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Effects of urotensin-Ⅱ on cytokines in early acute liver failure in mice

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World Journal of Gastroenterology 2015年第11期21卷 3239-3244页

作者： Liang-Ming Liu Liang Zhao Dong-yu Liang fang-ping yu Chang-Gen Ye Wen-Juan Tu Tong Zhu Department of Hepatology Songjiang Hospital Affiliated to the First People’s HospitalShanghai Jiaotong University

AIM:To investigate urotensin-Ⅱ(UⅡ) and its effects on tumor necrosis factor(TNF)-α and interleukin(IL)-1β in early acute liver failure(ALF).METHODS:We investigated the time-dependent alteration in UⅡ levels and its effects on TNF-αand IL-1β in liver and blood in the early stage of lipopolysaccharide/D-galactosamine-induced ***:After lipopolysaccharide/D-galactosamine challenge,UⅡ rose very rapidly and reached a maximal level 0.5 h,and the level remained significantly elevated after 2 h(P < 0.05).Six hours after challenge,UⅡ began to degrade,but remained higher than at 0 h(P < 0.05).Pretreatment with urantide,an inhibitor of the UⅡ receptor,suppressed the degree of UⅡ increase in liver and blood at 6 h after challenge(P < 0.05 vs paired controls).In addition,liver and blood TNF-α increased from 1 to 6 h,and reached a peak at 1 and 2 h,respectively; however,IL-1β did not rise until 6 h after *** pretreatment inhibited the degree of TNF-α and IL-1β increase following downregulation of UⅡ post-challenge(all P < 0.05).CONCLUSION:UⅡ plays a role in the pathogenesis and priming of ALF by triggering an inflammatory cascade and driving the early release of cytokines in mice.

关键词： Acute hepatic failure Interleukin-1β Mouse Tumor n

A new cause of snapping scapula and its arthroscopic treatment

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Chinese Medical Journal 2012年第22期125卷 4149-4151页

作者： LIU yu-lei CUI Guo-qing AO Ying-fang YANG yu-ping ZHENG Zhuo-zhao Peking Univ Inst Sports Med Hosp 3 Beijing 100191 Peoples R China Peking Univ Dept Radiol Hosp 3 Beijing 100191 Peoples R China

Snapping scapula is an uncommon condition described as palpable, audible, or painful crepitus of the scapula that causes diminished quality of life.l Until now it is still a largely under-recognized problem because of its diverse causes. The etiology of the problem is mainly divided into three major categories： bursitis, muscle abnormality, and bony or soft-tissue abnormality.

关键词： shoulder scapula rhomboideus muscle arthroscopy debridement

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan ping yu Emily Choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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三电极系统处理含藻水

环境工程学报 2017年第2期11卷 793-797页

作者：向平方宇张亚晴重庆大学三峡库区生态环境教育部重点实验室重庆400045

以铝、掺硼金刚石为阳极,不锈钢为阴极构建三电极系统处理含藻水,考察了电流密度、通电时间、沉降时间、初始pH、极板间距对处理效果的影响。结果表明,各因素对藻的去除率的影响顺序为:电流密度>通电时间>沉降时间>初始pH>极板间距,而... 详细信息

以铝、掺硼金刚石为阳极,不锈钢为阴极构建三电极系统处理含藻水,考察了电流密度、通电时间、沉降时间、初始pH、极板间距对处理效果的影响。结果表明,各因素对藻的去除率的影响顺序为:电流密度>通电时间>沉降时间>初始pH>极板间距,而且电流密度2 m A·cm^(-2),通电时间为30 min,沉降时间为15 min,pH=6,极板间距取1.0 cm为实验的最优工况点。

关键词：电化学铜绿微囊藻铝掺硼金刚石三电极系统

SYNTHESIS OF 3-BUTYLIDENE-5-HYDROXYPHTHALIDE

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Chinese Chemical Letters 1993年第4期4卷 295-296页

作者： Shao Bai LI Zhi Wei WANG Xiao ping fang yu Lin LI State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry,Lanzhou University,Lanzhou 730000

3-Butylidene-5-hydroxyphthalide(1)was prepared from 4-hydroxy- benzoic acid(2).

