAs in three GSE datasets,and to verify their effects as well as mechanisms on *** To identify overlapped BMSC-derived exosomal miRNAs in three GSE datasets and verify their effects as well as mechanisms on *** BMSC-derived exosomal miRNAs data(GSE71241,GSE153752,and GSE85341)were downloaded from the Gene Expression Omnibus(GEO)*** candidate miRNAs were obtained by the intersection of three data *** was used to predict potential target genes for the candidate *** and pathway analyses were conducted using the Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)databases,respectively,by processing data with the *** interconnected genes in the protein-protein interaction(PPI)network were analyzed using Cytoscape ***,wound healing assay,collagen contraction assay and the expression of COL I andα-smooth muscle actin positive were applied to investigate the cell proliferation,migration and collagen *** real-time reverse transcription polymerase chain reaction was applied to determine the cell fibroblastic,tenogenic,and chondrogenic *** Bioinformatics analyses found two BMSC-derived exosomal miRNAs,has-miR-144-3p and hasmiR-23b-3p,were overlapped in three GSE *** network analysis and functional enrichment analyses in the GO and KEGG databases indicated that both miRNAs regulated the PI3K/Akt signaling pathway by targeting phosphatase and tensin homolog(PTEN).In vitro experiments confirmed that miR-144-3p and miR-23b-3p stimulated proliferation,migration and collagen sy

关键词： Exosome MicroRNA Fibroblast Mesenchymal stem cell Tendon-bone healing

SPEP： Security Protocol to Enhance Privacy in Pervasive Computing

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通讯和计算机（中英文版） 2007年第1期4卷 27-34页

作者： YANG Fan PU fang CAO qi-ying li Tong Department of Computer Science and Technology Donghua University Shanghai 201620 China

Upper Bounds on the Multicolor Ramsey Numbers r_(k)(C_(4))

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Acta Mathematicae Applicatae Sinica 2025年第1期41卷 286-294页

作者： Tian-yu li qi-zhong liN Center for Discrete Mathematics Fuzhou UniversityFuzhou 350108China

The multicolor Ramsey number r_(k)(C_(4))is the smallest integer N such that any k-edge coloring of KN contains a monochromatic C_(4).The current best upper bound of r_(k)(C_(4))was obtained by Chung(1974)and independently by Irving(1974),i.e.,r_(k)(C_(4))≤k^(2)+k+1 for all k≥*** is no progress on the upper bound since *** this paper,we improve the upper bound of r_(k)(C_(4))by showing that r_(k)(C_(4))≤k^(2)+k-1 for even k≥*** improvement is based on the upper bound of the Turan number ex(n,C4),in which we mainly use the double counting method and many novel ideas from Firke,Kosek,Nash,and Williford[***,Ser.B 103(2013),327-336].

关键词： Multicolor Ramsey number Turan number 4-cycle

Reveal short range interactions between u/d quarks in the NN, D03, and D30 systems

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Science China(Physics,Mechanics & Astronomy) 2025年第3期Mechanics & Astronomy) .卷 106-115页

作者： qi-fang Lü Yu-Bing Dong Peng-Nian Shen Zong-Ye Zhang Department of Physics Hunan Normal University Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Key Laboratory for Matter Microstructure and Function of Hunan Province Hunan Normal University Institute of High Energy Physics Chinese Academy of Sciences School of Physical Sciences University of Chinese Academy of Sciences

The dynamic mechanism of short range interactions between u/d quarks remains an open and challenging problem. In order to reveal this quark dynamics, we perform a systematic analysis of N N, D03, and D30systems in the（extended） chiral SU（3） constituent quark models. By comparing results calculated with different models and different parameter sets, the effects of one gluon exchange and vector meson exchange terms are carefully examined. The results indicate that the vector meson exchange interactions dominate the short range interactions between u/d quarks, whereas the small residual one gluon exchange coupling strength is also allowed.

关键词： short range interactions dibaryons constituent quark models