关键词： ppm HNMR cm IR SYNTHESIS OF 3-BUTYLIDENE-5-HYDROXYPHTHALIDE TMEDA HRMS OCH

QTLs for Rice Leaf Chlorophyll Content Under Low N Stress

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Pedosphere 2004年第2期14卷 145-150页

作者： fangping yuXiao-Min ZHURi-Qing WUping CollegeofEnvironmentalandResourceSciences ZhejiangUniversityHangzhou310029（China）.E-mail：pfang@*** CollegeofLifeSciences ZhejiangUniversityHangzhou310029（China）

Quantitative trait loci (QTLs) for chlorophyll content of a rice leaf weremapped on to the molecular marker linkage map of a double-haploid (DH) population derived from across between two rice varieties 'IR64' and 'Azucena' in both nutrient solutionand soil cultureexperiments to detect rice nitrogen nutrition status under low N stress A chlorophyll meter was usedto measure the soil plant analysis development (SPAD) value of the topmost fully expanded leaf asthe index of chlorophyll content thatexpressed nitrogen status in rice plants. Totally 3 QTLs forSPAD values, two on chromosome 3 located at interval RG179-CDO337 and RG348-RZ329, respectively, andone on chromosome 10 at interval RZ500-RG134, were detected under stressed conditions of low N inthe soil and/or nutrient solution culture experiments. One QTL located at interval RG179-GDO337 onchromosome 3 associated with a relative change in SPAD value from a high N level to a low N level inthe soil culture experiment was also *** on the different responses to low N stressbetween the two parents, it was supposed that the QTLs identified in this study associated withnitrogen efficiency in rice at low N levels might be useful in applying marker technology to ricebreeding programs.

关键词： chlorophyll meter nitrogen efficiency QTLs rice (Oryza sativa L.) SPADvalue

Activated microglia are implicated in cognitive deficits,brain damage as well as recovery after intermittent ethanol exposure

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Activated microglia are implicated in cognitive deficits,bra...

大中型高桩码头不同类型桩基结构的应用与分析

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ya-Nan ZHAO,fang WANG,Yan-Xia FAN,Guan-fang ping,yu ZHOU,Jing-yu YANG~*,Chun-Fu WU~* Department of Pharmacology,Shenyang Pharmaceutical University,Shenyang 110016,China

＜正＞Objective Microglia are the primary immune effector cells in the brain and play a pivotal role in the neuroinflammatory processes,a critical component in several neurodegenerative *** abuse has been considered as one of the commonly substrates of neurodegeneration although the causative factors are poorly ***,we investigated whether activated microglia was implicated in neurodegeneration and cognitive dysfunctions in adult rats after long-term alcohol *** Rats were given orally a priming dose of 5 g/kg ethanol and 3 g/kg additionally every 8 h for 4 consecutive days,followed by a 3-day ethanol-withdrawal period, which was repeated four times to simulate the binge drinking of human *** activation and neuronal death in brain were detected by immunohistochemistry and Fluoro-Jade B staining,respectively,on days 0,4,7 and 14 post-ethanol ***,learning and memory abilities were assessed by novel object recognition and Y maze test on days 4,7 and *** The results showed that microglia activation was obvious in the cortex and hippocampus,which accompanied by neuronal ***,learning and memory abilities were also declined on day 4 post-ethanol ***,the hypertrophied microglia disappeared and the ramified microglia proliferation was observed on day 4 up to 14 after the abstinence from ethanol,along with the gradual recovery of neuronal damage and cognitive *** Thus the present study indicated that activated microglia are involved in neurodegeneration and cognitive dysfunctions induced by intermittent ethanol exposure,and neurotrophic microglia likely contribute to the recovery during abstinence.

关键词： intermittently binge neuroinflammation neuronal damage learning and memory

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水运工程 2009年第7期 87-92页

作者：方育平何文钦中交第四航务工程勘察设计院有限公司广东广州510230

基于若干高桩码头工程实践经验,结合国内高桩码头发展趋势,就大中型高桩码头工程应用较多的钢管桩、大管桩和PHC桩等桩基型式,根据工程实例进行桩基结构的技术和特点分析。

关键词：高桩码头桩基结构钢管桩大管桩 PHC桩

Advances in the Development of Gradient Scaffolds Made of Nano‑Micromaterials for Musculoskeletal Tissue Regeneration

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Nano-Micro Letters 2025年第3期17卷 455-500页

作者： Lei fang Xiaoqi Lin Ruian Xu Lu Liu yu Zhang Feng Tian Jiao Jiao Li Jiajia Xue Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneySydneyNSW 2007Australia

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered *** has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic *** on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the *** latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are ***,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration